NSAIDS: A RISK FACTOR AFFECTING PEPTIC ULCER PERFORATION

INTRODUCTION:Apeptic ulcer is a defect in the upper gastrointestinal mucosa that extends through the muscularis mucosa into deeper layers of the gut wall. Non-steroidal anti-inammatory drugs (NSAIDs) are the major risk factors for peptic ulcer disease.Long-term use of NSAIDs, however, can cause gastrointestinal (GI) ulcers and potentially life-threatening ulcer complications. MATERIALAND METHOD: The present study was conducted on 100 patients of peptic ulcer of either sex in Department of Surgery, Mahatma Gandhi Medical College & Hospital, Jaipur. History of any other co morbid illness and any drug being taken with its time duration were recorded in detail. RESULT AND DISCUSSION: From this study, it was observed that among the 69 patients of duodenal perforation, 73.91% were taking NSAID. Similarly among the 31 patients of gastric perforation 80.64% were taking NSAID. Overall total 76% patients were taking these drugs. CONCLUSION: It is concluded from this study that a strong statistical correlation was found between use of NSAIDs and peptic ulcer perforation.

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CLINICAL STUDY AND MANAGEMENT OF PERITONITIS SECONDARY TO PERFORATED PEPTIC ULCER

10.36106/ijsr/4127161 ◽

2020 ◽

pp. 1-4

Author(s):

Sanjay Kumar Suman ◽

Mukesh Kumar ◽

Pawan Kumar Jha ◽

Debarshi Jana

Keyword(s):

Peptic Ulcer ◽

Clinical Presentation ◽

Clinical Signs ◽

Perforated Peptic Ulcer ◽

Morbidity And Mortality ◽

Duodenal Perforation ◽

High Morbidity ◽

Peptic Ulcer Perforation ◽

Common Cause ◽

Ulcer Perforation

Background: Perforated peptic ulcer is the most common cause among all causes of gastrointestinal tract perforationwhich is an emergency condition of the abdomen that requires early recognition and timely surgical management. Peptic ulcer perforation is associated significant morbidity and mortality. The aim of study is to evaluate the incidence, clinical presentation, management and outcomes of the patient with peptic ulcer perforation undergoing emergency laparotomy. Methods: This retrospective study includes 45 patients who were operated for perforated peptic ulcer peritonitis atDepartment of Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar from October 2018 to March 2020. Paediatricpatients of age less than 14 years, patients presenting as recurrent perforation were excluded from the study. A detailed history, clinical presentation and routine investigations were done in all cases. Results: In the present study, most of the patients were male. Most of these patients presents with clinical signs ofperitonitis between 24-48 hours after onset of the pain. Among the patients of peptic ulcer perforation, duodenal perforation (93.3%) is more common and which is the most common cause of perforation peritonitis. The diagnosis is made clinically and confirmed by presence of gas under diaphragm on radiograph. Exploratory laparotomy with simple closure of perforation with omental patch was done in all cases. The most common post-operative complication was wound infection (57.5%). The overall mortality was 11.1%. Conclusions: Late presentation of peptic ulcer perforation is common with high morbidity and mortality. Surgicalintervention with Graham’s omentopexy with broad spectrum antibiotics is still commonly practiced.

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Peptic ulcer perforation in young Indians the causation and the trend

International Surgery Journal ◽

10.18203/2349-2902.isj20175895 ◽

2017 ◽

Vol 5 (1) ◽

pp. 200

Author(s):

Geeta Sabhnani ◽

Akula Nyna Sindhu

Keyword(s):

Young Adults ◽

Peptic Ulcer ◽

Young Adult ◽

Duodenal Perforation ◽

Peptic Ulcer Perforation ◽

Adult Males ◽

Ulcer Perforation ◽

Surgical Emergencies ◽

Causative Factors ◽

History Of

Background: Peptic ulcer perforation is the commonest surgical emergencies in India. Recent emergency surgical procedures show an increasing trend in peptic ulcer perforation surgery in young adults. This study is carried out with an aim to understand the trend, causation and complications of peptic ulcer perforation in young Indians.Methods: A prospective observational study of young adult Indian patients operated for emergency peptic ulcer perforation for a 3 years period from January 2014 to January 2017 was carried out. The incidence, causative factors and the complications were analyzed.Results: In study of 150 patients, maximum incidence of 42.85% was seen in age group of 21 to 30 years that is young adults. 80% of them were males. 59% patients had blood group O. Association with smoking and alcoholism was seen in about 64% and 66.6% respectively. In about 13.33% there was an association seen with history of NSAID / steroid ingestion / treatment with proton pump inhibitors or H2antagonists.The duodenal perforation was found in 84.66%. In 90% the perforation was less than 1cm.Wound infection was the commonest complication among all patients. Mortality was seen in 3.33%.Conclusions: Peptic ulcer perforation shows increasing incidence in young adult males. The increased incidence shows association to smoking, alcoholism, irregular food habits, use of NSAIDS/steroids and overall stressed lifestyle.

