scholarly journals HUBUNGAN KADAR LEUKOSIT DENGAN SEVERITAS LESI PEMBULUH DARAH KORONER PADA PASIEN SINDROM KORONER AKUT DI RSUP. PROF. DR. R. D. KANDOU PERIODE JULI-SEPTEMBER 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Lucky A. Tulung ◽  
A. Lucia Panda ◽  
Starry H. Rampengan
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Arteries ◽  
Pearson Correlation ◽  
Gensini Score ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Pearson Correlation Test ◽  
Artery Disease ◽  
The Relationship

Abstract: Acute Coronary Syndrome (ACS) is a set of manifestations or symptoms of coronary artery disease and thrombosis which can threaten the patien’s life due to interfering the blood supply of heart muscle. The infarct size is determined by assessing the coronary arteries lesion, stenosis. This study was aimed to determine the relationship between levels of leukocytes and the severity of coronary arteries lesions in patients with ACS. This was a descriptive analytical study with a cross-sectional retrospective design. The modified Gensini score was used to assess the severity of coronary artery lesion. The first leukocyte count examined when the patients was admitted to the hospital was obtained from the medical records period July to September 2015. Data were analyzed by using SPSS 20.0. The Pearson correlation test showed no significant relationship between the levels of leukocytes and the severity of coronary arteries lesions in patients with ACS (p >0.05). Conclusion: There was no significant correlation between the levels of leukocytes and the severity of coronary arteries lesions in patients with ACS.Keywords: leukocyte, severity of lesion, acute coronary syndrome, modified Gensini score Abstrak: Sindrom koroner akut (SKA) merupakan sekumpulan manifestasi atau gejala akibat penyakit arteri koroner dan trombosis yang dapat mengancam kehidupan pasien karena mengganggu pasokan darah ke otot jantung. Penilaian luas infark dilakukan dengan menilai lesi pembuluh darah koroner yang mengalami stenosis. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar leukosit dengan severitas lesi pembuluh darah koroner pada pasien SKA. Jenis penelitian ialah deskriptif analitik retrospektif dengan desain potong lintang. Penilaian severitas pembuluh darah yang mengalami lesi menggunakan skor modifikasi Gensini. Hitung leukosit yang digunakan ialah saat pasien pertama kali masuk Rumah Sakit yang diperoleh dari rekam medis periode Juli-September 2015. Data dianalisis menggunakan SPSS 20.0. Hasil uji korelasi Pearson memperlihatkan tidak terdapat hubungan bermakna antara kadar leukosit dan severitas lesi pembuluh darah koroner pada pasien SKA (p >0,05). Simpulan: Tidak terdapat hubungan bermakna antara kadar leukosit dan severitas lesi pembuluh darah koroner pada pasien Sindrom Koroner Akut. Kata kunci: leukosit, severitas lesi, sindrom koroner akut, skor modifikasi Gensini

scholarly journals Association of Thrombolysis in Myocardial Infarction (TIMI) Risk Score with Angiographic Severity of Coronary Artery Disease In Patients with Non-ST Elevation Acute Coronary Syndrome

2019 ◽  
Vol 15 (2) ◽  
pp. 68-73
Author(s):  
ABK Bashiruddin ◽  
Mohammad Ibrahim Chowdhury ◽  
Biplob Bhattacharjee ◽  
Abul Hossen Shahin ◽  
Syed Ali Ahsan ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
High Risk ◽  
Risk Score ◽  
Gensini Score ◽  
Coronary Syndrome ◽  
Timi Score ◽  
Artery Disease ◽  
Timi Risk Score

