Floating Drug Delivery System: An Overview

In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The recent developments in floating drug delivery systems are containing the physiological and formulation variables impacting on gastric retention time, approaches to formulating of single-unit and multiple-unit floating systems, and their classification and formulation aspects are discussed in detail. This review also summarizes evaluation parameters and application of floating drug delivery systems. Keywords: Floating drug delivery systems (FDDS), Gastric residence time, Swelling index, Buoyancy.

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SCOPE AND SIGNIFICANCE OF FLOATING DRUG DELIVERY SYSTEM

INDIAN DRUGS ◽

10.53879/id.49.10.p0005 ◽

2012 ◽

Vol 49 (10) ◽

pp. 5-12

Author(s):

S. R. Pattan ◽

◽

N. P Wani ◽

M. U Shelar ◽

S. A. Nirmal ◽

...

Keyword(s):

Drug Delivery ◽

Gastric Emptying ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Delivery Systems ◽

Oral Drug ◽

Gastric Residence Time ◽

Floating Drug Delivery ◽

Technological Developments ◽

Floating Drug Delivery System

In recent years there have been several scientific and technological advancements in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities,such as short gastric residence time (GRT) and unpredictable gastric emptying time (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems,polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.

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FLOATING DRUG DELIVERY SYSTEM: A REVIEW

International Journal of Indigenous Herbs and Drugs ◽

10.46956/ijihd.vi.112 ◽

2021 ◽

pp. 33-39

Author(s):

Archana Tomar ◽

Arpita Singh ◽

Amresh Gupta ◽

Satyawan Singh

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Delivery Systems ◽

Oral Drug ◽

Pharmaceutical Dosage Form ◽

Floating Drug Delivery ◽

Floating Drug Delivery System

The main motto of working on that article on floating drug delivery systems (FDDS) is to make a compiled report on the recent studies and research with special consideration on the principle mechanism of flotation to achieve gastric retention. The scientiﬁc and technological advancements were made in the last few years in the research and development of rate-controlled oral drug delivery systems by overcoming physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). This review also epitomized the in-vitro procedure, in-vivo to assess the pursuance and implementation of floating systems, and applications of these systems. These methods are useful to various queries experienced during the development of a pharmaceutical dosage form.

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Floating drug delivery system- a review

International Journal of Recent Advances in Science and Technology ◽

10.30750/ijrast.215 ◽

2015 ◽

Vol 2 (1) ◽

Author(s):

Sharma Anjali ◽

Sharma Devkant

Keyword(s):

Drug Delivery ◽

Gastric Emptying ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Gastric Retention ◽

Residence Times ◽

Principal Mechanism ◽

Floating Drug Delivery ◽

Floating Systems ◽

Floating Drug Delivery Systems

In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming various physiological problems such as short gastric residence times and unpredictable gastric emptying times. Several approaches are utilized in the prolongation of the gastric residence times, such as floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in-vitro techniques, in- vivo studies to evaluate the performance and application of floating systems, and applications of these systems.

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A Recent Update on Formulation and Development of Gastro-Retentive Drug Delivery Systems

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2021.14.1.1 ◽

2021 ◽

Vol 14 (1) ◽

pp. 5257-5270

Author(s):

Abhishek Kumar ◽

Meenakshi Bharkatiya

Keyword(s):

Drug Delivery ◽

Gastric Emptying ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Floating Drug Delivery ◽

Novel Drug ◽

Floating Drug Delivery Systems ◽

Gastro Retentive

Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastro retentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. In this context, various gastro retentive drug delivery systems have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. Various approaches are currently used including gastro retentive floating drug delivery systems, swelling and expanding system, polymeric bio adhesive systems, modified shape systems, high density system and other delayed gastric emptying devices. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. The present review briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. The purpose of this review is to bring together the recent literature with respect to the method of preparation, and various parameters affecting the performance and characterization of floating microspheres. Attempt has been made to summarize important factors controlling gastro retentive drug delivery systems. Overall, this review may inform and guide formulation scientists in designing the gastro retentive drug delivery system.

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Floating Drug Delivery Systems

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2009.2.3.2 ◽

2009 ◽

Vol 2 (3) ◽

pp. 595-604

Author(s):

Jagadeesh Nadigoti ◽

Shayeda

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

New Era ◽

Gastric Residence Time ◽

Floating Drug Delivery ◽

Recent Developments ◽

Multiple Unit ◽

Novel Drug ◽

Floating Drug Delivery Systems

Management of illness through medication is entering a new era in which growing number of novel drug delivery systems are being employed and are available for therapeutic use. Oral sustained release gastro-retentive dosage forms (GRDFs) offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medication. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. Multiple unit FDDS avoid “all-or-nothing” gastric emptying nature of single unit systems. Apart from the background, formulation aspects and evaluation of FDDS, recent developments are also covered in this review.

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Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system

GSC Advanced Research and Reviews ◽

10.30574/gscarr.2021.7.1.0070 ◽

2021 ◽

Vol 7 (1) ◽

pp. 035-044

Author(s):

Kajal D. Chaudhari ◽

Minakshee G. Nimbalwar ◽

Nikita S. Singhal ◽

Wrushali A. Panchale ◽

Jagdish V. Manwar ◽

...

