Effects of the Carrier Phrase on Word-Recognition Performances by Younger and Older Listeners Using Two Stimulus Paradigms

Author(s):  
Richard H. Wilson ◽  
Victoria A. Sanchez

Background: In the 1950s, with monitored live voice testing, the vu meter time constant and the shortdurations and amplitude modulation characteristics of monosyllabic words necessitated the use of the carrierphrase amplitude tomonitor (indirectly) the presentation level of the words. This practice continues withrecorded materials. To relieve the carrier phrase of this function, first the influence that the carrier phrasehas on word recognition performance needs clarification, which is the topic of this study.<br />Purpose: Recordings of Northwestern University Auditory Test No. 6 by two female speakers were usedto compare word recognition performances with and without the carrier phrases when the carrier phraseand test word were (1) in the same utterance stream with the words excised digitally from the carrier (VA-1speaker) and (2) independent of one another (VA-2 speaker). The 50-msec segment of the vowel in thetarget word with the largest root mean square amplitude was used to equate the target word amplitudes.<br />Research Design: A quasi-experimental, repeated measures design was used.<br />Study Sample: Twenty-four young normal-hearing adults (YNH; M = 23.5 years; pure-tone average[PTA] = 1.3-dB HL) and 48 older hearing loss listeners (OHL; M = 71.4 years; PTA = 21.8-dB HL) participatedin two, one-hour sessions.<br />Data Collection and Analyses: Each listener had 16 listening conditions (2 speakers 3 2 carrier phraseconditions 3 4 presentation levels) with 100 randomized words, 50 different words by each speaker.Each word was presented 8 times (2 carrier phrase conditions 3 4 presentation levels [YNH, 0- to24-dB SL; OHL, 6- to 30-dB SL]). The 200 recorded words for each condition were randomized as 8,25-word tracks. In both test sessions, one practice track was followed by 16 tracks alternated betweenspeakers and randomized by blocks of the four conditions. Central tendency and repeated measuresanalyses of variance statistics were used.<br />Results: With the VA-1 speaker, the overall mean recognition performances were 6.0% (YNH) and 8.3%(OHL) significantly better with the carrier phrase than without the carrier phrase. These differences werein part attributed to the distortion of some words caused by the excision of the words from the carrierphrases. With the VA-2 speaker, recognition performances on the with and without carrier phrase conditionsby both listener groups were not significantly different, except for one condition (YNH listeners at8-dB SL). The slopes of the mean functions were steeper for the YNH listeners (3.9%/dB to 4.8%/dB) thanfor the OHL listeners (2.4%/dB to 3.4%/dB) and were <1%/dB steeper for the VA-1 speaker than for theVA-2 speaker. Although the mean results were clear, the variability in performance differences betweenthe two carrier phrase conditions for the individual participants and for the individual words was strikingand was considered in detail.<br />Conclusion: The current data indicate that word recognition performances with and without the carrierphrase (1) were different when the carrier phrase and target word were produced in the same utterancewith poorer performances when the target words were excised from their respective carrier phrases(VA-1 speaker), and (2) were the same when the carrier phrase and target word were produced as independentutterances (VA-2 speaker).<br />See the Supplementary Data tab for supplementary materials.

2020 ◽  
Vol 31 (06) ◽  
pp. 412-441 ◽  
Author(s):  
Richard H. Wilson ◽  
Victoria A. Sanchez

