Faculty Opinions recommendation of Squamous cell carcinoma of the skin shows a distinct microRNA profile modulated by UV radiation.

2010 ◽  
Author(s):  
John Carucci
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Uv Radiation ◽  
Squamous Cell ◽  
Microrna Profile

scholarly journals Squamous Cell Carcinoma of the Skin Shows a Distinct MicroRNA Profile Modulated by UV Radiation

2010 ◽  
Vol 130 (11) ◽  
pp. 2686-2689 ◽  
Author(s):  
Piotr Dziunycz ◽  
Guergana Iotzova-Weiss ◽  
Jyrki J. Eloranta ◽  
Severin Läuchli ◽  
Jürg Hafner ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Uv Radiation ◽  
Squamous Cell ◽  
Microrna Profile

Multiple Keratoacanthomas Arising Post-UVB Therapy

2004 ◽  
Vol 8 (4) ◽  
pp. 239-243 ◽  
Author(s):  
Kenneth J. Craddock ◽  
Jaggi Rao ◽  
Gilles J. Lauzon ◽  
Victor A. Tron
Keyword(s):  
Adverse Effect ◽  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Uv Radiation ◽  
Squamous Cell ◽  
Etiologic Agent ◽  
Etiologic Factor ◽  
Uv Treatment ◽  
Uvb Phototherapy

Background: Ultraviolet (UV) radiation is known to be an important etiologic agent in the development of skin cancer. Keratoacanthoma is an unusual, well-described cutaneous neoplasm that resembes squamous cell carcinoma but spontaneously resolves. Rarely, multiple keratoacanthomas may develop. Objective We present a case of multiple keratoacanthomas in a patient with psoriasis who had received UVB phototherapy. These lesions were hyperkeratotic papules, many of which spontaneously resolved and demonstrated the histologic characteristics of keratoacanthoma. Conclusion: We believe that UV radiation is the most likely etiologic factor in this patient's development of multiple keratoacanthomas. We wish to bring to the attention of clinicians this unusual adverse effect of UV treatment.

scholarly journals Developments in the Treatment of Locally Advanced and Metastatic Squamous Cell Carcinoma of the Skin: A Rising Unmet Need

2014 ◽  
pp. e397-e404 ◽  
Author(s):  
Paul Palyca ◽  
Vadim P. Koshenkov ◽  
Janice M. Mehnert
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Uv Radiation ◽  
Squamous Cell ◽  
Advanced Disease ◽  
Clinical Investigation ◽  
Locally Advanced ◽  
Unmet Need ◽  
Lymph Node Biopsy ◽  
Disease Biology

Squamous cell carcinoma of the skin (SCCS) is a common malignancy with potentially devastating consequences in patients with locally advanced or metastatic disease. Its rising incidence, primarily a result of an aging population and increased ultraviolet (UV) radiation exposure, characterize an emerging unmet need. A firm understanding of the biology of this disease, likely distinct from that of other squamous malignancies because of the influence of UV radiation, is necessary in the evaluation of treatment paradigms. Careful recognition of high-risk features pertaining to tumor and host characteristics is paramount to proper management. However, a lack of standardization in guidelines in this regard creates a challenge for physicians. Questions persist regarding additional evaluation and treatment for advanced disease such as the roles for sentinel lymph node biopsy and the adjuvant use of radiation and chemotherapy. With respect to advanced disease, multiple combinations of chemotherapy have been tested with variable success, but no rigorous randomized studies have been conducted. In addition, EGFR inhibitors such as cetuximab and erlotinib have displayed antitumor activity and as such, warrant further investigation. In sum, the treatment of locally advanced and metastatic SCCS is a ripe area for clinical investigation. This article summarizes the current understanding of disease biology and emerging questions in the management of this disease.

scholarly journals Tumor microRNA profile and prognostic value for lymph node metastasis in oral squamous cell carcinoma patients

Oncotarget ◽  
2020 ◽  
Vol 11 (23) ◽  
pp. 2204-2215
Author(s):  
Kelly Yi Ping Liu ◽  
Sarah Yuqi Zhu ◽  
Denise Brooks ◽  
Reanne Bowlby ◽  
J. Scott Durham ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Node Metastasis ◽  
Microrna Profile

Multiple Large-Surface Photodynamic Therapy Sessions with Topical or Systemic Aminolevulinic Acid and Blue Light in UV-Exposed Hairless Mice

2004 ◽  
Vol 8 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Younan Liu ◽  
Gilles Viau ◽  
Robert Bissonnette
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Cell Carcinoma ◽  
Blue Light ◽  
Uv Radiation ◽  
Squamous Cell ◽  
Aminolevulinic Acid ◽  
Hairless Mice ◽  
Free Survival ◽  
Actinic Keratoses

Background: The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses. Objective: The current study compared the ability of topical and systemic ALA–PDT as well as topical ALA–PDT with blue light to delay the appearance of UV-induced skin cancer using the hairless mouse as a model. Methods: Groups of hairless mice were exposed daily to UV radiation and weekly to ALA–PDT. Tumor-free survival was compared for mice exposed to UV and treated weekly with ALA–PDT and mice exposed only to UV radiation. Results: Weekly topical or systemic ALA–PDT was able to delay the induction of skin tumors. A significant difference in tumor-free survival was also observed for both actinic keratoses and invasive squamous cell carcinoma in mice treated weekly with topical ALA–PDT performed with blue light. This was observed even when weekly ALA–PDT was started after 8 weeks of UV exposure. Conclusion: Large-surface topical ALA–PDT with blue light can delay the appearance of UV-induced actinic keratoses and squamous cell carcinoma in hairless mice.

scholarly journals MicroRNA profile in the squamous cell carcinoma: prognostic and diagnostic roles

Heliyon ◽  
2020 ◽  
Vol 6 (11) ◽  
pp. e05436 ◽  
Author(s):  
Soudeh Ghafouri-Fard ◽  
Mahdi Gholipour ◽  
Mohammad Taheri ◽  
Zeinab Shirvani Farsani
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Microrna Profile

scholarly journals Tissue and serum microRNA profile of oral squamous cell carcinoma patients

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Augusto Schneider ◽  
Berta Victoria ◽  
Yury Nunez Lopez ◽  
Wiktoria Suchorska ◽  
Wojciech Barczak ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Microrna ◽  
Microrna Profile

scholarly journals Characterization of the microRNA profile in early-stage cervical squamous cell carcinoma by next-generation sequencing

2017 ◽  
Vol 37 (3) ◽  
pp. 1477-1486 ◽  
Author(s):  
Wansong Lin ◽  
Mei Feng ◽  
Guilin Chen ◽  
Zhifeng Zhou ◽  
Jieyu Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Cervical Squamous Cell Carcinoma ◽  
Next Generation ◽  
Microrna Profile ◽  
Generation Sequencing

Subungual squamous cell carcinoma in Darier's disease

1997 ◽  
Vol 22 (6) ◽  
pp. 277-279
Author(s):  
A.M.R. DOWNS ◽  
K.A. WARD ◽  
R.D.G. PEACHEY
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Darier’S Disease ◽  
Darier's Disease ◽  
Subungual Squamous Cell Carcinoma
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