Faculty Opinions recommendation of Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.

2012 ◽  
Author(s):  
Jonathan Jones ◽  
Kristina Kligys
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Cell Motility ◽  
Cancer Cell ◽  
Target Gene ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Lung Cancer Cell ◽  
Integrin Α5β1 ◽  
Cancer Cell Motility

scholarly journals Inhibition of A549 Lung Cancer Cell Migration and Invasion by Ent-Caprolactin C via the Suppression of Transforming Growth Factor-β-Induced Epithelial—Mesenchymal Transition

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 465
Author(s):  
So Young Kim ◽  
Myoung-Sook Shin ◽  
Geum Jin Kim ◽  
Hyukbean Kwon ◽  
Myong Jin Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Cancer Cell ◽  
Transforming Growth Factor ◽  
Epithelial Mesenchymal Transition ◽  
A549 Cells ◽  
Transforming Growth Factor Β ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Mesenchymal Transition

The epithelial–mesenchymal transition (EMT) of cancer cells is a crucial process in cancer cell metastasis. An Aquimarina sp. MC085 extract was found to inhibit A549 human lung cancer cell invasion, and caprolactin C (1), a new natural product, α-amino-ε-caprolactam linked to 3-methyl butanoic acid, was purified through bioactivity-guided isolation of the extract. Furthermore, its enantiomeric compound, ent-caprolactin C (2), was synthesized. Both 1 and 2 inhibited the invasion and γ-irradiation-induced migration of A549 cells. In transforming growth factor-β (TGF-β)-treated A549 cells, 2 inhibited the phosphorylation of Smad2/3 and suppressed the EMT cell marker proteins (N-cadherin, β-catenin, and vimentin), as well as the related messenger ribonucleic acid expression (N-cadherin, matrix metalloproteinase-9, Snail, and vimentin), while compound 1 did not suppress Smad2/3 phosphorylation and the expression of EMT cell markers. Therefore, compound 2 could be a potential candidate for antimetastatic agent development, because it suppresses TGF-β-induced EMT.

scholarly journals CdGAP is required for transforming growth factor β- and Neu/ErbB-2-induced breast cancer cell motility and invasion

Oncogene ◽  
2010 ◽  
Vol 30 (9) ◽  
pp. 1032-1045 ◽  
Author(s):  
Y He ◽  
J J Northey ◽  
M Primeau ◽  
R D Machado ◽  
R Trembath ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cell Motility ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Cancer Cell Motility

scholarly journals Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137889 ◽  
Author(s):  
Yi Yang ◽  
So-Yeon Park ◽  
Thanh Thi Nguyen ◽  
Young Hyun Yu ◽  
Tru Van Nguyen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Motility ◽  
Secondary Metabolite ◽  
Cancer Cell ◽  
Lung Cancer Cell ◽  
Cancer Cell Motility
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