scholarly journals Quantitative analysis of gated myocardial perfusion SPECT

2018 ◽  
pp. 220-227
Author(s):  
Victor Ploskikh ◽  
Elena Kotina
Keyword(s):  
Quantitative Analysis ◽  
Myocardial Perfusion ◽  
Data Processing ◽  
Single Photon ◽  
Photon Emission ◽  
Myocardial Perfusion Spect ◽  
Mathematical Representation ◽  
Emission Computed Tomography ◽  
Gated Myocardial Perfusion Spect ◽  
Perfusion Spect

The paper considers the problem of gated myocardial perfusion single photon emission computed tomography (SPECT) data processing. An approach to the quantitative analysis of gated myocardial perfusion SPECT data used in software developed in the SPbSU is presented. The article presents and formalizes the complete data processing workflow. All the main tasks of the data processing are considered. Mathematical representation of problem domain objects is presented. A detailed algorithm of the data processing is given. The algorithmis implemented as component of the data processing software suite.

scholarly journals Challenges of gated myocardial perfusion SPECT processing

2021 ◽  
pp. 171-177
Author(s):  
Victor Ploskikh ◽  
Elena Kotina
Keyword(s):  
Myocardial Perfusion ◽  
Single Photon ◽  
Photon Emission ◽  
Myocardial Perfusion Spect ◽  
Mathematical Representation ◽  
Emission Computed Tomography ◽  
Gated Myocardial Perfusion Spect ◽  
Myocardial Perfusion Single Photon ◽  
Perfusion Spect ◽  
Photon Emission Computed Tomography

The paper provides an in-depth look at gated myocardial perfusion single photon emission computed tomography (SPECT) data processing. Attention paid to several unmentioned subjects of the quantitative analysis of gated myocardial perfusion SPECT data. The article considers several options in the construction process of the ellipsoid coordinate system of the left ventricle (LV). Mathematical representation of polar maps is given. Formulas of the regional parameters calculation are proposed. Issues of phase analysis are explored.

scholarly journals Radiomics analysis of myocardial perfusion SPECT images in patients with cardiomyopathy and heart failure

2021 ◽  
Vol 22 (Supplement_3) ◽  
Author(s):  
K Okuda ◽  
K Nakajima ◽  
H Saito ◽  
S Yamashita ◽  
M Hashimoto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Myocardial Perfusion ◽  
Single Photon ◽  
Photon Emission ◽  
Myocardial Perfusion Spect ◽  
Feature Reduction ◽  
Support Vector ◽  
Emission Computed Tomography ◽  
Operating Characteristics ◽  
Perfusion Spect

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): JSPS KAKENHI Grants Background Although myocardial perfusion heterogeneity due to focally damaged cardiomyocytes is observed in single−photon emission computed tomography (SPECT) imaging, a current perfusion defect scoring system does not allow us to provide sufficient diagnostic information for heterogeneity. Purpose The aim of this study was to perform radiomics analysis of myocardial perfusion SPECT (MPS) images to investigate the potential to detect myocardial perfusion heterogeneity. Methods Patients with hypertrophic cardiomyopathy (n = 3), heart failure (n = 9), and with a low likelihood of coronary artery disease (n =15) (Figure 1), who underwent a rest 99mTc-MIBI myocardial perfusion SPECT, were assessed using a LIFEx software. Four shape−based features, 6 histogram−based features, and 32 textural features were computed. The relevant features for the classification of the patients were selected using the Boruta algorithm, and hierarchical clustering of the selected features using the Spearman correlation coefficient was also performed for the feature reduction. The receiver operating characteristics (ROC) analysis was performed by the support vector machine to calculate the area under the ROC curve (AUC) for the selected features. Results Of 40 features, 17 were selected by the classification analysis, and these features were classified into 7 classes by the correlation analysis (Figure 2). The ROC AUCs for 7 features extracted from each class were 0.99, 0.97, 0.96, 0.92, 0.90, 0.86, and 0.83 for the contrast of NDGLDM, the entropy of histogram, ZLNU of GLZLM, the energy of GLCM, the energy of histogram, SZLGE of GLZLM, and the correlation of GLCM, respectively, as compared to 0.39 for a summed rest score. Conclusions Radiomics analysis successfully determined the myocardial perfusion heterogeneity in patients with cardiomyopathy and heart failure. It might be promising for the evaluation of myocardial damages that cannot be analyzed by the conventional scoring method.

