Limitations of regenerative medicine and cell therapy in cancer therapy

2019 ◽  
pp. 1-2
Keyword(s):  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Gravitational Wave ◽  
Wave Field ◽  
Evolutionary Process ◽  
The Relationship

In this paper, the mathematical regularity of the formation of cancer is deduced by the theory of the change and stability of gravitational wave field. The relationship between cancer and DNA information changes is presented. The cancer record of the cell DNA, which does not have a sudden mutation, needs to go through a long smooth evolutionary process.

scholarly journals Autophagy Modulators in Cancer Therapy

2021 ◽  
Vol 22 (11) ◽  
pp. 5804
Author(s):  
Kamila Buzun ◽  
Agnieszka Gornowicz ◽  
Roman Lesyk ◽  
Krzysztof Bielawski ◽  
Anna Bielawska
Keyword(s):  
Cancer Research ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Nutrient Deficiency ◽  
Molecular Regulation ◽  
Regulatory Pathways ◽  
Selective Autophagy ◽  
Atg Proteins ◽  
Different Types ◽  
The Relationship

Autophagy is a process of self-degradation that plays an important role in removing damaged proteins, organelles or cellular fragments from the cell. Under stressful conditions such as hypoxia, nutrient deficiency or chemotherapy, this process can also become the strategy for cell survival. Autophagy can be nonselective or selective in removing specific organelles, ribosomes, and protein aggregates, although the complete mechanisms that regulate aspects of selective autophagy are not fully understood. This review summarizes the most recent research into understanding the different types and mechanisms of autophagy. The relationship between apoptosis and autophagy on the level of molecular regulation of the expression of selected proteins such as p53, Bcl-2/Beclin 1, p62, Atg proteins, and caspases was discussed. Intensive studies have revealed a whole range of novel compounds with an anticancer activity that inhibit or activate regulatory pathways involved in autophagy. We focused on the presentation of compounds strongly affecting the autophagy process, with particular emphasis on those that are undergoing clinical and preclinical cancer research. Moreover, the target points, adverse effects and therapeutic schemes of autophagy inhibitors and activators are presented.

scholarly journals iPSC technology-based regenerative medicine for kidney diseases

2021 ◽  
Author(s):  
Kenji Osafune
Keyword(s):  
Regenerative Medicine ◽  
Cell Therapy ◽  
Kidney Development ◽  
Disease Modeling ◽  
Kidney Diseases ◽  
Collecting Duct ◽  
Current Status ◽  
Renal Tubules ◽  
Discovery Research ◽  
Drug Discovery Research

AbstractWith few curative treatments for kidney diseases, increasing attention has been paid to regenerative medicine as a new therapeutic option. Recent progress in kidney regeneration using human-induced pluripotent stem cells (hiPSCs) is noteworthy. Based on the knowledge of kidney development, the directed differentiation of hiPSCs into two embryonic kidney progenitors, nephron progenitor cells (NPCs) and ureteric bud (UB), has been established, enabling the generation of nephron and collecting duct organoids. Furthermore, human kidney tissues can be generated from these hiPSC-derived progenitors, in which NPC-derived glomeruli and renal tubules and UB-derived collecting ducts are interconnected. The induced kidney tissues are further vascularized when transplanted into immunodeficient mice. In addition to the kidney reconstruction for use in transplantation, it has been demonstrated that cell therapy using hiPSC-derived NPCs ameliorates acute kidney injury (AKI) in mice. Disease modeling and drug discovery research using disease-specific hiPSCs has also been vigorously conducted for intractable kidney disorders, such as autosomal dominant polycystic kidney disease (ADPKD). In an attempt to address the complications associated with kidney diseases, hiPSC-derived erythropoietin (EPO)-producing cells were successfully generated to discover drugs and develop cell therapy for renal anemia. This review summarizes the current status and future perspectives of developmental biology of kidney and iPSC technology-based regenerative medicine for kidney diseases.

scholarly journals Cell Therapy and Bioengineering in Experimental Liver Regenerative Medicine: In Vivo Injury Models and Grafting Strategies

