THE PROTECTIVE EFFECTS OF EXTRACT OF PUNICA GRANATUM L PEEL AND PIPER LONGUM FRUIT AGAINST HEPATOTOXICITY INDUCED BY THIOACETAMIDE IN MALE ALBINO RATS

2020 ◽  
Vol 23 (09) ◽  
Author(s):  
JAFAR S. N ◽  
MAWLOOD K. A
Keyword(s):  
Punica Granatum ◽  
Albino Rats ◽  
Protective Effects ◽  
Piper Longum ◽  
Punica Granatum L

scholarly journals Antidiabetic Action of Ethanolic Extracts of Punica granatum Linn. in Alloxan-induced Diabetic Albino Rats

1970 ◽  
Vol 2 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Swamamoni Das ◽  
Gayatri Sama
Keyword(s):  
Blood Glucose ◽  
Liver Glycogen ◽  
Punica Granatum ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Probable Mechanism ◽  
Albino Rats ◽  
Pharmaceutical Sciences ◽  
Ethanolic Extracts ◽  
Punica Granatum L

Antidiabetic action of ethanolic extracts of seed and rind of Punica granatum L. was evaluated on alloxan-induced diabetic albino rats. Both the extracts, each at a dose of 200mg/kg/d, were administered orally for two weeks to alloxan-induced diabetic rats. Blood glucose was estimated every week for two consecutive weeks. For evaluation of probable mechanism of action of the extracts, glycogen estimation was carried out in liver, heart and skeletal muscle and effect on adrenaline-induced hyperglycemia was observed. Both the extracts significantly (p<0.05) reduced the rise in blood glucose induced by alloxan, with the rind extract exhibiting significantly (p<0.05) better activity than seed extract. Both the extracts also produced significant (p<0.05) increase in liver glycogen and significantly (p<0.05) reduced adrenaline-induced hyperglycemia. These results support strong antidiabetic action in favor of P. granatum seed and rind extractsKey words: Punica granatum L.; Ethanolic extracts; Antidiabetic; Alloxan. DOI: 10.3329/sjps.v2i1.5810Stamford Journal of Pharmaceutical Sciences Vol.2(1) 2009: 14-21

scholarly journals Physico-Chemical Characteristics at Three Development Stages in Pomegranate cv. ‘Hicaznar’

2013 ◽  
Vol 39 (1) ◽  
pp. 241 ◽  
Author(s):  
Sadiye G OZLEKCI ◽  
Sezai ERCISLI ◽  
Filiz OKTUREN ◽  
Sahriye SONMEZ
Keyword(s):  
Punica Granatum ◽  
Development Stage ◽  
Fruit Weight ◽  
Solid Content ◽  
Soluble Solid Content ◽  
Chemical Characteristics ◽  
Protective Effects ◽  
Physico Chemical ◽  
Soluble Solid ◽  
Punica Granatum L

During the last decade consumption of pomegranate (Punica granatum L.) has been highly recommended, based on the presence of phytochemicals with health protective effects for humans. Apart from these compounds, pomegranate might apport high levels of minerals, however, they are likely to be affected by cultivar, environment and development stage of fruits. In this study, some physico-chemical characteristics along with minerals (P, K, Ca, Mg, Na, Fe, Mn, Zn and Cu) were determined in fruits in three development stage (immature, unripe and full ripe) of pomegranate cv. ‘Hicaznar’ grown in Antalya, Turkey. The most of physico-chemical characteristics and concentrations of minerals of pomegranate strongly influenced by development stage. Fruit weight was 7.25 g, 140.57 g and 423.16 g in immature, unripe and full ripe stages. 100 aril weight changed from 0.34 g to 33.21 g during development stage. Soluble solid content were 6.16%, 10.38% and 15.84% in immature, unripe and full ripe stages. The contribution to the intake of minerals was in general high, with special emphasis on the contributions of K, Ca and Mn.

PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT ACTIVITY AND ACUTE ORAL TOXICITY OF POMEGRANATE (PUNICA GRANATUM L.) FRUIT PEEL EXTRACT

2019 ◽  
pp. 7-14
Author(s):  
Hai Trieu Ly ◽  
Tuan Anh Vo ◽  
Viet Hong Phong Nguyen ◽  
Thi My Sa Pham ◽  
Bich Thao Lam ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Gallic Acid ◽  
Radical Scavenging ◽  
Dry Weight ◽  
Punica Granatum ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Fruit Peel ◽  
Total Polyphenol ◽  
Punica Granatum L

Background: The natural antioxidants have an important role in the prevention of many diseases. The aim of study is to investigate phytochemical components, antioxidant activity and acute oral toxicity of Pomegranate (Punica granatum L.) fruit peel (PFP) extract. Materials and methods: Phytochemicals of PFP were determined by qualitative chemical tests, thin layer chromatography, total polyphenol and flavonoid contents. The PFP extract was evaluated for antioxidant activity by DPPH assay and MDA assay. In vivo acute oral toxicity test was conducted using Karber-Behrens method to determine LD50. Results: Results illustrated that PFP mainly contains flavonoids, alkaloids, tannins, triterpenes, saponins, and coumarins. PFP extract exhibited the total polyphenol and flavonoid contents with 189.97 mg gallic acid equivalent/g dry weight and 9.42 mg quercetin equivalent/g dry weight, respectively. The DPPH free radical scavenging and anti-lipid peroxidation activities of PFP extract were expressed with IC50 value of 4.80 μg/mL and 0.38 μg/ mL, sequentially. Simultaneously, the Dmax (the maximum dose administered to mice that no toxicity was observed) of PFP extract was determined to be 21.28 g/kg, equivalent to 35.64 g dried herb. Conclusion: The PFP extract is relatively safe and revealed high antioxidant activity. Key words: Punica granatum L.; polyphenols; flavonoids; gallic acid; quercetin; antioxidant activity; acute oral toxicity

Anti-Stress Effect of Punica granatum L. Extract against Sleep Deprivation-Induced Impairment

2016 ◽  
Vol 45 (11) ◽  
pp. 1533-1543
Author(s):  
Ju-Ryun Na ◽  
Sunoh Kim ◽  
Ara Jo ◽  
Donghyuck Bae ◽  
Kyo-Nyeo Oh ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Punica Granatum ◽  
Stress Effect ◽  
Punica Granatum L
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