scholarly journals Faculty Opinions recommendation of A retrospective study of peanut and tree nut allergy: Sensitization and correlations with clinical manifestations.

2018 ◽  
Author(s):  
Lawrence Eichenfield
Keyword(s):  
Retrospective Study ◽  
Clinical Manifestations ◽  
Tree Nut ◽  
Tree Nut Allergy

scholarly journals A Retrospective Study of Peanut and Tree Nut Allergy: Sensitization and Correlations with Clinical Manifestations

2015 ◽  
Vol 6 (1) ◽  
pp. ar.2015.6.0108 ◽  
Author(s):  
Lihua Yang ◽  
Stacy Clements ◽  
Rauno Joks
Keyword(s):  
Retrospective Study ◽  
Clinical Manifestations ◽  
University Hospital ◽  
Clinical Allergy ◽  
Tree Nut ◽  
Organ Systems ◽  
History Of ◽  
Record Review ◽  
Retrospective Medical Record Review

Peanut (PN) and tree nut (TN) allergies are among the leading causes of fatal food-induced anaphylaxis and are increasing in prevalence, especially in children. Their cosensitization and concurrent clinical allergy have been understudied. This retrospective study investigated the correlation between PN and TN allergy, both in terms of in vitro sensitization (IVS) and clinical allergic manifestations. We conducted a retrospective medical record review at the Allergy Clinic at University Hospital of Brooklyn. Fourteen hundred six charts were reviewed, of which 76 (5.4%) had documented relevant clinical allergy: PN allergy but not TN allergy (n = 29) or TN allergy but not PN allergy (n = 11) or both (n = 30). Six patients with PN allergy but no TN exposure history were not included in the analysis. The majority of patients (67/76, 88.1%) had a concurrent history of asthma, rhinoconjunctivitis, or AD. Sensitivity of TN IVS predicting PN IVS was 38/39 (97%). Similarly, sensitivity of PN IVS predicting TN IVS was 38/42 (91%). Sensitivity of TN clinical allergy predicting PN allergy was 30/59 (51%). Sensitivity of PN clinical allergy predicting TN allergy was 30/41 (73%). The total number of organ systems involved in reported clinical reactions correlated with IVS to TN (p = 0.004) but not IVS to PN (p = 0.983). In summary, we found PN sensitization predicts TN sensitization in vitro, with lower predictability for clinical reactions.

scholarly journals Paediatric visceral leishmaniasis: a retrospective study on clinical manifestations, demographic features and laboratory findings of hospitalised cases in Iran between 2006 and 2016

2018 ◽  
Vol 49 (1) ◽  
pp. 59-61 ◽  
Author(s):  
Manijeh Nourian ◽  
Aliehsan Heidari ◽  
Saleheh Tajali ◽  
Erfan Ghasemi ◽  
Mehdi Mohebali ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Visceral Leishmaniasis ◽  
Clinical Manifestations ◽  
Laboratory Findings ◽  
Neglected Disease ◽  
Paediatric Hospital ◽  
Geographical Regions ◽  
Epidemiological Characteristics ◽  
Demographic Features

Visceral leishmaniasis (VL) is a neglected disease. Our retrospective study describes 38 clinical and epidemiological characteristics of VL in patients admitted to a paediatric hospital in Tehran, Iran, who came from different geographical regions, indicating that the disease has spread to most parts of the country. Some 76.3% of the children documented suffered with symptoms of the disease for two months before admission.

scholarly journals Age-Related Risk Factors and Complications of Patients With COVID-19: A Population-Based Retrospective Study

2022 ◽  
Vol 8 ◽  
Author(s):  
Han Zhang ◽  
Yingying Wu ◽  
Yuqing He ◽  
Xingyuan Liu ◽  
Mingqian Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Population Based ◽  
Male Gender ◽  
Poor Correlation ◽  
Age Related ◽  
Related Risk ◽  
Independent Risk Factors

Objective: To study the differences in clinical characteristics, risk factors, and complications across age-groups among the inpatients with the coronavirus disease 2019 (COVID-19).Methods: In this population-based retrospective study, we included all the positive hospitalized patients with COVID-19 at Wuhan City from December 29, 2019 to April 15, 2020, during the first pandemic wave. Multivariate logistic regression analyses were used to explore the risk factors for death from COVID-19. Canonical correlation analysis (CCA) was performed to study the associations between comorbidities and complications.Results: There are 36,358 patients in the final cohort, of whom 2,492 (6.85%) died. Greater age (odds ration [OR] = 1.061 [95% CI 1.057–1.065], p < 0.001), male gender (OR = 1.726 [95% CI 1.582–1.885], p < 0.001), alcohol consumption (OR = 1.558 [95% CI 1.355–1.786], p < 0.001), smoking (OR = 1.326 [95% CI 1.055–1.652], p = 0.014), hypertension (OR = 1.175 [95% CI 1.067–1.293], p = 0.001), diabetes (OR = 1.258 [95% CI 1.118–1.413], p < 0.001), cancer (OR = 1.86 [95% CI 1.507–2.279], p < 0.001), chronic kidney disease (CKD) (OR = 1.745 [95% CI 1.427–2.12], p < 0.001), and intracerebral hemorrhage (ICH) (OR = 1.96 [95% CI 1.323–2.846], p = 0.001) were independent risk factors for death from COVID-19. Patients aged 40–80 years make up the majority of the whole patients, and them had similar risk factors with the whole patients. For patients aged <40 years, only cancer (OR = 17.112 [95% CI 6.264–39.73], p < 0.001) and ICH (OR = 31.538 [95% CI 5.213–158.787], p < 0.001) were significantly associated with higher odds of death. For patients aged >80 years, only age (OR = 1.033 [95% CI 1.008–1.059], p = 0.01) and male gender (OR = 1.585 [95% CI 1.301–1.933], p < 0.001) were associated with higher odds of death. The incidence of most complications increases with age, but arrhythmias, gastrointestinal bleeding, and sepsis were more common in younger deceased patients with COVID-19, with only arrhythmia reaching statistical difference (p = 0.039). We found a relatively poor correlation between preexisting risk factors and complications.Conclusions: Coronavirus disease 2019 are disproportionally affected by age for its clinical manifestations, risk factors, complications, and outcomes. Prior complications have little effect on the incidence of extrapulmonary complications.

