scholarly journals Penggunaan Asam Lemak Omega-3 sebagai Terapi Pendukung dalam Perawatan Periodontitis

e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 209
Author(s):  
Pingkan A. Lengkong ◽  
Johanna A. Khoman ◽  
Pritartha S. Anindita
Keyword(s):  
Fatty Acids ◽  
Supportive Therapy ◽  
Periodontal Tissue ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Pocket Depth ◽  
Periodontal Tissues ◽  
Probing Pocket Depth ◽  
Surgical Methods ◽  
Randomized Control

Abstract: Periodontitis is an inflammation of periodontal tissue characterized by clinical attachment loss, periodontal pocket formation, gingival recession, and periodontal tissue destruction. Periodontitis can be treated by surgical or non-surgical methods. One of the non-surgical methods is host modulation therapy which can reduce the damage by treating the chronic inflammatory response. Host modulation therapy is in the form of drugs or supplements that have anti-inflammatory properties. Omega-3 fatty acids have anti-inflammatory properties that serve as a protection against inflammation and infection including periodontitis. This study was aimed to obtain the effect of using omega-3 fatty acids as supportive therapy in the treatment of periodontitis. This was a literature review study by using PubMed, Clinical Key and Google Scholar databases. The keywords used were omega-3 fatty acids and periodontitis. After being selected based on inclusion and exclusion criteria, a critical appraisal was carried out to obtain seven randomized control trial literature. The results showed that the use of omega-3 fatty acids had an effect on the mean value of decreasing probing pocket depth and increasing clinical attachment of periodontal tissues. In conclusion, omega-3 fatty acids have an effect and can be used as a supportive therapy in the treatment of periodontitis. Omega-3 fatty acids lead to a better increase in the resolution of inflammation and can accelerate the healing of periodontal tissues by decreasing probing pocket depth and increasing clinical attachment.Keywords: omega-3 fatty acids; periodontal tissue; periodontitis  Abstrak: Periodontitis adalah inflamasi jaringan periodontal yang ditandai dengan kehilangan perlekatan klinis, pembentukan saku periodontal, resesi gingiva, dan kerusakan jaringan peridontal. Periodontitis dapat diobati dengan metode bedah maupun non bedah. Salah satu metode non bedah yaitu terapi modulasi host yang dapat mengurangi kerusakan dengan mengobati aspek respons inflamasi kronis. Terapi modulasi host berupa pemberian obat maupun suplemen yang memiliki sifat anti inflamasi. Asam lemak omega-3 memiliki sifat anti inflamasi yang berfungsi sebagai perlindungan dalam melawan peradangan dan infeksi termasuk periodontitis. Penelitian ini bertujuan untuk mengetahui gambaran pengaruh penggunaan asam lemak omega-3 sebagai terapi pendukung dalam perawatan periodontitis. Jenis penelitian ialah suatu literature review menggunakan database PubMed, Clinical Key. dan Google Scholar. Kata kunci yang digunakan yaitu omega-3 fatty acids and periodontitis. Setelah diseleksi berdasarkan kriteria inklusi dan eksklusi, dilakukan critical appraisal dan didapatkan tujuh literatur randomized control trial. Hasil penelitian mendapatkan bahwa penggunaan asam lemak omega-3 memengaruhi nilai rerata penurunan kedalaman probing poket dan meningkatkan perlekatan klinis jaringan periodontal. Simpulan penelitian ini ialah asam lemak omega-3 memiliki pengaruh dan dapat digunakan sebagai terapi pendukung dalam perawatan periodontitis. Asam lemak omega-3 menyebabkan peningkatan yang lebih baik dalam resolusi peradangan dan dapat mempercepat penyembuhan jaringan periodontal dilihat dari penurunan kedalaman probing poket dan meningkatnya perlekatan klinis.Kata kunci: asam lemak omega-3; jaringan periodontal; periodontitis

scholarly journals Effect of omega 3 fatty acids plus low dose aspirin as a host modulating agent in the treatment of periodontitis patients- A Systematic Review

2021 ◽  
Vol 6 (2) ◽  
pp. 68-71
Author(s):  
Pooja Naik ◽  
◽  
Amit Benjamin ◽  
Shukra Paralkar ◽  
◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Acids ◽  
Low Dose ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Pocket Depth ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Background and Objectives: Host Modulatory Therapy is a treatment modality for periodontal diseases. It aims at reducing the periodontal destruction and enhances the regenerative capacity of periodontal tissues. Various host modulating agents are used as an adjunct to scaling and root planing. Omega 3 Fatty acids and non-steroidal anti-inflammatory drugs like Aspirin modify the activity of inflammatory mediators and exert anti-inflammatory effect. The objective of the systematic review was to evaluate the effect of Omega 3 Fatty acids plus low dose Aspirin as adjunct to mechanical debridement in reduction of pocket depth in patients with periodontitis. Methods: In this systematic review, Randomized controlled trials in subjects with periodontitis in age group of 25-70 years were considered. Follow up period ranged from 6 weeks to 6 months. A systematic review of literature was performed using Pubmed, PMC, Google scholar, EBSCO host databases. Studies concerning the use of Omega 3 Fatty acids plus low dose Aspirin as host modulating agent in periodontitis treatment were selected. A total 2650 of studies were selected through search strategy and 5 articles which attained the inclusion criteria have been included in present systematic review. Results: Oral supplementation of omega 3 fatty acids in combination of low dose Aspirin as adjunct to mechanical debridement reduces the pocket depth during the 6 weeks to 6 months follow up period. Limitations: There are limited studies which are available. Also there is lack of data evaluating the long term follow up of the intervention. Conclusion: Use of omega 3 fatty acids and low dose aspirin in periodontitis patients improves periodontal status but further long-term studies need to be conducted.

Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

2019 ◽  
pp. 1-7
Author(s):  
Hadeer Zakaria ◽  
Tarek M. Mostafa ◽  
Gamal A. El-Azab ◽  
Nagy AH Sayed-Ahmed
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Fish Oil ◽  
Wheat Germ ◽  
Hemodialysis Patients ◽  
Nutritional Indices ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wheat Germ Oil ◽  
Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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