scholarly journals Energy balance and macronutrient distribution in relation to C-reactive protein and HbA1c levels among patients with type 2 diabetes

2016 ◽  
Vol 60 (1) ◽  
pp. 29904 ◽  
Author(s):  
Hiba Bawadi ◽  
Rami Katkhouda ◽  
Ahmad Al-Haifi ◽  
Reema Tayyem ◽  
Cosette Fakih Elkhoury ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Energy Balance ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Macronutrient Distribution ◽  
Hba1c Levels

RELATIONSHIP BETWEEN HBA1C LEVELS AND INFLAMMATORY BIOMARKERS (C - REACTIVE PROTEIN, IL6 AND TNF-ALPHA) AMONG TYPE 2 DIABETES MELLITUS-KHARTOUM- SUDAN

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Maha Ali Omer ◽  
Abdalla E Ali
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Inflammatory Biomarkers ◽  
Tnf Alpha ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tnf Α ◽  
Hba1c Levels

Introduction: World most prevalence disease, is diabetes mellitus, with countless causes, it on increasing, genetic, lifestyle, infections could all be contributors as causative agents especially type 2 diabetes mellitus, increase inflammatory biomarkers plays extremely critical and vital role in progression of type 2 diabetes mellitus. So this study aimed to assess glycated hemoglobin levels and inflammatory biomarkers among T2DM and find such correlation and compare data with healthy control. Method: Cross-sectional case control study among 100 case group T2DM and 100 healthy subjects as control group, HbA1c and inflammatory biomarkers, C-reactive protein, IL6 and TNF-alpha were measured for study groups. Enzyme linked immunoassay (ELISA) used for measurement of inflammatory biomarkers TNF-α, CRP, IL6 and Cystatin C. while HbA1c assessed by ichroma device. Result:  HbA1c, C-reactive protein, IL6 and TNF-alpha were increased among T2DM patients than healthy subjects, giving increased significant difference for each, as p value <0.05. Pearson’s correlation of HbA1c with each of measured parameters showed that HbA1c has positive correlation with inflammatory biomarkers TNF-α. (R= 0.812** P=0.00), CRP(R= 0.527** P=0.00), IL6, (R= 0.778** P=0.00) and Cystatin C (R= 0.884** P=0.00) respectively. Conclusion: higher levels of inflammatory biomarkers associate with increase with glycated hemoglobin, Improvement of glycemic control reduce risk markers for development of diabetic complications. Key words: HbA1c Levels and inflammatory biomarkers, tumor necrosis factor, interleukin 6.

scholarly journals Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients

2018 ◽  
Vol 25 (4) ◽  
pp. 357-362
Author(s):  
Nartyr Sunarti ◽  
Sri Lestari Sulistyo Rini ◽  
Hemi Sinorita ◽  
Dini Ariani
Keyword(s):  
Type 2 Diabetes ◽  
Hdl Cholesterol ◽  
Atherogenic Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Before And After ◽  
Positive Effect ◽  
Hba1c Levels ◽  
Diabetes Patients

Abstract Background and aims: High levels of non-HDL and atherogenic cholesterol can induce inflammation, and as risk factor for cardiovascular diseases. This study was to evaluate the effects of fiber-rich snacks on non-HDL cholesterol, atherogenic index, and Creactive protein (CRP) levels in type 2 diabetes patients (T2DM). Material and Methods: Twenty T2DM patients, were recruited from the Policlinic of Endocrine, Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The subjects received daily 32g fiber-rich snacks made of Dioscorea esculenta, arrowroot, cassava and pumpkin for 4 weeks. Fasting non-HDL cholesterol, atherogenic index, CRP and HbA1c levels were measured before and after intervention. Paired t-test was used to evaluate the results. Results: The fiber-rich snack intervention in T2DM patients significantly reduced levels of non-HDL cholesterol and CRP levels (p<0.05), but the decreased the atherogenic index was not significant (p>0.05). The intervention also significantly reduced the CRP levels (p<0.05) but did not affect HbA1c levels. Body weight, body mass index (BMI), waist circumference decreased significantly after consuming the snacks (p<0.05). Conclusions: This study showed fiber-rich snack has a positive effect in improving non-HDL cholesterol, atherogenic index and CRP levels but does not affect HbA1c levels in T2DM patients.

scholarly journals Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients

2018 ◽  
Vol 25 (3) ◽  
pp. 271-276
Author(s):  
◽  
Sri Lestari Sulistyo Rini ◽  
Hemi Sinorita ◽  
Dini Ariani
Keyword(s):  
Type 2 Diabetes ◽  
Hdl Cholesterol ◽  
Atherogenic Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Before And After ◽  
Positive Effect ◽  
Hba1c Levels ◽  
Diabetes Patients

