Clinical implications on HBV preS/S mutations and the effects of preS2 deletion on mitochondria, liver fibrosis, and cancer development

Hepatology ◽  
2021 ◽  
Author(s):  
Yuh‐Jin Liang ◽  
Wei Teng ◽  
Chih‐Li Chen ◽  
Cheng‐Pu Sun ◽  
Rui‐Dung Teng ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Cancer Development ◽  
Clinical Implications

scholarly journals Epigenetic modifications of histones in cancer

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Zibo Zhao ◽  
Ali Shilatifard
Keyword(s):  
Histone Modifications ◽  
Functional Significance ◽  
Epigenetic Modifications ◽  
Cancer Development ◽  
Clinical Implications ◽  
Biological Processes ◽  
Disease Pathogenesis ◽  
Different Types ◽  
Histone Modifiers ◽  
The Many

AbstractThe epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types of histone modifications and the biological processes with which they are involved. Specifically, we review the enzymatic machineries and modifications that are involved in cancer development and progression, and how to apply currently available small molecule inhibitors for histone modifiers as tool compounds to study the functional significance of histone modifications and their clinical implications.

Procollagen‐3  N ‐terminal peptide measurements for the detection of liver fibrosis in methotrexate‐treated patients with psoriasis: daily practice use and clinical implications

2017 ◽  
Vol 177 (5) ◽  
pp. 1454-1457 ◽  
Author(s):  
J.M.P.A. Reek ◽  
S.P. Menting ◽  
W.W.L. Janssen ◽  
R. Dhaliwal ◽  
A.C. Heijboer ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Daily Practice ◽  
Clinical Implications

scholarly journals Asbestos and ovarian cancer: examining the historical evidence

2020 ◽  
Vol 31 (1) ◽  
pp. 122-128
Author(s):  
Brian Slomovitz ◽  
Christopher de Haydu ◽  
Michael Taub ◽  
Robert L Coleman ◽  
Bradley J Monk
Keyword(s):  
Ovarian Cancer ◽  
Observational Studies ◽  
Asbestos Exposure ◽  
Cancer Development ◽  
International Agency ◽  
Clinical Implications ◽  
Historical Evidence ◽  
History Of ◽  
Continue Research ◽  
Strength Of Association

Asbestos recently returned to the spotlight when Johnson & Johnson halted sales of baby powder due to lawsuits claiming that the talc in baby powder may have been contaminated with asbestos, which has been linked to the risk of ovarian cancer development. Although talc and asbestos have some structural similarities, only asbestos is considered causally associated with ovarian cancer by the WHO’s International Agency for Research on Cancer. While it is useful to understand the types and properties of asbestos and its oncologic biology, the history of its association with ovarian cancer is largely based on retrospective observational studies in women working in high asbestos exposure environments. In reviewing the literature, it is critical to understand the distinction between associative risk and causality, and to examine the strength of association in the context of how the diagnosis of ovarian cancer is made and how the disease should be distinguished from a similar appearing but unrelated neoplasm, malignant mesothelioma. Based on contextual misinterpretation of these factors, it is imperative to question the International Agency for Research on Cancer’s assertion that asbestos has a clear causal inference to ovarian cancer. This has important clinical implications in the way patients are conceivably counseled and provides motivation to continue research to improve the understanding of the association between asbestos and ovarian cancer.

Liver fibrosis: Pathophysiology and clinical implications

2020 ◽  
pp. e1499
Author(s):  
Jennifer Berumen ◽  
Jacopo Baglieri ◽  
Tatiana Kisseleva ◽  
Kristin Mekeel
Keyword(s):  
Liver Fibrosis ◽  
Clinical Implications

scholarly journals Cancer Risk in the Heart Failure Population: Epidemiology, Mechanisms, and Clinical Implications

2020 ◽  
Vol 23 (1) ◽  
Author(s):  
Alessandra Cuomo ◽  
Flora Pirozzi ◽  
Umberto Attanasio ◽  
Riccardo Franco ◽  
Francesco Elia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
General Population ◽  
Cancer Risk ◽  
Anticancer Drugs ◽  
Population Aging ◽  
Cancer Development ◽  
Clinical Implications ◽  
Similar Risk ◽  
New Onset

Abstract Purpose of Review Along with population aging, the incidence of both heart failure (HF) and cancer is increasing. However, little is known about new-onset cancer in HF patients. This review aims at showing recent discoveries concerning this subset of patients. Recent Findings Not only cancer and HF share similar risk factors but also HF itself can stimulate cancer development. Some cytokines produced by the failing heart induce mild inflammation promoting carcinogenesis, as it has been recently suggested by an experimental model of HF in mice. Summary The incidence of new-onset cancer is higher in HF patients compared to the general population, and it significantly worsens their prognosis. Moreover, the management of HF patients developing new-onset cancer is challenging, especially due to the limited therapeutic options for patients affected by both cancer and HF and the higher risk of cardiotoxicity from anticancer drugs.

Effects of Selected Rhinologic Disorders on the Perception of Nasal Resonance in Children

1984 ◽  
Vol 15 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Michael P. Rastatter ◽  
Melvin Hyman
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Implications ◽  
Normal Children ◽  
Nasal Resonance

A group of sophisticated listeners judged the nasal resonance characteristics of normal children versus children evidencing selected rhinologic disorders under three speaking conditions. Results showed that perceptions of denasality are influenced by both speakers and speaking tasks. That is, children with allergic rhinitis and edemic adenoids were perceived as being denasal when they produced VCV utterances and recited sentences. However, their resonance characteristics were deemed normal for vowel productions. Interestingly, children with severely deviated septums were judged to have normal nasal resonance under all speaking conditions. Clinical implications are discussed.

Perceptions of Stuttering of Different Age Groups

2019 ◽  
Vol 4 (6) ◽  
pp. 1311-1315
Author(s):  
Sergey M. Kondrashov ◽  
John A. Tetnowski
Keyword(s):  
Age Groups ◽  
School Age Children ◽  
Clinical Implications ◽  
School Age ◽  
Fourth Edition ◽  
Self Perception ◽  
Behavioral Measures ◽  
Self Rating ◽  
Comparison Results ◽  
Subject Pool

Purpose The purpose of this study was to assess the perceptions of stuttering of school-age children who stutter and those of adults who stutter through the use of the same tools that could be commonly used by clinicians. Method Twenty-three participants across various ages and stuttering severity were administered both the Stuttering Severity Instrument–Fourth Edition (SSI-4; Riley, 2009 ) and the Wright & Ayre Stuttering Self-Rating Profile ( Wright & Ayre, 2000 ). Comparisons were made between severity of behavioral measures of stuttering made by the SSI-4 and by age (child/adult). Results Significant differences were obtained for the age comparison but not for the severity comparison. Results are explained in terms of the correlation between severity equivalents of the SSI-4 and the Wright & Ayre Stuttering Self-Rating Profile scores, with clinical implications justifying multi-aspect assessment. Conclusions Clinical implications indicate that self-perception and impact of stuttering must not be assumed and should be evaluated for individual participants. Research implications include further study with a larger subject pool and various levels of stuttering severity.

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