Evaluation of Some immunological and biochemical parameters as markers in the early diagnosis of diabetic nephropathy

2019 ◽  
Vol 22 (07) ◽  
pp. 28-33
Author(s):  
Rawaa Behlul Al-Fatlawi ◽  
Kifah Jabbar Al-Yaqoobi ◽  
Ameera A Alsadawi ◽  
Najah R. Hadi ◽  
Kareem Ghaly ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Early Diagnosis ◽  
Biochemical Parameters

Distinct Biomarkers for Early Diagnosis of Diabetic Nephropathy

2017 ◽  
Vol 13 (6) ◽  
Author(s):  
Lalit Kishore ◽  
Navpreet Kaur ◽  
Randhir Singh
Keyword(s):  
Diabetic Nephropathy ◽  
Early Diagnosis

scholarly journals MicroRNA-451 as an Early Predictor of Chronic Kidney Disease in Diabetic Nephropathy

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Mostafa Abdelsalam ◽  
A. M. Wahab ◽  
Maysaa El Sayed Zaki ◽  
Mohamad Motawea
Keyword(s):  
Chronic Kidney Disease ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Early Diagnosis ◽  
Serum Creatinine ◽  
High Sensitivity ◽  
Urinary Albumin ◽  
Significant Difference ◽  
Plasma Microrna ◽  
Stage Renal Disease

Background. Diabetes mellitus is the leading cause of end-stage renal disease worldwide. Microalbuminuria is the cornerstone for the diagnosis of diabetic nephropathy. However, it is an inadequate marker for early diagnosis. MicroRNAs are not only new and promising markers for early diagnosis but also, but they may also play a role in the prevention of disease progression. Methods. This study included ninety patients with type 2 DM in addition to 30 control subjects. MicroRNA-451 expression in blood and plasma using real-time PCR was evaluated in addition to the classic diabetic nephropathy markers (serum creatinine, urinary albumin, and eGFR). Results. There was a significant difference between the studied groups versus control regarding serum creatinine, eGFR, urinary, and plasma microRNA-451 with p=0.0001. Patients with eGFR 60 ml/min/1.73 m2 showed a significantly higher plasma microRNA-451 (29.6 ± 1.6) and significantly lower urinary microRNA-451 (21 ± 0.9) in comparison to patients with eGFR >60 ml/min/1.73 m2 and p=0.0001. eGFR showed a positive correlation with urinary microRNA-451 and negative correlation with both plasma microRNA-451 and urinary albumin. Both plasma and urinary microRNA-451 are highly sensitive and specific markers for chronicity in diabetic nephropathy patients with sensitivity of 90.9% and 95.5% and specificity of 67.6% and 95.6%, respectively. Conclusion. MicroRNA-451 is a promising early biomarker for chronic kidney disease in diabetic nephropathy with high sensitivity and specificity.

Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in STZ-induced diabetic rats

2016 ◽  
Vol 27 (1) ◽  
Author(s):  
Alok Shiomurti Tripathi ◽  
Papiya Mitra Mazumder ◽  
Anil Vilasrao Chandewar
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Triglyceride Level ◽  
Biochemical Parameters ◽  
Treated Group ◽  
Diabetic Rats ◽  
Treatment Results ◽  
Phosphodiesterase Type 5 Inhibitor ◽  
Phosphodiesterase Type

AbstractThe present study evaluates the possible mechanism of sildenafil citrate (SIL) for the attenuation of renal failure in diabetic nephropathic (DN) animals.Diabetic nephropathy was induced by a single dose of streptozotocin (STZ) (60 mg/kg, i.p.) and confirmed by assessing the blood and urine biochemical parameters on the 28th day of its induction. The selected DN animals were treated with glimepiride (0.5 mg/kg, p.o.) and SIL (2.5 mg/kg, p.o.) for a period of 6 weeks. Biochemical parameters in blood and urine were estimated after the 29th and 70th day of the protocol for the estimation of the effect of SIL.There were significant alterations in the blood and urine biochemical parameters in STZ-treated groups which confirmed DN. There was a significant decrease in the triglyceride level in the SIL-only-treated group on the 70th day of the protocol. The histopathology study also suggested that SIL treatment results in the improvement in the podocyte count in DN animals.The present study concludes that SIL improves the renal function by decreasing the triglyceride level and improving the podocyte count in DN animals.

