CLINICOPATHOLOGICAL STUDY OF SURFACE EPITHELIAL OVARIAN TUMORS- A TERTIARY CARE CENTER STUDY.

Background: Ovarian tumors are one of the most common tumors, which occur in female genital tract. Despite the newer techniques in imaging and molecular biology, the diagnosis of ovarian tumors primarily depends on histopathological examination. Ovarian tumors manifests a wide spectrum of clinical, morphological and histological features. The aim of the study was to find the incidence of surface epithelial ovarian tumors in a tertiary referral centre. Materials and methods: A retrospective data of 3 years were collected for surface epithelial ovarian tumors submitted to the pathology department of the tertiary care hospital and analysed. The correlation of these surface epithelial ovarian tumors was done with age, clinical presentation and histomorphological patterns. Non-neoplastic lesions like simple ovarian cysts, tubo-ovarian mass and polycystic ovaries were excluded. Results: A total number of 56 cases were studied. Out of which 44 cases were benign and 12 cases were malignant. Maximum cases were observed between 21 to 30 years. Mass per abdomen was the most common presentation(36%) followed by mass and pain in abdomen(27%).Serous cystadenoma formed maximum 28 cases(50%) followed by Mucinous cystadenoma(16 cases) 28 % , Serous cysadenocarcinoma formed 5cases (9%), followed by Mucinous cystadenocarcinoma 3 cases(5%) & 2 cases each(4%) of clear cell carcinoma and endometrioid carcinoma were noted. The most common histopathological type of benign and malignant tumor was serous cystadenoma (50.2%) and serous cystadenocarcinoma(9%) respectively. Conclusion: In the study majority (78.6%) of the surface epithelial ovarian tumors were benign. Malignancy was seen in (21.4)% of the cases. Surface epithelial tumours present a great challenge to the gynecologic oncologist because non-neoplastic ovarian lesions can form a pelvic mass and potentially mimic a neoplasm. Correct histopathological diagnosis of surface epithelial ovarian tumors is of prime importance in view of their behavioral predictability and clinical correlation for proper management of the patient.

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Conjunctival Lesions: A 5-Year Basic Demographic Data and Clinicopathological Review in a Tertiary Eye Care Hospital

Journal of Epidemiology and Global Health ◽

10.1007/s44197-021-00017-1 ◽

2021 ◽

Author(s):

Hind M. Alkatan ◽

Khalid M. Alshomar ◽

Hala A. Helmi ◽

Wajda M. Alhothali ◽

Abdulaziz M. Alshalan

Keyword(s):

Wide Spectrum ◽

Care Center ◽

Demographic Data ◽

Tertiary Care ◽

Malignant Lesion ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Adult Males ◽

Duration Of Symptoms ◽

Malignant Lesions

Abstract Background Conjunctival lesions are common with a wide spectrum of benign, premalignant, and malignant lesions. Few histopathological studies have been conducted on conjunctival lesions with variable designs and results. Our aim in this study is to provide information on common conjunctival lesions seen in an ophthalmology tertiary care center in Saudi Arabia. Methods A retrospective, observational study of all consecutive conjunctival tissue specimens sent for histopathological assessment to the pathology department from 2015 to 2019 were analyzed. Clinical data were collected from medical records, and the histopathological slides were reviewed by a single pathologist. Results A total of 110 conjunctival specimens from 108 patients were included (mean age: 53 years, 67 males and 43 females). Bilateral involvement was mostly found in inflammatory lesions (40%). Most lesions were benign (91%), with a significantly longer duration of symptoms in malignant lesions (p = 0.036*). The clinical diagnosis matched the final histopathological diagnosis in 75.5% of the total specimens. The most frequent category of benign lesions was fibrodegenerative and proliferative lesions (53.6%), with a significantly higher prevalence among adult males (p < 0.001). Melanocytic lesions were more common in children (33.3%) than adults (9.8%), and the mean age of children was significantly lower (p = 0.013). The most frequent malignant lesion was ocular surface squamous neoplasia (50%), with equal prevalence among males and females. The overall outcome was favorable in 89.4% and unfavorable in 10.6%, mostly due to surgical complications, further progression of the lesion, or recurrence. Conclusion This study shows variability in the frequency of conjunctival lesions based on gender, age, geographical, racial, and environmental factors. There has been a shift in the gender-based prevalence of ocular squamous neoplasia over the last three decades, probably due to a change in lifestyle.

