scholarly journals Thrombotic Thrombocytopenic Purpura after Ischemic Stroke

2019 ◽  
Vol 13 (4) ◽  
pp. 219-221
Author(s):  
Sayonara Beatriz Ranciaro Fagundes
Keyword(s):  
Ischemic Stroke ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Hemolytic Anemia ◽  
The Body ◽  
Neurological Symptoms ◽  
Rare Disorder ◽  
Thrombocytopenic Purpura ◽  
Platelet Thrombi ◽  
Renal Abnormalities

Background and purpose: Thrombotic thrombocytopenic purpura (TTP) is a rare disorder, the exact cause of which is unknown. In addition to thrombocytopenia, it is characterized by hemolytic anemia, changing neurological symptoms, fever, and renal abnormalities. Most of these findings are caused by the formation of platelet thrombi in capillaries and arterioles throughout the body. This article reports a case of TTP after Ischemic Stroke and its purpose was to describe the clinical and pathophysiologic features of TTP. We describe a 52-year-old woman who presented three onset of ischemic stroke. A third episode of ischemic stroke was complicated by TTP. Hemolytic anemia and thrombocytopenia were identified.

The occurrence of thrombotic thrombocytopenic purpura during treatment of HCV with direct-acting antiviral agents

2018 ◽  
Vol 1 (1) ◽  
pp. 1-9
Author(s):  
Amr Hanafy ◽  
◽  
Waseem Seleem ◽  
Salem Mohamed ◽  
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Hemolytic Anemia ◽  
Peripheral Blood Smear ◽  
Hcv Infection ◽  
Severe Thrombocytopenia ◽  
Direct Acting Antivirals ◽  
Thrombocytopenic Purpura ◽  
Direct Acting Antiviral ◽  
Chronic Hcv ◽  
Direct Acting

Background and aim Experts have reported thrombocytopenia linked to chronic liver disease in up to 70% in patients with advanced fibrosis and portal hypertension. Thrombotic thrombocytopenic purpura (TTP) occurrence with HCV infection is a rare and life-threatening event. We aimed to investigate the cause of disturbed conscious level, acute hemolytic anemia, and severe thrombocytopenia in a male patient with chronic HCV and under treatment with direct-acting antivirals. Case report: Development of severe thrombocytopenia, acute hemolytic anemia, neurological symptoms in the form of fits and coma in a 32- year- old man with chronic HCV infection after one week of treatment with direct-acting antivirals (sofosbuvir 400mg PO daily, and daclatasvir 60 mg PO daily). Brain CT was normal, with a negative Coombs test and the presence of schistocytes in the peripheral blood smear. The patient presentation was suggestive of thrombotic thrombocytopenic purpura (TTP). Conclusion: This is a case of TTP after one week of direct-acting antiviral drugs despite the safety profile of these medications. Studying the pathophysiology of TTP after DAAs needs more clarifications.

scholarly journals Thrombotic Thrombocytopenic Purpura Following Honeybee Envenomation: A Case Report

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Zahra Khalighi ◽  
Golnaz Azami ◽  
Elham Shafiei ◽  
Ali Sahebi ◽  
Aliashraf Mozafari
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Case Reports ◽  
Major Complication ◽  
The Body ◽  
Severe Thrombocytopenia ◽  
Thrombocytopenic Purpura ◽  
Toxic Reaction ◽  
Bee Sting ◽  
Life Threatening ◽  
Underlying Diseases

Background: Thrombotic Thrombocytopenic Purpura (TTP) is a rare and life-threatening disorder characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, fever, renal dysfunction, and neurological deficient. TTP leads to the formation of blood clots in small blood vessels throughout the body. TTP is associated with many risk factors such as pregnancy, HIV, cancer, lupus, and infections. Recently there have been few published case reports of bee sting associated TTP.Methods: A 67-year-old man from a rural area of the Southwest Province of Iran, Ilam, was referred to the academic general hospital because of fever, chills, sweating, vomiting and dizziness following the honeybee sting on his body. Results: this study showed that,multiple co-morbidities including CVD and diabetes, along with coagulation abnormalities after honeybee stings, seriously exacerbated patient hemodynamic status.Conclusion: TTP, as a major complication due to the toxic reaction of a large number of bee stings with underlying diseases in patients, should be given more attention.

scholarly journals Thrombotic Thrombocytopenic Purpura: A Case Presenting with Acute Ischemic Colitis

