scholarly journals Conjunctival Lesions: A 5-Year Basic Demographic Data and Clinicopathological Review in a Tertiary Eye Care Hospital

2021 ◽  
Author(s):  
Hind M. Alkatan ◽  
Khalid M. Alshomar ◽  
Hala A. Helmi ◽  
Wajda M. Alhothali ◽  
Abdulaziz M. Alshalan
Keyword(s):  
Wide Spectrum ◽  
Care Center ◽  
Demographic Data ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Adult Males ◽  
Duration Of Symptoms ◽  
Malignant Lesions

Abstract Background Conjunctival lesions are common with a wide spectrum of benign, premalignant, and malignant lesions. Few histopathological studies have been conducted on conjunctival lesions with variable designs and results. Our aim in this study is to provide information on common conjunctival lesions seen in an ophthalmology tertiary care center in Saudi Arabia. Methods A retrospective, observational study of all consecutive conjunctival tissue specimens sent for histopathological assessment to the pathology department from 2015 to 2019 were analyzed. Clinical data were collected from medical records, and the histopathological slides were reviewed by a single pathologist. Results A total of 110 conjunctival specimens from 108 patients were included (mean age: 53 years, 67 males and 43 females). Bilateral involvement was mostly found in inflammatory lesions (40%). Most lesions were benign (91%), with a significantly longer duration of symptoms in malignant lesions (p = 0.036*). The clinical diagnosis matched the final histopathological diagnosis in 75.5% of the total specimens. The most frequent category of benign lesions was fibrodegenerative and proliferative lesions (53.6%), with a significantly higher prevalence among adult males (p < 0.001). Melanocytic lesions were more common in children (33.3%) than adults (9.8%), and the mean age of children was significantly lower (p = 0.013). The most frequent malignant lesion was ocular surface squamous neoplasia (50%), with equal prevalence among males and females. The overall outcome was favorable in 89.4% and unfavorable in 10.6%, mostly due to surgical complications, further progression of the lesion, or recurrence. Conclusion This study shows variability in the frequency of conjunctival lesions based on gender, age, geographical, racial, and environmental factors. There has been a shift in the gender-based prevalence of ocular squamous neoplasia over the last three decades, probably due to a change in lifestyle.

scholarly journals CLINICOPATHOLOGICAL STUDY OF SURFACE EPITHELIAL OVARIAN TUMORS- A TERTIARY CARE CENTER STUDY.

2020 ◽  
pp. 1-4
Author(s):  
Priyanka Nimbalkar Jadhav ◽  
Raviraj Jadhav
Keyword(s):  
Histopathological Examination ◽  
Wide Spectrum ◽  
Care Center ◽  
Tertiary Care ◽  
Female Genital Tract ◽  
Mucinous Cystadenoma ◽  
Serous Cystadenoma ◽  
Ovarian Tumors ◽  
Histopathological Diagnosis ◽  
Care Hospital

Background: Ovarian tumors are one of the most common tumors, which occur in female genital tract. Despite the newer techniques in imaging and molecular biology, the diagnosis of ovarian tumors primarily depends on histopathological examination. Ovarian tumors manifests a wide spectrum of clinical, morphological and histological features. The aim of the study was to find the incidence of surface epithelial ovarian tumors in a tertiary referral centre. Materials and methods: A retrospective data of 3 years were collected for surface epithelial ovarian tumors submitted to the pathology department of the tertiary care hospital and analysed. The correlation of these surface epithelial ovarian tumors was done with age, clinical presentation and histomorphological patterns. Non-neoplastic lesions like simple ovarian cysts, tubo-ovarian mass and polycystic ovaries were excluded. Results: A total number of 56 cases were studied. Out of which 44 cases were benign and 12 cases were malignant. Maximum cases were observed between 21 to 30 years. Mass per abdomen was the most common presentation(36%) followed by mass and pain in abdomen(27%).Serous cystadenoma formed maximum 28 cases(50%) followed by Mucinous cystadenoma(16 cases) 28 % , Serous cysadenocarcinoma formed 5cases (9%), followed by Mucinous cystadenocarcinoma 3 cases(5%) & 2 cases each(4%) of clear cell carcinoma and endometrioid carcinoma were noted. The most common histopathological type of benign and malignant tumor was serous cystadenoma (50.2%) and serous cystadenocarcinoma(9%) respectively. Conclusion: In the study majority (78.6%) of the surface epithelial ovarian tumors were benign. Malignancy was seen in (21.4)% of the cases. Surface epithelial tumours present a great challenge to the gynecologic oncologist because non-neoplastic ovarian lesions can form a pelvic mass and potentially mimic a neoplasm. Correct histopathological diagnosis of surface epithelial ovarian tumors is of prime importance in view of their behavioral predictability and clinical correlation for proper management of the patient.

