scholarly journals Accelerating the Bone Healing Process by the Intervention of the Platelet Growth Factors Impregnated in Collagen. An experimental and theoretical mathematical model

2019 ◽  
Vol 56 (4) ◽  
pp. 973-979
Author(s):  
Sidonia Susanu ◽  
Mara Popescu ◽  
Bogdan Caba ◽  
Petru Plamadeala ◽  
Andreea Moraru ◽  
...  
Keyword(s):  
Field Theory ◽  
Mathematical Model ◽  
Growth Factors ◽  
Symmetry Breaking ◽  
Bone Healing ◽  
Healing Process ◽  
Collagen Sponge ◽  
Morphogenetic Protein ◽  
Breaking Mechanism ◽  
Bone Healing Process

A bone defect with standard dimensions and localization is produced. Inside this defect a polymer (collagen sponge) impregnated with growing factors, i. e. bone morphogenetic protein - BMP, is introduced. For the witness lot, the same defect is produced, in which the same polymer is introduced, but without any growing factors. It is found that the growing factor not only remains at the initial site, but also has effect on the bone regeneration process. A mathematical model is constructed using a field theory of multifractal type based on the spontaneous symmetry breaking mechanism to exploit such dynamics in biostructures. This mechanism contains all the informational �ingredients�: the multivalent logic based multifractal bit, the algorithm based networks through spatial cnoidal modes of oscilation, etc. In such context, the evolution of all biostructures, through a mechanism that mimics a 3D biological printer, can become operational.

scholarly journals Investigation of Peri-Implant Bone Healing Using Autologous Plasma Rich in Growth Factors in the Canine Mandible After 12 Weeks: A Pilot Study

2011 ◽  
Vol 5 (1) ◽  
pp. 168-173 ◽  
Author(s):  
Reza Birang ◽  
Mohammad Tavakoli ◽  
Mohammad Shahabouei ◽  
Alireza Torabi ◽  
Ali Dargahi ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Healing ◽  
Healing Process ◽  
Optical Microscope ◽  
Autologous Plasma ◽  
Trabecular Thickness ◽  
Mixed Breed ◽  
Bone To Implant Contact ◽  
Bone Healing Process ◽  
Surrounding Bone

Introduction: Faster reconstruction of patients’ masticatory systems is the aim of modern dentistry. A number of studies have indicated that application of growth factors to the surface of a dental implant leads to accelerated and enhanced osseointegration. The objective of the present study was to investigate the effect of plasma rich in growth factors on peri-implant bone healing. Materials and Methods: For the purpose of this study, two healthy, mixed-breed canines were selected, and the premolars were extracted from both sides of the mandible. Three months after premolar removal, 12 implants, each 5 mm in diameter and 10 mm in length, were placed in osteotomy sites on both sides of the mandible. Prior to placement, plasma rich in growth factors was applied to the surfaces of six implants, while the other six were used without plasma rich in growth factors. The implants were removed after 12 weeks along with the bone surrounding the sites using a trephine bur. One mesiodistal section containing the surrounding bone from each implant block, 50 µm in diameter, was prepared for histologic and histomorphometric investigation with an optical microscope. Results: The sites with implants treated with plasma rich in growth factors showed more bone-to-implant contact compared to control sites. Also, higher values for bone trabecular thickness and bone maturity were recorded for the PRGF-treated sites than for the control sites. Conclusion: Application of plasma rich in growth factors to the surface of an implant may enhance the bone healing process as well as bone-to-implant contact, thereby helping to achieve faster osseointegration.

Bone healing process in critical-sized defects by rhBMP-2 using poloxamer gel and collagen sponge as carriers

Micron ◽  
2008 ◽  
Vol 39 (1) ◽  
pp. 17-24 ◽  
Author(s):  
João Paulo Mardegan Issa ◽  
Cássio do Nascimento ◽  
Mamie Mizusaki Iyomasa ◽  
Selma Siéssere ◽  
Simone Cecílio Hallak Regalo ◽  
...  
Keyword(s):  
Bone Healing ◽  
Healing Process ◽  
Collagen Sponge ◽  
Bone Healing Process ◽  
Poloxamer Gel

The Role of Bone Marrow-Derived Cells During the Bone Healing Process in the GFP Mouse Bone Marrow Transplantation Model

2012 ◽  
Vol 92 (3) ◽  
pp. 296-306 ◽  
Author(s):  
Hidetsugu Tsujigiwa ◽  
Yasuhisa Hirata ◽  
Naoki Katase ◽  
Rosario Rivera Buery ◽  
Ryo Tamamura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Bone Healing ◽  
Marrow Transplantation ◽  
Healing Process ◽  
Mouse Bone Marrow ◽  
Bone Marrow Derived Cells ◽  
Bone Healing Process ◽  
Transplantation Model

scholarly journals The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence

2020 ◽  
Vol 7 (1) ◽  
pp. 22
Author(s):  
Giuseppe Marongiu ◽  
Andrea Contini ◽  
Andrea Cozzi Lepri ◽  
Matthew Donadu ◽  
Marco Verona ◽  
...  
Keyword(s):  
Systematic Review ◽  
Growth Factors ◽  
Bone Healing ◽  
Healing Process ◽  
Bone Matrix ◽  
Femoral Fractures ◽  
Current Evidence ◽  
Long Bones ◽  
Cell Therapies ◽  
Diaphyseal Fractures

