scholarly journals Real time model-based diagnosis enabled by hybrid modeling

2020 ◽  
Vol 12 (1) ◽  
pp. 10
Author(s):  
Ion Matei ◽  
Alexander Feldman ◽  
Johan De Kleer ◽  
Alexandre Perez

In this paper we propose a hybrid modeling approach for generating reduced models of a high fidelity model of a physical system. We propose machine learning inspired representations for complex model components. These representations preserve in part the physical interpretation of the original components. Training platforms featuring automatic differentiation are used to learn the parameters of the new representations using data generated by the high-fidelity model. We showcase our approach in the context of fault diagnosis for a rail switch system. We generate three new model abstractions whose complexities are two order of magnitude smaller than the complexity of the high fidelity model, both in the number of equations and simulation time. Faster simulations ensure faster diagnosis solutions and enable the use of diagnosis algorithms relying heavily on large numbers of model simulations.

2018 ◽  
Vol 84 (10) ◽  
pp. 23-28
Author(s):  
D. A. Golentsov ◽  
A. G. Gulin ◽  
Vladimir A. Likhter ◽  
K. E. Ulybyshev

Destruction of bodies is accompanied by formation of both large and microscopic fragments. Numerous experiments on the rupture of different samples show that those fragments carry a positive electric charge. his phenomenon is of interest from the viewpoint of its potential application to contactless diagnostics of the early stage of destruction of the elements in various technical devices. However, the lack of understanding the nature of this phenomenon restricts the possibility of its practical applications. Experimental studies were carried out using an apparatus that allowed direct measurements of the total charge of the microparticles formed upon sample rupture and determination of their size and quantity. The results of rupture tests of duralumin and electrical steel showed that the size of microparticles is several tens of microns, the particle charge per particle is on the order of 10–14 C, and their amount can be estimated as the ratio of the cross-sectional area of the sample at the point of discontinuity to the square of the microparticle size. A model of charge formation on the microparticles is developed proceeding from the experimental data and current concept of the electron gas in metals. The model makes it possible to determine the charge of the microparticle using data on the particle size and mechanical and electrical properties of the material. Model estimates of the total charge of particles show order-of-magnitude agreement with the experimental data.


2021 ◽  
Author(s):  
Parsoa Khorsand ◽  
Fereydoun Hormozdiari

Abstract Large scale catalogs of common genetic variants (including indels and structural variants) are being created using data from second and third generation whole-genome sequencing technologies. However, the genotyping of these variants in newly sequenced samples is a nontrivial task that requires extensive computational resources. Furthermore, current approaches are mostly limited to only specific types of variants and are generally prone to various errors and ambiguities when genotyping complex events. We are proposing an ultra-efficient approach for genotyping any type of structural variation that is not limited by the shortcomings and complexities of current mapping-based approaches. Our method Nebula utilizes the changes in the count of k-mers to predict the genotype of structural variants. We have shown that not only Nebula is an order of magnitude faster than mapping based approaches for genotyping structural variants, but also has comparable accuracy to state-of-the-art approaches. Furthermore, Nebula is a generic framework not limited to any specific type of event. Nebula is publicly available at https://github.com/Parsoa/Nebula.


2017 ◽  
Vol 34 (5) ◽  
pp. 1485-1500
Author(s):  
Leifur Leifsson ◽  
Slawomir Koziel

Purpose The purpose of this paper is to reduce the overall computational time of aerodynamic shape optimization that involves accurate high-fidelity simulation models. Design/methodology/approach The proposed approach is based on the surrogate-based optimization paradigm. In particular, multi-fidelity surrogate models are used in the optimization process in place of the computationally expensive high-fidelity model. The multi-fidelity surrogate is constructed using physics-based low-fidelity models and a proper correction. This work introduces a novel correction methodology – referred to as the adaptive response prediction (ARP). The ARP technique corrects the low-fidelity model response, represented by the airfoil pressure distribution, through suitable horizontal and vertical adjustments. Findings Numerical investigations show the feasibility of solving real-world problems involving optimization of transonic airfoil shapes and accurate computational fluid dynamics simulation models of such surfaces. The results show that the proposed approach outperforms traditional surrogate-based approaches. Originality/value The proposed aerodynamic design optimization algorithm is novel and holistic. In particular, the ARP correction technique is original. The algorithm is useful for fast design of aerodynamic surfaces using high-fidelity simulation data in moderately sized search spaces, which is challenging using conventional methods because of excessive computational costs.