Background: Clinical guidelines recommend that optimal management of acute coronary syndrome (ACS) should include patient risk stratification. Predicting the anatomical extension of coronary artery disease (CAD) is also potentially useful for clinical decision. Objective: The objective of our study was to determine whether the TIMI risk score correlates with the angiographic extent and severity of CAD in patients with NSTE- ACS. Materials and Methods: This was a cross-sectional observational study carried out in the Department of Cardiology, Chattogram Medical College Hospital (CMCH) from September 2017 to May 2018. A total of 200 patients diagnosed with NSTE- Acute Coronary Syndrome were included as sample by purposive sampling method. TIMI risk score for each patient was calculated and the patients were stratified into 3 groups according to the TIMI risk score: low risk (0-2); intermediate risk (3-4); high risk (5-7). The severity of the CAD was assessed by Vessel score and Gensini score. Result: The mean ± SD of the age of study population was 53.7 ±10.8 years (range 37–77) and 142 (71%) were male. Regarding cardiovascular risk factors, 137 (68.5%) patients had diabetes mellitus, 83 (41.5%) had dyslipidaemia, 155 (77.5%) had hypertension, 136 (68%) were current smoker and 70 (35%) had a family history of CAD. The Gensini score was higher in patients at high risk TIMI group (p<0.001). Moreover, there was a signiûcant positive correlation between the TIMI and Gensini score (r=0.446,p<0.001). TIMI score can predict significant CAD moderately well (area under the curve 0.661, p=0.001). Patients with TIMI score > 4 were more likely to have significant three vessel CAD (65.9%) versus those with TIMI risk score 3-4 (17.9%) and TIMI risk score < 3 (2%) (p< 0.001). Conclusion: Study showed the TIMI score is significantly correlated with the extent of CAD as assessed by the Gensini score. It is accurate for predicting severe CAD among NSTE-ACS patients. University Heart Journal Vol. 15, No. 2, Jul 2019; 68-73

The Association Between Serum Procalcitonin Levels and Severity of Coronary Artery Disease Assessed by SYNTAX Score in Patients With Acute Coronary Syndrome

Angiology ◽  
2016 ◽  
Vol 68 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Ahmet Göktuğ Ertem ◽  
Tolga Han Efe ◽  
Çağrı Yayla ◽  
Mehmet Kadri Akboğa ◽  
Burak Açar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Inflammatory Marker ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Syntax Score ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Artery Disease

The SYNTAX score (SX score) is a useful score for assessing the severity of coronary artery disease (CAD). Previous studies have demonstrated a close relationship between SX score and inflammation. Procalcitonin (PCT) is an early inflammatory marker, especially during sepsis. Thus, in this study, we aimed to investigate the relationship between SX score and serum PCT levels. A total of 545 patients were enrolled in this prospective cross-sectional study and were divided into 2 subgroups, according to their SX score. Serum PCT and high-sensitivity C-reactive protein levels were measured. Serum PCT levels were higher in the high SX score group compared to the low–intermediate SX score group ( P < .001). Serum PCT levels were an independent predictor of a high SX score in patients with acute coronary syndrome ( P = .001). As patients with a higher SX score had increased serum PCT levels on admission, serum PCT may be useful for identifying patients with severe CAD.

scholarly journals Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry

2021 ◽  
Author(s):  
Negar Omidi ◽  
Saeed Sadeghian ◽  
Mojtaba Salarifar ◽  
Arash Jalali ◽  
Seyed Hesameddin Abbasi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Family History ◽  
Gensini Score ◽  
Coronary Syndrome ◽  
Artery Disease

Background: Acute coronary syndrome (ACS) is one of the main causes of mortality worldwide. We sought to evaluate the correlation between the severity of coronary artery disease (CAD) and conventional coronary artery risk factors in a large cohort of patients with ACS. Methods: This study included all patients admitted to the coronary care unit with a diagnosis of ACS between 2003 and 2017. The patients were divided into 2 groups: 1) unstable angina and 2) myocardial infarction. The aims of this study were to evaluate the effects of the risk factors and extension of coronary artery stenosis in patients with ACS according to the Gensini score. Results: Of a total 40 319 patients who presented with ACS, 18 862 patients (mean age =60.4±11.14 y, male: 67.2%) underwent conventional coronary angiography and met our criteria to enter the final analysis. The median of the Gensini score was 50 (25–88) in the study population. The multivariable analysis showed that age, sex, diabetes mellitus, hypertension, dyslipidemia, family history, cigarette smoking, opium consumption, and myocardial infarction increased the risk of positive Gensini scores. All the aforementioned risk factors, except cigarette smoking and opium consumption, increased the severity of stenosis in those with positive Gensini scores. The strongest relationship was seen vis-à-vis myocardial infarction, sex, and diabetes mellitus. Conclusion: Our findings suggest that age, sex, diabetes mellitus, dyslipidemia, hypertension, family history, and myocardial infarction have significant effects on the severity of CAD. The obesity paradox in relation to CAD should be taken into consideration and needs further investigation in patients with ACS.

scholarly journals N-Terminal Pro Brain Natriuretic Peptide in Assessment of Severity of Coronary Artery Disease in Patients with Non ST Elevation Acute Coronary Syndrome