Abstract Background In the 1950s, with monitored live voice testing, the vu meter time constant and the short durations and amplitude modulation characteristics of monosyllabic words necessitated the use of the carrier phrase amplitude to monitor (indirectly) the presentation level of the words. This practice continues with recorded materials. To relieve the carrier phrase of this function, first the influence that the carrier phrase has on word recognition performance needs clarification, which is the topic of this study. Purpose Recordings of Northwestern University Auditory Test No. 6 by two female speakers were used to compare word recognition performances with and without the carrier phrases when the carrier phrase and test word were (1) in the same utterance stream with the words excised digitally from the carrier (VA-1 speaker) and (2) independent of one another (VA-2 speaker). The 50-msec segment of the vowel in the target word with the largest root mean square amplitude was used to equate the target word amplitudes. Research Design A quasi-experimental, repeated measures design was used. Study Sample Twenty-four young normal-hearing adults (YNH; M = 23.5 years; pure-tone average [PTA] = 1.3-dB HL) and 48 older hearing loss listeners (OHL; M = 71.4 years; PTA = 21.8-dB HL) participated in two, one-hour sessions. Data Collection and Analyses Each listener had 16 listening conditions (2 speakers × 2 carrier phrase conditions × 4 presentation levels) with 100 randomized words, 50 different words by each speaker. Each word was presented 8 times (2 carrier phrase conditions × 4 presentation levels [YNH, 0- to 24-dB SL; OHL, 6- to 30-dB SL]). The 200 recorded words for each condition were randomized as 8, 25-word tracks. In both test sessions, one practice track was followed by 16 tracks alternated between speakers and randomized by blocks of the four conditions. Central tendency and repeated measures analyses of variance statistics were used. Results With the VA-1 speaker, the overall mean recognition performances were 6.0% (YNH) and 8.3% (OHL) significantly better with the carrier phrase than without the carrier phrase. These differences were in part attributed to the distortion of some words caused by the excision of the words from the carrier phrases. With the VA-2 speaker, recognition performances on the with and without carrier phrase conditions by both listener groups were not significantly different, except for one condition (YNH listeners at 8-dB SL). The slopes of the mean functions were steeper for the YNH listeners (3.9%/dB to 4.8%/dB) than for the OHL listeners (2.4%/dB to 3.4%/dB) and were <1%/dB steeper for the VA-1 speaker than for the VA-2 speaker. Although the mean results were clear, the variability in performance differences between the two carrier phrase conditions for the individual participants and for the individual words was striking and was considered in detail. Conclusion The current data indicate that word recognition performances with and without the carrier phrase (1) were different when the carrier phrase and target word were produced in the same utterance with poorer performances when the target words were excised from their respective carrier phrases (VA-1 speaker), and (2) were the same when the carrier phrase and target word were produced as independent utterances (VA-2 speaker).


2015 ◽  
Vol 26 (04) ◽  
pp. 346-354 ◽  
Author(s):  
Richard H. Wilson

Background: In 1940, a cooperative effort by the radio networks and Bell Telephone produced the volume unit (vu) meter that has been the mainstay instrument for monitoring the level of speech signals in commercial broadcasting and research laboratories. With the use of computers, today the amplitude of signals can be quantified easily using the root mean square (rms) algorithm. Researchers had previously reported that amplitude estimates of sentences and running speech were 4.8 dB higher when measured with a vu meter than when calculated with rms. This study addresses the vu–rms relation as applied to the carrier phrase and target word paradigm used to assess word-recognition abilities, the premise being that by definition the word-recognition paradigm is a special and different case from that described previously. Purpose: The purpose was to evaluate the vu and rms amplitude relations for the carrier phrases and target words commonly used to assess word-recognition abilities. In addition, the relations with the target words between rms level and recognition performance were examined. Research Design: Descriptive and correlational. Study Sample: Two recoded versions of the Northwestern University Auditory Test No. 6 were evaluated, the Auditec of St. Louis (Auditec) male speaker and the Department of Veterans Affairs (VA) female speaker. Data Collection and Analysis: Using both visual and auditory cues from a waveform editor, the temporal onsets and offsets were defined for each carrier phrase and each target word. The rms amplitudes for those segments then were computed and expressed in decibels with reference to the maximum digitization range. The data were maintained for each of the four Northwestern University Auditory Test No. 6 word lists. Descriptive analyses were used with linear regressions used to evaluate the reliability of the measurement technique and the relation between the rms levels of the target words and recognition performances. Results: Although there was a 1.3 dB difference between the calibration tones, the mean levels of the carrier phrases for the two recordings were −14.8 dB (Auditec) and −14.1 dB (VA) with standard deviations <1 dB. For the target words, the mean amplitudes were −19.9 dB (Auditec) and −18.3 dB (VA) with standard deviations ranging from 1.3 to 2.4 dB. The mean durations for the carrier phrases of both recordings were 593–594 msec, with the mean durations of the target words a little different, 509 msec (Auditec) and 528 msec (VA). Random relations were observed between the recognition performances and rms levels of the target words. Amplitude and temporal data for the individual words are provided. Conclusions: The rms levels of the carrier phrases closely approximated (±1 dB) the rms levels of the calibration tones, both of which were set to 0 vu (dB). The rms levels of the target words were 5–6 dB below the levels of the carrier phrases and were substantially more variable than the levels of the carrier phrases. The relation between the rms levels of the target words and recognition performances on the words was random.


