scholarly journals EFFICACY OF PLATELET RICH PLASMA AS MONOTHERAPY IN TREATMENT OF ALOPECIA AREATA.

2021 ◽  
pp. 32-33
Author(s):  
Archana Rede ◽  
V. V. Saoji ◽  
S. N. Agrawal
Keyword(s):  
Growth Factors ◽  
Treatment Response ◽  
Alopecia Areata ◽  
Platelet Rich Plasma ◽  
Hair Follicles ◽  
Post Treatment ◽  
Immune Disease

Context: Alopecia Areata is an inflammatory auto-immune disease mainly affecting the scalp and other hair bearing areas. Platelet rich plasma (PRP) is autologous preparation of plasma with concentrated platelets which containing various growth factors and cytokines that enhance the body's inherent capacity to repair and regenerate hair follicles. Aims And Objectives: To evaluate the efficacy of platelet rich plasma as monotherapy in alopecia areata. Materials And Methods : Total 20 patients , in that 10 male and 10 female with alopecia areata will be enrolled in this study. PRP will be injected in alopecia sites (hairless patches) every 30 days for a total 4 sessions. Follow up will be taken every month for 6 months and pre and post treatment response will be noted by using photographs .

scholarly journals A prospective study on the efficacy of platelet rich plasma in alopecia areata

2019 ◽  
Vol 5 (3) ◽  
pp. 583
Author(s):  
Ravichandran Velappan ◽  
Kamalanathan Nallu ◽  
Sindhuja Ramasamy ◽  
Muthusubramanian Chandrasekar
Keyword(s):  
Growth Factors ◽  
Prospective Study ◽  
Alopecia Areata ◽  
Whole Blood ◽  
Platelet Rich Plasma ◽  
High Concentration ◽  
Immune Disease ◽  
Effective Treatment Modality ◽  
One Year ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Alopecia areata is an inflammatory auto-immune disease mainly affecting the scalp and other hair bearing areas. Platelet rich plasma contains concentrated platelets (more than that present in whole blood). Due to the presence of high concentration of growth factors, PRP is used in various conditions in the field of medicine and surgery. The aim of the study was to evaluate the efficacy of platelet rich plasma in alopecia areata.</p><p class="abstract"><strong>Methods:</strong> 20 patients, 16 male and 4 female with alopecia areata were enrolled in the study. PRP was injected in the alopecia sites for a total of 4 sessions every 28 days. Patients were followed in every month for 6 months and then at the end of one year. Pre and post treatment response was noted.<strong></strong></p><p class="abstract"><strong>Results:</strong> 13 patients responded well to treatment (65%), moderate response was seen in 3 (15%) patients and 4 patients showed no response (20%). 2 patients had relapse at the end of the study (10%).</p><p class="abstract"><strong>Conclusions:</strong> PRP was found to be an effective treatment modality for alopecia areata.</p>

scholarly journals Genome-wide association study of response to cognitive–behavioural therapy in children with anxiety disorders

2016 ◽  
Vol 209 (3) ◽  
pp. 236-243 ◽  
Author(s):  
Jonathan R. I. Coleman ◽  
Kathryn J. Lester ◽  
Robert Keers ◽  
Susanna Roberts ◽  
Charles Curtis ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Association Study ◽  
Treatment Response ◽  
Genome Wide Association Study ◽  
Behavioural Therapy ◽  
Post Treatment ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Cognitive Behavioural

BackgroundAnxiety disorders are common, and cognitive–behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent.AimsTo perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980).MethodPresence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up.ResultsNo variants passed a genome-wide significance threshold (P=5×10–8) in either analysis. Four variants met criteria for suggestive significance (P<5×10–6) in association with response post-treatment, and three variants in the 6-month follow-up analysis.ConclusionsThis is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.

