Lesão do colo do útero associado ao HPV evidenciadas no papanicolau no Município de Santarém – Pará / HPV associated injury associated with hpv in the papanicolau in the Municipality of Santarém - Pará

Abstract Background After an animal-associated injury (AAI) in rabies-endemic regions, post-exposure prophylaxis (PEP) is needed to prevent infection.1,3 PEP consist of rabies vaccinations (RV) and in some cases also additional rabies immune globulins (RIG). Not always PEP medication, and RIG in particular, is accessible. Along with an increased number of exposure notifications among Dutch travelers, this might lead to treatment delay, and thus to increased health risks. Until now, research mainly focused on factors associated with exposition, but none on which factors are associated with PEP delay. This study aimed to identify which general sample characteristics are associated with PEP delay while being abroad. Methods A quantitative retrospective observational study was conducted. The study population consisted of insured Dutch international travelers who actively contacted their medical assistance company (2015-2019) because of an animal-associated injury (AAI) (N = 691). The association between general sample characteristics and delay of different PEP treatments was studied using survival analysis. Results Travelers without PrEP had an increased hazard, and therefore a shorter delay, for receiving their first RV as compared to travelers with PrEP (HR:1.11, 95%CI:1.01-1.22). The travelers needing both RV and RIG had a decreased hazard, and therefore a longer delay, as compared to travelers only needing RV (HR:0.81, 95%CI:0.67-0.96). General sample characteristic associated with RIG administration delay was travel destination. Travelers to Central and South America, East Mediterranean and Europe had a decreased hazard, and therefore a longer delay, for receiving RIG treatments relative to travelers to South East Asia (HR:0.31, 95%CI:0.13-0.70; HR:0.34, 95%CI:0.19-0.61; HR:0.46, 95%CI:0.24-0.89; HR:0.48, 95%CI:0.12-0.81 respectively). Conclusions Our results suggest that the advice for PrEP should be given based travel destination, as these was found to be the main factor for PEP delay, among travelers going to rabies endemic countries.

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Hippocampal Neuroprotection by Minocycline and Epigallo-Catechin-3-Gallate Against Cardiopulmonary Bypass-Associated Injury

Brain Pathology ◽

10.1111/bpa.12242 ◽

2015 ◽

Vol 25 (6) ◽

pp. 733-742 ◽

Cited By ~ 10

Author(s):

Aida Salameh ◽

Anne Einenkel ◽

Lydia Kühne ◽

Maria Grassl ◽

Sandy von Salisch ◽

...

Keyword(s):

Cardiopulmonary Bypass ◽

Associated Injury

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Ultrasound assessment of asymmetric hypertrophy of the rectus abdominis muscle and prevalence of associated injury in professional tennis players

Skeletal Radiology ◽

10.1007/s00256-012-1429-y ◽

2012 ◽

Vol 41 (12) ◽

pp. 1575-1581 ◽

Cited By ~ 11

Author(s):

Ramon Balius ◽

Carles Pedret ◽

Piero Galilea ◽

Fernando Idoate ◽

Angel Ruiz-Cotorro

Keyword(s):

Rectus Abdominis ◽

Rectus Abdominis Muscle ◽

Tennis Players ◽

Associated Injury ◽

Professional Tennis ◽

Ultrasound Assessment

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Manganese superoxide dismutase chemoprevention in a murine hepatitis associated injury model

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2008.06.037 ◽

2008 ◽

Vol 207 (3) ◽

pp. S24

Author(s):

Nathaniel Peter Reuter ◽

Robert C.G. Martin ◽

Yan Li

Keyword(s):

Superoxide Dismutase ◽

Manganese Superoxide Dismutase ◽

Associated Injury ◽

Manganese Superoxide ◽

Injury Model

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Factors Predisposing to Birth-Associated Injury

Advances in Perinatal Medicine ◽

10.1007/978-1-4684-7998-0_3 ◽

1985 ◽

pp. 101-161

Author(s):

John S. Curran

Keyword(s):

Associated Injury

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Effects of front and back squat techniques on patellofemoral joint kinetics in males

Journal of Biomedical Engineering and Informatics ◽

10.5430/jbei.v2n1p76 ◽

2015 ◽

Vol 2 (1) ◽

pp. 76 ◽

Cited By ~ 1

Author(s):

J Sinclair ◽

S Atkins ◽

N Kudiersky ◽

PJ Taylor ◽

H Vincent

Keyword(s):

Patellofemoral Joint ◽

Pain Syndrome ◽

Current Investigation ◽

Strength And Conditioning ◽

Joint Kinetics ◽

Associated Injury ◽

Back Squat ◽

Squat Exercise ◽

Experienced Male ◽

Joint Load

Purpose: The barbell squat is fundamental in strength and conditioning, with two principal variants; the back and front squat. Unfortunately, the propensity for injury is high particularly at the knee. The aim of the current investigation was examine the influence of front and back squat variations on patellofemoral joint load. Methods: Patellofemoral loads were obtained from thirty-five experienced male participants, who completed both back and front squats at 70% of 1 RM. Differences between squat conditions were examined using Bonferroni adjusted (P = .008) paired t-tests. Results: The results showed that significant differences (P < .008) in patellofemoral load were identified between both conditions with the highest load being experienced during the back squat exercise. Conclusions: Given the proposed relationship between the magnitude of the load experienced by the patellofemoral joint and associated injury pathology, the back squat appears to place lifters at greater risk from injury. Therefore, it may be prudent therefore for lifters who are predisposed to patellofemoral pain syndrome to utilize the front squat in their training.

