Faculty Opinions recommendation of Multicellular spheroids in ovarian cancer metastases: Biology and pathology.

2009 ◽  
Author(s):  
Rosemarie Heyn
Keyword(s):  
Ovarian Cancer ◽  
Multicellular Spheroids ◽  
Cancer Metastases

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

2009 ◽  
Vol 113 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Kristy Shield ◽  
M. Leigh Ackland ◽  
Nuzhat Ahmed ◽  
Gregory E. Rice
Keyword(s):  
Ovarian Cancer ◽  
Multicellular Spheroids ◽  
Cancer Metastases

scholarly journals In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel

2021 ◽  
Vol 22 (6) ◽  
pp. 3019
Author(s):  
Naike Casagrande ◽  
Cinzia Borghese ◽  
Francesco Agostini ◽  
Cristina Durante ◽  
Mario Mazzucato ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Chemotherapy Resistance ◽  
Multicellular Spheroids ◽  
Multicellular Tumor Spheroid ◽  
Activated Platelets ◽  
Clinical Responses ◽  
Bona Fide ◽  
Paclitaxel Treatment

A high platelet count is associated with a poor prognosis in ovarian cancer (OvCa). Despite good clinical responses with platinating agents in combination with taxanes, numerous OvCa patients relapse due to chemotherapy resistance. Here, we report that treatment of OvCa cells A2780, OVCAR5 and MDAH with releasate from activated platelets (PR) promoted multicellular tumor spheroid (MCTS) formation. These OvCa-MCTSs had increased percentages of CD133+ and aldehyde dehydrogenase (ALDH)+ cells, bona fide markers of OvCa cancer stem cells (CSCs). PR increased OVCAR5- and MDAH-MCTS viability and decreased the cytotoxic and pro-apoptotic effects of paclitaxel, cisplatin and carboplatin. PR increased the volume of spontaneously formed OVCAR8-MCTSs and counteracted their size reduction due to cisplatin, carboplatin and paclitaxel treatment. PR promoted the survival of ALDH+ and CD133+ OvCa cells during cisplatin, carboplatin and paclitaxel treatment. In conclusion, molecules and growth factors released by activated platelets (EGF, PDGF, TGF-β, IGF and CCL5) may protect tumor cells from chemotherapy by promoting the expansion of ALDH+ and CD133+ OvCa-CSCs, favoring drug resistance and tumor relapse.

scholarly journals CDC25A Facilitates Chemo-resistance in Ovarian Cancer Multicellular Spheroids by Promoting E-cadherin Expression and Arresting Cell Cycles

2019 ◽  
Vol 10 (13) ◽  
pp. 2874-2884 ◽  
Author(s):  
Yiting Sun ◽  
Song Li ◽  
Lu Yang ◽  
Di Zhang ◽  
Zeyi Zhao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Multicellular Spheroids ◽  
Cell Cycles ◽  
E Cadherin

Ovarian Cancer Metastases Mimicking Gastrointestinal Stromal Tumor: A Case Series

2016 ◽  
Vol 111 ◽  
pp. S1109-S1110
Author(s):  
Umar Hayat ◽  
Ari Garber ◽  
Bradley Confer ◽  
Tyler Stevens ◽  
John Vargo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gastrointestinal Stromal Tumor ◽  
Case Series ◽  
Stromal Tumor ◽  
Cancer Metastases

scholarly journals Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model

2009 ◽  
Vol 112 (3) ◽  
pp. 616-622 ◽  
Author(s):  
Rahul Anil Sheth ◽  
Rabi Upadhyay ◽  
Lars Stangenberg ◽  
Rucha Sheth ◽  
Ralph Weissleder ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clinical Model ◽  
Cancer Metastases ◽  
Quantitative Fluorescence

scholarly journals Therapeutic Targeting of Collective Invasion in Ovarian Cancer

2019 ◽  
Vol 20 (6) ◽  
pp. 1466 ◽  
Author(s):  
Laura Moffitt ◽  
Nazanin Karimnia ◽  
Andrew Stephens ◽  
Maree Bilandzic
Keyword(s):  
Ovarian Cancer ◽  
Primary Tumour ◽  
Survival Rates ◽  
Cell Types ◽  
Target Tissue ◽  
Multicellular Spheroids ◽  
Epithelial Cancers ◽  
Ovarian Cancers ◽  
Platinum Based Chemotherapy ◽  
Collective Invasion

