Morphological signs of neurogenic inflammation in the heart of rats during aging

2022 ◽  
pp. 831-840
Author(s):  
Е.И. Чумасов ◽  
Е.С. Петрова ◽  
Д.Э. Коржевский
Keyword(s):  
Neurogenic Inflammation ◽  
Plasma Cells ◽  
Nerve Fibers ◽  
Blood Capillaries ◽  
Pgp 9.5 ◽  
Sympathetic Nerve Fibers ◽  
Close Relationship ◽  
The Right ◽  
Inflammatory Infiltrates ◽  
Heart Apparatus

С помощью гистологических методов окраски толуидиновым синим, гематоксилином и эозином и иммуногистохимических реакций на белок PGP 9.5, тирозингидроксилазу (ТГ), белок Iba-1, изучены клеточные изменения в разных отделах сердца крыс линии Wistar в возрасте 18- 23 мес. В соединительной ткани основания сердца обнаружены очаговые воспалительные инфильтраты, внутри которых выявлены PGP 9.5 и ТГ сплетения, состоящие из парасимпатических и симпатических нервных волокон. В области клапанного аппарата, на границе фиброзного кольца и миокарда правого предсердия, обнаружены патологические изменения нервных структур - дегенерация нервных пучков и зернистый распад варикозных аксонов терминального сплетения. Установлены тесные взаимоотношения аксонов терминальной нервной сети с клетками воспалительных инфильтратов и кровеносными сосудами. Определены закономерности встречаемости в различных отделах миокарда у старых животных нейроклеточных воспалительных комплексов, состоящих из нервных волокон, кровеносных капилляров и клеток-участников местного воспалительного процесса (тучных клеток, макрофагов, фибробластов, плазмоцитов). Установлен хронический характер нейрогенного воспаления в сердце при старении. Using histological methods of staining with toluidine blue, hematoxylin-eosin and immunohistochemical reactions for the PGP 9,5 protein, tyrosine hydroxylase (TH), Iba-1 protein, cellular changes in different parts of the heart of Wistar rats at the age of 18-23 months were studied. In the connective tissue of the heart base, focal inflammatory infiltrates were found, near which PGP 9.5 and TH plexuses, consisting of parasympathetic and sympathetic nerve fibers, were detected. In the area of the valvular heart apparatus, at the border of the anneau fibreux and the myocardium of the right atrium, pathological changes in nerve structures were found: degeneration of nerve fibers and granular destruction varicose axons of the terminal plexus. A close relationship has been established between axons of the terminal nervous network and cells of inflammatory infiltrates and blood capillaries. The features of the localization of neurocellular inflammatory complexes consisting of nerve fibers, blood capillaries and cells participating in the local inflammatory process (mast cells, histiocytes, monocytes, fibroblasts, plasma cells) in various parts of the myocardium in old animals are described. The chronic nature of neurogenic inflammation in the heart during aging has been established.

Afferent sympathetic nerve fibers with mechanoreceptors in the right heart

1975 ◽  
Vol 228 (1) ◽  
pp. 223-230 ◽  
Author(s):  
Y Uchida
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricular ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
Right Atrial ◽  
Right Heart ◽  
Unmyelinated Fibers ◽  
Myelinated Fibers ◽  
Sympathetic Nerve Fibers ◽  
The Right

Mechanosensitivity of afferent sympathetic nerve fibers from the right heart and the pulmonary artery has been examined. Action potentials of the afferent fibers that responded to tapping the right heart and the pulmonary artery were derived from upper thoracic communicating rami of both sides of anesthetized dogs. The fibers were composed of myelinated Adelta fibers and unmyelinated fibers. The receptive fields of both groups of fibers were located widely in the right heart and the pulmonary artery. Myelinated fibers ceased to fire quickly whereas unmyelinated fibers continued to fire after withdrawl of a brief mechanical stimulus. In the myelinated group, the pressure threshold was 3-50, 6-58, and 3-10 mmHg for right ventricular, pulmonary and right atrial threshold was 15-58, 22-34, and 4-8 mmHg for right ventricular, pulmonary, and right atrial fibers, respectively. Spontaneous discharge of myelinated fibers was synchronous with each rise and/or fall in intracardiac or pulmonary pressure whereas that of unmyelinated fibers was irregular and independent. A rise in pressure produced by pulmonary embolization or occlusion caused an augumented discharge whereas a fall caused by caval vein occulsion eliminated the discharge. The results indicate the existence of both myelinated and unmyelinated fibers with mechanoreceptors in the right heart and the pulmonary artery.