Unactivated platelet leukocyte autoplasma in the treatment of non scarring alopecia

2016 ◽  
Vol 19 (6) ◽  
pp. 369-377
Author(s):  
G. A Ragimov ◽  
O. Yu Olisova ◽  
Kseniya G. Egorova
Keyword(s):  
Growth Factors ◽  
Clinical Cure ◽  
Clinical Observation ◽  
Platelet Rich Plasma ◽  
White Blood Cells ◽  
Treatment Method ◽  
Hair Follicles ◽  
Scarring Alopecia ◽  
Platelet Concentration

The literature review of the cellular functioning mechanisms of the hair follicles, the role of stem cells in the life cycle of the hair, the major effects of growth factors are presented. Authors, patented treatment method of non scarring alopecia is described. The technology ofpreparation and method of use of unactivated platelet leukocyte autoplasma in various forms of alopecia are described. Own clinical observation of 60 patients with non scarring alopecia and results of their unactivated platelet leukocyte autoplasma are presented. 80% of patients had a clinical cure. Investigations of platelet concentration, white blood cells and growth factors in platelet-rich plasma and platelet leukocyte unactivated autoplasma were performed. The results are shown in the article.

scholarly journals Infiltration of Autologous Growth Factors in Chronic Tendinopathies

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Antonio Crescibene ◽  
Marcello Napolitano ◽  
Raffaella Sbano ◽  
Enrico Costabile ◽  
Hesham Almolla
Keyword(s):  
Growth Factors ◽  
Functional Recovery ◽  
Sports Medicine ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Achilles Tendinopathy ◽  
Patellar Tendinopathy ◽  
Instrumental Evaluation ◽  
Therapeutic Alternative

Achilles tendinopathy and patellar tendinopathy are among the most frequent diagnoses in sports medicine. Therapeutic treatment of the disease is difficult, particularly in chronic cases. In literature, several studies suggest the employment of Platelet-Rich Plasma as a therapeutic alternative in tendinopathies. The choice of employing this method is based on the activity of growth factors contained in platelets which activate, amplify, and optimize the healing process. We selected 14 patients affected by Achilles tendinopathy and 7 patients affected by patellar tendinopathy, with a two-year final follow-up. These patients underwent a cycle of three tendinous infiltrations, after clinical and instrumental evaluation carried out by means of specific questionnaires and repeated ultrasound scans. Ultrasound scans of 18 patients showed signs of reduction in insertional irregularities. The result is confirmed by complete functional recovery of the patients, with painful symptomatology disappearing. The patients showed a clear pain reduction, along with an enhanced VISA score after the 24-month follow-up, equal to 84.2 points on a scale of 0 to 100. In conclusion, the present study provides evidence to suggest that PRP infiltration is a valid option to patients with chronic tendinopathy who did not benefit from other treatments.

scholarly journals EXPERIENCE OF PREMATURE EJACULATION CORRECTION BY COMBINED THERAPY OF PLATELET-RICH PLASMA AND LOW-INTENSITY SHOCK-WAVE THERAPY

2019 ◽  
pp. 33-38
Author(s):  
Юрий Заседа
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Combined Therapy ◽  
Health Clinic ◽  
Penile Induration ◽  
Combined Use ◽  
Reduction Of Pain ◽  
Icd 10 ◽  
Therapeutic Model

Relevance. The spectrum of combined mechanisms of action of PRP-therapy, LISWT and LNP therapy suggests the clinical eff ect for patients with fi broplastic penile induration, which currently does not have conservative therapies that have suffi cient effi cacy.The aim of the study was to determine the effi cacy of combined PRP-therapy with intracavernous activation of growth factors by LISWT method + LNP and ICA pharmacotherapy in treatment of fi broplastic penile induction.Design. The study group comprised 23 patients of the Men’s Health Clinic in Kyiv, suff ering from fi broplastic penile inducing (Peyronie’s disease, ICD-10: N48.6) with erectile dysfunction.Results of the study. A 6-month follow-up observation showed a reduction of pain during erection, a signifi cant improvement in erectile function, a total regression of the areas less than 25 mm2 and a signifi cant decrease in the density and area of the induration areas that over 25 mm2.Conclusions. It has been established that the therapeutic model of the combined use of PRP-therapy with intracavernous activation of growth factors by LISWT method + LOD + ICA in the treatment of fi broplastic penile induration, shows a pronounced clinical eff ect, which makes this therapeutic model a promising option for conservative correction of pain and erectile dysfunction in fi broplastic penile induration.

