scholarly journals Atrial fibrillation in the elderly: the potential contribution of reactive oxygen species

2013 ◽  
Vol 9 (4) ◽  
pp. 379-388 ◽  
Author(s):  
J. Schillinger Kurt ◽  
V. Patel Vickas
Keyword(s):  
Atrial Fibrillation ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
The Elderly ◽  
Potential Contribution ◽  
Oxygen Species

scholarly journals The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly

2008 ◽  
Vol 5 (1) ◽  
pp. 13 ◽  
Author(s):  
Kishiko Ogawa ◽  
Katsuhiko Suzuki ◽  
Mitsuharu Okutsu ◽  
Kyoko Yamazaki ◽  
Shoji Shinkai
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
The Elderly ◽  
Low Grade ◽  
Oxygen Species ◽  
Low Grade Inflammation

scholarly journals 142 Atrial sources of reactive oxygen species vary with the substrate and duration of atrial fibrillation: implications for the antiarrhythmic effect of statins

Heart ◽  
2011 ◽  
Vol 97 (Suppl 1) ◽  
pp. A79-A80 ◽  
Author(s):  
S. Reilly ◽  
R. Jayaram ◽  
C. Anroniades ◽  
S. Verheule ◽  
K. M. Channon ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Antiarrhythmic Effect ◽  
Oxygen Species

Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation

2018 ◽  
Vol 24 (26) ◽  
pp. 3062-3071 ◽  
Author(s):  
Xiaomeng Ren ◽  
Xiaofeng Wang ◽  
Mengchen Yuan ◽  
Chao Tian ◽  
Huilong Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atrial Fibrillation ◽  
Reactive Oxygen Species ◽  
Molecular Mechanisms ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Stress Markers ◽  
Related Substances ◽  
Health Care Burden ◽  
Oxide Synthase

Atrial fibrillation (AF) is a frequent cardiac arrhythmia. It is a common major cause of serious diseases and is an increasing health-care burden. AF is associated with an excess amount of reactive oxygen species. In this review, we summarize several possible reactive oxygen species pathways that induce AF based on atrial electrical and structural remodeling data. The sources and factors implicated in AF-related oxidative stress include NADPH oxidase activation, calcium overloading and mitochondrial damage, angiotensin system activation, nitric oxide synthase uncoupling, and xanthine oxidase activation-associated cardiovascular conditions. Scavenging oxidative stress markers and related substances are essential aspects of these molecular mechanisms, and may be a therapeutic target in AF.

scholarly journals Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation

Circulation ◽  
2011 ◽  
Vol 124 (10) ◽  
pp. 1107-1117 ◽  
Author(s):  
Svetlana N. Reilly ◽  
Raja Jayaram ◽  
Keshav Nahar ◽  
Charalambos Antoniades ◽  
Sander Verheule ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Circulating Glutamate and Taurine Levels Are Associated with the Generation of Reactive Oxygen Species in Paroxysmal Atrial Fibrillation

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Shintaro Takano ◽  
Kousuke Fujibayashi ◽  
Nakaba Fujioka ◽  
Ei-ichi Ueno ◽  
Minoru Wakasa ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Reactive Oxygen Species ◽  
Multiple Logistic Regression Analysis ◽  
Amino Acid Content ◽  
Reactive Oxygen ◽  
Active Role ◽  
Oxygen Species ◽  
Pathophysiological Role ◽  
History Of ◽  
Independent Association

Atrial fibrillation (AF) is the most common cardiac arrhythmia, but its proarrhythmic mechanism remains to be elucidated. Glutamate (Glu) and taurine (Tau) are present in the myocardium at substantially higher concentrations than in the plasma, suggesting their active role in myocardium. Here, we tested the hypothesis that the metabolism of Glu and Tau is altered in association with the generation of reactive oxygen species (ROS) in patients with AF. Fifty patients with paroxysmal AF and 50 control subjects without a history of AF were consecutively enrolled. Circulating Glu and Tau levels were measured and correlations between Glu/Tau and ROS levels were examined. Glu/Tau content was significantly higher in patients with AF versus controls (Glu:79.2±23.9versus60.5±25.2 nmol/L; Tau:78.8±19.8versus68.5±20.8 nmol/L; mean ± standard deviation (SD),p<0.001for both). Glu/Tau levels also showed an independent association with AF by multiple logistic regression analysis. Glu and Tau levels both showed significant positive associations with plasma hydroperoxide concentrations. These data suggest a novel pathophysiological role of Glu and Tau in association with ROS production in paroxysmal AF, providing new insights into the elevated amino acid content in cardiac disease.

