Floating Drug Delivery Systems

In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The recent developments in floating drug delivery systems are containing the physiological and formulation variables impacting on gastric retention time, approaches to formulating of single-unit and multiple-unit floating systems, and their classification and formulation aspects are discussed in detail. This review also summarizes evaluation parameters and application of floating drug delivery systems. Keywords: Floating drug delivery systems (FDDS), Gastric residence time, Swelling index, Buoyancy.

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A Recent Update on Formulation and Development of Gastro-Retentive Drug Delivery Systems

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2021.14.1.1 ◽

2021 ◽

Vol 14 (1) ◽

pp. 5257-5270

Author(s):

Abhishek Kumar ◽

Meenakshi Bharkatiya

Keyword(s):

Drug Delivery ◽

Gastric Emptying ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Floating Drug Delivery ◽

Novel Drug ◽

Floating Drug Delivery Systems ◽

Gastro Retentive

Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastro retentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. In this context, various gastro retentive drug delivery systems have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. Various approaches are currently used including gastro retentive floating drug delivery systems, swelling and expanding system, polymeric bio adhesive systems, modified shape systems, high density system and other delayed gastric emptying devices. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. The present review briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. The purpose of this review is to bring together the recent literature with respect to the method of preparation, and various parameters affecting the performance and characterization of floating microspheres. Attempt has been made to summarize important factors controlling gastro retentive drug delivery systems. Overall, this review may inform and guide formulation scientists in designing the gastro retentive drug delivery system.

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Development and Evaluation of Novel Floating Drug Delivery Systems of Metoclopramide Hydrochloride

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2011.4.3.5 ◽

2011 ◽

Vol 4 (3) ◽

pp. 1470-1477

Author(s):

Vinay Wamorkar ◽

A Samar ◽

A Reddy ◽

Anusha Ch ◽

C V Saikrishna ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

In Situ Gel ◽

Gastric Residence Time ◽

Accelerated Stability ◽

Floating Drug Delivery ◽

Metoclopramide Hydrochloride ◽

Floating Drug Delivery Systems

Several distinct novel drug delivery systems are being employed for effective delivery of medications to patients. Oral delivery is by far the most preferable route of drug delivery and oral sustained-release gastroretentive drug delivery systems offer several advantages. These drug delivery systems are beneficial for drugs with absorption from the upper parts of the gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of these drugs. Floating drug delivery systems (FDDS) are one of the gastroretentive drug delivery systems used to achieve prolonged gastric residence time. Multiple unit FDDS avoid the “all-or-none” gastric emptying nature of single unit systems. In the present research study, floating formulation as solid (capsule) or liquid (in situ gel) drug delivery systems were developed for improving the gastric residence time of the anti-emetic agent metoclopramide hydrochloride. Floating capsules were prepared using combinations of various natural and synthetic polymers. Simultaneously, in situ gel was prepared using completely bio-degradable natural polymers. Both systems were able to sustain drug release for up to 8 hours. These formulations were compared with marketed forms and found to be more convenient from a patient as well as a biopharmaceutical standpoint. To assess the stability of these formulations, accelerated stability testing was conducted as per ICH guidelines. Both formulations were found to be stable upon completion of the accelerated stability period.

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Design and evaluation of polymeric coated minitablets as multiple unit gastroretentive floating drug delivery systems for furosemide

Journal of Pharmaceutical Sciences ◽

10.1002/jps.21562 ◽

2009 ◽

Vol 98 (6) ◽

pp. 2122-2132 ◽

Cited By ~ 29

Author(s):

Lingam Meka ◽

Bhaskar Kesavan ◽

Venkatasimhadri Naidu Kalamata ◽

Chandra Mohan Eaga ◽

Suresh Bandari ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Floating Drug Delivery ◽

Multiple Unit ◽

Floating Drug Delivery Systems

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Characterizations of Plasticized Polymeric Film Coatings for Preparing Multiple-Unit Floating Drug Delivery Systems (muFDDSs) with Controlled-Release Characteristics

PLoS ONE ◽

10.1371/journal.pone.0100321 ◽

2014 ◽

Vol 9 (6) ◽

pp. e100321 ◽

Cited By ~ 12

Author(s):

Sheng-Feng Hung ◽

Chien-Ming Hsieh ◽

Ying-Chen Chen ◽

Yu-Chun Wang ◽

Hsiu-O Ho ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Polymeric Film ◽

Film Coatings ◽

Floating Drug Delivery ◽

Multiple Unit ◽

Floating Drug Delivery Systems

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Floating Drug Delivery System: An Overview

Asian Journal of Research in Pharmaceutical Science ◽

10.52711/2231-5659.2021.00046 ◽

2021 ◽

pp. 295-300

Author(s):

A.V.S. Hima Bindu ◽

G. Bhavya ◽

K. Padmalatha

Keyword(s):

Drug Delivery ◽

Gastric Emptying ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Delivery Systems ◽

Oral Drug ◽

Floating Drug Delivery ◽

Recent Developments ◽

Floating Drug Delivery System ◽

Floating Drug Delivery Systems

In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The recent developments in floating drug delivery systems are containing the physiological and formulation variables impacting on gastric retention time, approaches to formulating of single-unit and multiple-unit floating systems, and their classification and formulation aspects are discussed in detail. This review also summarizes evaluation parameters and application of floating drug delivery systems.

Download Full-text