scholarly journals Intralesional triamcinolone acetonide versus platelet rich plasma: a comparative study in the treatment of alopecia areata of scalp

2019 ◽  
Vol 5 (3) ◽  
pp. 521
Author(s):  
Rahul H. Ranpariya ◽  
Sanjeev B. Gupta ◽  
Mahendra S. Deora ◽  
Prachi V. Agrawal ◽  
Rachita Mathur ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Alopecia Areata ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Chronic Inflammatory Disease ◽  
The Body ◽  
Current Therapy ◽  
Group I ◽  
Group Ii

<p class="abstract"><strong>Background:</strong> Alopecia areata (AA) is a chronic inflammatory disease characterized by nonscarring hair loss involving any hair-bearing surface of the body. The current therapy for AA is not curative but rather aimed at controlling or limiting the pathogenic process. Corticosteroids are the most popular drugs used, however localized atrophy is a common complication, particularly with triamcinolone. Promoting hair growth by application of autologous blood extracted platelet rich plasma (PRP) is a simple, yet effective procedure. The aim of the study was to evaluate and compare the efficacy of intralesional triamcinolone acetonide (5 mg/ml) with intralesional PRP in the treatment of two different scalp AA patches of same individual.</p><p class="abstract"><strong>Methods:</strong> A total of 30 patients having ≥2 patches of AA were randomized and given two separate modalities of treatment in two different patches and divided in Group I, treated with intralesional triamcinolone acetonide (5 mg/ml) and Group II, treated with PRP. Interval time between every follow-up was 3 weeks and four such follow-ups were done. Hair regrowth was calculated according to Mac Donald Hull and Norris grading system at every follow-up and was compared with the initial grading.<strong></strong></p><p class="abstract"><strong>Results:</strong> Group I patches, treated with triamcinolone acetonide have the significantly higher mean grading score than the group II patches, treated with PRP at each follow up.</p><p class="abstract"><strong>Conclusions:</strong> Intralesional triamcinolone acetonide is more efficacious than intralesional PRP in the treatment of scalp alopecia areata with no recurrences and very few adverse effects like atrophy and hypopigmentation.</p>

scholarly journals Platelet rich plasma for the treatment of osteoarthrosis knee

2017 ◽  
Vol 3 (2) ◽  
pp. 242
Author(s):  
Prashant Maheshwari ◽  
Hemeshwar Harshwardhan
Keyword(s):  
Quality Of Life ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Womac Score ◽  
Knee Function ◽  
Vas Scores ◽  
The Mean ◽  
Grade 3

<p class="abstract"><strong>Background:</strong> New studies focused on modern therapeutic methods which stimulate cartilage healing and repair the damage, including the use of platelet-rich plasma (PRP) as a cocktail of growth factors. This study has the purpose to present the use of PRP in management of knee osteoarthrosis and its outcomes up to 6 month follow up.</p><p class="abstract"><strong>Methods:</strong> 58 patients with 100 knees (32 male, 26 female) with Kellgren Lawrence grade 1, 2,3 and 4, aged between 50 to 65 years between February 2015 to December 2015 treated with 4 ml of intra-articular PRP injections at 4 week interval in each affected knee and evaluated using WOMAC and VAS scores before injection and on follow up at end of the 1<sup>st</sup>, 3<sup>rd</sup>, and 6<sup>th</sup> month.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean age was 58.29 years. Improvement in WOMAC score for KL grade 1 (32.61%), grade 2 (31.12%), grade 3(26.54%) whereas only 13.68% in KL grade 4 at end of 6month follow up. Improvement in VAS score for KL grade 1 (41.30%), grade 2 (38.02%), grade 3 (47.68) whereas only 12.74% in grade 4 at the end of 6 month follow up. Results show statistically higher significant improvement seen in WOMAC and VAS for KL grade 1, 2, and 3 as compared to grade 4 at 6 months follow up.</p><p><strong>Conclusions:</strong> The results of our study illustrated that the treatment with intra articular PRP injections is safe and effective in reducing pain and stiffness as well as improve knee function and quality of life in early stages of knee osteoarthrosis. </p>

scholarly journals Efficacy of platelet rich plasma injection in treatment of plantar fasciitis