2020 ◽  
Author(s):  
Hesham Mohammed El Ashmawy ◽  
Mohammed Ahmed Sadaka ◽  
Gehan Magdy Youssef ◽  
Abdulkarem Saeed Hassan
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Syntax Score ◽  
Gensini Score ◽  
Coronary Syndrome ◽  
St Elevation ◽  
The Mean ◽  
Artery Disease

Introduction: N-Terminal pro Brain Natriuretic Peptide (NT-pro BNP) is an important biomarker in the management of patients with heart failure. Several studies reported its importance as a predictor of morbidity and mortality in Acute Coronary Syndrome (ACS) patients. Aim: To compare serum NT-proBNP levels in Non ST Elevation Acute Coronary Syndrome (NSTE-ACS) patients and controls and to assess the relation between Nt-proBNP and the severity of Coronary Artery Disease (CAD) in patients with NSTE-ACS including unstable Angina (UA) and Non ST Elevation Myocardial Infarction (NSTEMI). Materials and Methods: Sixty NSTE-ACS patients and 20 matched control without significant obstructive CAD were included in the study. Cardiac enzymes, blood urea, serum creatinine, serum NT-proBNP were measured in all patients immediately before coronary angiography. Gensini score and Syntax score were calculated for all study patients. The NSTE-ACS patients were followed-up for six months for Major Adverse Cardiovascular Events (MACE) including mortality, myocardial infarction, heart failure, stroke, revascularisation by primary percutaneous coronary intervention or Coronary Artery Bypass Grafting (CABG). Results: The mean serum NT-proBNP in NSTE-ACS (UA and NSTEMI) patients was significantly higher (662.7±635.2) pg/mL than that in the control (102.3±96.4) pg/mL, p<0.001. The effective cut-off value for the diagnosis of CAD was 139 pg/mL, Area Under Curve (AUC)=0.950, 95% CI: 0.890-1.00). The serum NT-proBNP was correlated with the severity and complexity of CAD as measured by Gensini score (r=0.496, p<0.001) and Syntax score (r=0.443, p<0.001). The mean value of NT-proBNP in patients with six months MACE was insignificantly higher than in patients without six months MACE with Interquartile Range (IQR) of 418.5 (139-2037) vs. 366 (175-3237) pg/mL, p=0.970. Conclusion: NT-proBNP was correlated with the severity and complexity of CAD in NSTE-ACS with preserved left ventricular systolic function, but it has no impact on six months MACE.

The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome

2015 ◽  
Vol 4 (3) ◽  
pp. 216-221
Author(s):  
Adem Bekler ◽  
Gökhan Erbağ ◽  
Hacer Şen ◽  
Muhammed Turgut, Alper Özkan ◽  
Ali Ümit Yener ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Risk Score ◽  
Coronary Syndrome ◽  
Grace Risk Score ◽  
Artery Disease ◽  
The Relationship

scholarly journals ACUTE CORONARY SYNDROME;

2017 ◽  
Vol 24 (12) ◽  
pp. 1818-1822
Author(s):  
Huma Muzaffar ◽  
Shakeel Ahmad ◽  
Naeem Asghar
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Study Population ◽  
Artery Disease ◽  
Medical Wards

Objectives: To determine the frequency of raised low density lipoprotein (LDL)cholesterol in patients with acute coronary syndrome. Study Design: Cross sectional study.Setting: Coronary care unit (CCU) and medical wards at Allied Hospital Faisalabad. Durationand Dates: Six months from 01-01-2010 to 30-06-2010. Methods: This was a cross sectionalstudy that included 215 patients fulfilling the criteria of acute coronary syndrome admittingin CCU and medical wards. The demographic details, history and clinical examination of thepatients were recorded and blood samples were collected for the estimation of LDL cholesterol.Statistical Test: Descriptive statistics like mean and standard deviation (S.D) was appliedon age and LDL cholesterol. Gender and type of coronary artery event will be presented aspercentages. Frequency of raised LDL cholesterol was calculated in patients with ACS. Results:In this study population, out 215 patients, 183 (85.1) were found to have raised LDL cholesterollevels. There were 117 (54.4) males and 98 (45.6) females. Mean age was 56.29+- 13.01. Thefrequency of raised level of LDL cholesterol was slightly high in among males. STEMI was mostcommon type of ACS followed by unstable angina and NSTEMI. Conclusions: Frequency ofraised LDL cholesterol was high among the patients with acute coronary syndrome. It supportsthe potential for preventive efforts in persons with high risk of coronary artery disease.

