Xanthan Matrix as Drug ZDelivery System

2021 ◽  
Vol 72 (1) ◽  
pp. 90-99
Author(s):  
Narcis Anghel ◽  
Maria Valentina Dinu ◽  
Florica Doroftei ◽  
Iuliana Spiridon
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Substantial Improvement ◽  
Gram Negative Bacteria ◽  
Inhibition Rate ◽  
Bioactive Substances ◽  
Gram Negative ◽  
Strength Tests ◽  
Scanning Electron Micrography ◽  
Drug Delivery Devices

Here we present a new drug delivery system based on xanthan esterified with acrylic acid. This material served as a matrix for the incorporation of bioactive substances with antimicrobial and anti-inflammatory properties. The materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) and Scanning Electron Micrography (SEM). Mechanical strength tests showed a substantial improvement in the resilience and flexibility of the polymer matrix modified by esterification under conditions of mechanical stress. The release of bioactive substances from the basic matrix follows a Korsmeyer-Peppas type kinetics. The modified xanthan-based transport system was shown to be antimicrobially active with an inhibition rate of almost 100% on gram-positive and gram-negative bacteria. The obtained results recommend this biomaterial for the manufacture of transdermal drug delivery devices.

scholarly journals Potential of biocompatible polymeric ultra-thin films, nanosheets, as topical and transdermal drug delivery devices

2019 ◽  
Vol 565 ◽  
pp. 41-49 ◽  
Author(s):  
Tomomi Hatanaka ◽  
Takanori Saito ◽  
Takaaki Fukushima ◽  
Hiroaki Todo ◽  
Kenji Sugibayashi ◽  
...  
Keyword(s):  
Thin Films ◽  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Devices

scholarly journals Effect of Light-Activated Hypocrellin B on the Growth and Membrane Permeability of Gram-NegativeEscherichia coliCells

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Yuan Jiang ◽  
Wingnang Leung ◽  
Qingjuan Tang ◽  
Hongwei Zhang ◽  
Chuanshan Xu
Keyword(s):  
Flow Cytometry ◽  
Growth Inhibition ◽  
Membrane Permeability ◽  
Gram Negative Bacteria ◽  
Inhibition Rate ◽  
Gram Negative ◽  
E Coli ◽  
Intracellular Ros ◽  
Hypocrellin B ◽  
Effect Of Light

Aim. To investigate the effect of light-activated hypocrellin B on the growth and membrane permeability of Gram-negative bacteria.Methods.Escherichia coli(E. coli) as a model bacterium of Gram-negative bacteria was incubated with various concentrations of hypocrellin B for 60 min and was subsequently irradiated by blue light with wavelength of 470 nm at the dose of 12 J/cm2. Colony forming units were counted and the growth inhibition rate ofE. colicells was calculated after light-activated hypocrellin B. Membrane permeability was measured using flow cytometry and confocal laser scanning microscopy (CLSM) with propidium iodide (PI) staining. Bacterial morphology was observed using transmission electron microscopy (TEM). Reactive oxygen species in bacterial cells were measured using flow cytometry with DCFH-DA staining.Results. Significant growth inhibition rate ofE. colicells was observed after photodynamic action of hypocrellin B. Remarkable damage to the ultrastructure ofE. coliwas also observed by TEM. Flow cytometry and CLSM observation showed that light-activated hypocrellin B markedly increased membrane permeability ofE. coli. Flow cytometry showed the intracellular ROS increase inE. colitreated by photodynamic action of hypocrellin B.Conclusion. Light-activated hypocrellin B caused intracellular ROS increase and structural damages and inhibited the growth of Gram-negativeE. colicells.

A numerical treatment of the release of drug in nonswelling transdermal drug-delivery devices

2013 ◽  
Vol 25 (4) ◽  
pp. 949-960
Author(s):  
M. Garshasbi ◽  
H. Kamal Gharibi ◽  
P. Reihani Ardabili
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Numerical Treatment ◽  
Drug Delivery Devices

Transdermal drug delivery devices

1989 ◽  
Vol 7 (3) ◽  
pp. 25-31 ◽  
Author(s):  
Philip W. Ledger ◽  
Kirstin C. Nichols
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Devices
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