Abstract Background and aims: High levels of non-HDL and atherogenic cholesterol can induce inflammation, and as risk factor for cardiovascular diseases. This study was to evaluate the effects of fiber-rich snacks on non-HDL cholesterol, atherogenic index, and C-reactive protein (CRP) levels in type 2 diabetes patients (T2DM). Material and Methods: Twenty T2DM patients, were recruited from the Policlinic of Endocrine, Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The subjects received daily 32g fiber-rich snacks made of Dioscorea esculenta, arrowroot, cassava and pumpkin for 4 weeks. Fasting non-HDL cholesterol, atherogenic index, CRP and HbA1c levels were measured before and after intervention. Paired t-test was used to evaluate the results. Results: The fiber-rich snack intervention in T2DM patients significantly reduced levels of non-HDL cholesterol and CRP levels (p<0.05), but the decreased the atherogenic index was not significant (p>0.05). The intervention also significantly reduced the CRP levels (p<0.05) but did not affect HbA1c levels. Body weight, body mass index (BMI), waist circumference decreased significantly after consuming the snacks (p<0.05). Conclusions: This study showed fiber-rich snack has a positive effect in improving non-HDL cholesterol, atherogenic index and CRP levels but does not affect HbA1c levels in T2DM patients.

scholarly journals Association between fasting insulin and C-reactive protein among adults without diabetes using a two-part model: NHANES 2005–2010

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Amanda L. Missel ◽  
Laura R. Saslow ◽  
Dina H. Griauzde ◽  
Donna Marvicsin ◽  
Ananda Sen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Waist Circumference ◽  
Low Grade ◽  
Fasting Insulin ◽  
C Reactive Protein ◽  
Glucose Levels ◽  
Reactive Protein ◽  
Part Model

Abstract Introduction Chronic inflammation is associated with the development, progression and long-term complications of type 2 diabetes. Hyperglycemia is associated with chronic low-grade inflammation, and thus has become the focus of many screening and treatment recommendations. We hypothesize that insulin may also be associated with inflammation and may be an additional factor to consider in screening and treatment. Methods This study used National Health and Nutrition Examination Survey data from 2005 to 2010 to analyze the association between fasting insulin and C-reactive protein (CRP). A two-part model was used due to the high number of values reported as 0.1 mg/L. Two models were analyzed, both with and without the addition of waist circumference to other covariates in the model. Results The final sample included 4527 adults with a mean age of 43.31 years. In the first model, higher fasting insulin was associated with increased odds of CRP > 0.1 mg/L (OR = 1.02, p < .001) and with higher CRP (β = 0.03, p < .001). In the adjusted model, including waist circumference as a covariate, higher fasting insulin was not associated with CRP > 0.1 mg/L (OR = 1.00, p = .307) but the association between higher fasting insulin and higher continuous CRP remained significant (β = 0.01, p = .012). Conclusion This study found that higher fasting insulin is associated with higher CRP. These results suggest that treatment approaches that simultaneously decrease insulin levels as well as glucose levels may provide additive anti-inflammatory effects, and therefore may improve long-term outcomes for adults with type 2 diabetes.

C-reactive protein: a marker or a player?

2007 ◽  
Vol 113 (2) ◽  
pp. 79-81 ◽  
Author(s):  
Thomas Nyström
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Events ◽  
Protein A ◽  
Low Grade ◽  
Phase Reaction ◽  
Clinical Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

It has been suggested that Type 2 diabetes may, in part, be precipitated or accelerated by an acute-phase reaction as part of the innate immune response, in which large amounts of cytokines are released from adipose tissue, creating a low-grade inflammatory milieu. There is also firm evidence that atherosclerosis is an immune-mediated inflammatory disease. Therefore it is reasonable to imply that low-grade inflammation is an important pathogenetic factor in atherosclerosis and cardiovascular events in patients with Type 2 diabetes. Over the last few years, there have been a lot of promising clinical markers proposed to link inflammation and atherosclerosis. Of these markers, hs-CRP (high-sensitivity C-reactive protein) might be a prognostic marker for further cardiovascular events, although this has been refuted recently. In this issue of Clinical Science, Castoldi and co-workers have demonstrated that, in patients with Type 2 diabetes categorized into low (<1.0 mg/l), medium (1.0–3.0 mg/l) and high (>3.0 mg/l) hs-CRP groups, serum levels of hs-CRP correlated with lipopolysaccharide-stimulated release of interleukin-1β and interleukin-6 in whole blood. This finding may indicate that low-grade inflammatory activity might influence cytokine production in these patients.

scholarly journals Prospective Relation of C-Reactive Protein With Type 2 Diabetes: Response to Han et al.

Diabetes Care ◽  
2003 ◽  
Vol 26 (5) ◽  
pp. 1656-1657 ◽  
Author(s):  
M. B. Snijder ◽  
J. M. Dekker ◽  
M. Visser ◽  
C. D.A. Stehouwer ◽  
J. S. Yudkin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
C Reactive Protein ◽  
Reactive Protein
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