Keyword(s):

Drug Delivery ◽

Gastric Emptying ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Dosage Forms ◽

Floating Drug Delivery ◽

Floating Drug Delivery System ◽

Floating Drug Delivery Systems ◽

Gastro Retentive

Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug delivery systems have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses characterizations and application of gastro-retentive floating drug delivery systems.

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A Review on Floating Multi-particulate Drug Delivery System

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00691 ◽

2021 ◽

pp. 3987-3992

Author(s):

Suraj B. Pund ◽

Vishwas C. Bhagat ◽

Madhuri T. Deshmukh ◽

Deepak P. Kardile ◽

Rajkumar V. Shete

Keyword(s):

Drug Delivery ◽

Gastric Emptying ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Gastric Retention ◽

Pharmaceutical Dosage Form ◽

Floating Drug Delivery ◽

Floating Drug Delivery System

The objective of writing this review on Floating Drug Delivery Systems (FDDS) was to accumulate new work with a special focus on the primary floatation mechanism for gastric retention. Drug delivery systems are those that instantly float on contact with gastric fluids and present promising approaches to improve the bioavailability of drugs with absorption windows in the stomach or upper small intestine, imbalanced in the intestinal or colonic environment, and exhibit low solubility at high pH standards. It is a novel drug delivery system that takes full advantage of effectiveness and compliance. Physical problems such as short gastric residence time and unpredictable gastric emptying time were overcome with the use of floating dosage forms that provide the possibility of local and systemic effects. The floating drug delivery system allows prolonged and continuous entry of the drug into the upper part of the gastric retention pathway and increases the bioavailability of the medication characterized by a narrow absorption window. This review provides detailed information on the pharmaceutical basis of its Introduction, Advantages, Disadvantages, Factors Affecting Gastric Emptying, and Criteria for Suitable Drug Products for Floating Gastric-Retention, Classification of Floating Multiparticulate Drug Delivery System, and Characterization of Floating Multiparticulate Drug Delivery System. These systems are beneficial for various difficulties encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. This review article has attempted to announce to readers about the floating drug delivery system.

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FLOATING TABLETS AND ITS POLYMERS

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5-s.1928 ◽

2018 ◽

Vol 8 (5-s) ◽

pp. 16-24 ◽

Cited By ~ 1

Author(s):

Shaika Saadia Zubedi ◽

Shahid Mohammed

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Oral Drug ◽

Advantages And Disadvantages ◽

Floating Drug Delivery ◽

Floating Drug Delivery Systems ◽

Natural And Synthetic

Oral drug delivery system is the most preferred route of administration for drug delivery. In the development of the drug delivery system many components play important role. Polymers are amongst those components which have evolved with the drug delivery system. Polymers are the macromolecule compound containing many monomer units joined to each other by bonds. The floating drug delivery systems (FDDS) become an additional advantage for drugs that are absorbed primarily in the upper segments of gastrointestinal (GI) tract, i.e., the stomach, duodenum and jejunum. The purpose of writing this review on floating drug delivery systems (FDDS) was to focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention and polymers used in floating Drug delivery systems. Polymers used in the drug delivery system are of two types Natural and Synthetic based on their origin. Both types of the polymers have some advantages and disadvantages. This particular article gives information about the different types of natural and synthetic polymer used in the drug delivery system. Natural polymers like guar gum, chitosan, xanthan gum, Gellan gum and sodium alginate are mentioned in the article. Synthetic polymers mentioned are HPMC, Eudragit, and Ethylcellulose. Keywords: Floating Drug Delivery System, Polymers, Natural gums, HPMC.

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Applications of Ion Exchange Resin in Oral Drug Delivery Systems

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i03.9556 ◽

2017 ◽

Vol 7 (03) ◽

Author(s):

Kathpalia Harsha ◽

Das Sukanya

Keyword(s):

Drug Delivery ◽

Ion Exchange ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Physical Stability ◽

Delivery Systems ◽

Oral Drug ◽

Ion Exchange Resins ◽

Exchange Resins ◽

Oral Drug Delivery Systems

Ion Exchange Resins (IER) are insoluble polymers having styrene divinylbenzene copolymer backbone that contain acidic or basic functional groups and have the ability to exchange counter ions with the surrounding aqueous solutions. From the past many years they have been widely used for purification and softening of water and in chromatographic columns, however recently their use in pharmaceutical industry has gained considerable importance. Due to the physical stability and inert nature of the resins, they can be used as a versatile vehicle to design several modified release dosage forms The ionizable drug is complexed with the resin owing to the property of ion exchange. This resin complex dissociatesin vivo to release the drug. Based on the dissociation strength of the drug from the drug resin complex, various release patterns can be achieved. Many formulation glitches can be circumvented using ion exchange resins such as bitter taste and deliquescence. These resins also aid in enhancing disintegrationand stability of formulation. This review focuses on different types of ion exchange resins, their preparation methods, chemistry, properties, incompatibilities and their application in various oral drug delivery systems as well as highlighting their use as therapeutic agents.

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