scholarly journals COMPARATIVE STUDY OF CT-SCAN FINDINGS WITH BIOPSY IN LIVER MASSES DONE AT A TERTIARY CARE CENTER

2020 ◽  
pp. 1-2
Author(s):  
Bhanupriya Singh ◽  
Khushal N Pawar ◽  
Suhas S Ghule ◽  
Dilip L Lakhkar
Keyword(s):  
Ct Scan ◽  
Predictive Value ◽  
Care Center ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Normal Liver ◽  
Liver Lesion ◽  
Cross Sectional Study ◽  
Histopathological Diagnosis ◽  
Cross Sectional

Background: More than 80% of all primary hepatic malignancies are hepatocellular carcinoma. Identification of a liver lesion depends on the attenuation difference between normal liver and the lesion. CT helps in detecting tumors and their size in liver quiet successfully. Accurate detection of liver mass is crucial for the deciding the treatment regimens. Objective: The study was undertaken to compare the results of CT-scan to histopathology findings. Methodology: This cross-sectional study was carried out in the Department of Radiodiagnosis and Imaging, Dr. Vitthalrao Vikhe Patil Foundation’s Medical College, Ahmednagar in association with Department of pathology of the concerned institute for histopathological diagnosis from 01-03-2014 to 28-02-2015 for a period of one year. Patients having hepatic mass of any sex or age presenting in the hospital were included in the study. The exclusion criteria were as patients refusing consent, or CT-scan and/or biopsy, known adverse reaction to contrast agent. CT scan and histopathology were done in all the subjects. Result: 50 subjects were studied in this study. Mean age of all subjects was 52.88 ± 16.03 years with a range of 18 year to 85 years. 40 cases were male in the study group. Maximum number of cases were in the age group 40-59 years. Out of 28 confirmed malignant cases by histopathology, 27 cases were diagnosed as malignant by CT scan too. Sensitivity of CT to diagnose malignant lesion was 96.4%, specificity 86.4%, accuracy 92%, positive predictive value 90% and negative predictive value 95%. Conclusion: CT scan can be used as a tool for the detecting of malignant liver masses.

scholarly journals Clinico-histopathological analysis of orbito-ocular lesions: a hospital-based study

2019 ◽  
Vol 6 (2) ◽  
pp. 39-44
Author(s):  
Santosh Upadhyaya Kafle ◽  
Mrinalini Singh ◽  
Prerna Arjyal Kafle ◽  
Bal Kumar KC ◽  
Sanjeev Kumar Yadav ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Demographic Data ◽  
Panel Study ◽  
College Teaching ◽  
Tissue Type ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Ocular Lesions ◽  
Malignant Lesions

Introductions: Preoperative diagnosis of orbital and ocular lesions is necessary for optimum treatment. The study aims to analyze the histomorphological spectrum of orbito-ocular lesions and to evaluate the need of ancillary techniques for confirmation of diagnosis. Methods: A cross sectional hospital based study of orbito-ocular surgical biopsy samples obtained in the Department of Pathology, at Birat Medical College Teaching Hospital, Nepal during one-year period was analysed for clinical and histopathological findings. Demographic data, site and tissue type, benign or malignant, recommendations for special stains and immunohistochemistry panel study were analysed. Results: Out of 185 total samples, male to female ratio of 1.1:1, age ranged from ten month to 82 years, 11-20 year age group had 39 (21.1%) orbito-ocular lesions and cornea-conjunctiva was involved in 104 (56.2%). Clinical diagnosis correlated well with histopathological diagnosis, p<0.001. The non-neoplastic, benign and malignant lesions were 36.7%, 33.5% and 29.7% respectively. Squamous cell carcinoma was seen in 28 (50.9%) of malignant lesions followed by sebaceous carcinoma 7 (12.7%). The special stains and immunohistochemistry panel was recommended in 38 (20.5% and 21 (11.3%) cases respectively. Conclusions: Findings suggest the clinical and histopathological diagnosis correlated well in diagnosis of a wide spectrum of orbito-ocular lesions.

scholarly journals HISTOPATHOLOGICAL STUDY OF BENIGN AND MALIGNANT LESIONS OF UTERUS AND CERVIX IN HYSTERECTOMY SPECIMENS