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Joseph R. H. See ◽  
Tarek Sabagh ◽  
Christopher J. Barde
Keyword(s):  
Case Report ◽  
Renal Disease ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Hemolytic Anemia ◽  
Ischemic Colitis ◽  
Disease Process ◽  
Good Prognosis ◽  
Atypical Presentation ◽  
Thrombocytopenic Purpura

Thrombotic thrombocytopenic purpura (TTP) consists of the pentad of thrombocytopenia, hemolytic anemia, fever, neurologic abnormalities, and renal disease. We present a case report of acute TTP following a bout of ischemic colitis. This report reminds the clinician that ischemic colitis can be an atypical presentation of TTP. The prompt recognition and treatment of this disease process resulted in a good prognosis for our patient.

scholarly journals Approach to Management of Thrombotic Thrombocytopenic Purpura at University of Cincinnati

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
N. Abdel Karim ◽  
S. Haider ◽  
C. Siegrist ◽  
N. Ahmad ◽  
A. Zarzour ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Renal Failure ◽  
Thrombotic Thrombocytopenic Purpura ◽  
B Lymphocytes ◽  
Ischemic Damage ◽  
Microangiopathic Hemolytic Anemia ◽  
Thrombocytopenic Purpura ◽  
The Common ◽  
University Of Cincinnati ◽  
Renal Abnormalities

Thrombotic Thrombocytopenic Purpura (TTP) is a rare hematologic emergency, congenital or acquired, characterized by ischemic damage of various organs because of platelet aggregation. It is the common name for adults with microangiopathic hemolytic anemia, thrombocytopenia, with or without neurologic or renal abnormalities, and without another etiology; children without renal failure are also described as TTP. Plasma exchange (PE) is the main stay of treatment in combination with steroids and immunosuppressive therapies. The monoclonal antibody against CD20 Rituximab decreases the production of antibodies from B lymphocytes and it is used for antibodies-mediated diseases including TTP. We present our data on retrospective analysis of rituximab in treatment of TTP at University of Cincinnati in a series of 22 patients from 1997 to 2009. Our results showed that PE with immunosuppressive therapy resulted in decreased duration of PE, relapse rate, and increased duration of remission in patients with TTP.

scholarly journals Thrombotic Microangiopathy with Skin Localization Secondary to Cytarabine-Daunorubicin Association: Report of a Case

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
S. Regragui ◽  
S. Amelal ◽  
S. Astati ◽  
M. Zine ◽  
N. Alami Drideb ◽  
...  
Keyword(s):  
Organ Failure ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Hemolytic Anemia ◽  
Induction Chemotherapy ◽  
Thrombotic Microangiopathy ◽  
Acute Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Organ Transplants ◽  
Thrombocytopenic Purpura ◽  
Acute Myelogenous

The thrombotic microangiopathy is a syndrome characterized by the combination of mechanical hemolytic anemia, peripheral thrombocytopenia, and organ failure of variable severity. In addition to the idiopathic form, several cases are identified as secondary to pregnancy, infections, disease systems, organ transplants, and cancer. Other forms are secondary to drugs including antimitotics. We report the case of a patient followed for acute myelogenous leukemia. She received induction chemotherapy combining daunorubicin and cytarabine, complicated by thrombotic thrombocytopenic purpura.

scholarly journals Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura

2021 ◽  
pp. 1814-1820
Author(s):  
Siew Lian Chong ◽  
Asral Wirda Ahmad Asnawi ◽  
Roszymah Hamzah ◽  
Pek Kuen Liew ◽  
Tee Chuan Ong ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Hemolytic Anemia ◽  
Metastatic Breast ◽  
Metastatic Carcinoma ◽  
Blood Film ◽  
Thrombocytopenic Purpura ◽  
Metastatic Breast Carcinoma ◽  
Threatening Condition ◽  
Life Threatening

Cancer-related microangiopathic hemolytic anemia (MAHA) is a rare and life-threatening condition. We present a patient who had been treated for invasive lobular breast carcinoma in clinical remission with fever and hemolytic anemia. The peripheral blood film showed MAHA and thrombocytopenia, and a functional deficiency of ADAMTS13 activity of 23% consistent with acquired thrombotic thrombocytopenic purpura. Bone marrow aspirate and trephine biopsy confirmed metastatic carcinoma. Further evaluation revealed the involvement of multiple bone sites without recurrence of the primary tumor. The patient received a daily plasma exchange with cryosupernatant and was pulsed with corticosteroids. MAHA related to breast cancer appears to be a rare occurrence.

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