2008 ◽  
Vol 19 (06) ◽  
pp. 496-506 ◽  
Author(s):  
Richard H. Wilson ◽  
Rachel McArdle ◽  
Heidi Roberts

Background: So that portions of the classic Miller, Heise, and Lichten (1951) study could be replicated, new recorded versions of the words and digits were made because none of the three common monosyllabic word lists (PAL PB-50, CID W-22, and NU–6) contained the 9 monosyllabic digits (1–10, excluding 7) that were used by Miller et al. It is well established that different psychometric characteristics have been observed for different lists and even for the same materials spoken by different speakers. The decision was made to record four lists of each of the three monosyllabic word sets, the monosyllabic digits not included in the three sets of word lists, and the CID W-1 spondaic words. A professional female speaker with a General American dialect recorded the materials during four recording sessions within a 2-week interval. The recording order of the 582 words was random. Purpose: To determine—on listeners with normal hearing—the psychometric properties of the five speech materials presented in speech-spectrum noise. Research Design: A quasi-experimental, repeated-measures design was used. Study Sample: Twenty-four young adult listeners (M = 23 years) with normal pure-tone thresholds (≤20-dB HL at 250 to 8000 Hz) participated. The participants were university students who were unfamiliar with the test materials. Data Collection and Analysis: The 582 words were presented at four signal-to-noise ratios (SNRs; −7-, −2-, 3-, and 8-dB) in speech-spectrum noise fixed at 72-dB SPL. Although the main metric of interest was the 50% point on the function for each word established with the Spearman-Kärber equation (Finney, 1952), the percentage correct on each word at each SNR was evaluated. The psychometric characteristics of the PB-50, CID W-22, and NU–6 monosyllabic word lists were compared with one another, with the CID W-1 spondaic words, and with the 9 monosyllabic digits. Results: Recognition performance on the four lists within each of the three monosyllabic word materials were equivalent, ±0.4 dB. Likewise, word-recognition performance on the PB-50, W-22, and NU–6 word lists were equivalent, ±0.2 dB. The mean recognition performance at the 50% point with the 36 W-1 spondaic words was ˜6.2 dB lower than the 50% point with the monosyllabic words. Recognition performance on the monosyllabic digits was 1–2 dB better than mean performance on the monosyllabic words. Conclusions: Word-recognition performances on the three sets of materials (PB-50, CID W-22, and NU–6) were equivalent, as were the performances on the four lists that make up each of the three materials. Phonetic/phonemic balance does not appear to be an important consideration in the compilation of word-recognition lists used to evaluate the ability of listeners to understand speech.A companion paper examines the acoustic, phonetic/phonological, and lexical variables that may predict the relative ease or difficulty for which these monosyllable words were recognized in noise (McArdle and Wilson, this issue).


2020 ◽  
Vol 31 (07) ◽  
pp. 531-546
Author(s):  
Mitzarie A. Carlo ◽  
Richard H. Wilson ◽  
Albert Villanueva-Reyes

Abstract Background English materials for speech audiometry are well established. In Spanish, speech-recognition materials are not standardized with monosyllables, bisyllables, and trisyllables used in word-recognition protocols. Purpose This study aimed to establish the psychometric characteristics of common Spanish monosyllabic, bisyllabic, and trisyllabic words for potential use in word-recognition procedures. Research Design Prospective descriptive study. Study Sample Eighteen adult Puerto Ricans (M = 25.6 years) with normal hearing [M = 7.8-dB hearing level (HL) pure-tone average] were recruited for two experiments. Data Collection and Analyses A digital recording of 575 Spanish words was created (139 monosyllables, 359 bisyllables, and 77 trisyllables), incorporating materials from a variety of Spanish word-recognition lists. Experiment 1 (n = 6) used 25 randomly selected words from each of the three syllabic categories to estimate the presentation level ranges needed to obtain recognition performances over the 10 to 90% range. In Experiment 2 (n = 12) the 575 words were presented over five 1-hour sessions using presentation levels from 0- to 30-dB HL in 5-dB steps (monosyllables), 0- to 25-dB HL in 5-dB steps (bisyllables), and −3- to 17-dB HL in 4-dB steps (trisyllables). The presentation order of both the words and the presentation levels were randomized for each listener. The functions for each listener and each word were fit with polynomial equations from which the 50% points and slopes at the 50% point were calculated. Results The mean 50% points and slopes at 50% were 8.9-dB HL, 4.0%/dB (monosyllables), 6.9-dB HL, 5.1%/dB (bisyllables), and 1.4-dB HL, 6.3%/dB (trisyllables). The Kruskal–Wallis test with Mann–Whitney U post-hoc analysis indicated that the mean 50% points and slopes at the 50% points of the individual word functions were significantly different among the syllabic categories. Although significant differences were observed among the syllabic categories, substantial overlap was noted in the individual word functions, indicating that the psychometric characteristics of the words were not dictated exclusively by the syllabic number. Influences associated with word difficulty, word familiarity, singular and plural form words, phonetic stress patterns, and gender word patterns also were evaluated. Conclusion The main finding was the direct relation between the number of syllables in a word and word-recognition performance. In general, words with more syllables were more easily recognized; there were, however, exceptions. The current data from young adults with normal hearing established the psychometric characteristics of the 575 Spanish words on which the formulation of word lists for both threshold and suprathreshold measures of word-recognition abilities in quiet and in noise and other word-recognition protocols can be based.


