Faculty Opinions recommendation of Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: a follow-up from 1990 to 2003.

2014 ◽  
Author(s):  
Rakesh Jalali
Keyword(s):  
Quality Of Life ◽  
Low Grade ◽  
Low Grade Gliomas

Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: a follow-up from 1990 to 2003

2006 ◽  
Vol 256 (8) ◽  
pp. 516-521 ◽  
Author(s):  
Arja Mainio ◽  
Satu Tuunanen ◽  
Helinä Hakko ◽  
Asko Niemelä ◽  
John Koivukangas ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Grade ◽  
Low Grade Gliomas

Low-grade gliomas in adults

2011 ◽  
pp. 1-18 ◽  
Author(s):  
Nader Sanai ◽  
Susan Chang ◽  
Mitchel S. Berger
Keyword(s):  
Quality Of Life ◽  
Molecular Markers ◽  
Diagnostic Imaging ◽  
Recent Literature ◽  
Low Grade ◽  
Operative Techniques ◽  
Comprehensive Review ◽  
Low Grade Gliomas ◽  
Adjuvant Therapies

In recent years, advances in the understanding of low-grade glioma (LGG) biology have driven new paradigms in molecular markers, diagnostic imaging, operative techniques and technologies, and adjuvant therapies. Taken together, these developments are collectively pushing the envelope toward improved quality of life and survival. In this article, the authors evaluate the recent literature to synthesize a comprehensive review of LGGs in the modern neurosurgical era.

scholarly journals Low Grade Gliomas in Eloquent Locations – Implications for Surgical Strategy, Survival and Long Term Quality of Life

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51450 ◽  
Author(s):  
Asgeir S. Jakola ◽  
Geirmund Unsgård ◽  
Kristin S. Myrmel ◽  
Roar Kloster ◽  
Sverre H. Torp ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Surgical Strategy ◽  
Low Grade ◽  
Low Grade Gliomas

OS09.4.A Health-related quality of life in low-grade glioma survivors 26 years after diagnosis

2021 ◽  
Vol 23 (Supplement_2) ◽  
pp. ii12-ii12
Author(s):  
F W Boele ◽  
J C Reijneveld ◽  
P C de Witt Hamer ◽  
H F van Thuijl ◽  
P Wesseling ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Grade ◽  
Group Level ◽  
Related Quality ◽  
Health Related ◽  
Changes Over Time ◽  
Over Time

Abstract BACKGROUND Many patients with low-grade gliomas (LGGs) continue to survive for many years, yet little is known about patients’ health-related quality of life (HRQOL) in long-term survivorship. We previously investigated HRQOL in LGG patients diagnosed on average 6 years prior to assessment (T1, N=195) with a follow-up in stable patients on average 12 years after diagnosis (T2, N=65). We present a final follow-up of LGG survivors (T3), now decades after diagnosis. MATERIAL AND METHODS We invited patients who participated in our previous assessment (N=65), regardless of disease status. Patients completed questionnaires to assess HRQOL, fatigue, and depressive symptoms: Short Form-36 Health Survey (SF-36), European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Brain Tumour Module (EORTC BN20), Checklist Individual Strength (CIS), and the Center for Epidemiological Studies Depression Scale (CES-D). Changes over time (T1-T2-T3) on group level and participant level were assessed. RESULTS Of the 65 patients, 18 (27.7%) were deceased, 3 (4.6%) experienced tumour progression to WHO III, 7 (10.8%) declined, and 3 (4.6%) could not be contacted. Thirty-four patients (52.3%) participated. Of these, 2 had missing HRQOL data, with 32 patients included in analysis. Survivors were M=52.0 (sd=11.3) years old and diagnosed M=26.2 (sd=3.7, range 19–35) years prior. On group level, a statistically significant (but not clinically relevant) improvement in mental health (p=0.049), and a clinically relevant (but not statistically significant) decline in emotional role functioning was found. No other group-level changes over time in HRQOL were found. Minimal detectable change in HRQOL scale scores over time was observed in individual participants (28.1% only improvement; 25.0% only decline; 21.9% both improvement and decline) with 25.0% remaining completely stable. At T3, 25.0% of survivors scored above the cut-off for high risk of clinical depression (≥16 CES-D), and 53.1% of survivors classed as severely fatigued (≥35 CIS). CONCLUSION In this cohort of LGG survivors, assessed decades after diagnosis and treatment, HRQOL does not appear to be greatly impacted during survivorship. However, depressive symptoms and fatigue remain relatively common. Findings can help inform patients, their families, and clinicians and can serve as a benchmark for treatment trials evaluating interventions that can have very long-term effects.

