scholarly journals Molnupiravir; an effective drug in treating COVID-19?

2021 ◽  
Vol 7 (1) ◽  
pp. e11-e11
Author(s):  
Alireza Pouramini ◽  
Fatemeh Kafi ◽  
Shakiba Hassanzadeh ◽  
Sanam Saeifar ◽  
Hamid Reza Jahantigh
Keyword(s):  
Effective Drug

Binding Mechanism and Structural Insights into the Identified Protein Target of Covid-19 with In-Vitro Effective Drug Ivermectin

2020 ◽  
Author(s):  
Parth Sarthi Sen Gupta ◽  
Satyaranjan Biswal ◽  
Saroj Kumar Panda ◽  
Abhik Kumar Ray ◽  
Malay Kumar Rana
Keyword(s):  
Ternary Complex ◽  
Bound State ◽  
Molecular Target ◽  
Cooperative Interaction ◽  
Effective Drug ◽  
Rna Dependent Rna Polymerase ◽  
Protein Target ◽  
Ternary Complex Formation ◽  
Structural Insights

<p>While an FDA approved drug Ivermectin was reported to dramatically reduce the cell line of SARS-CoV-2 by ~5000 folds within 48 hours, the precise mechanism of action and the COVID-19 molecular target involved in interaction with this in-vitro effective drug are unknown yet. Among 12 different COVID-19 targets studied here, the RNA dependent RNA polymerase (RdRp) with RNA and Helicase NCB site show the strongest affinity to Ivermectin amounting -10.4 kcal/mol and -9.6 kcal/mol, respectively. Molecular dynamics of corresponding protein-drug complexes reveals that the drug bound state of RdRp with RNA has better structural stability than the Helicase NCB site, with MM/PBSA free energy of -135.2 kJ/mol, almost twice that of Helicase (-76.6 kJ/mol). The selectivity of Ivermectin to RdRp is triggered by a cooperative interaction of RNA-RdRp by ternary complex formation. Identification of the target and its interaction profile with Ivermectin can lead to more powerful drug designs for COVID-19 and experimental exploration. </p>

Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery

2014 ◽  
Vol 20 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Dimitrios Roukos ◽  
Giannis Baltogiannis ◽  
Christos Katsouras ◽  
Aris Bechlioulis ◽  
Katerina Naka ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Drug Design ◽  
Therapeutic Targets ◽  
Effective Drug ◽  
Next Generation ◽  
Generation Sequencing

Combination of Hydroxychloroquine, Melatonin and Mercaptopurine as possible intervention for prophylaxis and treatment of Novel COVID-19 infection

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Gyan Vardhan ◽  
Vikas Kumar ◽  
Megha Agrawal ◽  
Puneet Dhamija
Keyword(s):  
Mechanism Of Action ◽  
Drug Combination ◽  
Treatment Strategies ◽  
Effective Drug ◽  
Effective Alternative ◽  
Potential Candidate ◽  
Potential Drug ◽  
Review Of Literature ◽  
Scientific Review ◽  
Repurposed Drugs

Background: COVID-19 has been declared as a pandemic recently and has caused many deaths worldwide. Till date no effective drug or vaccine is available against SARS-CoV-2. There is an urgent need to find effective alternative preventive and treatment strategies to deal with SARS-CoV-2 outbreak. Objective: This communication proposes a new potential drug combination (repurposed) for prophylaxis and treatment of SARS-CoV-2. Methods and Materials: We performed a brief review of literature on combination of Hydroxychloroquine, Melatonin and Mercaptopurine for prophylaxis and treatment of Novel COVID-19 infection and also assessed their possible mechanism of action against SARS-CoV-2. Observation: Proposed combination seems to be safe and target is unlikely to develop resistance to this combination. Conclusion: This scientific review proposes potential repurposed drugs and their combination targeting SARS-CoV-2. Conclusion: This scientific review proposes potential candidate repurposed drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2.

scholarly journals Case Series of Three Patients with Rifampicin-Induced Thrombocytopenia

2020 ◽  
Author(s):  
Chandramouli M.T
Keyword(s):  
Pulmonary Tuberculosis ◽  
Adverse Reactions ◽  
Rare Complication ◽  
Case Series ◽  
Tuberculosis Treatment ◽  
Effective Drug ◽  
Antitubercular Drugs ◽  
Short Course ◽  
Life Threatening

AbstractLife-threatening adverse reactions of antitubercular drugs are uncommon; however, thrombocytopenia is one such rare complication encountered with rifampicin, isoniazid, ethambutol, and pyrazinamide. Rifampicin is the most effective drug and its use in the tuberculosis treatment led to the emergence of modern and effective short-course regimens. I am reporting case series of three patients with pulmonary tuberculosis presented with rifampicin-induced thrombocytopenia.

scholarly journals Porous discoidal polymeric particles for effective drug delivery minimizing phagocytosis

2021 ◽  
Vol 49 (1) ◽  
pp. 390-396
Author(s):  
Susmita Aryal ◽  
Sanghyo Park ◽  
Chaewon Park ◽  
Moon Jung Choi ◽  
Jaehong Key
Keyword(s):  
Drug Delivery ◽  
Effective Drug ◽  
Polymeric Particles

Dual pH-responsive micelles with both charge-conversional property and hydrophobic–hydrophilic transition for effective cellular uptake and intracellular drug release

2016 ◽  
Vol 7 (12) ◽  
pp. 2202-2208 ◽  
Author(s):  
Shuai Li ◽  
Zhouxiang Zhao ◽  
Wei Wu ◽  
Chunmei Ding ◽  
Jianshu Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Uptake ◽  
Diblock Copolymers ◽  
Effective Drug ◽  
Ph Responsive ◽  
A Charge

Two types of diblock copolymers are synthesized to construct dual pH-responsive micelles with a charge-conversional property for effective drug delivery.

Sign in / Sign up

Export Citation Format

Share Document