scholarly journals Enhanced cardiomyocyte reactive oxygen species signaling promotes ibrutinib-induced atrial fibrillation

Redox Biology ◽  
2020 ◽  
Vol 30 ◽  
pp. 101432 ◽  
Author(s):  
Xinyu Yang ◽  
Na An ◽  
Changming Zhong ◽  
Manke Guan ◽  
Yuchen Jiang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Reactive Oxygen Species Signaling

scholarly journals Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

2019 ◽  
Vol 20 (18) ◽  
pp. 4472 ◽  
Author(s):  
Zuo ◽  
Prather ◽  
Stetskiv ◽  
Garrison ◽  
Meade ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Molecular Mechanisms ◽  
Reactive Oxygen ◽  
The Elderly ◽  
Chronic Obstructive ◽  
Oxygen Species ◽  
Novel Treatments ◽  
Disease States ◽  
Age Related

It has been proposed that a chronic state of inflammation correlated with aging known as inflammaging, is implicated in multiple disease states commonly observed in the elderly population. Inflammaging is associated with over-abundance of reactive oxygen species in the cell, which can lead to oxidation and damage of cellular components, increased inflammation, and activation of cell death pathways. This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis. Recently published mechanistic details of the roles of reactive oxygen species in inflammaging and various diseases will also be discussed. Advancements in potential treatments to ameliorate inflammaging, oxidative stress, and consequently, reduce the morbidity of multiple disease states will be explored.

scholarly journals The Investigation of DNA Damage Induced by Adrenaline in Human Lymphocytes in Vitro/Ispitivanja Oštećenja DNK Izazvanih Adrenalinom U Limfocitima Čoveka in Vitro

2014 ◽  
Vol 64 (3) ◽  
pp. 281-292 ◽  
Author(s):  
Radaković Milena ◽  
Đelić Ninoslav ◽  
Stevanović Jevrosima ◽  
Anđelković Marko ◽  
Kolarević Stoimir ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Human Lymphocytes ◽  
Reactive Oxygen ◽  
Potential Contribution ◽  
Oxygen Species ◽  
Genotoxic Effects ◽  
Isolated Human Lymphocytes ◽  
Primary Dna Damage

Abstract Adrenaline is a neurotransmitter and hormone that plays an important role in physiological regulatory mechanisms. The objective of this study was to assess primary DNA damage in isolated human lymphocytes exposed to adrenaline using the in vitro comet assay. Dose-response of human lymphocytes was determined at concentration range of adrenaline from 0.01 μM to 300 μM for various treatment times (1h, 2h, 4h and 24h). The obtained results showed that adrenaline induced DNA damage at concentration range from 5 μM to 300 μM after 1h, 2h and 4h of treatment. The slightest DNA damage was observed after 24 h of adrenaline treatment - only the highest concentrations of adrenaline (150 μM and 300 μM) caused increased level of DNA damage. In order to evaluate the potential contribution of reactive oxygen species (ROS) in adrenaline-induced DNA damage we used antioxidants catalase (100 IU/mL and 500 IU/mL) and quercetin (100 μM and 500 μM). Co-treatment of lymphocytes with adrenaline (300 μM) and antioxidants for 1 h, significantly reduced the quantity of DNA in the comet tails. Therefore, it can be concluded that adrenaline exhibits genotoxic effects mainly through induction of reactive oxygen species and that some of the DNA damage is repaired during the first four hours following the treatment with adrenaline.

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