scholarly journals Bacteriophage JSF4 can be a Potential Prophylaxis Therapy for Cholera: An Alternative Approach to Antibiotics

2020 ◽  
pp. 121-128
Keyword(s):  
Developing Countries ◽  
Bacterial Infections ◽  
Disease Burden ◽  
Phage Therapy ◽  
Prevention Strategies ◽  
Mice Model ◽  
Effective Prevention ◽  
Alternative Approach ◽  
Prophylaxis Therapy ◽  
Effective Prevention Strategies

Cholera remains a major risk in developing countries like Bangladesh, particularly after natural or man-made disasters and becoming increasingly resistant to antibiotics. Effective prevention strategies will be essential in reducing the disease burden of these bacterial infections. Here, we used the specificity and rapid-acting properties of bacteriophages as a potential prophylaxis therapy for cholera, a severely dehydrating disease caused by Vibrio cholerae 01 or 0139 serogroup. In this study, a single bacteriophage, JSF4 specific for V. cholerae 01 serogroup, was used to reduce the severity of cholera therapeutically in the infant mice model. Bacterial counts were decreased up to 106 times in the intestines of bacteriophage-treated animals and increased up to 24 times in the untreated control mice intestines. This is the first report that a single bacteriophage JSF4 might be useful to treat cholera caused by V. cholerae 01 serogroup strains and could be an alternative to antibiotics. In the future, JSF4 bacteriophages may also have profound implications in phage therapy for controlling cholera caused by pathogenic V. cholerae 01 serogroup strains.

scholarly journals A Phage Therapy Guide for Clinicians and Basic Scientists: Background and Highlighting Applications for Developing Countries

2021 ◽  
Vol 11 ◽  
Author(s):  
Ali Khalid ◽  
Ruby C. Y. Lin ◽  
Jonathan R. Iredell
Keyword(s):  
Developing Countries ◽  
Low Income ◽  
Bacterial Infections ◽  
Disease Burden ◽  
Phage Therapy ◽  
Critical Level ◽  
Low Income Countries ◽  
Global Health Research ◽  
Antibiotic Resistant ◽  
Feasible Option

Approximately 10% of global health research is devoted to 90% of global disease burden (the so-called “10/90 Gap”) and it often neglects those diseases most prevalent in low-income countries. Antibiotic resistant bacterial infections are known to impact on healthcare, food security, and socio-economic fabric in the developing countries. With a global antibiotic resistance crisis currently reaching a critical level, the unmet needs in the developing countries are even more striking. The failure of traditional antimicrobials has led to renewed interest in century-old bacteriophage (phage) therapy in response to the urgent need to develop alternative therapies to treat infections. Phage therapy may have particular value in developing countries where relevant phages can be sourced and processed locally and efficiently, breaking specifically the economic barrier of access to expensive medicine. Hence this makes phage therapy an attractive and feasible option. In this review, we draw our respective clinical experience as well as phage therapy research and clinical trial, and discuss the ways in which phage therapy might reduce the burden of some of the most important bacterial infections in developing countries.

scholarly journals Sex-Related Differences of Acute and Chronic Pancreatitis in Adults

2021 ◽  
Vol 10 (2) ◽  
pp. 300
Author(s):  
Madeline Drake ◽  
Shah-Jahan M. Dodwad ◽  
Joy Davis ◽  
Lillian S. Kao ◽  
Yanna Cao ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
The United States ◽  
Prevention Strategies ◽  
Endoscopic Retrograde ◽  
Effective Prevention ◽  
Type 1 Autoimmune Pancreatitis ◽  
Acute And Chronic Pancreatitis ◽  
Effective Prevention Strategies