How do we know when peanut and tree nut allergy have resolved, and how do we keep it resolved?

2010 ◽  
Vol 40 (9) ◽  
pp. 1303-1311 ◽  
Author(s):  
A. M. Byrne ◽  
J. Malka-Rais ◽  
A. W. Burks ◽  
D. M. Fleischer
Keyword(s):  
Tree Nut ◽  
Tree Nut Allergy

scholarly journals Management of testicular torsion <360° in children: a single-center, retrospective study

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051989586
Author(s):  
Xiang Guo ◽  
Lan Sun ◽  
Wei Lei ◽  
Shuang Li ◽  
Hui Guo
Keyword(s):  
Blood Flow ◽  
Retrospective Study ◽  
Survival Rate ◽  
Physical Examination ◽  
Testicular Torsion ◽  
Age Of Onset ◽  
Clinical Manifestations ◽  
Single Center ◽  
Laboratory Examination ◽  
Duration Of Symptoms

Objective This study aimed to summarize clinical manifestations, and physical examination, laboratory examination, and ultrasound results of children with testicular torsion <360°. Methods We performed a retrospective study of children who were diagnosed with testicular torsion <360° between October 2007 and October 2017. Results There were 11 (19.2%) patients with testicular torsion of 90°, 33 (58.0%) with 180°, and 13 (22.8%) with 270°. The median age of onset was 5.7 years (range, 1–14 years) and the median duration of symptoms was 4.2 days (range, 0.5–5 days). Ultrasound showed low blood flow in 46 (80.8%) patients. The testis was retained in 41 (72.0%) patients and resected in 16 (28.0%). The testes appeared necrotic at 2 to 3 days after onset for patients with 270° torsion, appeared necrotic at 3 to 4 days after onset for those with 180° torsion, and were not necrotic at 4 to 5 days after onset for those with 90° torsion. The duration of symptoms in children decreased as the torsion angle increased. Conclusion Children with testicular torsion <360° are relatively young, while the duration of symptoms is relatively long. A high postoperative testicular survival rate is one of the clinical features in this study.

scholarly journals IgE-binding to vicilin-like antimicrobial peptides is associated with systemic reactions to macadamia nut

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anna M. Ehlers ◽  
Stefanie Rohwer ◽  
Henny G. Otten ◽  
Bettina Brix ◽  
Thuy-My Le ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Antimicrobial Peptides ◽  
Dietary Habits ◽  
Allergic Reactions ◽  
Ige Binding ◽  
Tree Nut ◽  
Systemic Reactions ◽  
Macadamia Nut ◽  
Tree Nut Allergy ◽  
Industrialised Countries

Abstract Background Macadamia nut can induce fatal allergic reactions and changes in dietary habits will raise their consumption in industrialised countries. Until now diagnosis of macadamia nut allergy by sIgE solely relies on the macadamia nut extract, but single components are lacking. Methods Macadamia nut proteins recognised by IgE from 2 macadamia nut extract positive sera were identified by mass spectrometry (vicilin-like antimicrobial peptides: VLAP). Sensitisation to macadamia nut extract and heterologously expressed isoform VLAP-2–3 was evaluated in 82 nut allergic (NA) and 27 tolerant (NT) patients (no tree nut allergy reported) comprehending 10 macadamia nut allergic (MA) and 18 explicitly reported macadamia nut tolerant patients (MT), using line blots. Co-sensitisation to additional VLAP isoforms and other vicilins was evaluated in 8 MA, 12 MT and 14 NA patients sensitised to VLAP-2–3. Functional properties were determined by indirect basophil activation. Results Even though proteins recognised by IgE were identified as VLAP-2–1, 2–2 and 2–3, only peptides specifically belonging to VLAP-2–3 were detected by mass spectrometry. The macadamia nut extract was recognised by 33% of NA patients (27/82) including 3 MA patients and 26% of NT patients (7/27, 3 MT). Similarly, 29% of NA (24/82) patients showed partly strong sIgE-binding to VLAP-2–3 including 3 MA patients with systemic reactions to macadamia nut. Contrary, VLAP-2–3 was recognised by only 2 NT (1 MT) patients (7%) with very low sIgE titres. Simultaneous recognition of the isoforms VLAP-2–1 and 2–2 was observed in all patients positive for VLAP-2–3 with partly reduced sIgE titres in 59% of these patients. Additionally, all three VLAP isoforms were able to repeatedly induce BAT reactivity upon sensitisation with a MA serum. Conclusion VLAP proteins are the first described macadamia nut components with serological and functional allergenic properties and they are associated with systemic reactions to macadamia nut.

An Approach to the Diagnostic Challenges of Tree Nut Allergy

2019 ◽  
Vol 15 (1) ◽  
pp. 2-3
Author(s):  
Helen Wang ◽  
Aikaterini Anagnostou
Keyword(s):  
Tree Nut ◽  
Tree Nut Allergy
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