EXPERIMENTAL EVIDENCE FOR THE MOST EFFECTIVE MODE OF AEROSOL LAPAROSCOPIC INTRAPERITONEAL CHEMOTHERAPY (PIPAC)

2017 ◽  
Vol 63 (3) ◽  
pp. 490-496
Author(s):  
Aleksandr Zakharenko ◽  
Sergey Bagnenko ◽  
Mariya Yakovleva ◽  
Natalya Blyum ◽  
Oleg Ten ◽  
...  
Keyword(s):  
Animal Model ◽  
Surgical Treatment ◽  
Experimental Evidence ◽  
Peritoneal Carcinomatosis ◽  
Intraperitoneal Chemotherapy ◽  
Poor Prognosis ◽  
Malignant Tumors ◽  
Experimental Studies ◽  
Chemotherapy Drugs ◽  
Selection Of

Peritoneal carcinomatosis (PC) is one of metastatic spread variant of malignant tumors, which shows significantly poor prognosis in patients. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) - is a modern regional therapy method for implantation metastases. Currently there are still unresolved issues in native equipment, optimal chemotherapy drugs doses for PIPAC, ability in adjuvant and neoadjuvant application of method and a combination with surgical treatment. Concerning this we carried out series of experimental studies on animal model (rabbits, n=71), which resulted in development of the device for laparoscopy aerosol chemotherapy also with selection of effective and safe PIPAC mode.

Multimodality treatment combining chemotherapy, liver surgery, peritoneal resection and hyperthermic intraperitoneal chemotherapy (HIPEC) for metastatic colorectal cancer (mCRC) patients with synchronous liver metastases (LM) and peritoneal carcinomatosis (PC): A multicenter study of the French Association of Surgery.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e14534-e14534 ◽  
Author(s):  
Rea Lo Dico ◽  
Guillaume Passot ◽  
Dominique Elias ◽  
Gerard Lorimier ◽  
Francois Quenet ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Liver Metastases ◽  
Peritoneal Carcinomatosis ◽  
Multicenter Study ◽  
Intraperitoneal Chemotherapy ◽  
Cytoreductive Surgery ◽  
Primary Tumor ◽  
Multimodality Treatment ◽  
Curative Intent ◽  
French Association

e14534 Background: Pts with synchronous PC and LM are generally considered for exclusive systemic palliative chemotherapy only. Aggressive surgical approaches combining hepatectomy associated to peritoneal resection with curative intent remain controversial in such a setting and almost no data are available on such patients.The aim of this prospective cohort was to assess morbidity, mortality, disease-free survival (DFS) and overall survival (OS) of peritoneal and liver mCRC patients (pts) treated with an aggressive therapeutic approach combining surgical treatment of liver and peritoneal lesions followed by HIPEC. Methods: All patients registered in the French Association of Surgeryprospective database with PC and synchronous LM who had undergone cytoreductive surgery and LM resection followed by intraperitoneal chemotherapy were analysed. The primary endpoint was survival from the time of surgery. The following criteria were recorded and analyzed: sex, age, differentiation and localization of the primary tumor, lymph node involvement (pN+), peritoneal cancer index (PCI), completeness of cytoreduction of peritoneal carcinomatosis, number of associated liver metastases. Results: From 1993 to 2011, 101 pts with PC and LM were analyzed. After a mean follow-up of 25 months, the median OS and DFS, were respectively 24.9 and 9.5 months. Post-operative morbidity and mortality was 14.8 and 0%, respectively. In pts with a complete cytoreductive surgery OS was 29 months (n=), as compared to 4 months in pts (n=) with incomplete cytoreduction (p=0.0001). Rectal primary tumor, PCI of 13 or more, pN+ status, and more than 3 LM were not identified as independent factors for poor OS. Conclusions: This multicenter study confirms that prolonged survival can be achieved in selected patients suitable for PC and LM surgery if they underwent multimodality treatment including surgical treatment of PC and LM with curative intent, using intraperitoneal chemotherapy.

scholarly journals Neoadjuvant intraperitoneal chemotherapy with paclitaxel for the radical surgical treatment of peritoneal carcinomatosis in ovarian cancer: a prospective pilot study

2011 ◽  
Vol 68 (1) ◽  
pp. 267-274 ◽  
Author(s):  
Francisco C. Muñoz-Casares ◽  
Sebastián Rufián ◽  
Álvaro Arjona-Sánchez ◽  
María J. Rubio ◽  
Rafael Díaz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Surgical Treatment ◽  
Pilot Study ◽  
Peritoneal Carcinomatosis ◽  
Intraperitoneal Chemotherapy ◽  
Prospective Pilot Study

ROLE OF ULTRASOUND IN THE DETECTION OF RECURRENT OVARIAN CANCER

2020 ◽  
Vol 6 (1) ◽  
pp. 23-31
Author(s):  
M. Alisherova ◽  
◽  
M. Ismailova
Keyword(s):  
Ovarian Cancer ◽  
Surgical Treatment ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Recurrent Ovarian Cancer ◽  
Primary Diagnosis ◽  
Female Reproductive System

Currently, there are no standard approaches to monitoring patients with ovarian cancer (OC). While the role of ultrasound (US) has been identified in the primary diagnosis of OS, it is still controversial during the subsequent surgical treatment of OC. In world statistics, ovarian cancer is consistently among the four main localizations of malignant tumors of the female reproductive system, along with tumors of the breast, body and cervix.

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