Faculty Opinions recommendation of Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.

2009 ◽  
Author(s):  
Yutaka Tagaya
Keyword(s):  
Liver Fibrosis ◽  
Cancer Development ◽  
Tgf Beta

scholarly journals Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent

2018 ◽  
Vol 841 ◽  
pp. 33-48 ◽  
Author(s):  
Diptadip Dattaroy ◽  
Ratanesh Kumar Seth ◽  
Sutapa Sarkar ◽  
Diana Kimono ◽  
Muayad Albadrani ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Focal Adhesion ◽  
Tgf Beta ◽  
Sparstolonin B

scholarly journals SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway

RSC Advances ◽  
2018 ◽  
Vol 8 (54) ◽  
pp. 30919-30924
Author(s):  
Jinhang Zhang ◽  
Yanping Li ◽  
Qinhui Liu ◽  
Rui Li ◽  
Shiyun Pu ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Signaling Pathway ◽  
Inos Expression ◽  
Tgf Beta ◽  
Hepatocellular Injury ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Inos Inhibitor

NASH is characterized by hepatocellular injury accompanied by steatosis, inflammation and fibrosis. SKLB023 as a potent iNOS inhibitor, suppressed the activation of TGF-β/Smad signaling pathway by blocking iNOS expression to attenuate liver fibrosis in MCD diet-induced mice.

Clinical implications on HBV preS/S mutations and the effects of preS2 deletion on mitochondria, liver fibrosis, and cancer development

Hepatology ◽  
2021 ◽  
Author(s):  
Yuh‐Jin Liang ◽  
Wei Teng ◽  
Chih‐Li Chen ◽  
Cheng‐Pu Sun ◽  
Rui‐Dung Teng ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Cancer Development ◽  
Clinical Implications

scholarly journals Yu Gan Long Inhibits Liver Fibrosis by Repressing TGF-beta/Smad Signaling and Th17 differentiation

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO2-12-36
Author(s):  
Pengtao You ◽  
Xia Yu ◽  
Xiaochuan Ye ◽  
Yanfang Yang ◽  
Yanwen Liu ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Tgf Beta ◽  
Smad Signaling ◽  
Th17 Differentiation
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