scholarly journals Сравнительный анализ данных перфузионной сцинтиграфии миокарда у пациентов с поражением коронарных артерий различной степени выраженности

2019 ◽  
Author(s):  
E DENISENKO-KANKIYA ◽  
F.N. CHANAKHCHIAN ◽  
E.I. VASILENKO ◽  
M.N. VAKHROMEEVA
Keyword(s):  
Myocardial Perfusion ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Vulnerable Atherosclerotic Plaque ◽  
Gated Perfusion Spect ◽  
Perfusion Spect ◽  
Perfusion Defects ◽  
Reversible Ischemia ◽  
Myocardial Perfusion Defects

Известно, что дестабилизация атеросклеротической бляшки коронарных артерий (КА) играет ключевую роль в развитии осложнений хронической ишемической болезни сердца (ИБС). Ранняя диагностика ишемии миокарда и определение субклинического стеноза КА с помощью неинвазивного метода визуализации сердца может стать важным методом в предотвращении развития сердечно-сосудистых осложнений у данной популяции больных. Цель исследования. Определить выраженность преходящих нарушений перфузии миокарда, выявленных при однофотонной эмиссионной компьютерной томографии (ОЭКТ) миокарда у пациентов со стенозами КА различной степени тяжести. Материал и методы. В исследование включен 231 пациент (средний возраст 6210лет). Проанализированы факторы кардиального риска. Всем пациентам проводили ОЭКТ миокарда по стандартному протоколу. Региональную перфузию миокарда оценивали с использованием стандартизированной 20-сегментной модели, на которой оценивали: SSS общий счет снижения перфузии миокарда при нагрузке SDS общую разницу счета, соответствующую степени выраженности преходящей ишемии левого желудочка (ЛЖ). На основании полученных данных обследуемых пациентов классифицировали на группы: с нормальной перфузией (SSS4), незначительной (SSS4-6), умеренной и выраженной степенью снижения (SSS712 и SSS13 соответственно) перфузии миокарда ЛЖ. Результаты SDS классифицировали как: отсутствие ишемии (SDS2), умеренная преходящая ишемия (SDS2-6) и выраженная преходящая ишемия (SDS7). Количественные показатели перфузии миокарда сравнивали с результатами инвазивной коронароангиографии (КАГ). Результаты. Из 231 пациента у 69 (29,9) по данным КАГ были выявлены стенозы до 20, у 126 (54,5) стенозы 2049, у 36 (15,6) стенозы 50 и более. Сравнительный анализ количественных показателей перфузии миокарда (SSS и SDS) и результатов КАГ показал, что достоверные дефекты перфузии после нагрузки и преходящая ишемия ЛЖ определены в основном у пациентов со стенозами КА50 (47,2 и 63,9 соответственно, р0,01). В группе пациентов с стенозами КА 2049 у 42,1 показатели SSS соответствовали незначительной (25,4) и умеренной (16,7) степени снижения перфузии после нагрузки (р0,01). При сопоставлении данных перфузионной сцинтиграфии миокарда выявлена связь между показателем SSS, наличием факторов риска и наличием сопутствующих заболеваний у пациентов с ИБС (р0,05). Заключение. Перфузионная ОЭКТ миокарда может использоваться в качестве метода выявления преходящей ишемии миокарда у пациентов со стенозами КА различной тяжести. Ключевые слова: ишемическая болезнь сердца, однофотонная эмиссионная компьютерная томография, перфузия миокарда, сцинтиграфия миокарда, необструктивное поражение, обструктивное поражение, коронароангиография.Vulnerable atherosclerotic plaque in coronary arteries (CA) is the primary mechanism responsible for complications of CAD even in the terms of non-obstructive CAD. Early determination of myocardial ischemia and CA stenosis with non-invasive imaging technique could predict the development of major cardiac events in patients with CAD. Aim: evaluation the severity of myocardial perfusion defects with single photon emission computed tomography (SPECT) in patients with obstructive or non-obstructive CAD. Material and methods: Overall 231patients (average age of 6210) were analyzed. All patients underwent 1-day gated perfusion SPECT protocol before coronary angiography (CAG). SPECT images were quantified by SSS and SDS using Cedars-Sinai QPS. Normal myocardial perfusion was considered if SSS4 mildly abnormal: SSS4-7 moderate and significantly abnormal: SSS8-12 and SSS13, respectively. Reversible ischemia was defined as SDS2. Degree of ischemia was assessed to moderate (SDS2-7) and severe (SDS7). Obstructive CAD was defined as 50 stenosis in 1 vessel on CAG. Results: From 231 patients 69 (29,9) have non-significant CA stenosis (20), 126 (54,5) have non-obstructive CAD (20-49) and 36 (15,6) - obstructive CAD (50). There were significant differences between CA stenosis severity via CAG and SSS via SPECT. In obstructive CAD significant myocardial perfusion defect at stress (SSS) and reversible ischemia (SDS) were observed in 47,2 and 63,9 patients, respectively (p0,01). In patients with non-obstructive CAD although the majority has normal myocardial perfusion in stress (SSS4 55,6), 42,1 has both mild (25,4) and moderate (16,7) myocardial perfusion defects in stress (p0,001). In this subgroup 45,2 of patients have moderate and 18,3 - severe reversible ischemia according to SDS (p0,001). Abnormal perfusion in stress was associated with hazards of cardiac risk factors or associated diseases (p0,05). Conclusion: Perfusion SPECT has a prognostic value over invasive CAG. The addition SPECT quantitative analysis to CAG allows improved risk stratification of patients with non-obstructive CAD.