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Shikha Raghuwanshi ◽  
Dharmendra Singh Bhadouria ◽  
Surendra Raghuwanshi ◽  
Arun Saxena ◽  
S.K. Nema
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Common Finding ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Fibroid Uterus ◽  
Malignant Lesions ◽  
Chronic Cervicitis ◽  
Insight Into

Background: The present study was aimed to obtain insight into the varied histopathological patterns of lesions of uterus and cervix in hysterectomy specimens and their age-wise distribution in Index MedicalCollege, Hospital and Research Center. Methodology: This was anobservational study conducted on 100 cases of hysterectomy specimens received at tertiary care hospital Indore. All the specimen was subjected to detailed gross and histopathological examination. Results: Mean age of patients was 44.78±8.64 years. The most common age group was 41-50yrs (42%). Maximum cases were diagnosed as AUB/ DUB/Menorrhagia (31%) followed by fibroid uterus (28%). Uterus was bulky in 70%, cut sections revealed single fibroid in majority i.e. 39% cases and endometrium was in proliferative phase (early 12%, mid 30%, late 19%). Most common histopathological diagnosis of uterus was leiomyoma in 39% cases whereas chronic nonspecific cervicitis (47%) was most common histological diagnosis of cervix. Intramural leiomyoma were most common and were associated with degenerative changes in 33 cases. Hyaline degeneration was observed in maximum cases. Conclusion: The most common indication for hysterectomies in our institution is excessive uterine bleeding. Fibroid uterus as the cause of bleeding is the most common pathology for which hysterectomy is performed. Chronic cervicitis is the most common finding and Adenomyosis continued to be missed preoperatively and diagnosed postoperatively on histopathological examination. Every hysterectomy specimen should be subjected to histopathological examination to confirm various pathological lesions. Keywords: Leiomyoma, histopathology, spectrum, uterus, cervix, hysterectomy

scholarly journals TUMORS OF PALATALMINOR SALIVARY GLANDS: A RETROSPECTIVE ANALYSIS

1969 ◽  
Vol 4 (2) ◽  
pp. 537-541
Author(s):  
MUHAMMAD JAVED ◽  
BAKHT ZADA ◽  
KHURSHID ANWAR ◽  
FARHAN SALAM ◽  
NADAR KHAN ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Correct Diagnosis ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Neck Surgery ◽  
Salivary Gland Neoplasms ◽  
Histopathological Diagnosis ◽  
Minor Salivary Glands ◽  
Malignant Lesions

BACKGROUND: Salivary gland neoplasms make about 3 % of all Head & Neck tumours. Thesetumors are uncommon, accounting for 10 to 15% of all salivary gland neoplasms. Unfortunately themajority of such tumours are malignant. The study aims to give an account of the nature of these tumors.PATIENTS AND METHODS: This retrospective descriptive study was conducted in the departmentsof ENT Head & Neck Surgery of two main tertiary care hospitals of Khyber Pukhtoon Khwa i.e. PGMIHayatabad Medical Complex Peshawar and PGMI Govt lady Reading Hospital Peshawar from July2008 to June 2013. Data extracted from charts review of patients contained age, sex, geographicaldistribution, symptoms, histopathological diagnosis, and treatment. Patients presented to thesedepartments with lesions on the palate and who were managed there were included in the audit. Datathus obtained were analyzed using SPSS 16.RESULTS: A total of 46 patients including 19 male and 27 female presented with primary neoplasmsoriginating in the palatal minor salivary glands were enrolled in the audit. These included 11 benign and35 malignant lesions. Most of the patients were Pakistani (29) as compared to Afghani population (17).Patients ranged in age from the second to the eighth decades, with a female preponderance. The mostcommon malignant lesion was mucoepidermid carcinoma followed by adenoid cystic carcinomawhereas in benign category pleomorphic adenoma was more common tumor.CONCLUSION: The vast majority of neoplasms of the minor salivary glands in the palate aremalignant. These should be managed without delay with wide excision and subsequently subjected tohistopathology to arrive at a correct diagnosis..KEY WORDS: Minor salivary glands, neoplasms, palate, malignant, Benign.

SPECTRUM OF MEDICOLEGAL AUTOPSIES IN A TERTIARY CARE CENTER IN ANDAMAN AND NICOBAR ISLANDS : CAUSES AND TRENDS OVER TWO DECADES.

