THE RESULT OF THE STUDY OF THE DEGREE OF ATROPHIC PROCESSES OF PROSTHETIC BED TISSUES UNDER THE BASES OF PROSTHESES OF VARIOUS DESIGNS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AGAINST THE BACKGROUND OF THE USE OF A BIO-SOLUBLE ADHESIVE FILM AND A VITAMIN-MINERAL COMPLEX

2021 ◽  
pp. 47-53
Author(s):  
Наталия Александровна Полушкина ◽  
Наталия Владимировна Чиркова ◽  
Кристина Павловна Кубышкина ◽  
Татьяна Александровна Попова
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
The Body ◽  
Special Equipment ◽  
Adhesive Film ◽  
Removable Denture ◽  
Removable Plate ◽  
Anti Inflammatory

Литературные данные за последнее десятилетие свидетельствуют о неуклонном росте количества больных, нуждающихся в съемных конструкциях зубных протезов. Адаптация пациентов к съемным пластиночным протезам, в особенности изготовленным из акриловой пластмассы, несомненно, является актуальной проблемой. Известно, что базис протеза изготовлен из материалов, не являющихся полностью биологически инертным веществом, а, следовательно, возможно их местное и общее воздействие на организм. В целях профилактики негативного действия съемных пластиночных протезов и улучшения качества протезирования многими исследователями были предложены различные способы, такие как уменьшение концентрации примесей, путем кипячения, применение СВЧ-полимеризации. Широкое применение получили эластичные материалы для изготовления базисов съемных протезов. Недостатком данных методов является то, что требуются наличие специального оборудования и материальных затрат как со стороны пациентов, так и стоматологических учреждений. В последние годы клиницистов привлекает возможность применения лекарственных препаратов для лечения и профилактики осложнений со стороны тканей протезного ложа. Идет постоянный поиск фармакологических средств, позволяющих оказывать противовоспалительное, противомикробное, антиаллергическое и иммуномодулирующeе действие. Перспективным направлением в профилактике осложнений является использование биорастворимых лекарственных пленок. Биорастворимая адгезивная плёнка имеет отличную особенность значительным противовоспалительным эффектом, подтверждаемым микробиологическими и клиническими показателями. Комплексное лечение заболеваний пародонта с применением рекомендуемой биорастворимой адгезивной плёнки позволит увеличить период ремиссии у пациентов с сахарным диабетом. Согласно последним данным доказано, что они нетоксичны, инертны для организма, пролонгируют действие биологически активных веществ, входящих в их состав. Таким образом, разработка биорастворимой адгезивной плёнки для профилактики и лечения местных осложнений со стороны слизистой оболочки протезного ложа у пациентов с сахарным диабетом 2-го типа, является на наш взгляд актуальным Iterature data over the past decade indicate a steady increase in the number of patients in need of removable denture structures. The adaptation of patients to removable plate prostheses, especially those made of acrylic plastic, is undoubtedly an urgent problem. It is known that the basis of the prosthesis is made of materials that are not completely biologically inert, and, therefore, their local and general effects on the body are possible. In order to prevent the negative effects of removable plate prostheses and improve the quality of prosthetics, many researchers have proposed various methods, such as reducing the concentration of impurities by boiling, the use of microwave polymerization. Elastic materials have been widely used for the manufacture of removable prosthesis bases. The disadvantage of these methods is that special equipment and material costs are required both from patients and dental institutions. In recent years, clinicians have been attracted by the possibility of using medications for the treatment and prevention of complications from the tissues of the prosthetic bed. There is a constant search for pharmacological agents that can provide anti-inflammatory, antimicrobial, antiallergic and immunomodulatory effects. A promising direction in the prevention of complications is the use of bio-soluble medicinal films. The bio-soluble adhesive film has an excellent feature of a significant anti-inflammatory effect, confirmed by microbiological and clinical indicators. Complex treatment of periodontal diseases with the use of the recommended bio-soluble adhesive film will increase the remission period in patients with diabetes mellitus. According to the latest data, it has been proven that they are non-toxic, inert to the body, prolong the action of biologically active substances that make up their composition. Thus, the development of a bio-soluble adhesive film for the prevention and treatment of local complications from the mucous membrane of the prosthetic bed in patients with type 2 diabetes mellitus is, in our opinion, relevant

scholarly journals Insights into the Molecular Role of Endocannabinoids in Diabetes Mellitus

2021 ◽  
Vol 12 (1) ◽  
pp. 470-485
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cannabinoid Receptors ◽  
The Body ◽  
Diabetic Patients ◽  
Depth Analysis ◽  
Anti Inflammatory

