Faculty Opinions recommendation of Home and work neighbourhood environments in relation to body mass index: the Multi-Ethnic Study of Atherosclerosis (MESA).

Background Higher body mass index (BMI) is associated with increased risk of incident atrial fibrillation (AF), but it is not known whether this relationship varies by race/ethnicity. Methods and Results Eligible participants (6739) from MESA (Multi‐Ethnic Study of Atherosclerosis) were surveilled for incident AF using MESA hospital surveillance, scheduled MESA study ECG, and Medicare claims data. After a median 13.8 years of follow‐up, 970 participants (14.4%) had incident AF. With BMI modeled categorically in a Cox proportional hazards model, only those with grade II and grade III obesity had increased risks of AF (hazard ratio [HR], 1.50; 95% CI, 1.14–1.98, P =0.004 for grade II obesity and HR, 2.13; 95% CI, 1.48–3.05, P <0.0001 for grade III obesity). The relationship between BMI and AF risk was J‐shaped. However, the risk of AF as a function of BMI varied substantially by race/ethnicity ( P value for interaction=0.02), with Chinese‐American participants having a much higher risk of AF with higher BMI and Black participants having minimal increased risk of AF with higher BMI. Conclusions Obesity is associated with an increased risk of incident AF, but the relationship between BMI and the risk of AF is J‐shaped and this relationship differs by race/ethnicity, such that Chinese‐American participants have a more pronounced increased risk of AF with higher BMI, while Black participants have minimal increased risk. Further exploration of the differential effects of BMI by race/ethnicity on cardiovascular outcomes is needed.

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Neighborhood Ethnic Composition, Spatial Assimilation, and Change in Body Mass Index Over Time Among Hispanic and Chinese Immigrants: Multi-Ethnic Study of Atherosclerosis

American Journal of Public Health ◽

10.2105/ajph.2014.302154 ◽

2014 ◽

Vol 104 (11) ◽

pp. 2138-2146 ◽

Cited By ~ 14

Author(s):

Félice Lê-Scherban ◽

Sandra S. Albrecht ◽

Theresa L. Osypuk ◽

Brisa N. Sánchez ◽

Ana V. Diez Roux

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Chinese Immigrants ◽

Ethnic Composition ◽

Ethnic Study ◽

Spatial Assimilation ◽

Over Time

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Neighborhood Physical Environment and Changes in Body Mass Index: Results From the Multi-Ethnic Study of Atherosclerosis

American Journal of Epidemiology ◽

10.1093/aje/kwx186 ◽

2017 ◽

Vol 186 (11) ◽

pp. 1237-1245 ◽

Cited By ~ 22

Author(s):

Tonatiuh Barrientos-Gutierrez ◽

Kari A B Moore ◽

Amy H Auchincloss ◽

Mahasin S Mujahid ◽

Carmella August ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Physical Environment ◽

Ethnic Study

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Home and work neighbourhood environments in relation to body mass index: the Multi-Ethnic Study of Atherosclerosis (MESA)

Journal of Epidemiology & Community Health ◽

10.1136/jech-2013-202682 ◽

2013 ◽

Vol 67 (10) ◽

pp. 846-853 ◽

Cited By ~ 56

Author(s):

Kari Moore ◽

Ana V Diez Roux ◽

Amy Auchincloss ◽

Kelly R Evenson ◽

Joel Kaufman ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Ethnic Study

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Change in Walking and Body Mass Index Following Residential Relocation: The Multi-Ethnic Study of Atherosclerosis

American Journal of Public Health ◽

10.2105/ajph.2013.301773 ◽

2014 ◽

Vol 104 (3) ◽

pp. e49-e56 ◽

Cited By ~ 79

Author(s):

Jana A. Hirsch ◽

Ana V. Diez Roux ◽

Kari A. Moore ◽

Kelly R. Evenson ◽

Daniel A. Rodriguez

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Residential Relocation ◽

Ethnic Study

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Obesity Severity and Duration Are Associated With Incident Metabolic Syndrome: Evidence Against Metabolically Healthy Obesity From the Multi-Ethnic Study of Atherosclerosis

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2016-2460 ◽

2016 ◽

Vol 101 (11) ◽

pp. 4117-4124 ◽

Cited By ~ 52

Author(s):

Morgana Mongraw-Chaffin ◽

Meredith C. Foster ◽

Rita R. Kalyani ◽

Dhananjay Vaidya ◽

Gregory L. Burke ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Mass Index ◽

Weight Loss ◽

Body Mass ◽

World Health ◽

Cumulative Number ◽

Metabolically Healthy Obesity ◽

Ethnic Study ◽

Metabolically Healthy ◽

Number Of Visits

Context:Although the health risks of obesity compared to normal weight have been well studied, the cumulative risk associated with chronic obesity remains unknown. Specifically, debate continues about the importance of recommending weight loss for those with metabolically healthy obesity.Objective:We hypothesized that relatively greater severity and longer duration of obesity are associated with greater incident metabolic syndrome.Design, Setting, Participants, and Measures:Using repeated measures logistic regression with random effects, we investigated the association of time-varying obesity severity and duration with incident metabolic syndrome in 2,748 Multi-Ethnic Study of Atherosclerosis participants with obesity (body mass index ≥30 kg/m2) at any visit. Obesity duration was defined as the cumulative number of visits with measured obesity and obesity severity by the World Health Organization levels I–III based on body mass index. Metabolic syndrome was defined using Adult Treatment Panel III criteria modified to exclude waist circumference.Results:Higher obesity severity (level II odds ratio [OR], 1.32 [95% confidence interval, 1.09–1.60]; level III OR, 1.63 [1.25–2.14] vs level I) and duration (by number of visits: two visits OR, 4.43 [3.54–5.53]; three visits OR, 5.29 [4.21–6.63]; four visits OR, 5.73 [4.52–7.27]; five visits OR, 6.15 [4.19–9.03] vs one visit duration of obesity) were both associated with a higher odds of incident metabolic syndrome.Conclusion:Both duration and severity of obesity are positively associated with incident metabolic syndrome, suggesting that metabolically healthy obesity is a transient state in the pathway to cardiometabolic disease. Weight loss should be recommended to all individuals with obesity, including those who are currently defined as metabolically healthy.

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