Changes in peptidergic fiber density in the synovium of mice with collagenase-induced acute arthritis

2015 ◽  
Vol 93 (6) ◽  
pp. 435-441 ◽  
Author(s):  
Kohei Murakami ◽  
Hiroshi Nakagawa ◽  
Kazuhiko Nishimura ◽  
Saburo Matsuo
Keyword(s):  
Synovial Tissue ◽  
Left Knee ◽  
Nerve Fibers ◽  
Knee Joints ◽  
Poor Correlation ◽  
Fiber Density ◽  
Pgp 9.5 ◽  
Protein Gene Product ◽  
Collagenase Injection ◽  
The Right

The effect of acute osteoarthritis (OA) on peripheral nerve fibers (NFs) in synovial tissue, and their association with histological changes were investigated in collagenase-induced OA mice. Collagenase (10 U in 5 μL saline) was injected into the right knee, and the same volume of saline was injected into the left knee as the control. Mice were sacrificed 1, 2, 3, and 4 weeks after the collagenase injection. Histopathological changes in the knee joints were evaluated. The numbers of protein gene product (PGP) 9.5-, calcitonin-gene-related peptide (CGRP)-, and substance P (SP)-positive NFs in the synovial tissue were determined, and their densities in the tissue were calculated. The densities of PGP 9.5- and CGRP-positive NFs in the synovium were drastically decreased 1 week after the collagenase injection. However, by week 4, the density of PGP 9.5- and CGRP-positive NFs had recovered to 84% and 79% of their normal levels, respectively. Despite the poor correlation between the synovitis score and the density of CGRP- or SP-positive NFs in the synovium, the ossification rate of chondrophytes in chondro/osteophyte lesions correlated strongly with the density of CGRP-positive NFs (R = 0.855). These results suggest that the ossification of chondrophytes occurred in parallel with the increase in CGRP-positive fiber density in the synovium during the acute phase of collagenase-induced OA.

scholarly journals First-Bite syndrome and Eagle syndrome

2018 ◽  
Vol 24 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Benat Gauthier ◽  
Georg Ségolène ◽  
Courtois Bruno
Keyword(s):  
Mouth Opening ◽  
Nerve Fibers ◽  
X Rays ◽  
Sympathetic Nerve Fibers ◽  
Body Sensation ◽  
Cervical Surgery ◽  
Eagle Syndrome ◽  
Stylohyoid Ligament ◽  
The Right ◽  
First Bite Syndrome

Introduction: Eagle Syndrome (ES) is caused by the ossification/calcification of the stylohyoid ligament and is associated with many different symptoms such as otalgia, restricted mouth opening, or an intrapharyngeal foreign body sensation. First-bite syndrome (FBS) is characterized by pain in the parotid and retromandibular region, when taking the first bite in a meal and occurs more or less invariably. Observation: A 50-year-old female patient presented complaining of right retromandibular pain, that irradiated to the right side of the mandible and right shoulder, only when eating for the first time a day and at the first bite. Medical history and clinical examination did not reveal any signs of cervical surgery or cervical trauma. Palpation was painful at a specific point in right retromandibular point region, the rest of the intraoral and extraoral examinations were normal. The right and left condylar x-rays (open mouth and closed mouth) revealed an elongation of both the right and left stylohyoid ligaments. Discussion: Usually, FBS occurs after cervical surgery, for example after resection of the stylohyoid ligament for ES. Our case report shows, on the contrary, FBS that was associated with ES. The pathophysiological explanation of FBS depends on an irritative or traumatic factor in the sympathetic nerve fibers of the parotid gland. Conclusion: This association allows us to present both syndromes and to carry out an up to date pathophysiological examination and therapeutic proposals concerning FBS.

Device therapy of resistant hypertension

2013 ◽  
Vol 154 (6) ◽  
pp. 203-208 ◽  
Author(s):  
Gábor Simonyi ◽  
J. Róbert Bedros ◽  
Mihály Medvegy
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Resistant Hypertension ◽  
Carotid Sinus ◽  
Maximum Tolerated Dose ◽  
Reduce Blood Pressure ◽  
Nerve Fibers ◽  
Uncontrolled Hypertension ◽  
Sympathetic Nerve Fibers ◽  
Treatment Of Hypertension

It is well known that hypertension is an independent cardiovascular risk factor. Treatment of hypertension frequently includes administration of three or more drugs. Resistant hypertension is defined when blood pressure remains above target value despite full doses (the patient’s maximum tolerated dose) of antihypertensive medication consisting of at least three different classes of drugs including a diuretic. Pharmacological treatment of hypertension is often unsuccessful despite the increasing number of drug combinations. Uncontrolled hypertension, however, increases the cardiovascular risk. Device treatment of resistant hypertension is currently testing two major fields. One of them the stimulation of baroreceptors in the carotid sinus and the other is radiofrequency ablation of sympathetic nerve fibers around renal arteries to reduce blood pressure in drug resistant hypertension. Orv. Hetil., 2013, 154, 203–208.