In the past few years, the pathophysiological role of various factors in type 2 diabetes mellitus has been fully explored. Subsequently, this marked the progression in the development of a novel therapeutic agent. Such brain-derived neurotropic factors, including neurotrophic factor-2 and anti-inflammatory agents for the treatment of diabetes, have emerged. However, the therapeutic potential of endocannabinoids in type 2 diabetes mellitus is still not fully understood. At present, cannabinoids are under research for their therapeutic and safety profile issues in numerous thrust areas. Its wide biological actions are implemented through cannabinoid receptor type 1(CB1) and CB2 receptors, which find major applications as anti-arthritic, anti-inflammatory, neuroprotective, anti-cancer, and antidiabetic therapeutics with lesser side effects than any other traditional therapy. The current review aims to reveal detailed aspects of pathological and physiological pathways with endocannabinoids followed in disease progression. Different alterations induced by them in the pancreas, such as 2-arachidonylglycerol and anandamide during hyperglycemia, clearly verify their participation in the progression of type 2 diabetes. Activation of both cannabinoid receptors results in metabolic changes inside the body, and receptor antagonist rimonabant has been proven to be protective in controlling insulin resistance in diabetic patients. Therefore, endocannabinoids are a promising target in new drug developments and further in-depth analysis of their hidden aspects, which would help develop alternate beneficial targets in combating the progression of diabetes.

scholarly journals STUDY OF HBA1C, LIPID PROFILE AND CYCLOPHILIN-A IN DIABETES MELLITUS

2019 ◽  
Vol 3 (12) ◽  
Author(s):  
Rakesh Kumar Jha ◽  
Badade ZG ◽  
Sandeep Rai ◽  
Badade VZ
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Glycosylated Hemoglobin ◽  
General Medicine ◽  
Cyclophilin A ◽  
The Body ◽  
Glucose Levels

Introduction: Diabetes is a chronic disease that occurs when not enough insulin is produced by the pancreas or the body does not use the insulin produced. Because of increased blood glucose levels in the body, serious heart, kidneys, blood vessels, nerves and eyes damage are caused. Report says about 400 million people suffer from diabetes. Therefore present study is aimed to assess levels of HbA1c, Lipid profile and Cyclophilin A in diabetic patient. Material and Methods: The present study includes total 126 subjects comprising of 66 type 2 Diabetes Mellitus patients and 60 healthy individual. Blood samples are collected from the all subjects were processed for HbA1c, Lipid Profile and Cyclophilin A estimation, from OPD and General Medicine Wards. HbA1c is estimated by HPLC, lipid Profile by AU480 and the Cyclophilin A by ELISA method using commercially available Qayee-bio ELISA kit. Conclusion: Present study showed significantly increased levels of HbA1c, Lipid Profile and Cyclophilin A in T2DM patients. The elevated lipid profile may be due to the complication of Diabetic mellitus. CyA is increased as an inflammation marker. Keywords: T2DM: Type 2 diabetes mellitus, HbA1c: Glycosylated Hemoglobin, CyA: Cyclophilin-A

Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas

2015 ◽  
Vol 6 (9) ◽  
pp. 3065-3071 ◽  
Author(s):  
Wenbin Yin ◽  
Baoying Li ◽  
Xiaoli Li ◽  
Fei Yu ◽  
Qian Cai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Grape Seed ◽  
Therapeutic Strategies ◽  
Anti Inflammatory

The prevalence of type 2 diabetes mellitus (T2DM) has increased considerably in recent years, highlighting the importance of developing new therapeutic strategies.

Screening of secondary metabolites, bioactive compounds, in vitro antioxidant, antibacterial, antidiabetic and anti-inflammatory activities of chia seeds (Salvia hispanica L.)

2021 ◽  
pp. 6289-6294
Author(s):  
Saffiya Banu. A ◽  
Sheila John ◽  
Sarah Jane Monica ◽  
Saraswathi. K ◽  
Arumugam. P
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Type 2 Diabetes Mellitus ◽  
Dpph Radical ◽  
Anti Inflammatory