2017 ◽  
Vol 3 (3) ◽  
pp. 451
Author(s):  
Rahul Kadam ◽  
Sukant Vijay ◽  
Abhay Chhallani ◽  
Santosh Pandhare ◽  
Abhishek Gupta ◽  
...  
Keyword(s):  
Growth Factors ◽  
Plantar Fasciitis ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Activity Level ◽  
Long Term Results ◽  
Vas Score ◽  
Plasma Injection ◽  
The Mean

<p class="abstract"><strong>Background:</strong> Platelet rich plasma is a recently introduced therapy for treatment of chronic painful conditions in orthopaedics, it acts mainly by promoting healing process. PRP has an increased concentration of platelets which initiate tissue repair by releasing growth factors.<span class="apple-converted-space"> </span>Increased concentrations of autologous platelets yield high concentrations of growth factors, subsequently leading to intensified healing of soft tissue on a cellular level. This study was conducted to evaluate the efficacy of platelet rich plasma injection in treatment of plantar fasciitis<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> This study was conducted on the patients coming to orthopaedic OPD at MGM medical college and hospital, kamothe, Navi Mumbai. Total of 40 planter fasciitis cases were taken in this study. Out these 40 patients 23 were Male and 17 were female. The mean age 45.85 (range 25-75). Patients were followed up for 3 months with regular interval and at each visit vas score was evaluated and noted.Total duration of study was 3 months from October 2016 to December 2016.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean pre injection vas score was 7.15 (Male – 7.13, Female – 6.70). The mean vas score at time of follow up after one week was 6.20 (Male – 6.22 Female – 6.18). The mean vas score at time of follow up after 6 week was 5.62 (Male – 5.66 Female – 5.70).  The mean vas score at time of follow up after 3 months was 3.20 (Male – 3.13 Female – 3.29)<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> PRP in plantar fasciitis shows promising short term results providing patients with gradual sustained pain relief, improving daily function and lifestyle activity level. However long term results needs to be evaluated<span lang="EN-IN">.</span></p>

scholarly journals THE TLINICAL EFFICACY OF AUTOLOGOUS CONCENTRATED PLATELETS IN TREATMENT OF TMJ DISORDERS - A PILOT STUDY

2014 ◽  
Vol 04 (03) ◽  
pp. 070-074
Author(s):  
S.M. Sharma ◽  
Dhruvit Thakar
Keyword(s):  
Growth Factors ◽  
Temporomandibular Joint ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Venous Blood ◽  
Mouth Opening ◽  
Adhesive Properties ◽  
Novel Approach ◽  
Plasma Cytokines

AbstractPlatelet rich plasma is a natural concentrate of autologous blood growth factor which is obtained by sequestering and concentrating platelets by gradient density centrifugation experimented in different fields of medicine in order to test its potential to enhance tissue regeneration. These platelets when activated undergo degranulation to release growth factors with healing properties. It also contains plasma, cytokines, thrombin, and other growth factors that are implicated in wound healing and have inherent biological and adhesive properties. The aim of the study is to explore a novel approach to treat degenerative lesion of the articular cartilage of temporomandibular joint. Patients with chronic degenerative conditions of the joint, were treated with intra articular PRP injections. The procedure involved collection of 10 ml of venous blood and twice centrifuged to obtain 2 ml of PRP which was used for injection after activation by calcium chloride. The patients were clinically prospectively evaluated before and at the end of the treatment, and at 2, 4, and 6 months of follow up. Inter incisical mouth opening, clicking of temporomandibular joint and VAS for pain were used for clinical evaluation. The results showed significant improvement of all clinical scores from basal evaluation to the end of the therapy and on follow up at 2-6 months. The preliminary results indicate that the treatment with PRP injections are safe and has the potential to reduce pain and improvement joint function with low degree of articular degeneration.

Sign in / Sign up

Export Citation Format

Share Document