1991 ◽  
Vol 113 (3) ◽  
pp. 314-329 ◽  
Author(s):  
F. Yuan ◽  
S. Chien ◽  
S. Weinbaum

In this paper a new theoretical framework is presented for analyzing the filtration and macromolecular convective-diffusive transport processes in the intimal region of an artery wall with widely dispersed macromolecular cellular leakage sites, as proposed in the leaky junction-cell turnover hypothesis of Weinbaum et al. [11]. In contrast to existing convection-diffusive models, which assume that the transport is either 1-D, or convection is primarily in a direction normal to the endothelial surface, the present model considers for the first time the nonuniform subendothelial pressure field that arises from the different hydraulic resistances of normal and leaky endothelial clefts and the special role of the internal elastic lamina (IEL) in modulating the horizontal transport of macromolecules after they have passed through the leaky clefts of cells that are either in mitosis or demonstrate IgG labeling. The new theory is able to quantitatively explain the growing body of recent experiments in which an unexpectedly rapid early-time growth of the leakage spot has been observed and the longer time asymptotic behavior in which the leakage spot appears to approach an equilibrium diameter. The new theory also predicts the observed doubling in macromolecular permeability between EBA labeled blue and white areas when the frequency of leakage sites is doubled. This frequency for doubling of permeability, however, is an order of magnitude smaller than predicted by the author’s previous model, Tzeghai et al. [10], in which only convection normal to the endothelial surface was considered and the pressure was uniform in the intima. The longer time model predictions are used to explain the time scale for the formation of liposomes [4] in subendothelial tissue matrix in animal feeding experiments where it has been observed that the extracellular lipid concentration rises sharply prior to the entry of monocytes into the intima [45].


2018 ◽  
Vol 48 (9) ◽  
pp. 1941-1950 ◽  
Author(s):  
Ekaterina Ezhova ◽  
Claudia Cenedese ◽  
Luca Brandt

AbstractSubglacial discharges have been observed to generate buoyant plumes along the ice face of Greenland tidewater glaciers. These plumes have been traditionally modeled using classical plume theory, and their characteristic parameters (e.g., velocity) are employed in the widely used three-equation melt parameterization. However, the applicability of plume theory for three-dimensional turbulent wall plumes is questionable because of the complex near-wall plume dynamics. In this study, corrections to the classical plume theory are introduced to account for the presence of a wall. In particular, the drag and entrainment coefficients are quantified for a three-dimensional turbulent wall plume using data from direct numerical simulations. The drag coefficient is found to be an order of magnitude larger than that for a boundary layer flow over a flat plate at a similar Reynolds number. This result suggests a significant increase in the melting estimates by the current parameterization. However, the volume flux in a wall plume is found to be one-half that of a conical plume that has 2 times the buoyancy flux. This finding suggests that the total entrainment (per unit area) of ambient water is the same and that the plume scalar characteristics (i.e., temperature and salinity) can be predicted reasonably well using classical plume theory.


2018 ◽  
Vol 27 (2) ◽  
pp. 118-124 ◽  
Author(s):  
Andrei Odobescu ◽  
Isak Goodwin ◽  
Djamal Berbiche ◽  
Joseph BouMerhi ◽  
Patrick G. Harris ◽  
...  