Loss of sympathetic nerve fibers in vital intertrochanteric bone cylinders lateral to osteonecrosis of the femoral head

2013 ◽  
Vol 80 (2) ◽  
pp. 188-194 ◽  
Author(s):  
Johannes Beckmann ◽  
Matthias Knödl ◽  
Eva Bauser ◽  
Markus Tingart ◽  
Joachim Grifka ◽  
...  
Keyword(s):  
Femoral Head ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
Sympathetic Nerve Fibers

scholarly journals THE ABSORPTION OF PROTEIN SOLUTIONS FROM THE PULMONARY ALVEOLI

1937 ◽  
Vol 66 (4) ◽  
pp. 449-458 ◽  
Author(s):  
Cecil K. Drinker ◽  
Madeleine Field Warren ◽  
Margaret MacLanahan
Keyword(s):  
Thoracic Duct ◽  
Horse Serum ◽  
Molecular Size ◽  
The Other ◽  
Immunological Methods ◽  
Protein Solutions ◽  
Blood Capillaries ◽  
Egg Albumin ◽  
Pulmonary Alveoli ◽  
The Right

Horse serum, crystallized hemoglobin, and crystallized egg albumin have been injected into the lung alveoli of dogs in which the entrances of the right lymphatics have been tied and the thoracic duct cannulated. Samples of blood and lymph have been taken following this injection. Only after several hours in the case of the horse serum and hemoglobin have these proteins been detected by immunological methods and invariably they have appeared first in the blood. Egg albumin also enters the blood capillaries, but much more rapidly than the other two proteins, due probably to the smaller molecular size.

Cholinesterase activity in quail primary lymphoid organs

Biologia ◽  
2013 ◽  
Vol 68 (6) ◽  
Author(s):  
František Dorko ◽  
Jaroslav Horáček ◽  
Ján Tokarčík ◽  
Michal Miko
Keyword(s):  
Germinal Center ◽  
Cholinesterase Activity ◽  
Histochemical Study ◽  
Nerve Fibers ◽  
Lymphoid Organs ◽  
Bursa Of Fabricius ◽  
Lymphoid Follicles ◽  
Age Dependent ◽  
Close Relationship ◽  
Thymic Medulla

AbstractThe present histochemical study was carried out to analyze the distribution and topography of acetylcholinepositive nerve fibers in the thymus and bursa of Fabricius of quails. The AChE-positive nerve fibers were demonstrated by direct thiocholine histochemical method. Nerve fibers present in the thymuses form periarterial nerve plexuses located mostly in the interlobular septa and on the cortico-medullary junction. Vessels-independent nerve fibers occur also in the parenchyma of thymic medulla, but rarely in parenchyma of the cortex. Within the connective tissue between the bursa of Fabricius and the wall of proctodeum we observed conspicuous AChE-positive ganglia, often in close relationship to greater arteries. Within the wall of bursa of Fabricius, AChE-positive nerve fibers create nerve plexuses around arteries. We observed a close relationship between lymphoid follicules in bursal submucosa and mucosa and AChE-positive nerve fibers. Nerve fibers create a ring around lymphoid follicles, but do not penetrate into the germinal center of the follicle. Arteries inside quail thymuses and bursae of Fabricius contain rich AChE-positive nerve plexuses, when compared to the veins, which have a very poor presence of AChE-positive nerves. According to lesser presence and decreased density of AChE-positive nerve fibers in older animals, we described age-dependent changes in both quail primary lymphoid organs.

Topography and distribution of sympathetic nerve fibers in the rat temporomandibular joint: immunocytochemistry and ultrastructure

2001 ◽  
Vol 203 (5) ◽  
pp. 357-366 ◽  
Author(s):  
M. A. Kido ◽  
Jing-Qi Zhang ◽  
Harue Muroya ◽  
Takayoshi Yamaza ◽  
Yoshihiro Terada ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
Sympathetic Nerve Fibers
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