2021 ◽  
pp. 37-39
Author(s):  
Wajid Ali Shah ◽  
Sakshi Batra ◽  
Harsh Batra ◽  
C.P. Paul
Keyword(s):  
Human Life ◽  
Care Center ◽  
Demographic Data ◽  
Tertiary Care ◽  
Care Hospital ◽  
Andaman And Nicobar Islands ◽  
Female Ratio ◽  
Unnatural Death ◽  
Nicobar Islands ◽  
Te Material

Introduction: Deaths can be due to natural and unnatural causes. While the trend in natural deaths in an area reects the prevalent healthcare practices in an area, the pattern of unnatural deaths in an area conforms with the psychosocial, environmental and mental health. This was a retrospective study of autopsies conducted at a te Material And Methods: rtiary care hospital in Andaman and Nicobar islands over a period of 20 years from 1995-2015. The demographic data was collected from the institutional register. Record and analysis were done using MS Excel. Out of total of 3374 deaths, males Results: were 72.8% and females were 27.2%. Majority of deaths were in the productive age group of 20-39 years (46.5%). Cardiovascular deaths comprised maximum cases of natural deaths (59.8%). Hanging was the most common cause of unnatural death (25.1%) followed by RTA (17.4%). Amongst deaths due to RTA, male to female ratio was 2.5:1. However, deaths due to burns showed a higher predominance in females with female to male ratio of 6.4:1. Medicolegal Conclusion: proling of autopsy provides an important statistical measure to gauge the causes and patterns of untimely loss of human life. Analyzing these and taking imperative measures to curb the same helps in preserving human resources and contribute to country' s development.

scholarly journals SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTAN

2021 ◽  
Vol 71 (3) ◽  
pp. 942-46
Author(s):  
Khurram Mansoor ◽  
Muhammad Osama ◽  
Muhammad Ishaque ◽  
Sohail Sabir ◽  
Hafeez Ud Din ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Care Center ◽  
Tertiary Care ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Graft Dysfunction ◽  
Tubular Atrophy ◽  
Common Cause ◽  
Allograft Dysfunction

Objective: To evaluate outcome of diagnostic kidney biopsy in patients with renal allograft dysfunction at a tertiary care hospital. Study Design: Retrospective observational study. Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi, from Jan 2014 to Jan 2020. Methodology: A consolidate registry review was carried to formulate this study. The registry data exists at our center containing information about the graft dysfunction (manifesting as proteinuria, deranged urea and creatinine or urine sediment abnormalities) and other major indications which warrant probing with biopsy. The histopathological diagnosis of these biopsies is confirmed from the nephro-pathology registry before finalization of diagnosis. Results: A total of 94 diagnostic kidney biopsies were performed in patients with graft dysfunction. Out of 94 biopsies, 80 (85.1%) patients were male while 14 (14.9%) were female patients. The most frequent single cause for graft dysfunction was Cell Mediated Rejection (n 12, 24.5%) followed by Interstitial Fibrosis and Tubular Atrophy/Acute Tubular Injury. The most common cause among the glomerulonephritis was Membranoproliferative Glomerulonephritis (n 3, 6.1%) followed by others. The most common cause for mixed pathology remainedcell mediated rejection with Interstitial fibrosis and tubular atrophy (n 8, 17.8%). Conclusion: Cell mediated rejection is thecommonest pathology responsible for renal allograft dysfunction both as a single lesion as well as part of mixed pathology.

Comparing the Treatment Algorithm and Complications for Patients Undergoing an Anterior Cervical Discectomy and Fusion at a Physician-Owned Specialty Hospital and a University-Owned Tertiary Care Hospital

2016 ◽  
Vol 32 (2) ◽  
pp. 208-214 ◽  
Author(s):  
Gregory D. Schroeder ◽  
Mark F. Kurd ◽  
Christopher K. Kepler ◽  
Kris E. Radcliff ◽  
Jeffery A. Rihn ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Care Center ◽  
Demographic Data ◽  
Tertiary Care ◽  
Treatment Algorithm ◽  
Anterior Cervical Discectomy ◽  
Care Hospital ◽  
Cervical Discectomy ◽  
Specialty Hospital ◽  
Control Study

The purpose of this case-control study is to compare the treatment algorithm and complication rate for patients who undergo an anterior cervical discectomy and fusion at a physician-owned specialty hospital to those who undergo surgery at a university-owned tertiary care hospital. Two controls were identified for 77 patients, and no differences in demographic data were identified. The median time between the onset of symptoms and surgery was shorter for patients who had surgery at the tertiary care center than for patients who had surgery at the specialty hospital (26.7 weeks vs 32.7 weeks, P = .0004). Furthermore, a higher percentage of patients who had surgery at the specialty hospital attempted nonoperative treatments than patients who underwent surgery at the tertiary care hospital.