Gamma Knife Radiosurgery for Low-Grade Gliomas: Clinical Results at Long-Term Follow-Up of Tumor Control and Patients' Quality of Life

2017 ◽  
Vol 101 ◽  
pp. 540-553 ◽  
Author(s):  
Filippo Gagliardi ◽  
Michele Bailo ◽  
Alfio Spina ◽  
Carmine A. Donofrio ◽  
Nicola Boari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Clinical Results ◽  
Tumor Control ◽  
Low Grade ◽  
Long Term Follow Up

Health-Related Quality of Life in Stable, Long-Term Survivors of Low-Grade Glioma

2015 ◽  
Vol 33 (9) ◽  
pp. 1023-1029 ◽  
Author(s):  
Florien W. Boele ◽  
Linda Douw ◽  
Jaap C. Reijneveld ◽  
Rianne Robben ◽  
Martin J.B. Taphoorn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Stable Disease ◽  
Low Grade ◽  
Sf 36 ◽  
Related Quality ◽  
Long Term Follow Up ◽  
Health Related

Purpose Patients with low-grade glioma (LGG) often experience long periods of stable disease, emphasizing the importance of maintaining good health-related quality of life (HRQOL). We assessed the changes in HRQOL in long-term survivors of WHO grade I or II astrocytoma, oligodendroglioma, or oligoastrocytoma with clinically and radiologically stable disease. Patients and Methods Patients completed self-report measures of generic HRQOL (Short Form-36 [SF-36]) and disease-specific HRQOL (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire–Brain Cancer Module). Assessments took place at midterm and long-term follow-up, on average 6 and 12 years after histologic diagnosis and initial treatment, respectively. Comparisons between patients with LGG and individually matched healthy controls were made, and change within the patients with LGG was calculated, as was minimal detectable change. Results Although no statistically significant differences between patients with LGG and healthy matched controls were found at midterm follow-up, patients with LGG had worse physical role functioning (P = .004) and general health perceptions (P = .004) than controls at long-term follow-up. Within patients with stable LGG (n = 65), physical HRQOL (the SF-36 physical component summary and the physical functioning subscale) was significantly worse at long-term than at midterm follow-up (both P < .001). Although 48% of patients improved or remained stable on all HRQOL scales, 38.5% of patients experienced detectable decline on one or more scales. Conclusion Although HRQOL remains mostly preserved in the majority of patients with LGG, a subset of patients experience detectable decline on one or more HRQOL scales despite long-term stable disease. For this subgroup, further research is recommended to better aid patients in dealing with the consequences of LGG.

Low-grade gliomas in adults

2011 ◽  
Vol 115 (5) ◽  
pp. 948-965 ◽  
Author(s):  
Nader Sanai ◽  
Susan Chang ◽  
Mitchel S. Berger
Keyword(s):  
Quality Of Life ◽  
Molecular Markers ◽  
Diagnostic Imaging ◽  
Recent Literature ◽  
Low Grade ◽  
Operative Techniques ◽  
Comprehensive Review ◽  
Low Grade Gliomas ◽  
Adjuvant Therapies

In recent years, advances in the understanding of low-grade glioma (LGG) biology have driven new paradigms in molecular markers, diagnostic imaging, operative techniques and technologies, and adjuvant therapies. Taken together, these developments are collectively pushing the envelope toward improved quality of life and survival. In this article, the authors evaluate the recent literature to synthesize a comprehensive review of LGGs in the modern neurosurgical era.

Cognitive functions and quality of life in patients with low-grade gliomas: The impact of radiotherapy

1994 ◽  
Vol 36 (1) ◽  
pp. 48-54 ◽  
Author(s):  
M. J. B. Taphoorn ◽  
A. Klein Schiphorst ◽  
F. J. Snoek ◽  
J. Lindeboom ◽  
J. G. Wolbers ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Functions ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
The Impact
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