scholarly journals EFFECT OF ORAL INSULIN AND HYPERLIPIDIC DIET ON INTESTINAL EPITHELIUM AND ADIPOSE TISSUE / EFEITO DA INSULINA ORAL E DA DIETA HIPERLIPÍDICA NO EPITÉLIO INTESTINAL E TECIDO ADIPOSO

2021 ◽  
Vol 7 (3) ◽  
pp. 30383-30397
Author(s):  
Isabella Maravieski Lipinski ◽  
Gilberto Baroni ◽  
Adriana Yuriko Koga ◽  
Bruna Carletto ◽  
Ricardo Rodrigues ◽  
...  
PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90995 ◽  
Author(s):  
María del Mar Romero ◽  
Stéphanie Roy ◽  
Karl Pouillot ◽  
Marisol Feito ◽  
Montserrat Esteve ◽  
...  

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 686 ◽  
Author(s):  
Margarete D. Johnson ◽  
Deborah A. Witherden ◽  
Wendy L. Havran

While forming a minor population in the blood and lymphoid compartments, γδ T cells are significantly enriched within barrier tissues. In addition to providing protection against infection, these tissue-resident γδ T cells play critical roles in tissue homeostasis and repair. γδ T cells in the epidermis and intestinal epithelium produce growth factors and cytokines that are important for the normal turnover and maintenance of surrounding epithelial cells and are additionally required for the efficient recognition of, and response to, tissue damage. A role for tissue-resident γδ T cells is emerging outside of the traditional barrier tissues as well, with recent research indicating that adipose tissue-resident γδ T cells are required for the normal maintenance and function of the adipose tissue compartment. Here we review the functions of tissue-resident γδ T cells in the epidermis, intestinal epithelium, and adipose tissue, and compare the mechanisms of their activation between these sites.


2016 ◽  
Vol 7 (3) ◽  
pp. 1554-1563 ◽  
Author(s):  
Sofía Arriarán ◽  
Silvia Agnelli ◽  
Xavier Remesar ◽  
Marià Alemany ◽  
José Antonio Fernández-López

Under high-energy diets, amino acid N is difficult to dispose of, as a consequence of the availability of alternative substrates.


2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Nelson Inacio Pinto Neto ◽  
Maria Elizabeth Sousa Rodrigues ◽  
Ana Claudia Losinskas Hachul ◽  
Mayara Franzoi Moreno ◽  
Valter Tadeu Boldarine ◽  
...  

Four-week-old female Wistar rats were divided into two groups and fed a control diet (C) or a hyperlipidic diet (H) for 4 weeks. Rats from each group underwent ovariectomy (OVX) or sham surgery (SHAM). They received C or H for the next four weeks. The body weight gain (BW), food efficiency (FE), and carcass lipid content were higher in the OVX H than in the SHAM H. The OVX H exhibited a higher serum leptin level than other groups. IL-6, TNF-α, and IL-10 content of mesenteric (MES) adipose tissue was lower in the OVX H than in the OVX C. IL-6, TNF-α, and IL-10 content of retroperitoneal (RET) adipose tissue was lower in the SHAM H than in the SHAM C. The SHAM H showed decreased TG relative to the SHAM C. Similar results were obtained in relation to IL-6Rα, TNFR1, TLR-4, and MyD88 contents in the MES and RET white adipose tissue among the groups. A hyperlipidic diet for 8 weeks combined with short-term ovariectomy decreases the cytokine content of MES adipose tissues but increases BW, enhancing FE and elevating serum leptin levels. These suggest that the absence of estrogens promotes metabolic changes that may contribute to installation of a proinflammatory process induced by a hyperlipidic diet.


Author(s):  
W. G. Banfield ◽  
G. Kasnic ◽  
J. H. Blackwell

An ultrastructural study of the intestinal epithelium of mice infected with the agent of epizootic diarrhea of infant mice (EDIM virus) was first performed by Adams and Kraft. We have extended their observations and have found developmental forms of the virus and associated structures not reported by them.Three-day-old NLM strain mice were infected with EDIM virus and killed 48 to 168 hours later. Specimens of bowel were fixed in glutaraldehyde, post fixed in osmium tetroxide and embedded in epon. Sections were stained with uranyl magnesium acetate followed by lead citrate and examined in an updated RCA EMU-3F electron microscope.The cells containing virus particles (infected) are at the tips of the villi and occur throughout the intestine from duodenum through colon. All developmental forms of the virus are present from 48 to 168 hours after infection. Figure 1 is of cells without virus particles and figure 2 is of an infected cell. The nucleus and cytoplasm of the infected cells appear clearer than the cells without virus particles.


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