2021 ◽  
Author(s):  
G. Amato ◽  
T. Saleh ◽  
G. Carpino ◽  
E. Gaudio ◽  
D. Alvaro ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Cell Therapy ◽  
Cell Delivery ◽  
Effective Strategies ◽  
Multiple Strategies ◽  
End Stage ◽  
Therapy Strategies ◽  
Injury Models ◽  
Experimental Liver

Abstract Purpose of Review To describe experimental liver injury models used in regenerative medicine, cell therapy strategies to repopulate damaged livers and the efficacy of liver bioengineering. Recent Findings Several animal models have been developed to study different liver conditions. Multiple strategies and modified protocols of cell delivery have been also reported. Furthermore, using bioengineered liver scaffolds has shown promising results that could help in generating a highly functional cell delivery system and/or a whole transplantable liver. Summary To optimize the most effective strategies for liver cell therapy, further studies are required to compare among the performed strategies in the literature and/or innovate a novel modifying technique to overcome the potential limitations. Coating of cells with polymers, decellularized scaffolds, or microbeads could be the most appropriate solution to improve cellular efficacy. Besides, overcoming the problems of liver bioengineering may offer a radical treatment for end-stage liver diseases.

scholarly journals Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

RSC Advances ◽  
2020 ◽  
Vol 10 (66) ◽  
pp. 40206-40214
Author(s):  
Wararat Montha ◽  
Weerakanya Maneeprakorn ◽  
I-Ming Tang ◽  
Weeraphat Pon-On
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Alternating Magnetic Field ◽  
Composite Particles ◽  
Stimuli Responsive ◽  
Zn Ferrite

Drug delivery particles in which the release of biomolecules is triggered by a magnetic simulant have attracted much attention and may have great potential in the fields of cancer therapy and tissue regenerative medicine.

Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies

2021 ◽  
Author(s):  
Lianxu Cui ◽  
Yasmeen Saeed ◽  
Haomin Li ◽  
Jingli Yang
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Stem Cell ◽  
Brain Injury ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Therapeutic Strategies ◽  
Study Data ◽  
Health Concern ◽  
Standardized Treatment

Traumatic brain injury (TBI) is a serious health concern, yet there is a lack of standardized treatment to combat its long-lasting effects. The objective of the present study was to provide an overview of the limitation of conventional stem cell therapy in the treatment of TBI and to discuss the application of novel acellular therapies and their advanced strategies to enhance the efficacy of stem cells derived therapies in the light of published study data. Moreover, we also discussed the factor to optimize the therapeutic efficiency of stem cell-derived acellular therapy by overcoming the challenges for its clinical translation. Hence, we concluded that acellular therapy possesses the potential to bring a breakthrough in the field of regenerative medicine to treat TBI.

The Iranian National Guideline for Cell Therapy and Regenerative Medicine

2021 ◽  
Author(s):  
Javad Verdi ◽  
Mahdi Shadnoush ◽  
Ghasem Janbabai ◽  
Alireza Shoae-Hassani ◽  
Seyed Abdolreza Mortazavi-Tabatabei ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Cell Therapy ◽  
National Guideline

Stabilizing species selection in the Archaeogastropoda

Paleobiology ◽  
1981 ◽  
Vol 7 (3) ◽  
pp. 316-331 ◽  
Author(s):  
Norman L. Gilinsky
Keyword(s):  
Factor Analysis ◽  
Evolutionary Process ◽  
Species Selection ◽  
Differential Mortality ◽  
Morphometric Data ◽  
Progressive Reduction ◽  
General Process ◽  
Primary Mechanism ◽  
The Relationship ◽  
Innovative Concept