Recent research studies indicate the role of functional foods in preventing the development of complications associated with type 2 diabetes mellitus. Chia seeds are an excellent source of dietary fibre, essential fatty acids, micronutrients and non-nutritive components. The objective of the study was to evaluate the antioxidant, antibacterial, antidiabetic and anti-inflammatory potential of chia seeds. TPC and TFC were estimated using Folin-Ciocalteu Reagent and Alumininum Chloride method. The antioxidant activity was determined using DPPH● radical, ABTS●+ radical, Superoxide (O2-) radical, Fe3+ reducing and phosphomolybdenum reduction assay. Agar well diffusion method was used to determine the antibacterial activity against Escherichia coli, Proteus vulgaris, Shigella flexneri, Micrococcus luteus, Bacillus subtilis and Staphylococcus aureus. Antidiabetic and anti-inflammatory activities were evaluated using alpha amylase inhibition assay and heat induced haemolysis method. Volatile functional compounds were identified using Gas chromatography mass spectrometry. Upon quantification, TPC and TFC were found to be 850.67±14.14µg/mg GAE and 171.21±12.86µg/mg QE. Free radical scavenging activity of chia seeds was ranked in the order of DPPH● radical >ABTS●+ radical > Superoxide (O2-) radical. The capability of chia seeds to function as electron donors was evident through its strong reducing power. With regard to antibacterial activity, maximum inhibition was observed for Staphylococcus aureus, with a zone of inhibition of 31mm at 500µg/mL. Results of antidiabetic assay highlighted the alpha amylase inhibitory action of chia seeds with an IC50 value of 121.46µg/mL. The anti-inflammatory activity of chia seeds increased linearly in a dose dependent manner. GC-MS analysis showed the presence of functionally active compounds such as coumarine, napthoquinone, phytol, fatty acids, flavone and flavone derivatives. Findings of the study highlight that chia seeds have several essential therapeutic properties. Furthermore, clinical studies are required to validate the role of chia seeds in preventing the development of complications associated with type 2 diabetes mellitus.

scholarly journals Insulin Resistance in Osteoarthritis: Similar Mechanisms to Type 2 Diabetes Mellitus

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Elena V Tchetina ◽  
Galina A Markova ◽  
Eugeniya P Sharapova
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
The Body ◽  
Whole Body ◽  
Insulin Resistant ◽  
Resistant State ◽  
Insulin Resistant State

Osteoarthritis (OA) and type 2 diabetes mellitus (T2D) are two of the most widespread chronic diseases. OA and T2D have common epidemiologic traits, are considered heterogenic multifactorial pathologies that develop through the interaction of genetic and environmental factors, and have common risk factors. In addition, both of these diseases often manifest in a single patient. Despite differences in clinical manifestations, both diseases are characterized by disturbances in cellular metabolism and by an insulin-resistant state primarily associated with the production and utilization of energy. However, currently, the primary cause of OA development and progression is not clear. In addition, although OA is manifested as a joint disease, evidence has accumulated that it affects the whole body. As pathological insulin resistance is viewed as a driving force of T2D development, now, we present evidence that the molecular and cellular metabolic disturbances associated with OA are linked to an insulin-resistant state similar to T2D. Moreover, the alterations in cellular energy requirements associated with insulin resistance could affect many metabolic changes in the body that eventually result in pathology and could serve as a unified mechanism that also functions in many metabolic diseases. However, these issues have not been comprehensively described. Therefore, here, we discuss the basic molecular mechanisms underlying the pathological processes associated with the development of insulin resistance; the major inducers, regulators, and metabolic consequences of insulin resistance; and instruments for controlling insulin resistance as a new approach to therapy.

scholarly journals The Aqueous Extract of Gynura divaricata (L.) DC. Improves Glucose and Lipid Metabolism and Ameliorates Type 2 Diabetes Mellitus

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Jinnan Li ◽  
Jinlei Feng ◽  
Hong Wei ◽  
Qunying Liu ◽  
Ting Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Water Extract ◽  
The Body ◽  
Peripheral Tissues ◽  
Insulin Resistant ◽  
Glucose And Lipid Metabolism

Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia and dyslipidemia caused by impaired insulin secretion and resistance of the peripheral tissues. A major pathogenesis of T2DM is obesity-associated insulin resistance. Gynura divaricata (L.) DC. (GD) is a natural plant and has been reported to have numerous health-promoting effects on both animals and humans. In this study, we aimed to elucidate the regulatory mechanism of GD improving glucose and lipid metabolism in an obesity animal model induced by high-fat and high-sugar diet in combination with low dose of streptozocin and an insulin-resistant HepG2 cell model induced by dexamethasone. The study showed that the water extract of GD (GD extract A) could significantly reduce fasting serum glucose, reverse dyslipidemia and pancreatic damage, and regulate the body weight of mice. We also found that GD extract A had low toxicity in vivo and in vitro. Furthermore, GD extract A may increase glucose consumption in insulin-resistant HepG2 cells, markedly inhibit NF-κB activation, and decrease the impairment in signaling molecules of insulin pathway, such as IRS-1, AKT, and GLUT1. Overall, the results indicate that GD extract A is a promising candidate for the prevention and treatment of T2DM.

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