2017 ◽  
Vol 28 (01) ◽  
pp. 068-079
Author(s):  
Richard H. Wilson ◽  
Kadie C. Sharrett

AbstractTwo previous experiments from our laboratory with 70 interrupted monosyllabic words demonstrated that recognition performance was influenced by the temporal location of the interruption pattern. The interruption pattern (10 interruptions/sec, 50% duty cycle) was always the same and referenced word onset; the only difference between the patterns was the temporal location of the on- and off-segments of the interruption cycle. In the first study, both young and older listeners obtained better recognition performances when the initial on-segment coincided with word onset than when the initial on-segment was delayed by 50 msec. The second experiment with 24 young listeners detailed recognition performance as the interruption pattern was incremented in 10-msec steps through the 0- to 90-msec onset range. Across the onset conditions, 95% of the functions were either flat or U-shaped.To define the effects that interruption pattern locations had on word recognition by older listeners with sensorineural hearing loss as the interruption pattern incremented, re: word onset, from 0 to 90 msec in 10-msec steps.A repeated-measures design with ten interruption patterns (onset conditions) and one uninterruption condition.Twenty-four older males (mean = 69.6 yr) with sensorineural hearing loss participated in two 1-hour sessions. The three-frequency pure-tone average was 24.0 dB HL and word recognition was ≥80% correct.Seventy consonant-vowel nucleus-consonant words formed the corpus of materials with 25 additional words used for practice. For each participant, the 700 interrupted stimuli (70 words by 10 onset conditions), the 70 words uninterrupted, and two practice lists each were randomized and recorded on compact disc in 33 tracks of 25 words each.The data were analyzed at the participant and word levels and compared to the results obtained earlier on 24 young listeners with normal hearing. The mean recognition performance on the 70 words uninterrupted was 91.0% with an overall mean performance on the ten interruption conditions of 63.2% (range: 57.9–69.3%), compared to 80.4% (range: 73.0–87.7%) obtained earlier on the young adults. The best performances were at the extremes of the onset conditions. Standard deviations ranged from 22.1% to 28.1% (24 participants) and from 9.2% to 12.8% (70 words). An arithmetic algorithm categorized the shapes of the psychometric functions across the ten onset conditions. With the older participants in the current study, 40% of the functions were flat, 41.4% were U-shaped, and 18.6% were inverted U-shaped, which compared favorably to the function shapes by the young listeners in the earlier study of 50.0%, 41.4%, and 8.6%, respectively. There were two words on which the older listeners had 40% better performances.Collectively, the data are orderly, but at the individual word or participant level, the data are somewhat volatile, which may reflect auditory processing differences between the participant groups. The diversity of recognition performances by the older listeners on the ten interruption conditions with each of the 70 words supports the notion that the term hearing loss is inclusive of processes well beyond the filtering produced by end-organ sensitivity deficits.