Background: The Thiel embalmment method has recently been used in a number of medical simulation fields. The authors investigate the use of Thiel vessels as a high fidelity model for microvascular simulation and propose a new checklist-based evaluation instrument for microsurgical training. Methods: Thirteen residents and 2 attending microsurgeons performed video recorded microvascular anastomoses on Thiel embalmed arteries that were evaluated using a new evaluation instrument (Microvascular Evaluation Scale) by 4 fellowship trained microsurgeons. The internal validity was assessed using the Cronbach coefficient. The external validity was verified using regression models. Results: The reliability assessment revealed an excellent intra-class correlation of 0.89. When comparing scores obtained by participants from different levels of training, attending surgeons and senior residents (Post Graduate Year [PGY] 4-5) scored significantly better than junior residents (PGY 1-3). The difference between senior residents and attending surgeons was not significant. When considering microsurgical experience, the differences were significant between the advanced group and the minimal and moderate experience groups. The differences between minimal and moderate experience groups were not significant. Based on the data obtained, a score of 8 would translate into a level of microsurgical competence appropriate for clinical microsurgery. Conclusions: Thiel cadaveric vessels are a high fidelity model for microsurgical simulation. Excellent internal and external validity measures were obtained using the Microvascular Evaluation Scale (MVES).


2021 ◽  
Author(s):  
Dihui Chen ◽  
Yanjie Shen ◽  
Juntao Wang ◽  
Yang Gao ◽  
Huiwang Gao ◽  
...  

Abstract. To study sea-derived gaseous amines, ammonia, and primary particulate aminium ions in the marine atmospheres of China's marginal seas, an onboard URG-9000D Ambient Ion Monitor-Ion chromatography (AIM-IC, Thermo Fisher) was set up on the front deck of the R/V Dongfanghong 3 to semi-continuously measure the spatiotemporal variations in the concentrations of atmospheric trimethylamine (TMAgas), dimethylamine (DMAgas), and ammonia (NH3gas) along with their particulate matter (PM2.5) counterparts. In this study, we differentiated marine emissions of the gas species originating from continental transport using data obtained from December 9 to 22, 2019 during the cruise over the Yellow and Bohai Seas, facilitated by additional measurements collected at a coastal site near the Yellow Sea during summer 2019. The data obtained during the cruise and the coastal site demonstrated that the observed TMAgas and protonated trimethylamine (TMAH+) in PM2.5 over the Yellow and Bohai Seas overwhelmingly originated from marine sources. During the cruise, there was no significant correlation (P > 0.05) between the simultaneously measured TMAH+ and TMAgas concentrations. Additionally, the concentrations of TMAH+ in the marine atmosphere varied around 0.28 ± 0.18 μg m−3 (average  ±  standard deviation), with several episodic hourly average values exceeding 1 μg m−3, which were approximately one order of magnitude larger than those of TMAgas (approximately 0.031 ± 0.009 μg m−3). Moreover, there was a significant negative correlation (P < 0.01) between the concentrations of TMAH+ and NH4+ in PM2.5 during the cruise. Therefore, the observed TMAH+ in PM2.5 was overwhelmingly derived from primary sea-spray aerosols. Using the TMAgas and TMAH+ in PM2.5 as tracers for sea-derived basic gases and sea-spray particulate aminium ions, the values of non-sea-derived DMAgas and NH3gas, as well as non-sea-spray particulate DMAH+ in PM2.5, were estimated, and the estimated average values of each species contributed to 16 %, 34 %, and 65 % of the observed average concentrations, respectively. Uncertainties remained in the estimations as TMAH+ may decompose into smaller molecules in seawater to varying extents. The non-sea-derived gases and non-sea-spray particulate DMAH+ likely originated from long-range transport from the upwind continents, according to the recorded offshore winds and increased concentrations of SO42− and NH4+ in PM2.5. The lack of a detectable increase in the particulate DMAH+, NH4+, and SO42− concentrations in several SO2 plumes did not support the secondary formation of particulate DMAH+ in the marine atmosphere.


PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0201172 ◽  
Author(s):  
Shreyas K. Roy ◽  
Qinghe Meng ◽  
Benjamin D. Sadowitz ◽  
Michaela Kollisch-Singule ◽  
Natesh Yepuri ◽  
...  