scholarly journals Impact of Chronic Cadmium Exposure on the Nephrotoxicity Sensitivity of Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 7 (12) ◽  
pp. 5174-5178
Author(s):  
N’Guessan Assue Adja Julien ◽  
Adon Mousan Arsène ◽  
Kouassi Martin KONAN ◽  
Djaman Allico Joseph ◽  
Dosso Mireille
Keyword(s):  
Diabetic Nephropathy ◽  
Biochemical Parameters ◽  
Histopathological Examination ◽  
Inorganic Ions ◽  
Diabetic Rats ◽  
Cadmium Exposure ◽  
Renal Tubules ◽  
Tissue Samples ◽  
Cadmium Poisoning

The present study aimed to assess the role of subchronic cadmium exposure in the development of diabetic nephropathy. Diabetic rats induced by streptozotocin (STZ + Cd) and normal non-diabetic rats (Cd) were exposed to cadmium sulphate in drinking water at a dose of 200 mg / l for 30 days. After 30 days of cadmium poisoning, blood and tissue samples were taken to determine markers of kidney function (urea, uric acid, creatinine, total protein and inorganic ions) and for the achievement histological couples. Cadmium poisoning resulted in an increase in relative kidney weights and a change in biochemical parameters in serum. Histopathological examination of the kidneys revealed degeneration and necrosis of the renal tubules and shrinking of the glomeruli in rats poisoned with Cd. However, our results showed that diabetic rats induced by streptozotocin are more sensitive to nephrotoxicity of cadmium than rats normal. our results suggest that cadmium may be a factor in the development of diabetic nephropathy.

scholarly journals Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Cristina Gluhovschi ◽  
Gheorghe Gluhovschi ◽  
Ligia Petrica ◽  
Romulus Timar ◽  
Silvia Velciov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Early Diagnosis ◽  
Gold Standard ◽  
Tubular Injury ◽  
Inflammation Markers ◽  
Vascular Biomarkers ◽  
Early Diabetic Nephropathy ◽  
Biomarkers Of Oxidative Stress

Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition—mainly cardiovascular ones—and for monitoring its progression. New researches are pointing that some of these biomarkers (i.e., glomerular, tubular, inflammation markers, and biomarkers of oxidative stress) precede albuminuria in some patients. However, their usefulness is widely debated in the literature and has not yet led to the validation of a new “gold standard” biomarker for the early diagnosis of DN. Currently, microalbuminuria is an important biomarker for both glomerular and tubular injury. Other glomerular biomarkers (transferrin and ceruloplasmin) are under evaluation. Tubular biomarkers in DN seem to be of a paramount importance in the early diagnosis of DN since tubular lesions occur early. Additionally, biomarkers of inflammation, oxidative stress, podocyte biomarkers, and vascular biomarkers have been employed for assessing early DN. The purpose of this review is to provide an overview of the current biomarkers used for the diagnosis of early DN.

scholarly journals Nephrology Referral in Diabetes Practice

2018 ◽  
Vol 06 (02) ◽  
pp. 106-108
Author(s):  
Sanjay Kalra ◽  
Manisha Sahay ◽  
Rakesh Sahay
Keyword(s):  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Diabetic Kidney Disease ◽  
Major Complication ◽  
Diabetic Kidney ◽  
Delayed Referral

AbstractDiabetic nephropathy, including diabetic kidney disease (DKD), is a major complication of diabetes. Appropriate management of DKD requires multispecialty intervention under the guidance of endocrinology and nephrology. However, delayed referral to specialized nephrology services usually occurs, and this leads to suboptimal outcomes. This multispecialty consensus suggests simple clinical and biochemical parameters that should prompt referral of DKD patients to nephrology. A checklist for physicians who manage DKD is also provided.

scholarly journals Early diagnosis of diabetic nephropathy using spot urine microalbumin in type 2 diabetes mellitus patients

2019 ◽  
Vol 9 (1) ◽  
pp. 01-04
Author(s):  
Ketham Veera Sudhakar ◽  
◽  
B Ravindra Reddy ◽  
A Padma Vijaya Sree ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Early Diagnosis ◽  
Spot Urine
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