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HISTOPATHOLOGICAL STUDY OF UTERINE LESIONS IN HYSTERECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL.

10.36106/ijsr/8128882 ◽

2020 ◽

pp. 1-2

Author(s):

Reddythota Sujeeva Swapna ◽

V Siva Sankar Naik ◽

C Bhavani ◽

M Neeraja

Keyword(s):

Histopathological Examination ◽

Tertiary Care ◽

Female Genital Tract ◽

Total Abdominal Hysterectomy ◽

Abdominal Hysterectomy ◽

The Body ◽

Histopathological Study ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Wide Range

Background: The Female Genital Tract is a hormone-responsive system to a degree unmatched by any other system in the body. The gross configuration of the uterus changes dramatically throughout life. It is a kind of 'Puppet on a string", thus manipulated throughout life by altering levels of ovarian hormones. Objective of the study: The present study is aimed at detailed histopathological evaluation of uterine lesions of hysterectomy specimens. Methodology: A total of 448 cases of hysterectomy specimens were received in the department of pathology GGH Ananthapur, for two years, were reviewed. The specimens were processed, and the histopathological diagnosis was studied. Result: Peak age group of hysterectomy was 40-49 years with 186 (41.51%) cases. The youngest patient was 21 years old, and the oldest was 75 years old. The most frequent type of hysterectomy done was total abdominal hysterectomy in 293 (65.4%) cases. Conclusion: Hysterectomy is the most common surgery performed in gynecological practice. A wide range of lesions were noted when hysterectomy specimens are subjected to histopathological examination.

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Histopathological audit of appendectomy specimen in a Tertiary Care Center.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.10.3449 ◽

2019 ◽

Vol 26 (10) ◽

pp. 1702-1705

Author(s):

Sikandar-e-Azam Yousfani ◽

Inayat Ali Zardari ◽

Mashoque Ali Khoja

Keyword(s):

Acute Appendicitis ◽

Ct Scan ◽

Ultrasound Examination ◽

Histopathological Examination ◽

Care Center ◽

Tertiary Care ◽

Mucinous Cystadenoma ◽

Histopathological Analysis ◽

Negative Appendectomy ◽

Histopathological Diagnosis

Objectives: To evaluate the histopathological findings in appendectomy specimens and observe the negative appendectomy rate (NAR). Study Design: Observational study. Setting: Department of Surgery Unit III, Peoples University of Medical & Health Sciences, Nawabshah. Period: January to December 2018. Material and Methods: 117 consecutive cases of appendectomy. All the demographic data and the clinicopathological details were recorded on a proforma designed for the study. The histopathological assessment was carried out in all cases. The ultrasound examination and CT scan was carried out in selected cases. The data collected was statistically analyzed and the results were tabulated. Results: During study period 117 appendectomies were performed. The mean age of patient was 27+9.4 years, majority of patients (53.8%) were females with female to male ratio of 1.2:1. The histopathological diagnosis was made in all cases and the results indicates that 105 cases having positive appendectomy and in 12 (10.3%) cases the appendix was found histologically normal. Among 105 positive cases, 97 (83%) were diagnosed as acute appendicitis, 2 (1.7%) cases show fibrous obliteration and 6 (5.1%) cases were having unusual pathologies. The cases having histological diagnosis of acute appendicitis includs acute mucosal appendicitis, acute suppurative appendicitis with or without periappendicitis and peritonitis, acute necrotizing appendicitis and perforated gangrenous appendicitis. The 6 cases of unusual pathologies includes 3 cases of granulomatous lesions and one case each of carcinoid tumor, mucinous cystadenoma and worm infestation. The ultrasound was performed in 48 (41%) patients out of them 30 cases had positive findings on ultrasound examination were confirmed on histological examination and all 5 positive cases that were reported on CT scan were confirmed on histopathological examination. Conclusion: High rates of negative appendectomy in the female sex were observed, that can be reduced by the use of diagnostic imaging modalities specially ultrasound. The findings of abnormal pathologies on histopathological examination of the appendix suggest that histopathological analysis is necessary in all of the resected specimens.