Coexistence of Metallo Beta Lactamase Resistant Gene Variants Among Clinical Isolates in Tertiary Care Hospital

2021 ◽  
Vol 18 (4) ◽  
pp. 429-436
Author(s):  
Santhiya K. ◽  
Jayanthi S. ◽  
Ananthasubramanian M. ◽  
Appalaraju B.
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Medical Science ◽  
Geographical Location ◽  
Carbapenem Resistance ◽  
Clinical Isolates ◽  
Care Hospital ◽  
Detection Rates ◽  
Carbapenem Resistant ◽  
Global Threat

Background: Carbapenem-resistant Enterobacteriaceae (CRE) has emerged as a global threat with mortality risk ranging from 48%-71% worldwide. The emergence of MBL resistance is threatening as carbapenem is one of the last line antibiotics. A total 24 variants of NDM resistance raises a concern to the clinicians and epidemiologists worldwide. Objective: The study aims at identifying MBL resistance (NDM, IMP, VIM, GIM, SPM, and SIM) and its coexistence in clinical isolates in a single tertiary care center. Methodology: Forty five clinical isolates characterized phenotypically for Carbapenem resistance obtained from PSG Institute of Medical Science and Research (PSG IMSR), Coimbatore, between February to March 2018 were taken for analysis. Result: Out of the 45 Clinical isolates, 38 isolates (84%) were detected as MBL carriers. VIM, NDM, GIM, and SPM were the predominant resistance genes, with detection rates of 48.8%, 28.8%, 24.4%, and 22.2% respectively. Fifteen isolates were observed to harbor more than one MBL gene in coexistence. Two isolates - U42 and R714 (K. pneumoniae) were found to harbor all 5 MBL variants in combination. Conclusion: 33% of clinical isolates harboring multiple MBL variants is a concern in clinical settings. The presence of SPM and GIM gene amongst isolates in this geographical location within India is an indicator demanding continuous monitoring of these resistance determinants.

scholarly journals Relationship between trajectories of post-stroke disability and self-rated health (NeuroAdapt): protocol for a prospective observational study

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e049944
Author(s):  
Sarah K Schäfer ◽  
Robert Fleischmann ◽  
Bettina von Sarnowski ◽  
Dominic Bläsing ◽  
Agnes Flöel ◽  
...  
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Tertiary Care ◽  
Functional Health ◽  
Care Hospital ◽  
Duration Of Symptoms ◽  
Post Stroke ◽  
Self Rated Health ◽  
Modifying Factors ◽  
Study Results

IntroductionStroke is the leading neurological cause of adult long-term disability in Europe. Even though functional consequences directly related to neurological impairment are well studied, post-stroke trajectories of functional health according to the International Classification of Functioning, Disability and Health are poorly understood. Particularly, no study investigated the relationship between post-stroke trajectories of activities of daily living (ADL) and self-rated health (SRH). However, such knowledge is of major importance to identify patients at risk of unfavourable courses. This prospective observational study aims to investigate trajectories of ADL and SRH, and their modifying factors in the course of the first year after stroke.Methods and analysisThe study will consecutively enrol 300 patients admitted to a tertiary care hospital with acute ischaemic stroke or transient ischaemic attack (TIA; Age, Blood Pressure, Clinical Features, Duration of symptoms, Diabetes score ≥3). Patient inclusion is planned from May 2021 to September 2022. All participants will complete an interview assessing ADL, SRH, mental health, views on ageing and resilience-related concepts. Participants will be interviewed face-to-face 1–5 days post-stroke/TIA in the hospital; and will be followed up after 6 weeks, 3 months, 6 months and 12 months via telephone. The 12-month follow-up will also include a neurological assessment. Primary endpoints are ADL operationalised by modified Rankin Scale scores and SRH. Secondary outcomes are further measures of ADL, functional health, physical activity, falls and fatigue. Views on ageing, social support, resilience-related concepts, affect, frailty, illness perceptions and loneliness will be examined as modifying factors. Analyses will investigate the bidirectional relationship between SRH and ADL using bivariate latent change score models.Ethics and disseminationThe study has been approved by the institutional review board of the University Medicine Greifswald (Ref. BB 237/20). The results will be disseminated through scientific publications, conferences and media. Moreover, study results and potential implications will be discussed with patient representatives.Trial registration numberNCT04704635.

Sign in / Sign up

Export Citation Format

Share Document