Background: The healing of long bones diaphyseal fractures can be often impaired and eventually end into delayed union and non-union. A number of therapeutic strategies have been proposed in combination with surgical treatment in order to enhance the healing process, such as scaffolds, growth factors, cell therapies and systemic pharmacological treatments. Our aim was to investigate the current evidence of bone healing enhancement of acute long bone diaphyseal fractures. Methods: A systematic review was conducted by using Pubmed/MEDLINE; Embase and Ovid databases. The combination of the search terms “long-bones; diaphyseal fracture; bone healing; growth factors; cell therapies; scaffolds; graft; bone substitutes; orthobiologics; teriparatide”. Results: The initial search resulted in 4156 articles of which 37 papers fulfilled the inclusion criteria and were the subject of this review. The studies included 1350 patients (837 males and 513 females) with a mean age of 65.3 years old. Conclusions: General lack of high-quality studies exists on the use of adjuvant strategies for bone healing enhancement in acute shaft fractures. Strong evidence supports the use of bone grafts, while only moderate evidence demineralized bone matrix and synthetic ceramics. Conflicting results partially supported the use of growth factors and cell therapies in acute fractures. Teriparatide showed promising results, particularly for atypical femoral fractures and periprosthetic femoral fractures.

scholarly journals Effect of platelet-rich plasma on implant bone defects in rabbits through the FAK/PI3K/AKT signaling pathway

2019 ◽  
Vol 14 (1) ◽  
pp. 311-317
Author(s):  
Wei Liu ◽  
Ben Chen ◽  
Youyang Zheng ◽  
Yuehua Shi ◽  
Zhuojin Shi
Keyword(s):  
Growth Factor ◽  
Bone Healing ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Bone Defects ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Tissue Healing ◽  
Bone Healing Process

AbstractPlatelet-rich plasma (PRP) has been shown to be a beneficial growth factor for bone tissue healing and is used in implantology. The aim of this study was to investigate the effects of PRP on bone defects in rabbits. Twenty rabbits were used to establish the implant bone defect model in this study. An intrabony defect (5mm × 5mm × 3mm) was created in alveolar bone in the lower jar of each rabbit. The wound was treated with PRP. The expression of platelet-derived growth factor BB (PDGFBB) was assessed by enzyme-linked immunosorbent assay (ELISA). Focal adhesion kinase (FAK) and related phosphatidylinositol 3-kinase (PI3K)/AKT (protein kinase B) levels were measured by Western blot. The results show that PRP could significantly improve the bone healing process when compared with control, and 10% PRP could markedly increase fibroblast proliferation 48-h post treatment. PDGFBB was higher in the PRP group than that in the control group. PRP treatment also could elevate the phosphorylation of FAK and PI3K/AKT, although the inhibitor of PDGFR could reverse this trend. These results suggest that PRP treatment improves the bone healing process through the FAK/PI3K/AKT pathway.

Hypertension modifies OPG, RANK, and RANKL expression during the dental socket bone healing process in spontaneously hypertensive rats

2015 ◽  
Vol 19 (6) ◽  
pp. 1319-1327 ◽  
Author(s):  
Natalia Manrique ◽  
Cassiano Costa Silva Pereira ◽  
Eloá Rodrigues Luvizuto ◽  
Maria Del Pilar Rodriguez Sánchez ◽  
Tetuo Okamoto ◽  
...  
Keyword(s):  
Bone Healing ◽  
Spontaneously Hypertensive Rats ◽  
Healing Process ◽  
Rankl Expression ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Bone Healing Process

The Effect of Novel Flax Oil-Based Implant Coating on Bone Healing Process (In Vivo Animal Study)

2015 ◽  
Vol 119 (3) ◽  
pp. e126
Author(s):  
Nazih Shaaban Mustafa ◽  
Basma E. Mustafa Al Ahmad ◽  
Ammar A. Mustafa ◽  
Muhannad A. Kashmoola
Keyword(s):  
Animal Study ◽  
Bone Healing ◽  
Healing Process ◽  
Flax Oil ◽  
Implant Coating ◽  
Bone Healing Process

The effects of photobiomodulation and low-amplitude high-frequency vibration on bone healing process: a comparative study

2016 ◽  
Vol 31 (9) ◽  
pp. 1827-1836 ◽  
Author(s):  
M. Rajaei Jafarabadi ◽  
G. Rouhi ◽  
G. Kaka ◽  
S. H. Sadraie ◽  
J. Arum
Keyword(s):  
Comparative Study ◽  
Bone Healing ◽  
High Frequency ◽  
Healing Process ◽  
High Frequency Vibration ◽  
Bone Healing Process ◽  
Low Amplitude
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