Effect of Growth Inhibition and Quinone Reductase Activity Stimulation of Makgeoly Fractions in Various Cancer Cells

2008 ◽  
Vol 37 (3) ◽  
pp. 288-293 ◽  
Author(s):  
Mi-Ok Shin ◽  
Dae-Yeon Kang ◽  
Mi-Hyang Kim ◽  
Song-Ja Bae
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Reductase Activity ◽  
Quinone Reductase ◽  
Stimulation Of

Efficacious fluorescence turn-on probe for high-contrast imaging of human cells overexpressing quinone reductase activity

2017 ◽  
Vol 53 (4) ◽  
pp. 783-786 ◽  
Author(s):  
Quinn A. Best ◽  
Bijeta Prasai ◽  
Alexandra Rouillere ◽  
Amanda E. Johnson ◽  
Robin L. McCarley
Keyword(s):  
Cancer Cells ◽  
Reductase Activity ◽  
Quinone Reductase ◽  
High Contrast ◽  
Positive Signal ◽  
Contrast Imaging ◽  
Turn On ◽  
High Contrast Imaging ◽  
Fluorescence Images ◽  
Fluorescence Turn On

A turn-on substrate probe is activated by an oxidoreductase, offering fluorescence images of cancer cells with unprecedented positive signal-to-negative background ratios.

scholarly journals Svalbamides A and B, Pyrrolidinone-Bearing Lipodipeptides from Arctic Paenibacillus sp.

Marine Drugs ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 229
Author(s):  
Young Eun Du ◽  
Eun Seo Bae ◽  
Yeonjung Lim ◽  
Jang-Cheon Cho ◽  
Sang-Jip Nam ◽  
...  
Keyword(s):  
Reductase Activity ◽  
Quinone Reductase ◽  
The Arctic ◽  
Amino Acid Residues ◽  
Chemopreventive Agents ◽  
Svalbard Archipelago ◽  
Paenibacillus Sp ◽  
Combinational Analysis ◽  
Culture Extract ◽  
The Absolute

Two new secondary metabolites, svalbamides A (1) and B (2), were isolated from a culture extract of Paenibacillus sp. SVB7 that was isolated from surface sediment from a core (HH17-1085) taken in the Svalbard archipelago in the Arctic Ocean. The combinational analysis of HR-MS and NMR spectroscopic data revealed the structures of 1 and 2 as being lipopeptides bearing 3-amino-2-pyrrolidinone, d-valine, and 3-hydroxy-8-methyldecanoic acid. The absolute configurations of the amino acid residues in svalbamides A and B were determined using the advanced Marfey’s method, in which the hydrolysates of 1 and 2 were derivatized with l- and d- forms of 1-fluoro-2,4-dinitrophenyl-5-alanine amide (FDAA). The absolute configurations of 1 and 2 were completely assigned by deducing the stereochemistry of 3-hydroxy-8-methyldecanoic acid based on DP4 calculations. Svalbamides A and B induced quinone reductase activity in Hepa1c1c7 murine hepatoma cells, indicating that they represent chemotypes with a potential for functioning as chemopreventive agents.

scholarly journals BI-69A11 enhances susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt

2014 ◽  
Vol 111 (1) ◽  
pp. 101-111 ◽  
Author(s):  
I Pal ◽  
S Sarkar ◽  
S Rajput ◽  
K K Dey ◽  
S Chakraborty ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Colon Cancer Cells

Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells

2010 ◽  
pp. no-no ◽  
Author(s):  
Sara Proietti ◽  
Alessandra Cucina ◽  
Fabrizio D’Anselmi ◽  
Simona Dinicola ◽  
Alessia Pasqualato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Vitamin D3 ◽  
Breast Cancer Cells ◽  
Dependent Growth
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