Ovarian cancer is the seventh most commonly diagnosed cancer amongst women and has the highest mortality rate of all gynaecological malignancies. It is a heterogeneous disease attributed to one of three cell types found within the reproductive milieu: epithelial, stromal, and germ cell. Each histotype differs in etiology, pathogenesis, molecular biology, risk factors, and prognosis. Furthermore, the origin of ovarian cancer remains unclear, with ovarian involvement secondary to the contribution of other gynaecological tissues. Despite these complexities, the disease is often treated as a single entity, resulting in minimal improvement to survival rates since the introduction of platinum-based chemotherapy over 30 years ago. Despite concerted research efforts, ovarian cancer remains one of the most difficult cancers to detect and treat, which is in part due to the unique mode of its dissemination. Ovarian cancers tend to invade locally to neighbouring tissues by direct extension from the primary tumour, and passively to pelvic and distal organs within the peritoneal fluid or ascites as multicellular spheroids. Once at their target tissue, ovarian cancers, like most epithelial cancers including colorectal, melanoma, and breast, tend to invade as a cohesive unit in a process termed collective invasion, driven by specialized cells termed “leader cells”. Emerging evidence implicates leader cells as essential drivers of collective invasion and metastasis, identifying collective invasion and leader cells as a viable target for the management of metastatic disease. However, the development of targeted therapies specifically against this process and this subset of cells is lacking. Here, we review our understanding of metastasis, collective invasion, and the role of leader cells in ovarian cancer. We will discuss emerging research into the development of novel therapies targeting collective invasion and the leader cell population.

PERITONEAL CARCINOMATOSIS SECONDARY TO OVARIAN CANCER: IMAGING FINDINGS

2021 ◽  
pp. 15-17
Author(s):  
Nataly Sofia Valdiviezo Allauca ◽  
Selene Alexandra López Orozco ◽  
Astrid Estefanía Negrete Burbano ◽  
Leonidas Alejandro Silva Ortiz
Keyword(s):  
Ovarian Cancer ◽  
Germ Cell Tumors ◽  
Medical Personnel ◽  
Ovarian Metastasis ◽  
Stage Iii ◽  
Cancer Metastases ◽  
Positron Emission ◽  
Impact On Treatment ◽  
Magnetic Resonance Imaging Mri ◽  
Sinus Tumor

Summary: Peritoneal lesions are a relatively common site of metastases, particularly from tumors of the abdomen and pelvis, which generally carry a poor prognosis, often with a signicant impact on treatment. One of the tumors implicated in peritoneal metastasis is ovarian cancer. Ovarian cancer is the fth most commonly diagnosed cancer among women worldwide and the second most common gynecologic malignancy. Despite clinical screening, ovarian cancer in more than 60% of those affected is diagnosed at an advanced stage with a reported 5-year survival rate of 37% (stage III disease) or 25% (stage III disease). IV). Therefore, ovarian cancer is one of the deadliest cancers affecting women. Ovarian tumors are classied according to the origin of the tumor into epithelial tumors (serous and mucinous tumors, endometrioid and clear cell carcinomas, Brenner's tumor), germ cell tumors (mature and immature teratomas, dysgerminoma, endodermal sinus tumor, carcinoma embryonic), sex cord - stromal tumors (brothecoma; granulosa cell, sclerosing stroma and Sertoli-Leydig cell tumors) and metastatic tumors. Metastases to the ovary are relatively common with a documented incidence of 5% to 30% of all malignant ovarian masses. Ovarian cancer metastases differ from other tumors: they are primarily peritoneal rather than parenchymal in location. These implants are usually isodense in tomography, in relation to the viscera, which makes their detection difcult. For this, a multidisciplinary approach is used, such as physical examination, tumor marker levels and diagnostic images. Such as CT, magnetic resonance imaging (MRI) and positron emission tomography (PET). Objective: Describes ovarian metastasis in a patient with no signicant history, emphasizing peritoneal lesions, through a clinical case. Design: Prospective, observational in a single center. Methodology: This is a systematic review of ovarian metastasis, detailing its clinical characteristics and short-term complications. The information and images obtained belong to the medical personnel in charge of the case, whose reinforcements are provided by the Excel, Word and JPG statistical package.

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