scholarly journals Machine learning predicts per-vessel early coronary revascularization after fast myocardial perfusion SPECT: results from multicentre REFINE SPECT registry

2019 ◽  
Vol 21 (5) ◽  
pp. 549-559 ◽  
Author(s):  
Lien-Hsin Hu ◽  
Julian Betancur ◽  
Tali Sharir ◽  
Andrew J Einstein ◽  
Sabahat Bokhari ◽  
...  
Keyword(s):  
Machine Learning ◽  
Myocardial Perfusion ◽  
Single Photon ◽  
Coronary Revascularization ◽  
Stress Test ◽  
Invasive Coronary Angiography ◽  
Photon Emission ◽  
Myocardial Perfusion Spect ◽  
Patient Specific ◽  
Emission Computed Tomography

Abstract Aims To optimize per-vessel prediction of early coronary revascularization (ECR) within 90 days after fast single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using machine learning (ML) and introduce a method for a patient-specific explanation of ML results in a clinical setting. Methods and results A total of 1980 patients with suspected coronary artery disease (CAD) underwent stress/rest 99mTc-sestamibi/tetrofosmin MPI with new-generation SPECT scanners were included. All patients had invasive coronary angiography within 6 months after SPECT MPI. ML utilized 18 clinical, 9 stress test, and 28 imaging variables to predict per-vessel and per-patient ECR with 10-fold cross-validation. Area under the receiver operator characteristics curve (AUC) of ML was compared with standard quantitative analysis [total perfusion deficit (TPD)] and expert interpretation. ECR was performed in 958 patients (48%). Per-vessel, the AUC of ECR prediction by ML (AUC 0.79, 95% confidence interval (CI) [0.77, 0.80]) was higher than by regional stress TPD (0.71, [0.70, 0.73]), combined-view stress TPD (AUC 0.71, 95% CI [0.69, 0.72]), or ischaemic TPD (AUC 0.72, 95% CI [0.71, 0.74]), all P < 0.001. Per-patient, the AUC of ECR prediction by ML (AUC 0.81, 95% CI [0.79, 0.83]) was higher than that of stress TPD, combined-view TPD, and ischaemic TPD, all P < 0.001. ML also outperformed nuclear cardiologists’ expert interpretation of MPI for the prediction of early revascularization performance. A method to explain ML prediction for an individual patient was also developed. Conclusion In patients with suspected CAD, the prediction of ECR by ML outperformed automatic MPI quantitation by TPDs (per-vessel and per-patient) or nuclear cardiologists’ expert interpretation (per-patient).

