scholarly journals Growth inhibitory effects ofPhyllanthus niruriextracts in combination with cisplatin on cancer cell lines

2012 ◽  
Vol 18 (31) ◽  
pp. 4162 ◽  
Author(s):  
Raimundo Fernandes de Araújo Júnior
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Inhibitory Effects ◽  
Growth Inhibitory

scholarly journals In VitroGrowth Inhibitory Activities of Natural Products from Irciniid Sponges against Cancer Cells: A Comparative Study

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Yosr BenRedjem Romdhane ◽  
Monia Elbour ◽  
Marianna Carbone ◽  
Maria Letizia Ciavatta ◽  
Margherita Gavagnin ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antimicrobial Properties ◽  
Human Tumor ◽  
Cancer Cell Lines ◽  
Marine Sponges ◽  
Inhibitory Effects ◽  
Experimental Conditions ◽  
Growth Inhibitory

Marine sponges of the Irciniidae family contain both bioactive furanosesterterpene tetronic acids (FTAs) and prenylated hydroquinones (PHQs). Both classes of compounds are known for their anti-inflammatory, antioxidant, and antimicrobial properties and known to display growth inhibitory effects against various human tumor cell lines. However, the different experimental conditions of the reportedin vitrobioassays, carried out on different cancer cell lines within separate studies, prevent realistic actual discrimination between the two classes of compounds from being carried out in terms of growth inhibitory effects. In the present work, a chemical investigation of irciniid sponges from Tunisian coasts led to the purification of three known FTAs and three known PHQs. Thein vitrogrowth inhibitory properties of the six purified compounds have been evaluated in the same experiment in a panel of five human and one murine cancer cell lines displaying various levels of sensitivity to proapoptotic stimuli. Surprisingly, FTAs and PHQs elicited distinct profiles of growth inhibitory-responses, differing by one to two orders of magnitude in favor of the PHQs in all cell lines. The obtained comparative results are discussed in the light of a better selection of drug candidates from natural sources.

Growth inhibitory effects of interferon-? subtypes vary according to human liver cancer cell lines

2006 ◽  
Vol 21 (11) ◽  
pp. 1720-1725 ◽  
Author(s):  
Hirohisa Yano ◽  
Yoshiaki Yanai ◽  
Seiya Momosaki ◽  
Sachiko Ogasawara ◽  
Jun Akiba ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Liver ◽  
Cancer Cell Lines ◽  
Liver Cancer Cell ◽  
Inhibitory Effects ◽  
Growth Inhibitory ◽  
Human Liver Cancer Cell ◽  
Human Liver Cancer

scholarly journals Identification of ubiquitin in bovine milk and its growth inhibitory effects on human cancer cell lines

2010 ◽  
Vol 93 (8) ◽  
pp. 3442-3452 ◽  
Author(s):  
C. Freiburghaus ◽  
C. Welinder ◽  
U. Tjörnstad ◽  
H. Lindmark-Månsson ◽  
M. Paulsson ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Bovine Milk ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Inhibitory Effects ◽  
Human Cancer Cell Lines ◽  
Growth Inhibitory

scholarly journals Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells

2021 ◽  
Vol 14 (1) ◽  
pp. 49
Author(s):  
David Méndez-Luna ◽  
Loreley Araceli Morelos-Garnica ◽  
Juan Benjamín García-Vázquez ◽  
Martiniano Bello ◽  
Itzia Irene Padilla-Martínez ◽  
...  
Keyword(s):  
Binding Site ◽  
Cell Lines ◽  
Cancer Cell ◽  
Inhibitory Activity ◽  
In Silico ◽  
Cancer Cell Lines ◽  
Pancreatic Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
New Compounds

The implementation of chemo- and bioinformatics tools is a crucial step in the design of structure-based drugs, enabling the identification of more specific and effective molecules against cancer without side effects. In this study, three new compounds were designed and synthesized with suitable absorption, distribution, metabolism, excretion and toxicity (ADME-tox) properties and high affinity for the G protein-coupled estrogen receptor (GPER) binding site by in silico methods, which correlated with the growth inhibitory activity tested in a cluster of cancer cell lines. Docking and molecular dynamics (MD) simulations accompanied by a molecular mechanics/generalized Born surface area (MMGBSA) approach yielded the binding modes and energetic features of the proposed compounds on GPER. These in silico studies showed that the compounds reached the GPER binding site, establishing interactions with a phenylalanine cluster (F206, F208 and F278) required for GPER molecular recognition of its agonist and antagonist ligands. Finally, a 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay showed growth inhibitory activity of compounds 4, 5 and 7 in three different cancer cell lines—MIA Paca-2, RCC4-VA and Hep G2—at micromolar concentrations. These new molecules with specific chemical modifications of the GPER pharmacophore open up the possibility of generating new compounds capable of reaching the GPER binding site with potential growth inhibitory activities against nonconventional GPER cell models.

scholarly journals Draft Genome Sequence of the Symbiotically Competent Cyanobacterium Nostoc sp. Strain KVJ20

2019 ◽  
Vol 8 (45) ◽  
Author(s):  
Marie-Josée H. Halsør ◽  
Anton Liaimer ◽  
Seila Pandur ◽  
Inger L. U. Ræder ◽  
Arne O. Smalås ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Cell Lines ◽  
Cancer Cell ◽  
Genome Sequence ◽  
Draft Genome ◽  
Cancer Cell Lines ◽  
Draft Genome Sequence ◽  
Inhibitory Effects ◽  
Content Type

Nostoc sp. strain KVJ20 was isolated from the symbiotic organs of the liverwort Blasia pusilla. This cyanobacterium has been shown to have broad symbiotic competence, and bacterial extracts have inhibitory effects on cancer cell lines and microbes. An array of genes for the production of secondary metabolites is present.

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