scholarly journals The Relationship Between Bacterial Pattern with Degree of Airflow Limitation FEV1 in Acute Exacerbation of COPD at Adam Malik General Hospital and Pirngadi Hospital

2019 ◽  
Vol 39 (3) ◽  
pp. 204-209
Author(s):  
Rianti Tarigan ◽  
Amira P Tarigan ◽  
Dian Dwi Wahyuni ◽  
Putri C Eyanoer
Keyword(s):  
General Hospital ◽  
Acute Exacerbation ◽  
Sputum Culture ◽  
Susceptibility Test ◽  
Airflow Limitation ◽  
Streptococcus Pneumonia ◽  
Acute Exacerbation Of Copd ◽  
Exacerbation Of Copd ◽  
Tract Infections ◽  
The Relationship

Background: Respiratory tract infections are the leading cause of acute exacerbation of COPD (AECOPD). The aim of this study was to investigate the relationship between bacterial pattern and the degree of airflow limitation (FEV1) in patients with acute exacerbation of COPD at Adam Malik General Hospital and Pirngadi Hospital, also the sensitive antibiotics according to the susceptibility test. Methods: This was a cross sectional study of all patients admitted to Adam Malik and Pirngadi Hospital with AECOPD from September 2015 until September 2016. In all 45 subjects who fulfilled the inclusion criteria, the spirometry was examination undergone to evaluate the degree of severity of COPD according to GOLD 2017. In each sample sputum expectoration, the gram smear was made. Barttlet criteria was used to calculate the amount of epithelial cells and PMN. The sample was then grown on blood agar medium. Bacterial susceptibility test to antibiotics was conducted using VITEC 2 methods. Results: From 45 patients, 30 patients (66,7%) had positive sputum cultures. The most frequently isolated pathogen was Streptococcus pneumonia (26,7%). The most sensitive antibiotic was Amikacin (100%). There were no correlation between the in degree of airflow limitation FEV1 and bacterial sputum culture result. There were no significant differences between gram positive or negative bacteria with the degree of airflow limitation. Conclusion: The incidence of bacterial infection based on positive sputum culture in AECOPD was about 66,7% Streptococcus pneumonia was the most common pathogen and Amikacin was the most sensitive antibiotic. There were no significant correlation between the degree of airflow limitation FEV1 with the positive or negative sputum culture and also with the result of gram staining. (J Respir Indo. 2019; 39(3):204-9)

Effect of phosphate level on the outcome of COPD patients in the Intensive Care Unit

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Gihan S Mohamed ◽  
Ahmed A El Shebiny ◽  
Mohammed M Maarouf ◽  
Ahmed M Heikal
Keyword(s):  
Intensive Care ◽  
Acute Exacerbation ◽  
Airflow Limitation ◽  
Chronic Obstructive ◽  
Copd Exacerbation ◽  
Acute Exacerbation Of Copd ◽  
Poor Outcome ◽  
Number Of Patients ◽  
Exacerbation Of Copd ◽  
Phosphorus Levels

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is a preventable ano treatable oisease with some sienificant extra pulmonary effects that may contribute to the severity in inoivioual patients. Its pulmonary component is characterizeo by airflow limitation that is not fully reversible. The airflow limitation is usually proeressive ano is associateo with an abnormal inflammatory response of the lune to noxious particles or eases. Aim of the Work to evaluate the effect of hypophosphatemia on patients with acute exacerbation of COPD reearoine severity of COPD exacerbation, neeo for ventilation, ouration of ventilation ano outcome. Patients and Methods This observational stuoy was performeo on 50 patients with acute exacerbation of COPD were aomitteo to intensive care oepartment of Ain Shams University. Serum of phosphorus was measureo on aomission, hypophosphatemia is consioereo if serum phosphorus is below 2.5me/ol. In our stuoy 32 patients hao hypophosphatemia ano 18 patients hao normal phosphorus levels out of the 50 patients in our stuoy. Results Severity of COPD exacerbation ano ventilation necessity increaseo in males with olo aee who were heavy smokers with lone ouration of smokine. Hieh levels of PaCO2 increaseo the neeo for ventilation. Hypophosphatemia without other electrolytes oeficiency increaseo severity of COPD exacerbation, also it increaseo neeo for ventilation. Also our results showeo that hypophosphatemia associateo with lone ouration of ventilation, poor outcome ano hieh rate of mortality as it causeo oiaphraematic ano respiratory muscle weakness so it leo to weanine failure ano so oeath. Combineo hypophosphatemia with multiple electrolytes oeficiency increaseo neeo for ventilation, ouration of ventilation ano poor outcome, while multiple electrolytes oeficiency without hypophosphatemia hao no effect on neeo for ventilation, ouration of ventilation ano outcome. We coulon't comment on hypomaenesemia oue to small number of patients as only one patient hao hypomaenesemia in our stuoy. Therefore, low blooo phosphorus levels contributes to increase severity of COPD, neeo for ventilation, ouration of ventilation ano poor outcome, so correction of hypophosphatemia may improve proenosis of COPD exacerbation. Conclusion Hypophosphatemia increases the severity of COPD exacerbation, neeo for ventilation, ouration of ventilation, weanine failure ano so increases the rate of mortality. Also, combineo hypophosphatemia with multiple electrolytes oeficiency increaseo neeo for ventilation.

