Faculty Opinions recommendation of Variations in bone mineral density of proximal femora of elderly people with hip fractures: a case-control analysis.

Author(s):  
Anwar Marthya
2019 ◽  
Vol 69 (12) ◽  
pp. 3520-3523
Author(s):  
Raluca Alexandra Trifanescu ◽  
Dan Soare ◽  
Catalin Carstoiu ◽  
Gheorghe Popescu ◽  
Alina Mihaela Pascu ◽  
...  

Low serum sodium levels were associated with increased prevalence of osteoporosis and fractures. The aim of the study was to assess the relationship between serum sodium and bone mineral density and/or osteoporotic fractures� prevalence in elderly people. A total number of 260 patients (23 men / 237 women), aged 66.5 � 12.8 years, were retrospectively assessed. Serum sodium levels were measured in all patients. Bone mineral density (BMD) was measured by dual X-ray absorptiometry (DXA). Results: serum natremia was 140.3 � 4.4 mmol/L; prevalence of hyponatremia was 7.3%; frailty fractures were present in 117 out of 260 patients (45%). Patients with fractures had lower serum sodium levels as compared to patients without fractures (139 � 3.9 vs. 141.5 � 4.6 mmol/L, p [ 0.001). Patients with osteoporosis (n = 179) also showed lower natremia as compared to patients with normal BMD and osteopenia (n = 81): 139.9 � 4.7 vs. 141.2 � 3.8 mmol/L, p = 0.035. In patients admitted in the hospital for fractures (n = 92), prevalence of hyponatremia was 13.04%. Hyponatremic patients had significantly higher prevalence of fractures (73.7% vs. 42.7%, p = 0.0147) as compared to normonatremic patients. Odds ratio (OR) for fractures in patients with hyponatremia was 3.75 [95% C.I.: 1.3-10.75], p = 0.0138; OR for hip fractures in patients with hyponatremia was 3.65 [95% C.I.: 1.38-9.64], p = 0.0089. Both incidence and prevalence of hyponatremia increase with age, especially in patients treated with diuretics. Several clinical studies found an association between mild chronic hyponatremia in elderly and increased odds ratio of osteoporosis at the total and at femoral neck; the study also showed an increased odds ratio for all fractures and for hip fractures in hyponatremic patients. Elderly people at risk of osteoporotic fractures should have sodium serum measured.


2013 ◽  
Vol 57 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Zeynel Abidin Öztürk ◽  
Yusuf Yesil ◽  
Mehmet Emin Kuyumcu ◽  
Muhammed Bilici ◽  
Nazire Öztürk ◽  
...  

2018 ◽  
Vol 92 ◽  
pp. S50
Author(s):  
R. De Freitas Junior ◽  
L.V. Gonçalves ◽  
R.M. Schingaglia ◽  
J. Godinho-Mota ◽  
K.A. Martins ◽  
...  

2012 ◽  
Vol 25 (3) ◽  
pp. 310-318 ◽  
Author(s):  
Kira B. Harris ◽  
Kimberly L. Nealy ◽  
Delilah J. Jackson ◽  
Phillip L. Thornton

Osteoporosis is a leading cause of debility and declining quality of life in postmenopausal women worldwide. Treatment of osteoporosis has been ubiquitous throughout the developed world since the mid-1990s, most notably with the introduction of bisphosphonates in 1995. Nonetheless, the incidence of hip fractures increased by 25% between 1990 and 2000, despite advances in osteoporosis therapy. Studies indicate that bone density increases over the first 3 years of bisphosphonate therapy and then plateaus or perhaps even declines, placing these patients at greater risk of fracture. Since hip fractures are associated with increased morbidity, mortality, and increased cost of health care, improvements in treating osteoporosis are critical. Denosumab is a novel monoclonal antibody targeted against the receptor activator of nuclear factor-κB ligand (RANKL) that inhibits osteoclast activity. Initial data suggest that denosumab increases bone mineral density for greater than 3 years. Of greater importance, denosumab has been shown to decrease vertebral fractures by 68%, nonvertebral fractures by 19%, and hip fractures by 42% for at least 36 months. Data also indicate that the safety profile of denosumab is equivalent to other drugs used in osteoporosis management, but potential risks of immunosuppression and cancer have been hypothesized.


2019 ◽  
Vol 10 ◽  
Author(s):  
Marta Camacho-Cardenosa ◽  
Alba Camacho-Cardenosa ◽  
Martin Burtscher ◽  
Javier Brazo-Sayavera ◽  
Pablo Tomas-Carus ◽  
...  

2019 ◽  
Vol 112 (11) ◽  
pp. 472-475 ◽  
Author(s):  
Manuel Sosa Henríquez ◽  
María Jesús Gómez de Tejada Romero ◽  
María Escudero-Socorro ◽  
Oscar Torregrosa Suau

Summary A significant loss of bone mineral density and the appearance of multiple vertebral fractures after discontinuation of denosumab treatment have been described. To date, no hip fractures have been reported. We present three cases of patients who suffered femoral fractures after denosumab suppression.


CHEST Journal ◽  
2013 ◽  
Vol 144 (4) ◽  
pp. 683A
Author(s):  
Gopi Khilnani ◽  
N Raj Kanna ◽  
Nandita Gupta ◽  
Vijay Hadda ◽  
Neetu Jain ◽  
...  

2018 ◽  
Vol Volume 13 ◽  
pp. 1525-1530 ◽  
Author(s):  
Qian Tong ◽  
Wanzhen Wu ◽  
Qing Wu ◽  
Yanbo Yu ◽  
Xiaoling Lv ◽  
...  

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