scholarly journals Neurological soft signs in patients with schizophrenia: current knowledge and future perspectives in the post-genomics era

2016 ◽  
Vol 4 (1) ◽  
pp. 30071
Author(s):  
Sergi Papiol ◽  
Mar Fatjó-Vilas ◽  
Thomas G Schulze
Keyword(s):  
Current Knowledge ◽  
Future Perspectives ◽  
Neurological Soft Signs

scholarly journals The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1266
Author(s):  
Andreja Figurek ◽  
Merita Rroji ◽  
Goce Spasovski
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Current Knowledge ◽  
Fibroblast Growth Factor 23 ◽  
Mechanisms Of Action ◽  
Fibroblast Growth ◽  
Normal Kidney ◽  
Future Perspectives ◽  
Therapeutic Possibilities

Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed.

Sulfur aerosols in the Arctic, Antarctic, and Tibetan Plateau: Current knowledge and future perspectives

2021 ◽  
pp. 103753
Author(s):  
Qiaomin Pei ◽  
Eri Saikawa ◽  
Susan Kaspari ◽  
David Widory ◽  
Chuanfeng Zhao ◽  
...  
Keyword(s):  
Tibetan Plateau ◽  
Current Knowledge ◽  
The Arctic ◽  
Future Perspectives

scholarly journals The Prenatal Microbiome: A New Player for Human Health

2018 ◽  
Vol 7 (4) ◽  
pp. 38 ◽  
Author(s):  
Valeria D’Argenio
Keyword(s):  
Health Status ◽  
Microbial Communities ◽  
Fetal Development ◽  
Reproductive Medicine ◽  
Current Knowledge ◽  
Human Microbiome ◽  
Future Perspectives ◽  
Microbiome Composition ◽  
Umbilical Blood ◽  
Technological Advances

The last few years have featured an increasing interest in the study of the human microbiome and its correlations with health status. Indeed, technological advances have allowed the study of microbial communities to reach a previously unthinkable sensitivity, showing the presence of microbes also in environments usually considered as sterile. In this scenario, microbial communities have been described in the amniotic fluid, the umbilical blood cord, and the placenta, denying a dogma of reproductive medicine that considers the uterus like a sterile womb. This prenatal microbiome may play a role not only in fetal development but also in the predisposition to diseases that may develop later in life, and also in adulthood. Thus, the aim of this review is to report the current knowledge regarding the prenatal microbiome composition, its association with pathological processes, and the future perspectives regarding its manipulation for healthy status promotion and maintenance.

scholarly journals Current Status of- and Future Perspectives in- Bacterial Degradation of Benzo[a]pyrene

2020 ◽  
Author(s):  
Alexis Nzila ◽  
Musa M. Musa
Keyword(s):  
Molecular Weight ◽  
Current Knowledge ◽  
Bacterial Degradation ◽  
Current Status ◽  
Low Molecular Weight ◽  
Future Perspectives ◽  
Aromatic Rings ◽  
Compound A ◽  
Current Review ◽  
Polycyclic Aromatic

Polycyclic aromatic hydrocarbons (PAHs), which consist of low-molecular-weight PAHs (LMW-PAHs) and high-molecular-weight PAHs (HMW-PAHs), form an important class of pollutants. Pyrene and benzo[a]pyrene (BaP) are the main pollutants belonging to HMW-PAHs, and their degradation by microorganisms remains an important strategy for their removal from the environments. Extensive studies have been carried out on the isolation and characterisation of microorganisms that actively degrade LMW-PAHs, and to a certain extent, the HMW-PAH pyrene. However, so far, limited work has been carried out on BaP biodegradation. BaP consists of five fused aromatic rings, which confers this compound a high stability, rendering it less amenable to biodegradation. The current review summarizes the emerging reports on BaP biodegradation. More specifically, work carried out on BaP bacterial degradation and current knowledge gaps that limit our understanding of BaP degradation are highlighted. Moreover, new avenues of research on BaP degradation are proposed, specifically in the context of the development of “omics” approaches

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