scholarly journals VULNERABLE ATHEROSCLEROTIC PLAQUES OF CORONARY ARTERIES IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

2018 ◽  
Vol 7 (3) ◽  
pp. 65-71 ◽  
Author(s):  
N. A. Kochergin ◽  
A. M. Kochergina ◽  
V. I. Ganjukov ◽  
O. L. Barbarash
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Arteries ◽  
Stable Coronary Artery Disease ◽  
Lumen Area ◽  
Coronary Syndrome ◽  
Vulnerable Plaques ◽  
Luminal Stenosis ◽  
Artery Disease

Background. Acute coronary syndrome remains the leading cause of death worldwide. The rupture of vulnerable atherosclerotic plaque in the coronary artery is a common pathogenetic mechanism contributing to the onset of acute coronary syndrome. Therefore, one of the main goals of the practical cardiology is to ensure the development of sensitive early diagnostic methods and set preventive and treatment strategies for acute coronary event. Aim To evaluate the incidence of vulnerable plaques in the non-target coronary arteries in patients with stable coronary artery disease.Methods. 58 patients with stable coronary artery disease were included in a prospective observational cohort study. After the target vessel had been stented, virtual histology intravascular ultrasound (VH-IVUS) of the proximal and middle segments (6–8 cm) of one non-target artery (i.e. without any significant stenotic lesions on coronary angiography) was performed.Results. The mean age of patients was 60.4±6.6 years. In addition to the targeted hemodynamically significant lesions subjected to stenting, 56 patients had 58 lesions (96.5%) in the non-target coronary arteries. Of them, 5 lesions (8.6%) were with >70% luminal stenosis (including >70% luminal stenosis + lumen area <4 mm2 in 4 cases), 10 lesions (17.2%) – with minimum lumine area <4 mm2 and without any other signs of vulnerable plaque, 12 lesions (20.7%) – with a large necrotic core and a thin cap (including thin-cap fibroatheroma + >70% luminal stenosis in 2 patients; thin-cap fibroatheroma + lumen area <4 mm2 – 2 cases, thin-cap fibroatheroma + >70% luminal stenosis + lumen area <4 mm2 – 2 cases).Conclusion. In vivo evaluation of the plaques in the non-target vessels ensures the detection of vulnerable plaques in stable patients. The long-term follow-up of the study group allows assessing the risk of developing adverse cardiovascular events in those patients who have vulnerable coronary plaques.

scholarly journals Serum and Saliva Levels of Cathepsin L in Patients with Acute Coronary Syndrome

2011 ◽  
Vol 12 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Iraj Mirzaii-Dizgah ◽  
Esmail Riahi
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Cathepsin L ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Coronary Syndrome ◽  
Artery Disease ◽  
Student’S T

ABSTRACT Aim Coronary artery disease (CAD) is the major cause of death nearly all over the world, and accurate and rapid diagnosis of CAD is of major medical and economic importance. The aim of this study was to evaluate the serum and saliva levels of cathepsin L in patients with acute coronary syndrome (ACS). Materials and methods In a cross-sectional study, 39 patients with ACS and 28 with controls were recruited to the study, and cathepsin L levels were measured in serum, resting saliva, and stimulated saliva obtained 12 and 24 h after the onset of ACS by ELISA method. Statistical analyses of Fisher's exact test, the Student's t-test or Kruskal-Wallis test were performed. Results Stimulated saliva cathepsin L levels in patients with ACS 12 hours but not 24 hours after admission showed significant decrease compared with that in control subjects. However, there were no significant differences in serum and unstimulted saliva cathepsin L levels between groups. Conclusion Serum and saliva levels of cathepsin L remain unchanged in patients with ACS and hence may not be a promising factor in CAD risk assessment. Clinical significance It seems that serum and saliva cathepsin L may not be a good biomarker for CHD. Abbreviations CAD: Coronary artery disease, ACS: Acute coronary syndrome, CHD: Coronary heart disease, EU: Emergency unit, MI: Myocardial infarction. How to cite this article Mirzaii-Dizgah I, Riahi E. Serum and Saliva Levels of Cathepsin L in Patients with Acute Coronary Syndrome. J Contemp Dent Pract 2011;12(2):114-119.

Sign in / Sign up

Export Citation Format

Share Document