scholarly journals SVM en paralelo para optimizar el tiempo de respuesta en la predicción de co-receptores de los virus R5, X4 Y R5X4 (mutado) que causan el Sida (VIH-1) en células CD4

Author(s):  
Gricelda Medina-Veloz ◽  
Francisco Javier Luna-Rosas ◽  
Kelly Carolina Martínez-Valadez ◽  
Juan Felipe Tavarez-Avendaño

In particular, the R5 HIV-1 viruses use CCR5 as co-receptor for the virus entrance, the X4 virus HIV-1 use the CXCR4, while some strange viruses known as R5X4 or D-tropic, have the ability to use both co-receptors. The X4 and R5X4 viruses are associated with rapid progress in HIV-1. In this article a series of experiments will be carried out to implement a Supervised Learning Machine in Parallel that allows optimizing the response time in the prediction of co-receptors (CCR5, CXCR4) of the virus that cause AIDS (HIV-1) in CD4 cells. To implement the machine in parallel we will use Snow in R. Snow provides the support to easily execute functions in R in parallel. Most functions in parallel in Snow are variations of the standard lapply () function. To implement the functions in parallel, Snow uses a master / slave architecture where the teacher sends tasks to the workers, and the workers execute the tasks and return the results to the teacheR.

Apmis ◽  
2003 ◽  
Vol 111 (6) ◽  
pp. 625-633 ◽  
Author(s):  
LARS E. ERIKSSON ◽  
THOMAS LEITNER ◽  
BRITTA WAHREN ◽  
ANN-CHARLOTTE BOSTROM ◽  
KERSTIN I. FALK

Author(s):  
F.J.L. Rosas ◽  
J.C.M. Romo ◽  
C.A. de Luna Ortega ◽  
R.M. Gonzalez ◽  
V.L. Rivas ◽  
...  
Keyword(s):  

Virology ◽  
1990 ◽  
Vol 179 (2) ◽  
pp. 609-617 ◽  
Author(s):  
H.A. Lehr ◽  
J.P. Zimmer ◽  
C. Hübner ◽  
M. Ballmann ◽  
W. Hachmann ◽  
...  

1999 ◽  
Vol 19 (4) ◽  
pp. 317-325 ◽  
Author(s):  
Anu Puri ◽  
Peter Hug ◽  
Kristine Jernigan ◽  
Patrick Rose ◽  
Robert Blumenthal

We have recently shown that addition of human erythrocyte glycosphingolipids (GSL) to non-human CD4+ or GSL-depleted human CD4+ cells rendered those cells susceptible to gp120-gp41-mediated cell fusion (Puri et al., BBRC, 1998). One GSL fraction (Fraction 3) isolated from human erythrocyte GSL mixture exhibited the highest recovery of fusion following incorporation into CD4+ non-human and GSL-depleted HeLa-CD4 cells (HeLa-CD4/GSL-). Structural analysis of Fraction 3 showed that this GSL had identical head group as the known GSL, Gal(α1→4)Gal(β1→4)Glc-Ceramide (Gb3) (Puri et al., PNAS, 1998). Here we report that presence of Gb3 in CD4+/CXCR4+ cells but not CD4+/CXCR4- cells allows fusion with HIV-1Lai-envelope glycoprotein expressing cells (TF228). Therefore, Gb3 functions in conjunction with HIV-1 co-receptor, CXCR4 to promote fusion. We propose that Gb3 functions by recruiting CD4 and/or CXCR4 at the fusion site through structurally specific interactions.


2000 ◽  
Vol 94 (3) ◽  
pp. 153-159 ◽  
Author(s):  
Franco Pandolfi ◽  
Marina Pierdominici ◽  
Marco Marziali ◽  
Maria Livia Bernardi ◽  
Guido Antonelli ◽  
...  

Author(s):  
S. Jaffar ◽  
A. Wilkins ◽  
P. T. Ngom ◽  
S. Sabally ◽  
T. Corrah ◽  
...  
Keyword(s):  

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