A review of research on the development of instruments for therapeutic efficacy evaluation of traditional Chinese medicine

2012 ◽  
Vol 10 (7) ◽  
pp. 726-737
Author(s):  
WH Xu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Efficacy ◽  
Efficacy Evaluation

scholarly journals Therapeutic Efficacy of Fuzheng-Huayu Tablet Based Traditional Chinese Medicine Syndrome Differentiation on Hepatitis-B-Caused Cirrhosis: A Multicenter Double-Blind Randomized Controlled Trail

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Ya-Nan Song ◽  
Ji-Jia Sun ◽  
Yi-Yu Lu ◽  
Lie-Ming Xu ◽  
Yue-Qiu Gao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Hepatitis B ◽  
Therapeutic Efficacy ◽  
Life Quality ◽  
Classification Model ◽  
Syndrome Differentiation ◽  
Double Blind ◽  
Forecasting Method ◽  
Tcm Syndrome

Aim. To evaluate and predict the therapeutic efficacy of Fuzheng-Huayu tablet (FZHY) based traditional Chinese Medicine (TCM) syndrome differentiation or TCM symptoms on chronic hepatitis B caused cirrhosis (HBC).Methods.The trial was designed according to CONSORT statement. It was a multi-center, double-blind, randomized, placebo-controlled trail. Several clinical parameters, Child-Pugh classification and TCM symptoms were detected and evaluated. The FZHY efficacy was predicted by an established Bayes forecasting method following the Bayes classification model.Results.The levels of HA and TCM syndrome score in FZHY group were significantly decreased (P<0.05) compared to placebo group, respectively. The efficacy of FZHY on TCM syndrome score in HBC patients with some TCM syndromes was better. In TCM syndrome score evaluation, there were 53 effective and 22 invalid in FZHY group. TCM symptoms predicted FZHY efficacy on HBC were close to Child-Pugh score prediction.Conclusion.FZHY decreases the levels of HA and TCM syndrome scores, improves the life quality of HBC patients. Moreover, there were different therapeutic efficacies among different TCM syndromes, indicating that accurate TCM syndrome differentiation might guide the better TCM treatment. Furthermore, the FZHY efficacy was able to predict by Bayes forecasting method through the alteration of TCM symptoms.

The Impact of Artificial Intelligence on Traditional Chinese Medicine

2021 ◽  
pp. 1-18
Author(s):  
Yulin Wang ◽  
Xiuming Shi ◽  
Li Li ◽  
Thomas Efferth ◽  
Dong Shang
Keyword(s):  
Artificial Intelligence ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Modern Science ◽  
Diagnostic Methods ◽  
Digital Data ◽  
Syndrome Differentiation ◽  
Efficacy Evaluation ◽  
Combination Rules ◽  
The Impact

Traditional Chinese Medicine (TCM) is a well-established medical system with a long history. Currently, artificial intelligence (AI) is rapidly expanding in many fields including TCM. AI will significantly improve the reliability and accuracy of diagnostics, thus increasing the use of effective therapeutic methods for patients. This systematic review provides an updated overview on the major breakthroughs in the field of AI-assisted TCM four diagnostic methods, syndrome differentiation, and treatment. AI-assisted TCM diagnosis is mainly based on digital data collected by modern electronic instruments, which makes TCM diagnosis more quantitative, objective, and standardized. As a result, the diagnosis decisions made by different TCM doctors exhibit more consistency, accuracy, and reliability. Meanwhile, the therapeutic efficacy of TCM can be evaluated objectively. Therefore, AI is promoting TCM from experience to evidence-based medicine, a genuine scientific revolution. Furthermore, huge and non-uniform knowledge on formula-syndrome relationships and the combination rules of herbal TCM formulae could be better standardized with the help of AI analysis, which is necessary for the clinical efficacy evaluation and further optimization on the standardized TCM formulae. AI bridges the gap between TCM and modern science and technology. AI may bring clinical TCM diagnostics closer to western medicine. With the help of AI, more scientific evidence about TCM will be discovered. It can be expected that more unified guidelines for specific TCM syndromes will be issued with the development of AI-assisted TCM therapies in the future.

scholarly journals The Challenges of Ethical Review in Clinical Research of Traditional Chinese Medicine

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Jie Zhang ◽  
Zong-Ming Zhang
Keyword(s):  
Risk Assessment ◽  
Informed Consent ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Research ◽  
Modern Medicine ◽  
Ethical Review ◽  
Syndrome Differentiation ◽  
Efficacy Evaluation ◽  
Five Elements

The ethical review of TCM (traditional Chinese medicine) clinical research in China is highly consistent with that of Western medicine, but it lacks the characteristics and culture of TCM. Compared with modern medicine, TCM has its own characteristics, such as the theory of Yin-Yang and the five elements, the treatment of syndrome differentiation, and the compatibility of prescriptions. These characteristics determine the ethical particularity of TCM clinical research. This article discusses the challenges in the ethical review of TCM clinical research, such as scientific design, efficacy evaluation, risk assessment, informed consent, and placebo use. We propose opportunities and difficulties in the ethical review of TCM clinical research and provide some relevant suggestions.

Recent Advances in Drug Delivery System for Bioactive Glycosides from Traditional Chinese Medicine

2018 ◽  
Vol 46 (08) ◽  
pp. 1791-1824 ◽  
Author(s):  
Lei Li ◽  
Yi Feng ◽  
Yanlong Hong ◽  
Xiao Lin ◽  
Lan Shen
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Design Strategies ◽  
Active Ingredients ◽  
Recent Advances ◽  
Delivery Vehicles

Traditional Chinese Medicine (TCM) has been used in China for thousands of years for the prevention and treatment of various diseases. The materials that exert a therapeutic effect are called the active ingredients. The bioactive glycosides are important active ingredients from TCM that can make significant contributions to treating diseases. Because of the possibilities of various clinical applications, the properties and administration of these bioactive glycosides deserve further investigation. Their promising treatment effects, however, are hindered by their poor solubility, poor stability and rapid elimination. Therefore, it is necessary that we improve the therapeutic efficacy of bioactive glycosides by overcoming these problems. Meanwhile, some practical design strategies and novel drug delivery vehicles based on drug delivery systems provide favorable support in clinical practice for these active ingredients. This review summarizes diverse pharmacological activities of bioactive glycosides and focuses on recent advances in delivery system for these active constitutes; in particular, some glycol glycosides can effectively cure intractable diseases through targeted drug delivery. This review elucidates some design strategies for drug delivery system that are mainly based on two methods (avoiding physical barriers by changing dosage forms and enhancing the ability to bind to receptors or proteins after administration) and indicate the current challenges during the combination of delivery vehicles and these glycosides in hopes of promoting the process of receiving ideal therapeutic efficacy of them in future studies.

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