A COMPARATIVE STUDY TO EVALUATE C-REACTIVE PROTEIN AND PROCALCITONIN AS A MARKER OF BACTERIAL INFECTION IN PATIENTS WITH ACUTE EXACERBATION OF COPD.

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Nipun Agrawal ◽  
Anshul Jain ◽  
Lalit Singh ◽  
Abhishek Jain
Keyword(s):  
Bacterial Infection ◽  
Acute Exacerbation ◽  
Sensitivity And Specificity ◽  
Area Under Curve ◽  
Comorbid Condition ◽  
C Reactive Protein ◽  
Acute Exacerbation Of Copd ◽  
Reactive Protein ◽  
Exacerbation Of Copd ◽  
Tract Infections

INTRODUCTION: Exacerbations of COPD can be precipitated by several factors. The most common causes appear to be respiratory tract infections. Overuse of antibiotics is common and accelerates the development of drug resistance and hospital acquired infections. In some recent studies, both C-reactive protein as well as Procalcitonin levels have been shown to be useful in differentiating bacterial etiology of exacerbations and thus helping in guiding the treatment as well as in prediction of outcome. Evaluate sensitivity and specificity of C-reactive protein and Procalcitonin as a marker of bacterial infection in patients with acute exacerbation of COPD. MATERIAL AND METHODS: The present hospital-based observational study was carried out at Department of Pulmonary Medicine, SRMSIMS, Bareilly. 50 patients from patients of COPD with acute exacerbation attending/admitted to Pulmonary OPD/IPD were included in the study excluding those below 40yrs old or presenting with acute breathlessness due to comorbid condition. Demographic information, relevant clinical data and lab investigations were recorded from all patients including C-reactive protein and Procalcitonin on admission following which the patients were started antibiotics as per guidelines. Reassessment of S. Procalcitonin and C-reactive protein was done on 3rd and 7th day of hospitalization. ROC Curve was applied to compare sensitivity and specificity. RESULTS: Sputum culture was found positive in 27 (54.0%) patients. At all the three intervals, CRP levels had ROC area under curve (ROCAUC) values above 0.70. Area under curve value was maximum at day 3. For Procalcitonin, the area under curve values were >0.8 at day 1 and day 3 but on day 7 this value was only 0.624. On evaluating the correlation between S. C-Reactive Protein and Procalcitonin levels, a mild positive and significant correlation was observed at day 1 and day 7 intervals whereas on day 3 a moderate positive and significant correlation was observed between the two markers.CONCLUSION: CRP is good marker when tested early and late while PCT is better when tested early.

Study of serum magnesium levels in acute exacerbation of COPD

2016 ◽  
Vol 3 (1) ◽  
pp. 56-64
Author(s):  
M.G.Krishna Murthy ◽  
◽  
Tarigopula Pramod Kumar ◽  
M. Kiran kumar
Keyword(s):  
Acute Exacerbation ◽  
Serum Magnesium ◽  
Acute Exacerbation Of Copd ◽  
Exacerbation Of Copd

Characteristics and outcomes of diabetic patients with acute exacerbation of COPD

2021 ◽  
Author(s):  
Elio Monsour ◽  
Lyd-Marie Rodriguez ◽  
Randa Abdelmasih ◽  
Kubra Tuna ◽  
Khalid Abusaada
Keyword(s):  
Acute Exacerbation ◽  
Diabetic Patients ◽  
Acute Exacerbation Of Copd ◽  
Exacerbation Of Copd
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