Editorial: Monitoring Blood Rheology in Diabetes Mellitus

Traditional Chinese medicine (TCM) is an important complementary strategy for treating diabetes mellitus (DM) in China. Traditional Chinese blood circulation activating drugs are intended to guide an overall approach to the prevention and treatment of microvascular complications of DM. The core mechanism is related to the protection of the vascular endothelium and the basement membrane. Here, we reviewed the scientific evidence underpinning the use of blood circulation activating drugs to prevent and treat DM-induced microvascular complications, including diabetic nephropathy (DN), diabetic peripheral neuropathy (DPN), and diabetic retinopathy (DR). Furthermore, we summarized the effects and mechanism of TCM on improving blood rheology, inhibiting aggregation of platelet, forming advanced glycation end products (AGEs), regulating oxidative stress, reducing blood fat, and improving lipid metabolism. The paper provides a new theoretical basis for the clinical practice of TCM in the prevention and treatment of DM and its microvascular complications.

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Measurements of Transcutaneous Oxygen Pressure and Changes in Blood Rheology as Markers of Prognosis of Critically Ischemic Limb in Diabetes Mellitus Patients

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734603002001003 ◽

2003 ◽

Vol 2 (1) ◽

pp. 13-18 ◽

Cited By ~ 7

Author(s):

T. Khodabandehlou ◽

M. Vimeux ◽

C. Le Dévéhat

Keyword(s):

Diabetes Mellitus ◽

Oxygen Pressure ◽

Blood Rheology ◽

Transcutaneous Oxygen ◽

Ischemic Limb ◽

Transcutaneous Oxygen Pressure

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Improvement of Blood Rheology by Extract of Asana, Pterocarpus marsupium -Suppression of Platelet Aggregation Activity and Pterostilbene, as a Main Stilbene in the Extract

Natural Product Communications ◽

10.1177/1934578x1701200722 ◽

2017 ◽

Vol 12 (7) ◽

pp. 1934578X1701200

Author(s):

Kazuya Murata ◽

Takahiro Deguchi ◽

Masayuki Yasuda ◽

Ryutaro Endo ◽

Takanori Fujita ◽

...

Keyword(s):

Diabetes Mellitus ◽

Arachidonic Acid ◽

Platelet Aggregation ◽

Blood Rheology ◽

Passage Time ◽

Active Principle ◽

Pterocarpus Marsupium ◽

Beneficial Effects ◽

Aggregation Activity ◽

Lifestyle Related Diseases

The decoction from a tumbler made of heartwood of the Indian kino tree (Asana, Pterocarpus marsupium, PM) was a remedy for diabetes mellitus in Ayurveda. Diabetes mellitus is a one of the lifestyle-related diseases that finally leads to the induction of fatal diseases such as arterial sclerosis and cerebral infarction. In this study, effects on blood fluidity was investigated using extract obtained from the heartwood of PM. Oral administration of the extract reduced passage time of the blood obtained from disseminated intravascular coagulation model rats. In addition, the extract inhibited the reduction of platelets, which suggests that this attributed to the inhibition of platelet aggregation. The extract also demonstrated suppressive effects on both collagen- and arachidonic acid-induced platelet aggregation. Moreover, the extract showed inhibition against cyclooxygenase. The active principle was determined to be pterostilbene by collagen-induced platelet aggregation inhibitory activity-guided purification. Pterostilbene is a derivative of resveratrol, which is known to be in red wine and to possess beneficial effects for prevention of life-style related diseases. Pterostilbene exhibited 56 and 57% inhibition on both collagen- and arachidonic acid-induced platelet aggregation at 20 μM, respectively. These results demonstrate that the extract of PM heartwood may be a promising candidate as a multifunctional agent for treating lifestyle-related diseases.

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Blood rheology in experimental diabetes mellitus

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00785476 ◽

1993 ◽

Vol 116 (6) ◽

pp. 1480-1482

Author(s):

Kh. Ya. Karimov ◽

B. U. Iriskulov ◽

M. K. Ergashev

Keyword(s):

Diabetes Mellitus ◽

Experimental Diabetes ◽

Blood Rheology ◽

Experimental Diabetes Mellitus

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Blood rheology and retinopathy in adult type I diabetes mellitus

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-1992-12310 ◽

1992 ◽

Vol 12 (3) ◽

pp. 437-448 ◽

Cited By ~ 2

Author(s):

B. Bertram ◽

S. Wolf ◽

O. Arend ◽

K. Schulte ◽

T.W. Pesch ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type I Diabetes ◽

Blood Rheology ◽

Type I Diabetes Mellitus ◽

Type I ◽

Adult Type

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The Pathophysiology of Peripheral Arterial Disease: Rational Targets for Drug Intervention

Vascular Medicine ◽

10.1177/1358863x9700200311 ◽

1997 ◽

Vol 2 (3) ◽

pp. 227-230 ◽

Cited By ~ 23

Author(s):

John P Cooke

Keyword(s):

Diabetes Mellitus ◽

Peripheral Arterial Disease ◽

Plaque Rupture ◽

Tissue Injury ◽

Blood Rheology ◽

Arterial Disease ◽

Common Cause ◽

Available Nutrients ◽

Peripheral Arterial ◽

Progression Of Atherosclerosis

The most common cause of peripheral arterial disease (PAD) is atherosclerosis, which begins with an alteration in endothelial biology due to hypercholesterolemia, diabetes mellitus, hypertension, tobacco use, elevated levels of lipoprotein(a) or homocystinemia. With chronic and severe arterial disease, changes begin to occur in the microcirculation, including obstruction at the microvascular level and tissue injury. Based on insights into the vascular biology of PAD, new therapies have been developed and are at various stages of clinical trials. Future pharmacotherapy for PAD will include agents that have one or more of the following attributes: (1) reduce, or even reverse, the progression of atherosclerosis; (2) inhibit plaque rupture; (3) inhibit thrombosis by a novel mechanism; (4) induce angiogenesis; (5) reverse microvascular derangements; (6) affect blood rheology; and (7) enhance skeletal muscle's ability to use available nutrients.

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