Faculty Opinions recommendation of Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis.

2010 ◽  
Author(s):  
Sreeram Ramagopalan ◽  
Lahiru Handunnetthi
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Relapse Rate ◽  
Vitamin D Status ◽  
Pediatric Onset

scholarly journals A Scoping Review of Modifiable Risk Factors in Pediatric Onset Multiple Sclerosis: Building for the Future

Children ◽  
2018 ◽  
Vol 5 (11) ◽  
pp. 146 ◽  
Author(s):  
Julie Pétrin ◽  
Max Fiander ◽  
Prenitha Doss ◽  
E. Yeh
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Vitamin D ◽  
Relapse Rate ◽  
Scoping Review ◽  
Full Text ◽  
Lifestyle Factors ◽  
Increased Risk ◽  
Modifiable Lifestyle Factors ◽  
Pediatric Onset

Knowledge of the effect of modifiable lifestyle factors in the pediatric multiple sclerosis (MS) population is limited. We therefore conducted a scoping review, following the framework provided by Arksey and O’Malley. Four databases were searched for pediatric MS and modifiable lifestyle factors using index terms and keywords, from inception to May 2018. All quantitative and qualitative primary articles were included and limited to English and full text. Of the 7202 articles identified and screened, 25 full-text articles were relevant to our objective and were included. These articles focused on diet obesity, physical activity, and sleep. In cross-sectional analyses, these lifestyle factors were associated with increased risk of pediatric onset MS (POMS), and increased disease activity. Diet, particularly vitamin D and vegetable intake, was associated with reduced relapse rate. Obesity was linked to increased risk of POMS, and physical activity was associated with reduced relapse rate and sleep/rest fatigue. Thus, available studies of lifestyle related outcomes in pediatric MS suggest specific lifestyle related factors, including obesity, higher vitamin D levels, and higher physical activity may associate with lower disease burden in POMS. Studies reviewed are limited by their observational designs. Future studies with longitudinal and experimental designs may further clarify the role of modifiable lifestyle factors in this population.

Vitamin D status is associated with relapse rate in pediatric-onset MS

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Ellen M. Mowry ◽  
Lauren B. Krupp ◽  
Maria Milazzo ◽  
Dorothee Chabas ◽  
Jonathan B. Strober ◽  
...  
Keyword(s):  
Vitamin D ◽  
Relapse Rate ◽  
Vitamin D Status ◽  
Pediatric Onset

scholarly journals Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis

2011 ◽  
Vol 17 (6) ◽  
pp. 666-671 ◽  
Author(s):  
Ellen M Mowry ◽  
Judith A James ◽  
Lauren B Krupp ◽  
Emmanuelle Waubant
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Disease Status ◽  
Nuclear Antigen ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
Remote Infection ◽  
Epstein Barr ◽  
Antibody Levels ◽  
Pediatric Onset

Background: The relative contribution and interaction of risk factors for multiple sclerosis (MS) have not been evaluated. Objectives: To determine whether vitamin D status is associated with antibody levels to common viruses in pediatric-onset MS or clinically isolated syndrome (CIS) patients and controls. Methods: We assessed whether vitamin D status was associated with viral antibody levels to Epstein–Barr virus, cytomegalovirus (CMV), and herpes simplex virus (HSV)-1 or -2 in subjects who demonstrated evidence of remote infection with these viruses and whether these associations differed depending on disease status. Results: In 140 subjects, vitamin D status was weakly associated with antibody levels to CMV but not to the other viruses. However, there were some interactions between vitamin D status and disease state. Among those with vitamin D sufficiency (≥30 ng/ml), MS/CIS patients had higher antibody levels to Epstein–Barr nuclear antigen-1 than controls. Vitamin D sufficiency was associated with higher CMV antibody levels in MS/CIS subjects but lower CMV antibody levels in controls. Higher vitamin D levels appeared to be associated with higher titers to HSV-2 in MS/CIS patients but not controls. Conclusions: Vitamin D status may be differentially associated with antibody levels to common childhood viruses among seropositive subjects.

scholarly journals Relationship between 25-OH-D serum level and relapse rate in multiple sclerosis patients before and after vitamin D supplementation

2012 ◽  
Vol 5 (4) ◽  
pp. 187-198 ◽  
Author(s):  
Charles Pierrot-Deseilligny ◽  
Sophie Rivaud-Péchoux ◽  
Pierre Clerson ◽  
Raphaël de Paz ◽  
Jean-Claude Souberbielle
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Serum Level ◽  
Relapse Rate ◽  
Vitamin D Supplementation ◽  
Before And After ◽  
Multiple Sclerosis Patients

scholarly journals Genetic predictors of relapse rate in pediatric MS

2016 ◽  
Vol 22 (12) ◽  
pp. 1528-1535 ◽  
Author(s):  
Jennifer S Graves ◽  
Lisa F Barcellos ◽  
Xiaorong Shao ◽  
Janelle Noble ◽  
Ellen M Mowry ◽  
...  
Keyword(s):  
Vitamin D ◽  
Relapse Rate ◽  
Negative Binomial ◽  
Direct Sequencing ◽  
Genetic Risk Score ◽  
Disease Onset ◽  
European Ancestry ◽  
Carrier Status ◽  
Vitamin D Status ◽  
Disease Modifying

Background: Genetic ancestry, sex, and individual alleles have been associated with multiple sclerosis (MS) susceptibility. Objective: To determine whether established risk factors for disease onset are associated with relapse rate in pediatric MS. Methods: Whole-genome genotyping was performed for 181 MS or high-risk clinically isolated syndrome patients from two pediatric MS centers. Relapses and disease-modifying therapies were recorded as part of continued follow-up. Participants were characterized for 25-hydroxyvitamin D serum status. Ancestral estimates (STRUCTURE v2.3.1), human leukocyte antigen ( HLA) -DRB1*15 carrier status (direct sequencing), sex, and a genetic risk score (GRS) of 110 non-HLA susceptibility single-nucleotide polymorphisms (SNPs) were evaluated for association with relapse rate with Cox and negative binomial regression models. Results: Over 622 patient-years, 408 relapses were captured. Girls had greater relapse rate than boys (incident rate ratio (IRR) = 1.40, 95% confidence interval (CI) = 1.04–1.87, p = 0.026). Participants were genetically diverse; ~40% ( N = 75) had <50% European ancestry. HLA-DRB1*15 status modified the association of vitamin D status ( pixn = 0.022) with relapse rate (per 10 ng/mL, in DRB1*15+ hazard ratio (HR) = 0.72, 95% CI = 0.58–0.88, p = 0.002; in DRB1*15− HR = 0.96, 95% CI = 0.83–1.12, p = 0.64). Neither European ancestry nor GRS was associated with relapse rate. Conclusion: We demonstrate that HLA-DRB1*15 modifies the association of vitamin D status with relapse rate. Our findings emphasize the need to pursue disease-modifying effects of MS genes in the context of environmental factors.

scholarly journals Multiple sclerosis prevalence in Ireland: relationship to vitamin D status and HLA genotype

2011 ◽  
Vol 82 (3) ◽  
pp. 317-322 ◽  
Author(s):  
R. Lonergan ◽  
K. Kinsella ◽  
P. Fitzpatrick ◽  
J. Brady ◽  
B. Murray ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Vitamin D Status ◽  
Hla Genotype
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