Factor analysis of morphometric data from fossil and recent Archaeogastropoda reveals that there has been a progressive reduction in the variety of archaeogastropod shell shapes through time. High and low spired genera have slowly disappeared while equidimensional forms, which have always been the most common, have become even more abundant. The taxonomic manifestation of this trend has long been appreciated and involves: 1) the extinction of most of the Pleurotomariacea, the Euomphalacea, Trochonematacea, and several other superfamilies, which collectively comprise most of the variation in shape among early archaeogastropods, and 2) the proliferation of the primarily equidimensional Trochacea and Neritacea. I suggest that this macroevolutionary trend may be explained by the general process I refer to as “stabilizing species selection.” More specifically, I suggest that the mechanism of stabilizing species selection in the case presented here may have been differential rates of origination.I believe that the innovative concept of species selection has been burdened by the adherence of its advocates to the idea that differential extinction is its primary mechanism. This preference for differential extinction is rooted in our emphasis upon differential mortality in microevolution and is not based upon data of macroevolutionary change. I argue that differential origination may be as important as differential extinction in directing macroevolutionary change and that demographical and autecological properties of species may be its agents. Recognition of the importance of differential origination will have an important impact upon our concept of the relationship between adaptation and the evolutionary process.

scholarly journals An evolutionary process without variation and selection

2021 ◽  
Vol 18 (180) ◽  
pp. 20210334
Author(s):  
Liane Gabora ◽  
Mike Steel
Keyword(s):  
Germ Cells ◽  
Cultural Evolution ◽  
Self Assembly ◽  
Early Life ◽  
Evolutionary Process ◽  
Adaptive Change ◽  
Assembly Code ◽  
The Relationship ◽  
Special Case ◽  
Variation And Selection

Natural selection successfully explains how organisms accumulate adaptive change despite that traits acquired over a lifetime are eliminated at the end of each generation. However, in some domains that exhibit cumulative, adaptive change—e.g. cultural evolution, and earliest life—acquired traits are retained; these domains do not face the problem that Darwin’s theory was designed to solve. Lack of transmission of acquired traits occurs when germ cells are protected from environmental change, due to a self-assembly code used in two distinct ways: (i) actively interpreted during development to generate a soma, and (ii) passively copied without interpretation during reproduction to generate germ cells. Early life and cultural evolution appear not to involve a self-assembly code used in these two ways. We suggest that cumulative, adaptive change in these domains is due to a lower-fidelity evolutionary process, and model it using reflexively autocatalytic and foodset-generated networks. We refer to this more primitive evolutionary process as self–other reorganization (SOR) because it involves internal self-organizing and self-maintaining processes within entities, as well as interaction between entities. SOR encompasses learning but in general operates across groups. We discuss the relationship between SOR and Lamarckism, and illustrate a special case of SOR without variation.

scholarly journals Memahami Sensionalisme dalam Berita Televisi: Perspektif Evolusi Biologi

2020 ◽  
Vol 16 (2) ◽  
Author(s):  
Gentur Agustinus Naru
Keyword(s):  
Human Brain ◽  
Evolutionary Biology ◽  
Evolutionary Process ◽  
Time Difference ◽  
Evolutionary Perspective ◽  
History Of ◽  
The Relationship

Although there have been many studies regarding sensationalism on television, there have not been enough studies to explain why sensational news always attracts viewers' attention regardless of space or time difference. Encouraged by this background, this research tries to answer the question, "What makes sensational news interesting to television viewers?" Inspired by a biological evolutionary perspective, this article formulates a hypothesis that reads, "Sensationalism can draw the attention of the audience because sensational news arouses the most basic instincts of humans, namely the mode of survival (Gurven, 2017)". In this view, the model has become inherent in humans as a result of the evolutionary process. In other words, this hypothesis also believes that audience interest in sensational news is universal rather than contextual.   This article explores a variety of literature in biology, psychology, and communication to try to answer that hypothesis. In order to that, this article is divided into three main sections. We will first explore the history of sensational journalism on television to show the historicity of sensational topics and techniques on television. Second, we will demonstrate the philosophical roots of an evolutionary biology view that explains the relationship between information stimuli and the workings of the human brain and the basic instincts we have carried since evolution thousands of years ago. Finally, we will show studies that prove empirically how news patterns (both sensational topics and production formats) impact viewing interest.

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