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What we need to know about lipid-associated injury in case of renal ischemia-reperfusion

AJP Renal Physiology ◽

10.1152/ajprenal.00322.2018 ◽

2018 ◽

Vol 315 (6) ◽

pp. F1714-F1719 ◽

Cited By ~ 3

Author(s):

Pauline Erpicum ◽

Pascal Rowart ◽

Jean-Olivier Defraigne ◽

Jean-Marie Krzesinski ◽

François Jouret

Keyword(s):

Energy Demand ◽

Ischemia Reperfusion Injury ◽

Tissue Injury ◽

Current Knowledge ◽

Ischemia Reperfusion ◽

Acid Oxidation ◽

Metabolic Switch ◽

Cell Functions ◽

Associated Injury ◽

Cortex Area

Renal segmental metabolism is reflected by the complex distribution of the main energy pathways along the nephron, with fatty acid oxidation preferentially used in the cortex area. Ischemia/reperfusion injury (IRI) is due to the restriction of renal blood flow, rapidly leading to a metabolic switch toward anaerobic conditions. Subsequent unbalance between energy demand and oxygen/nutrient delivery compromises kidney cell functions, resulting in a complex inflammatory cascade including the production of reactive oxygen species (ROS). Renal IRI especially involves lipid accumulation. Lipid peroxidation is one of the major events of ROS-associated tissue injury. Here, we briefly review the current knowledge of renal cell lipid metabolism in normal and ischemic conditions. Next, we focus on renal lipid-associated injury, with emphasis on its mechanisms and consequences during the course of IRI. Finally, we discuss preclinical observations aiming at preventing and/or attenuating lipid-associated IRI.

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Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival

AJP Renal Physiology ◽

10.1152/ajprenal.1999.277.3.f352 ◽

1999 ◽

Vol 277 (3) ◽

pp. F352-F359 ◽

Cited By ~ 21

Author(s):

Chuan-Ming Hao ◽

Martin Kömhoff ◽

Youfei Guan ◽

Reyadh Redha ◽

Matthew D. Breyer

Keyword(s):

Cell Survival ◽

Interstitial Cell ◽

Renal Medulla ◽

Selective Inhibitor ◽

Nuclear Fragmentation ◽

Major Site ◽

Associated Injury ◽

Selective Targeting ◽

Inflammatory Drugs

Renal medullary interstitial cells (MICs) are a major site of cyclooxygenase (COX)-mediated PG synthesis. These studies examined the role of COX in MIC survival. Immunoblot and nuclease protection demonstrate that cultured MICs constitutively express COX2, with little constitutive COX1 expression. SC-58236, a COX2-selective inhibitor, but not SC-58560, a COX1 inhibitor, preferentially blocks PGE2 synthesis in MICs. Transduction with a COX2 antisense adenovirus reduced MIC COX2 protein expression and also decreased PGE2production. Antisense downregulation of COX2 was associated with MIC death, whereas a control adenovirus was without effect. Similarly, the COX2-selective inhibitor SC-58236 (30 μM) and several nonselective COX-inhibiting nonsteroidal anti-inflammatory drugs (NSAIDs), including sulindac, ibuprofen, and indomethacin, all caused MIC death. In contrast, SC-58560, a COX1-selective inhibitor, was 100-fold less potent for inducing MIC death than its structural congener SC-58236. NSAID-induced MIC death was associated with DNA laddering and nuclear fragmentation, consistent with apoptosis. These results suggest that COX2 plays an important role in MIC survival. COX2 inhibition may contribute to NSAID-associated injury of the renal medulla.

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Hemodynamic Instability of the Closed Fractures Femur in Children

10.21203/rs.3.rs-300694/v1 ◽

2021 ◽

Author(s):

Ahmed Alkhuzai

Keyword(s):

Vital Sign ◽

Hypovolemic Shock ◽

Femoral Fractures ◽

Hemodynamic Instability ◽

High Energy ◽

The Body ◽

Associated Injury ◽

Fracture Femur ◽

Multiple Injured ◽

Closed Fractures

Abstract Background: This is a prospective Study to assess the occurrence of hypovolemic shock in children with traumatic isolated closed fractures femur. This is common in children and adolescent as result of trivial to high energy trauma. Methods: A prospective descriptive study was performed on children with traumatic femoral fractures from the 20th of September 2015 to the 15th August 2018. Selection of 100 patients presented with isolated closed fracture femur in children, were admitted to the Sul. Emergency Hospital. Reason was to correct the old criteria of blood transfusion immediately, without suitable indication of replacement with real blood requirements. Depend on the children clinical parameters rather than on hemoglobin or hematocrit concentration; pulse rate. Systolic blood pressure, respiratory rate, Skin capillary refill time, and the mental status. Excluded open fractures and bilateral fracture femur in children, also excluded any fracture associated with trauma to the body organ as associated injury. Results: There was no evidence of hemodynamic instability in the 100 patients of these type fractures, selection inclusion criteria of the study when compared with internationally accepted normal vital sign parameters. No any patients in the study had hemoglobin less than 8.5 g/dl, the vital sign between these groups were similar, 2-6% incidence with hemodynamic instability has found among multiple injured children with femoral fractures, has excluded from the study. Conclusions: No evidence of hemodynamic instability was found in children with traumatic isolated femoral fractures bone. The Hemoglobin and hematocrit ratios early were non dependable, later on not significantly decreased or change to abnormal rate. Depending on vital signs parameters in the femur bone fractures patients after exclusion of bilateral fractures femur, and associated injury or patients with compound fractures, we confirmed that isolated closed femoral fractures are hemodynamically stable.

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