scholarly journals TO EVALUATE SAFETY AND EFFECTIVENESS OF KETAMINE-PROPOFOL COMBINATION AND PROPOFOL ALONE IN DIAGNOSTIC RADIOLOGICAL PROCEDURES (MRI) IN PEDIATRIC PATIENTS.

2020 ◽  
pp. 10-13
Author(s):  
M. Sajith ◽  
K. Manogna ◽  
G. Nagaraj Yadav
Keyword(s):  
Pediatric Patients ◽  
Study Results ◽  
Blinded Study ◽  
Brain Scan ◽  
Small Doses ◽  
Pediatric Mri ◽  
Magnetic Resonance Imaging Mri ◽  
Group Recovery ◽  
Double Blinded ◽  
Radiological Procedures

Introduction: There is a growing need for magnetic resonance imaging (MRI) in children for accurate diagnosis and appropriate medical treatment. In recent times, small doses of ketamine have been used along with propofol for pediatric MRI sedation. Aims and objectives: to evaluate safety and effectiveness of Ketamine-propofol combination and propofol alone in diagnostic radiological procedures (MRI) in pediatric patients. Materials and methods: The present prospective randomized double blinded study was undertaken at Government General Hospital, Tirupati. Pediatric patients aged between 2 to 12 years of both sex, belonging to ASA grade I & II and posted for elective MRI Brain scan were included in the study. Results: KP group had significantly more reactions than P group. Recovery time (time taken to achieve modified aldrete recovery score of 9-10) was 37.33±2.88 min and 19.6±2.67 min in Ketofol group and propofol group respectively. Conclusion: Ketofol is an attractive combination for procedural sedation.

scholarly journals Randomized controlled and double‐blinded study of Caphosol versus saline oral rinses in pediatric patients with cancer

2020 ◽  
Vol 67 (10) ◽  
Author(s):  
Egle Immonen ◽  
Liisa Aine ◽  
Atte Nikkilä ◽  
Mataleena Parikka ◽  
Marika Grönroos ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Patients With Cancer ◽  
Randomized Controlled ◽  
Blinded Study ◽  
Double Blinded

Effect of Febuxostat on the Endothelial Dysfunction in Hemodialysis Patients: A Randomized, Placebo-Controlled, Double-Blinded Study

2017 ◽  
Vol 45 (5) ◽  
pp. 452-459 ◽  
Author(s):  
Mona Alshahawey ◽  
Sara Mahmoud Shahin ◽  
Tamer Wahid Elsaid ◽  
Nagwa Ali Sabri
Keyword(s):  
Placebo Group ◽  
Endothelial Dysfunction ◽  
Group Treatment ◽  
Hemodialysis Patients ◽  
Oxidase Inhibitor ◽  
Xanthine Oxidase Inhibitor ◽  
Study Results ◽  
Significant Difference ◽  
Blinded Study ◽  
Double Blinded

Background: Endothelial dysfunction is an important risk factor for cardiovascular diseases to occur in end-stage renal disease patients. Febuxostat, being a novel xanthine oxidase inhibitor, is apparently having a beneficial role in improving the endothelial dysfunction; however, data among hemodialysis patients are still limited. Methods: A prospective, placebo-controlled, block-randomized, double-blinded study was carried out to evaluate the effect of oral febuxostat on the endothelial dysfunction in hemodialysis patients. Fifty-seven eligible hemodialysis patients were randomly assigned to either the drug group (40 mg thrice weekly) or the placebo group. Serum Asymmetric dimethylarginine (ADMA), Serum uric acid (UA), and serum high sensitivity C-reactive protein (hsCRP) were measured at baseline and at the end of a 2-month study. Serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), and the occurrence of pancytopenia were tested as safety parameters at baseline and at the end of study. Results: Serum UA significantly decreased from 7.5 ± 0.8 to 5.1 ± 1.2 mg/dL in the febuxostat group, while it did not change significantly in the placebo group. Treatment with febuxostat resulted in a significant decrease in the serum ADMA level from 1.027 ± 0.116 to 0.944 ± 0.104 µmol/L and the serum hsCRP level from 12.5 ± 1.65 to 12.1 ± 1.70 mg/L. Testing of serum ALT, serum AST, and pancytopenia revealed no significant difference in both groups. Conclusion: Febuxostat appears to improve hyperuricemia and endothelial dysfunction and ameliorate inflammation in hemodialysis patients with no safety concerns.

scholarly journals Randomized controlled and double-blinded study of Caphosol versus saline oral rinses in pediatric patients with cancer

2020 ◽  
Author(s):  
Egle Immonen ◽  
Liisa Aine ◽  
Atte Nikkil ◽  
Mataleena Parikka ◽  
Marika Gr nroos ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Patients With Cancer ◽  
Randomized Controlled ◽  
Blinded Study ◽  
Double Blinded
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