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Clinico-pathological profile of ovarian cysts in a tertiary care hospital

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174456 ◽

2017 ◽

Vol 6 (10) ◽

pp. 4642 ◽

Cited By ~ 1

Author(s):

Sairem Mangolnganbi Chanu ◽

Biswajit Dey ◽

Vandana Raphael ◽

Subrat Panda ◽

Yookarin Khonglah

Keyword(s):

Tertiary Care Hospital ◽

Tertiary Care ◽

Lower Abdominal Pain ◽

Cystic Teratoma ◽

Serous Cystadenoma ◽

Mature Cystic Teratoma ◽

Ovarian Cysts ◽

Histopathological Diagnosis ◽

Care Hospital ◽

North East

Background: Ovarian cystic neoplasms are common in gynaecological practice. These may pose diagnostic difficulty to the pathologists. This study was conducted to analyse the clinical and histological profile of ovarian cystic neoplasms.Methods: This is a retrospective study done from January 2016 to April 2017 in a tertiary care hospital in North East India. All the patients, who were clinically and radiologically diagnosed as ovarian cysts, which had histopathological confirmation were included in the study. Data including the age, parity, clinical symptoms, laterality and histopathological findings were analysed.Results: A total of 101 patients operated for ovarian cysts in the study period were analysed. The most common clinical presentation was lower abdominal pain. There were 11 (10.9%) malignant cases, 4 (4%) were intermediate grade and borderline in nature, and 85 (84.1%) cases were benign in nature. There was 1 (1%) case of metastasis to ovary. Mature cystic teratoma was most common (20.8%) histopathological diagnosis. The second most common cyst was serous cystadenoma (19.8%).Conclusion: Ovarian cysts are commonly encountered in gynaecological practice and equally encountered by the pathologists. Most commonly found ovarian cysts were mature cystic teratoma followed by serous cystadenoma.

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Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh

Journal of Laboratory Physicians ◽

10.4103/jlp.jlp_117_18 ◽

2019 ◽

Vol 11 (01) ◽

pp. 075-081 ◽

Cited By ~ 1

Author(s):

Neha Gupta ◽

Mahima Yadav ◽

Vikas Gupta ◽

Deepshikha Chaudhary ◽

Shashikant C. U. Patne

Keyword(s):

Germ Cell ◽

Who Classification ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Germ Cell Tumors ◽

Serous Cystadenoma ◽

Ovarian Tumors ◽

Care Hospital ◽

Stromal Tumors ◽

Sex Cord Stromal Tumors

Abstract BACKGROUND: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India. MATERIALS AND METHODS: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Data were classified according to the latest World Health Organization (WHO) Classification into epithelial tumors, germ cell tumors, sex cord–stromal tumors, and others. RESULTS: A total of 212 cases of ovarian tumors were studied, 186 were unilateral and 26 were bilateral. Resection specimen, part of specimen, and block review formed 80.2%, 15.1%, 4.7%, respectively. Epithelial tumors formed the majority in 71.7% of cases followed by germ cell tumors (22.2%), sex cord–stromal tumors (3.8%) and others (2.3%). Maximum number of cases in the respective groups occurred in the age groups 31–40, 21–30, 51–60, and 41–50 years, respectively. Overall, benign tumors were 63.7%, malignant tumors were 31.1%, and borderline were 5.2%. The most common histopathological type of benign and malignant tumor was benign serous cystadenoma (18.8%) and serous carcinoma (9.9%), respectively. CONCLUSION: In the present study, ovarian tumors were classified according to the WHO classification, epithelial and germ cell tumors were the major types of ovarian tumors. Benign epithelial tumor formed the majority with 46.2% cases. Serous cystadenoma and mature cystic teratoma were the predominant type of epithelial and germ cell tumors, respectively.

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A retrospective clinico-pathological study of hysterectomy cases in a tertiary care hospital in India – a review of 950 cases.

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v17i1.35287 ◽

2018 ◽

Vol 17 (1) ◽

pp. 88-92

Author(s):

Pal Subrata ◽

Chakrabarti Srabani ◽

Sinha Anuradha ◽

Phukan Jyoti Prakash ◽

Bose Kingshuk ◽

...