2021 ◽  
Author(s):  
Francesco Rizzi ◽  
Eric Parish ◽  
Patrick Blonigan ◽  
John Tencer

&lt;p&gt;This talk focuses on the application of projection-based reduced-order models (pROMs) to seismic elastic shear waves. Specifically, we present a method to efficiently propagate parametric uncertainties through the system using a novel formulation of the Galerkin ROM that exploits modern many-core computing nodes.&lt;/p&gt;&lt;p&gt;Seismic modeling and simulation is an active field of research because of its importance in understanding the generation, propagation and effects of earthquakes as well as artificial explosions. We stress two main challenges involved: (a) physical models contain a large number of parameters (e.g., anisotropic material properties, signal forms and parametrizations); and (b) simulating these systems at global scale with high-accuracy requires a large computational cost, often requiring days or weeks on a supercomputer. Advancements in computing platforms have enabled researchers to exploit high-fidelity computational models, such as highly-resolved seismic simulations, for certain types of analyses. Unfortunately, for analyses requiring many evaluations of the forward model (e.g., uncertainty quantification, engineering design), the use of high-fidelity models often remains impractical due to their high computational cost. Consequently, analysts often rely on lower-cost, lower-fidelity surrogate models for such problems.&lt;/p&gt;&lt;p&gt;Broadly speaking, surrogate models fall under three categories, namely (a) data fits, which construct an explicit mapping (e.g., using polynomials, Gaussian processes) from the system's parameters to the system response of interest, (b) lower-fidelity models, which simplify the high-fidelity model (e.g., by coarsening the mesh, employing a lower finite-element order, or neglecting physics), and (c) pROMs which reduce the number of degrees of freedom in the high-fidelity model by a projection process of the full-order model onto a subspace identified from high-fidelity data. The main advantage of pROMs is that they apply a projection process directly to the equations governing the high-fidelity model, thus enabling stronger guarantees (e.g., of structure preservation or of accuracy) and more accurate a posteriori error bounds.&lt;/p&gt;&lt;p&gt;State-of-the-art Galerkin ROM formulations express the state as a rank-1 tensor (i.e., a vector), leading to computational kernels that are memory bandwidth bound and, therefore, ill-suited for scalable performance on modern many-core and hybrid computing nodes. In this work, we introduce a reformulation, called rank-2 Galerkin, of the Galerkin ROM for linear time-invariant (LTI) dynamical systems which converts the nature of the ROM problem from memory bandwidth to compute bound, and apply it to elastic seismic shear waves in an axisymmetric domain. Specifically, we present an end-to-end demonstration of using the rank-2 Galerkin ROM in a Monte Carlo sampling study, showing that the rank-2 Galerkin ROM is 970 times more efficient than the full order model, while maintaining excellent accuracy in both the mean and statistics of the field.&lt;/p&gt;


Author(s):  
Marco Baldan ◽  
Alexander Nikanorov ◽  
Bernard Nacke

Purpose Reliable modeling of induction hardening requires a multi-physical approach, which makes it time-consuming. In designing an induction hardening system, combining such model with an optimization technique allows managing a high number of design variables. However, this could lead to a tremendous overall computational cost. This paper aims to reduce the computational time of an optimal design problem by making use of multi-fidelity modeling and parallel computing. Design/methodology/approach In the multi-fidelity framework, the “high-fidelity” model couples the electromagnetic, thermal and metallurgical fields. It predicts the phase transformations during both the heating and cooling stages. The “low-fidelity” model is instead limited to the heating step. Its inaccuracy is counterbalanced by its cheapness, which makes it suitable for exploring the design space in optimization. Then, the use of co-Kriging allows merging information from different fidelity models and predicting good design candidates. Field evaluations of both models occur in parallel. Findings In the design of an induction heating system, the synergy between the “high-fidelity” and “low-fidelity” model, together with use of surrogates and parallel computing could reduce up to one order of magnitude the overall computational cost. Practical implications On one hand, multi-physical modeling of induction hardening implies a better understanding of the process, resulting in further potential process improvements. On the other hand, the optimization technique could be applied to many other computationally intensive real-life problems. Originality/value This paper highlights how parallel multi-fidelity optimization could be used in designing an induction hardening system.


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