scholarly journals C - REACTIVE PROTEIN: AN INFLAMMATORY BIOMARKER PRESENT IN MULTIPLE DISEASE PATHOGENESIS

2019 ◽  
pp. 1-4
Author(s):  
Parvinder Kaur
Keyword(s):  
Bacterial Infection ◽  
Biological Function ◽  
Acute Phase Protein ◽  
C Reactive Protein ◽  
Inflammatory Biomarker ◽  
Classical Complement Pathway ◽  
Reactive Protein ◽  
Phase Protein ◽  
Clinical Conditions ◽  
Classical Complement

C-reactive protein (CRP) is an acute-phase protein belongs to pentraxins family with a feature of ve identical globular subunits. Two different isoforms i.e. pentameric CRP (pCRP) and monomeric CRP (mCRP) have different key role in regulation. The key biological function of CRP is host defense using classical complement pathway against bacterial infection and involved in removal of apoptotic and necrotic cells. Although CRP is mainly associated with inammation in bacterial infection such as tuberculosis or Pneumococcus infection, however it is also presence in atherosclerosis, cardiovascular disease (CVD) and in various cancers which make it good candidate for prognostic study in different clinical conditions.

scholarly journals C-Reactive Protein Triggers Cell Death in Ischemic Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Ahmed Sheriff ◽  
Stefan Kayser ◽  
Patrizia Brunner ◽  
Birgit Vogt
Keyword(s):  
Blood Pressure ◽  
Physiological Function ◽  
Acute Phase Protein ◽  
C Reactive Protein ◽  
Classical Complement Pathway ◽  
Reactive Protein ◽  
Additional Influence ◽  
External Wound ◽  
Classical Complement ◽  
Alveolar Edema

C-reactive protein (CRP) is the best-known acute phase protein. In humans, almost every type of inflammation is accompanied by an increase of CRP concentration. Until recently, the only known physiological function of CRP was the marking of cells to initiate their phagocytosis. This triggers the classical complement pathway up to C4, which helps to eliminate pathogens and dead cells. However, vital cells with reduced energy supply are also marked, which is useful in the case of a classical external wound because an important substrate for pathogens is disposed of, but is counterproductive at internal wounds (e.g., heart attack or stroke). This mechanism negatively affects clinical outcomes since it is established that CRP levels correlate with the prognosis of these indications. Here, we summarize what we can learn from a clinical study in which CRP was adsorbed from the bloodstream by CRP-apheresis. Recently, it was shown that CRP can have a direct effect on blood pressure in rabbits. This is interesting in regard to patients with high inflammation, as they often become tachycardic and need catecholamines. These two physiological effects of CRP apparently also occur in COVID-19. Parts of the lung become ischemic due to intra-alveolar edema and hemorrhage and in parallel CRP increases dramatically, hence it is assumed that CRP is also involved in this ischemic condition. It is meanwhile considered that most of the damage in COVID-19 is caused by the immune system. The high amounts of CRP could have an additional influence on blood pressure in severe COVID-19.

scholarly journals DIAGNOSTIC OF C-REACTIVE PROTEIN IN FEBRILE CHILDREN

2018 ◽  
Vol 18 (2) ◽  
pp. 117
Author(s):  
Johanis Johanis ◽  
Aryati Aryati ◽  
Dominicus Husada ◽  
Djoko Marsudi ◽  
M. Y. Probohoesodo
Keyword(s):  
Bacterial Infection ◽  
Bacterial Infections ◽  
Area Under Curve ◽  
Acute Phase Protein ◽  
C Reactive Protein ◽  
Optimal Test ◽  
Data Set ◽  
Reactive Protein ◽  
Phase Protein ◽  
Outcome Result

The measurement of C-reactive protein (CRP), an acute-phase protein synthesized by hepatocytes, is valuable to distinguish bacterialinfection from non-bacterial infections in children. The aim of this study is to know the diagnostic properties of quantitative CRPassociated with clinically bacterial and non-bacterial infection in febrile children. Febrile children which was studied were presentingin the Paediatric Emergency Department, their ages were up to 12 years, with axillary’s temperature ≥38.5° C, and the clinicallyundetectable source of fever were enrolled in this consecutive study from September, 2009, up to August, 2010. Informed consent wasobtained for the use of CRP evaluation. The CRP concentration was measured with immunoturbidimetry method (Pure auto S CRP latex(SS-type), Sekisui Medical Co., Ltd) and an auto photometer TMS 1024i. The main outcome result was the presence of the laboratoryexamination results, blood culture, or radio graphically. The receiver operator characteristic (ROC) curve was modelled for quantitativeCRP to identify the optimal test value. Eighty-six patients were enrolled in this study. Forty-one (47.6%) had bacterial infection and 45(52.3%) had non-bacterial infection. The CRP concentration was significantly different between the two groups (p=0.003). The ROCanalysis demonstrated an area under curve (AUC) 0.689, standard error (SE) 0.059, and 95% confidence interval (CI): 0.573-0.805.The optimal cut-off point for CRP in this data set at 5 mg/L, achieved sensitivity of 0.61, specificity of 0.71, and likelihood ratio 2.11(Kappa 0.003, McNemar 0.711) for the detection of bacterial infection in this population. The Quantitative CRP concentration is avaluable laboratory test for the evaluation of febrile children who are at risk of bacterial infection.