Keyword(s):

Clinical Diagnosis ◽

Histopathological Examination ◽

Tertiary Care ◽

Medical Science ◽

Abdominal Hysterectomy ◽

Uterine Bleeding ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Dysfunctional Uterine Bleeding ◽

Common Indication

Introduction: Hysterectomy is the most commonly performed gynaecological surgery in India as well as in abroad. It is frequently done in myometrial and endometrial pathologies and rarely for other causes. Hysterectomy is definitive management for diseases like fibroid, adenomyosis, dysfunctional bleeding, prolapsed uterus and malignant lesions of uterus and adenexa. We aimed our study to observe incidence of different pathologies of uterus and other reproductive organs in hysterectomy specimens and retrospective correlation between clinical diagnosis and histopathological finding of hysterectomy cases.Materials and Methods: Retrospective data were collected from our routine histopathological laboratory. Detailed history, clinical examination and operative findings and provisional diagnosis of all 950 hysterectomy cases were recorded during study period of 2 years. Histopathological diagnosis was correlated with clinical and preoperative diagnosis.Observations: Abdominal hysterectomy (734 cases, 77.26%) was the most common route of approach during surgery. Common pre-operative diagnoses were fibroid uterus (32%), dysfunctional uterine bleeding (28.95%), uterine prolapsed (22.74%). Other causes included uterine polyps (1.6%), complications of pregnancy (2.74%), ovarian tumours (8.42%), cervical carcinomas (2.97%) etc. Common pathologies on histology were leiomyoma (32%), adenomyosis (20.32%), atrophic endometrium (17.26%) and endometrial pathology (8.95%).Discussion: Our study has been correlated with other studies of India and other south Asian countries. Most common indication of hysterectomy in our study is dysfunctional uterine bleeding (32%) but Gupta et al and Jha R et al found utero-vaginal prolapse as most common indication. Leiomyoma was the most common histology diagnosed in the present series. Clinical diagnosis was possible in 67.57% cases in our study similar to Khan et al (70.51%).Conclusions: Histopathological examination of hysterectomy specimens helps to detect the exact causes and underlined pathology.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.88-92

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Retrospective study of tumor and tumor like conditions of ovary from a rural hospital in Kerala

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20173074 ◽

2017 ◽

Vol 6 (8) ◽

pp. 3275 ◽

Cited By ~ 1

Author(s):

H. Valson ◽

Satish Arakeri ◽

Dally Maria Davis ◽

Divya S.

Keyword(s):

Germ Cell ◽

Histopathological Examination ◽

Wide Spectrum ◽

Germ Cell Tumors ◽

Ovarian Tumors ◽

Ovarian Cysts ◽

Histopathological Diagnosis ◽

Emergency Setting ◽

Reproductive Life ◽

Mucinous Cyst

Background: Ovarian tumor and tumor like conditions are seen in women from early childhood to post-menopausal age. The ovaries are a pair of female sex glands responsible for the germ cell maturation, storage and release; cyclically. It also plays an important role in steroidogenesis. The ovaries are a totipotential structure and hence, neoplasms from all 3 germinal layers can be seen arising from it and manifesting clinically as ovarian tumors and tumor like conditions with its occurrence more during the late reproductive life. Ovarian tumors represent about 30% of all cancers of the female genital system. They manifesting in a wide spectrum of clinical, morphological and histological features.Methods: This is retrospective observational study where analysis of all cases which were encountered surgically during the period Mar 2012 to Mar 2017. The cases diagnosed as ovarian tumors were subjected to thorough investigation by CA125, ultrasound (USG) abdomen and pelvis and Computerised Tomography (CT) scan. Emergency presentations with twisted cysts were operated in emergency setting and histopathological examination (HPE) done to identify the nature of tumor. IHC was done wherever necessary to sub classify and confirm the histological diagnosis. Surgeries were done either by conventional laparotomy or by laparoscopy.Results: We have analyzed 175 cases retrospectively after histopathological diagnosis. The commonest lesions were ovarian cysts, out of which 63 cases (36%) were simple serous cyst adenomas followed by mucinous cyst adenomas 30 cases (17.14%). Germ cell tumors with struma ovarii were 34 cases (19.42%). The interesting part of the study was that we had a very high incidence of large endometriomas diagnosed as ovarian cysts before surgery 16 cases (9.4%). Two cases (1.14%) of ovarian malignancy were detected.Conclusions: The above study has revealed a spectrum of ovarian tumors over a wide age range from adolescent to late reproductive to menopausal and late menopausal age group. The incidence of malignancy was (1.14%).