scholarly journals Impact of iterative reconstruction with resolution recovery in myocardial perfusion SPECT: phantom and clinical studies

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Koichi Okuda ◽  
Kenichi Nakajima ◽  
Hiroto Yoneyama ◽  
Takayuki Shibutani ◽  
Masahisa Onoguchi ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Iterative Reconstruction ◽  
Clinical Studies ◽  
Photon Emission ◽  
Myocardial Perfusion Spect ◽  
Correction Method ◽  
Emission Computed Tomography ◽  
Variable Depth ◽  
Clinical Patient ◽  
Perfusion Spect

AbstractThe corrections of photon attenuation, scatter, and depth-dependent blurring improve image quality in myocardial perfusion single-photon emission computed tomography (SPECT) imaging; however, the combined corrections induce artifacts. Here, we present the single correction method of depth-dependent blurring and its impact for myocardial perfusion distribution in phantom and clinical studies. The phantom and clinical patient images were acquired with two conditions: circular and noncircular orbits of gamma cameras yielded constant and variable depth-dependent blurring, respectively. An iterative reconstruction with the correction method of depth-dependent was used to reconstruct the phantom and clinical patient images. We found that the single correction method improved the robustness of phantom images whether the images contained constant or variable depth-dependent blurring. The myocardial perfusion databases generated from 72 normal patients exhibited uniform perfusion distribution of whole myocardium. In summary, the single correction method of depth-dependent blurring with iterative reconstruction is helpful for myocardial perfusion SPECT.

Abstract 1641: Attenuation-correction Does Not Improve Quantitative Diagnostic Performance of Myocardial Perfusion SPECT in Women

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Arik Wolak ◽  
Piotr J Slomka ◽  
Mathews B Fish ◽  
James Gerlach ◽  
Santiago Lorenzo ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Myocardial Perfusion ◽  
Attenuation Correction ◽  
Diagnostic Performance ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Imaging Data ◽  
Female Population ◽  
Segmental Analysis

BACKGROUND: Attenuation Correction (AC) for myocardial perfusion single photon emission computed tomography (MPS) had not been evaluated separately in female population despite specific considerations in this group due to breast photon attenuation. We aimed to compare the performance of AC in women using automated quantitative analysis of MPS. METHODS: Consecutive female pts, 137 low likelihood (LLk) and 115 with coronary angiography performed within < 3 months of MPS, referred for rest/stress ECG gated Tc-99m sestamibi MPS with AC (Vantage Pro, Philips), were considered. Imaging data were evaluated for contour quality control (QC). Additional 50 female LLk studies were used to create equivalent normal limits for studies with AC and with no correction (NC). An experienced technologist (JG) blinded to the angiography and other results performed contour QC. All other processing was performed in a fully automated manner. Quantitative analysis was performed using Cedars Cardiac Suite version 2005, (QPS). All automatic segmental analysis was performed in 17-segment/5 point AHA model. Summed Stress Scores (SSS) ≥ 4 were considered abnormal. Receiver Operator Characteristics (ROC) areas-under- curve (AUC) were obtained by Analyze-It (v 1.171) statistical package. RESULTS: CAD (≥ 70% stenosis) was present in 70/115 (61%) pts. The normalcy rates were 96% and 98% for studies with and without AC, respectively (P=NS). SSS in studies with or without AC were the same with the exception of normal patients were SSS was higher for studies with AC. The diagnostic performance of MPS with and without AC for detection of CAD is summarized in the table . Conclusions: There are no diagnostic differences between quantitative MPS analysis with or without AC in women and no gain in specificity or normalcy rates contrary to previously reported findings in general populations.

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