scholarly journals THE LIVER AS THE SITE OF C-REACTIVE PROTEIN FORMATION

1966 ◽  
Vol 123 (2) ◽  
pp. 365-378 ◽  
Author(s):  
J. Hurlimann ◽  
G. J. Thorbecke ◽  
G. M. Hochwald
Keyword(s):  
Amino Acid ◽  
Serum Proteins ◽  
Acute Phase Protein ◽  
Human Beings ◽  
C Reactive Protein ◽  
Amino Acid Incorporation ◽  
Reactive Protein ◽  
Acid Incorporation ◽  
Phase Protein

The site of formation of C-reactive protein (CxRP, CRP) has been studied with tissues from rabbits, monkeys, and human beings. Rabbits and monkeys were stimulated to produce the acute phase protein by injection of turpentine, croton oil, endotoxin, paratyphoid-typhoid vaccine, or pneumococci. C14-amino acid incorporation in vitro was demonstrated by means of autoradiography of immunoelectrophoretic patterns made with culture fluids. It was found that among many different tissues tested liver was the only tissue which incorporated C14-lysine and isoleucine into CxRP or CRP. Only livers taken 16 to 24 hr after various stimuli were active; livers from normal animals or from animals killed 3 to 9 hr after stimulation did not produce detectable amounts of CxRP. Inflamed muscle from the injection site did not show C14-amino acid incorporation into CxRP. Several human tissues were also cultured, and a few liver cultures found to contain labeled CRP. The formation of CxRP or CRP by the liver was always accompanied by enhanced C14-amino acid incorporation into other serum proteins, but the reverse was not always found.

Serum Amyloid A and C-Reactive Protein Concentrations Are Differently Associated with Markers of Autoimmunity in Patients with Primary Sjögren’s Syndrome

2009 ◽  
Vol 36 (11) ◽  
pp. 2487-2490 ◽  
Author(s):  
MARJA PERTOVAARA ◽  
JUULIA JYLHÄVÄ ◽  
HANNU UUSITALO ◽  
JUHANI PUKANDER ◽  
HEIKKI HELIN ◽  
...  
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Protein ◽  
Inverse Correlation ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Phase Protein ◽  
Sicca Symptoms ◽  
Protein Serum

Objective.Primary Sjögren’s syndrome (pSS) is an autoimmune disease in which the concentration of the acute-phase protein serum C-reactive protein (CRP) is low. We investigated whether levels of another acute-phase protein, serum amyloid A (SAA), are increased in patients with pSS and whether the immunological markers in patients with pSS are associated with variation in SAA levels.Methods.Serum SAA concentrations were measured by ELISA in 74 patients with pSS and in 56 control subjects with sicca symptoms.Results.Median SAA levels did not differ significantly between patients with pSS and subjects with sicca symptoms. In patients with pSS SAA concentrations correlated significantly with age, leukocyte count, CRP, interleukin 6, and C4. Unlike CRP, there was a significant inverse correlation between SAA and serum IgG levels and anti-SSA antibody titers, as well as a trend towards an inverse correlation between SAA and antinuclear antibody and rheumatoid factor titers.Conclusion.Our data imply that high SAA production could constitute a protective element in pSS: high SAA levels inhibit in particular various signs of B cell hyperreactivity, i.e., IgG and autoantibody production.

scholarly journals AN IMMUNOLOGICAL AND ELECTROPHORETIC COMPARISON OF THE ANTIBODY TO C POLYSACCHARIDE AND THE C-REACTIVE PROTEIN OF ACUTE PHASE SERUM

1943 ◽  
Vol 77 (2) ◽  
pp. 97-110 ◽  
Author(s):  
Ely Perlman ◽  
Jesse G. M. Bullowa ◽  
Ruth Goodkind
Keyword(s):  
Acute Phase ◽  
Gamma Globulin ◽  
Acute Phase Protein ◽  
Precipitation Reaction ◽  
Globulin Fraction ◽  
C Reactive Protein ◽  
C Protein ◽  
Reactive Protein ◽  
Phase Protein ◽  
Acute Phase Serum

1. Studies of the precipitation reaction of C polysaccharide with C protein, and of C polysaccharide with C antibody are reported. The similarity between these two systems in this respect is demonstrated. 2. The differences between C protein and C antibody are emphasized. The differences between this protein and antibodies in general have been reported previously by others. 3. Electrophoretic studies show that C antibody is in the gamma globulin fraction of serum whereas C protein migrates with the alpha1 globulin fraction of acute phase protein.

Biominetic-mineralized multifunctional nanoflowers for anodic-stripping voltammetric immunoassay of rehabilitation-related proteins

The Analyst ◽  
2021 ◽  
Author(s):  
Fan Cai ◽  
Jun Wang ◽  
Yao Lin ◽  
Dianping Tang
Keyword(s):  
Cerebral Infarction ◽  
Acute Phase ◽  
Acute Phase Protein ◽  
Acute Cerebral Infarction ◽  
Neurological Rehabilitation ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Anodic Stripping ◽  
Phase Protein ◽  
Related Proteins

C-reactive protein (CRP; an acute-phase protein) in patients with initial acute cerebral infarction neurological rehabilitation prediction has a significant correlation. Herein, a simple and sensitive anodic-stripping voltammetric (ASV) immunosensing system...

C-reactive protein: a predominant LPS-binding acute phase protein responsive to Pseudomonas infection

2004 ◽  
Vol 10 (3) ◽  
pp. 163-174 ◽  
Author(s):  
Patricia M.L. Ng ◽  
Zhenxiao Jin ◽  
Sandra S.H. Tan ◽  
Bow Ho ◽  
Jeak L. Ding
Keyword(s):  
Acute Phase ◽  
Acute Phase Protein ◽  
Protein A ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Phase Protein ◽  
Pseudomonas Infection ◽  
Lps Binding
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