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Diagnostic Accuracy of Intraoperative Frozen Section Analysis in Correlation with Histopathological Diagnosis of Ovarian Tumors in a Tertiary Care Center – A Retrospective Study

Cancer Investigation ◽

10.1080/07357907.2020.1865395 ◽

2020 ◽

pp. 1-6

Author(s):

AC Senthil Kumar ◽

Vimal Chander ◽

Jayaganesh Parthasarathy

Keyword(s):

Retrospective Study ◽

Diagnostic Accuracy ◽

Frozen Section ◽

Care Center ◽

Tertiary Care ◽

Ovarian Tumors ◽

Histopathological Diagnosis ◽

Tertiary Care Center ◽

Frozen Section Analysis ◽

Section Analysis

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HISTOPATHOLOGICAL STUDY OF BENIGN AND MALIGNANT LESIONS OF UTERUS AND CERVIX IN HYSTERECTOMY SPECIMENS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i1.1666 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Shikha Raghuwanshi ◽

Dharmendra Singh Bhadouria ◽

Surendra Raghuwanshi ◽

Arun Saxena ◽

S.K. Nema

Keyword(s):

Histopathological Examination ◽

Tertiary Care ◽

Common Finding ◽

Histopathological Study ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Fibroid Uterus ◽

Malignant Lesions ◽

Chronic Cervicitis ◽

Insight Into

Background: The present study was aimed to obtain insight into the varied histopathological patterns of lesions of uterus and cervix in hysterectomy specimens and their age-wise distribution in Index MedicalCollege, Hospital and Research Center. Methodology: This was anobservational study conducted on 100 cases of hysterectomy specimens received at tertiary care hospital Indore. All the specimen was subjected to detailed gross and histopathological examination. Results: Mean age of patients was 44.78±8.64 years. The most common age group was 41-50yrs (42%). Maximum cases were diagnosed as AUB/ DUB/Menorrhagia (31%) followed by fibroid uterus (28%). Uterus was bulky in 70%, cut sections revealed single fibroid in majority i.e. 39% cases and endometrium was in proliferative phase (early 12%, mid 30%, late 19%). Most common histopathological diagnosis of uterus was leiomyoma in 39% cases whereas chronic nonspecific cervicitis (47%) was most common histological diagnosis of cervix. Intramural leiomyoma were most common and were associated with degenerative changes in 33 cases. Hyaline degeneration was observed in maximum cases. Conclusion: The most common indication for hysterectomies in our institution is excessive uterine bleeding. Fibroid uterus as the cause of bleeding is the most common pathology for which hysterectomy is performed. Chronic cervicitis is the most common finding and Adenomyosis continued to be missed preoperatively and diagnosed postoperatively on histopathological examination. Every hysterectomy specimen should be subjected to histopathological examination to confirm various pathological lesions. Keywords: Leiomyoma, histopathology, spectrum, uterus, cervix, hysterectomy

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Clinicopathological profile of sinonasal masses-a tertiary care centre study in rural India

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20204182 ◽

2020 ◽

Vol 6 (10) ◽

pp. 1821

Author(s):

Vidya Rokade ◽

Kiran J. Shinde ◽

Girishkumar R. More

Keyword(s):

Histopathological Examination ◽

Tertiary Care ◽

Rural India ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Tertiary Care Centre ◽

Radiological Investigation ◽

Male Predominance ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Background: A variety of mass lesions occur within the paranasal sinus (PNS) and nasal cavity and thus it becomes mandatory for otorhinolaryngologist to elicit detailed history and thorough examination before reaching a final diagnosis. This is retrospective study of all sinonasal masses who were undergone surgical management in the institute of rural India and so in the environment.Methods: This is a retrospective observational study of 70 patients with sinonasal masses treated at a rural tertiary care hospital in rural western Maharashtra from period of Jan 2016 to May 2018. History, clinical assessment and histopathological examination (HPE) was done in all cases as per hospital record supplemented by radiological investigation as per requirement. The patients were grouped as per their histopathological diagnosis as non-neoplastic/inflammatory and neoplastic.Results: A total of 70 patients were analysed age ranging (11-70 years). Majority of the patients were in the age groups 21-40 years (47%). There were 43 (61%) male and 27 (39%) female with M:F ratio 1.6:1. On HPE, 50 (71%) cases were non neoplastic/inflammatory and 20 (29%) cases were neoplastic lesions. HPE revealed that 50 (71%) cases were non neoplastic and 20 (29%) cases were neoplastic lesions.Conclusions: Sinonasal masses have various differential diagnoses. They are fairly common with male predominance. Benign conditions show a peak during 2nd to 4th decade of life while malignancy increasing with the age after 4th decade. In non-neoplastic lesion, Allergic nasal polyp is the commonest histological pattern seen while in malignant lesions squamous cell carcinoma is noted with 100% male predominance.

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