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RETROSPECTIVE STUDY OF PERFORATED PEPTIC ULCER: A TERTIARY HOSPITAL BASED STUDY

10.36106/ijar/6400560 ◽

2020 ◽

pp. 1-3

Author(s):

Omprakash Raj ◽

Sumit Dhruve

Keyword(s):

Peptic Ulcer ◽

Retrospective Study ◽

Standard Procedure ◽

Common Factor ◽

Perforated Peptic Ulcer ◽

Duodenal Perforation ◽

Peptic Ulcer Perforation ◽

Peptic Ulcers ◽

Case File ◽

Ulcer Perforation

Background: Peptic Ulcer Perforation is an important and common emergency. One of the most dreaded and common complication of peptic ulcers is perforation. Perforations account for about 5% of peptic ulcers. Aim and Objectives: The aim of this study is clinical study of perforated peptic ulcer with objectives to assess the socio demographic distribution of peptic ulcer and to assess the clinical presentations and management of peptic ulcer perforation. Methodology: This was a retrospective study conducted in Chhattisgarh Institute of Medical Sciences Bilaspur in year 2018-2019. Total 158 patients were taken, who were diagnosed and operated for perforated peptic ulcer. Detail history and clinical findings were taken from case file. Result: a total 158 patients were studied, 76% were male, and 41-50 years age group was commonly affected. Alcohol consumption, old age, comorbid illness and pre admission delayed was most common factor. Abdominal pain i.e. 100% was most common presentation. Duodenal perforation was common i.e.38.60%. omentopaxy was preferable mode of repair perforation. Conclusion: Perforation of peptic ulcer is one of the common surgical emergencies and requires awareness and prompt management and operation. It mostly affects young and middle aged males in the thirties. Simple closure with omentopaxy is standard procedure.

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PERFORATED PEPTIC ULCER

The Professional Medical Journal ◽

10.29309/tpmj/2011.18.01.1878 ◽

2011 ◽

Vol 18 (01) ◽

pp. 124-127

Author(s):

SIKANDER HAYAT KHAN ◽

MIRZA INAM UL HAQ ◽

SHAHZAD AKHTAR AZIZ

Keyword(s):

Peptic Ulcer ◽

Past History ◽

Armed Forces ◽

Perforated Peptic Ulcer ◽

Radiological Examination ◽

Duodenal Perforation ◽

Peptic Ulcer Perforation ◽

Ulcer Perforation ◽

Operative Complications ◽

Post Operative Complications

Objectives: To evaluate the epidemiology of peptic ulcer perforation in Armed Forces and further management / outcome of the patients. Methods: Data of 36 patients with perforated peptic ulcer collected. This data was analyzed on SPSS 13. Period and Setting: CMH Rawalpindi from Jan 1979 to July 1981, Jan 1985 to Dec 1987 and Jan 2001 to Dec 2003. Results: Out of 36 patients 35 were male and only one was female. Twenty four (67%) were between 31-50 years. No past history was taken from eight (22%) patients. Thirty four (94%) patients presented with duodenal perforation. Twenty patients (55%) had rigidity all over abdomen and peristalsis were present in ten (28%) patients who reported within twelve hours. Seventy eight (78%) were diagnosed by history and simple radiological examination. All the patients were treated by laparotomy (simple closure with omental patch). Post operative complications occur in ten (28%) patients and mortality rate was 8%. Conclusion: Predominantly the peptic ulcer perforation occurs between 30-50 years of age. The incidence reduces with succeeding years of study. Post operative complications were less in younger age group .Early diagnosis can be made easily by taking good history and performing simple radiological examination.

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Giant peptic ulcer perforation- omentopexy versus omental plugging: a comparative study

International Surgery Journal ◽

10.18203/2349-2902.isj20200823 ◽

2020 ◽

Vol 7 (3) ◽

pp. 787

Author(s):

Rakesh Kumar ◽

Sneh Kiran ◽

H. N. Singh Hariaudh

Keyword(s):

Peptic Ulcer ◽

Mortality Rate ◽

Randomized Study ◽

Surgical Techniques ◽

Peptic Ulcer Perforation ◽

Biliary Leak ◽

Ulcer Perforation ◽

Medical College ◽

One Year ◽

A Prospective Study

Background: Giant peptic ulcer perforation is a life-threatening surgical emergency with high mortality rate. This study compares two different surgical techniques omentopexy and omental plugging for the treatment of giant peptic perforation.Methods: This study was a prospective study comparing the efficacy of omental plugging and omentopexy. The study was done at Emergency Department of General Surgery in Nalanda Medical College and Hospital, Patna over one-year period from October 2017 to September 2018. Patients were randomly allocated to two groups: one for omental plugging (cases) and other for omentopexy (controls).Results: A prospective non-randomized study of 12 patients with giant peptic perforation (≥2 cm in diameter) was carried out over a period of 24 months. The highest incidence was seen in males over 50 years of age. Biliary leak rates were 33% in the omentopexy group compared to no leak in the omental plugging group. This rate when calculated on standard error of proportion was significant at 5% level (p<0.05). Mortality rate was higher in omentopexy group compared to omental plugging group.Conclusions: Omental plugging seems to be associated with low rates of biliary leak compared to omentopexy and hence should be the procedure of choice in giant peptic ulcer perforation compared to omentopexy.

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Laparascopic Management of Peptic Ulcer Perforation: Initial Experience in Chittagong Medical College Hospital

Journal of Chittagong Medical College Teachers Association ◽

10.3329/jcmcta.v21i2.7731 ◽

1970 ◽

Vol 21 (2) ◽

pp. 16-20

Author(s):

Md Nur Hossain Bhuiyan ◽

Md Yunus Haroon Chowdhury ◽

Syed Md Muhsin ◽

SM Ashraf Ali ◽

Omar Faruque Yusuf

Keyword(s):

Peptic Ulcer ◽

Return To Work ◽

Key Words ◽

Laparoscopic Repair ◽

Peptic Ulcer Perforation ◽

Initial Experience ◽

College Hospital ◽

Ulcer Perforation ◽

Medical College ◽

Early Return

Key Words: laparoscopic repair; early return to work; peptic ulcer performationDOI: 10.3329/jcmcta.v21i2.7731 Journal of Chittagong Medical College Teachers' Association 2010: 21(2):16-20

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