The incidence of acute and chronic pancreatitis is increasing in the United States. Rates of acute pancreatitis (AP) are similar in both sexes, but chronic pancreatitis (CP) is more common in males. When stratified by etiology, women have higher rates of gallstone AP, while men have higher rates of alcohol- and tobacco-related AP and CP, hypercalcemic AP, hypertriglyceridemic AP, malignancy-related AP, and type 1 autoimmune pancreatitis (AIP). No significant sex-related differences have been reported in medication-induced AP or type 2 AIP. Whether post-endoscopic retrograde cholangiopancreatography pancreatitis is sex-associated remains controversial. Animal models have demonstrated sex-related differences in the rates of induction and severity of AP, CP, and AIP. Animal and human studies have suggested that a combination of risk factor profiles, as well as genes, may be responsible for the observed differences. More investigation into the sex-related differences of AP and CP is desired in order to improve clinical management by developing effective prevention strategies, diagnostics, and therapeutics.

Canakinumab for secondary prevention of coronary artery disease

2021 ◽  
Author(s):  
Luis Ortega-Paz ◽  
Davide Capodanno ◽  
Dominick J Angiolillo
Keyword(s):  
Secondary Prevention ◽  
Outcome Study ◽  
Prevention Strategies ◽  
Effective Prevention ◽  
New Era ◽  
Development Status ◽  
The Cantos ◽  
Artery Disease ◽  
Effective Prevention Strategies

Cardiovascular disease manifestations (CVD) are the world's leading cause of death, and their impact on morbidity requires effective prevention strategies of recurrent adverse events. For decades, inflammation has been proposed as a key promoter for atherosclerosis and its complications. However, studies on the use of drugs to target the excess inflammation in CVD are limited. In 2017, the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial confirmed the key role of inflammation on atherosclerotic disease. Canakinumab is a monoclonal antibody that blocks an inflammatory pathway mediated by IL-1β. The results of the CANTOS trial opened a new era of investigating new therapeutics targeting inflammation for CVD secondary prevention. This review presents the canakinumab's pharmacology, current clinical development status and regulatory perspectives.

scholarly journals Prevention of Sepsis in Children: A New Paradigm for Public Policy

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Carley Riley ◽  
Derek S. Wheeler
Keyword(s):  
Causes Of Death ◽  
Healthcare Quality ◽  
Global Burden ◽  
Prevention Strategies ◽  
New Paradigm ◽  
Effective Prevention ◽  
Global Priority ◽  
The World ◽  
Important Means ◽  
Effective Prevention Strategies

Sepsis is one of the leading causes of death worldwide. While the management of critically ill patients with sepsis is certainly better now compared to 20 years ago, sepsis-associated mortality remains unacceptably high. Annual deaths from sepsis in both children and adults far surpass the number of deaths from acute myocardial infarction (AMI), stroke, or cancer. Given the substantial toll that sepsis takes worldwide, prevention of sepsis remains a global priority. Multiple effective prevention strategies exist. Antibiotic prophylaxis, immunizations, and healthcare quality improvement initiatives are important means through which we may reduce the morbidity and mortality from sepsis around the world. Inclusion of these strategies in a coordinated and thoughtful campaign to reduce the global burden of sepsis is necessary for the improvement of pediatric health worldwide.

scholarly journals Biomecânica e Traumatologia do Boxe

2021 ◽  
Vol 12 (6) ◽  
pp. 10-12
Author(s):  
Pedro Martins Farinha ◽  
◽  
Diogo Lino Moura ◽  
Keyword(s):  
Head And Neck ◽  
Olympic Games ◽  
Neck Injuries ◽  
Prevention Strategies ◽  
Severe Injuries ◽  
Effective Prevention ◽  
Amateur Boxing ◽  
Professional Boxing ◽  
Effective Prevention Strategies ◽  
The Olympic Games

Amateur boxing practiced at the Olympic Games has been evolving in conditions of safety for its athletes. The most common injuries are head wounds and lacerations, brain concussions and fractures. However, professional boxing has not kept up with this trend of revising rules and promoting greater safety, turning their athletes prone to severe injuries, especially head and neck injuries. The knowledge of epidemiology and biomechanics of boxing injuries may allow athletes and coaches to anticipate injuries and adopt effective prevention strategies.

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