2015 ◽  
Vol 26 (07) ◽  
pp. 670-677 ◽  
Author(s):  
Richard H. Wilson ◽  
Heather M. Hamm

Background: A previous experiment with 70 interrupted monosyllabic words demonstrated that recognition performance was influenced by the location of an interruption pattern (Wilson, 2014). The interruption paradigm (10 interruptions/sec, 50% duty cycle periodic interruption) was referenced to word onset. The words were interrupted such that alternate 50-msec segments were parsed to separate files. In the 0-msec condition the first on-segment coincided with the word onset, whereas in the 50-msec condition the first on-segment occurred 50 msec after word onset. The 0- and 50-msec conditions were complementary halves. Recognition performance by young listeners was 19% better on the 0-msec condition (86%) than on the 50-msec condition (68%); there were a minority number of words on which the results were just the opposite. A second study using the same interruption paradigm but 300 different words reported similar relations, with 63% correct recognition on the 0-msec condition and 48% on the 50-msec condition (Wilson and Irish, 2015). Both studies suggest the importance that the first 50 msec of the target word has on intelligibility. Purpose: To define in detail the effects that interruption patterns have on word recognition as the interruption pattern was incremented with reference to word onset from 0 to 90 msec in 10-msec steps. Research Design: A repeated-measures design with ten interruption patterns (onset conditions). Study Sample: Twenty-four young listeners (19–29 yr) with normal hearing for pure tones participated in this study. Data Collection and Analyses: Seventy consonant-nucleus-consonant words formed the corpus of materials with 25 additional words used for practice. For each participant, the 700 stimuli (70 words by ten onset conditions) were interrupted (10 interruptions/sec; 50% duty cycle), randomized, and recorded on compact disc in 28, 25-word tracks. Results: The overall mean recognition performance was 80.4% with mean performances for the ten conditions ranging from 73.0% (50-msec condition) to 87.7% (90-msec condition). The mean recognition performances changed systematically, decreasing from the 0-msec condition to the 50-msec condition and then increasing to the 90-msec condition, which formed a U-shaped function of the means. Of the 45 mean paired comparisons (post hoc t-tests with Bonferroni corrections), there were 17 significant differences at the p ≤ 0.001 level, increasing to 31 significant differences when the significance level was increased to the p ≤ 0.01 level. Visual inspection of the 70-word performance functions revealed that 32 words had flat functions, 34 words had U-shaped functions, two functions were rising, one was an inverted V-shape, and one was irregular. Conclusions: First, some words (utterances of those words) were immune to any differential effects of the ten interruption patterns. These words with flat performance functions constituted 46% of the word corpus. Second, 49% of the words exhibited U-shaped performance functions that were always systematic, going from maximum to minimum and back to maximum. These words were thought to be more dependent on the initial consonant to attain maximum performance. The conclusion is that some words are not affected by the location of the interruption pattern (those with flat functions) whereas other words are substantially affected (those with U-shaped functions).


2021 ◽  
Vol 77 (1) ◽  
pp. 235-244
Author(s):  
Darío Martínez-García ◽  
Ángela Rodríguez-Perea ◽  
Álvaro Huerta-Ojeda ◽  
Daniel Jerez-Mayorga ◽  
Daniel Aguilar-Martínez ◽  
...  

Abstract The purpose of this study was to investigate the acute effect of pre-activation with Variable Intra-Repetition Resistance and isometry on the overhead throwing velocity in handball players. Fourteen female handball players took part in the study (age: 21.2 ± 2.7 years, experience: 10.9 ± 3.5 years). For Post-Activation Potentiation, two pre-activation methods were used: (I) Variable Intra-Repetition Resistance: 1 x 5 maximum repetitions at an initial velocity of 0.6 m·s-1 and a final velocity of 0.9 m·s-1; (II) Isometry: 1 x 5 s of maximum voluntary isometric contraction. Both methods were "standing unilateral bench presses" with the dominant arm, using a functional electromechanical dynamometer. The variable analysed was the mean of the three overhead throws. Ball velocity was measured with a radar (Stalker ATS). The statistical analysis was performed using ANOVA with repeated measures. No significant differences were found for either method (variable resistance intra-repetition: p = 0.194, isometry: p = 0.596). Regarding the individual responses, the analysis showed that 86% of the sample increased throwing velocity with the variable resistance intra-repetition method, while 93% of the sample increased throwing velocity with the isometric method. Both the variable intra-repetition resistance and isometric methods show improvements in ball velocity in female handball players. However, the authors recommend checking individual responses, since the results obtained were influenced by the short rest interval between the pre-activation and the experimental sets.


2013 ◽  
Vol 24 (10) ◽  
pp. 927-940 ◽  
Author(s):  
Erin C. Schafer ◽  
Denise Romine ◽  
Elizabeth Musgrave ◽  
Sadaf Momin ◽  
Christy Huynh

Background: Previous research has suggested that electrically coupled frequency modulation (FM) systems substantially improved speech-recognition performance in noise in individuals with cochlear implants (CIs). However, there is limited evidence to support the use of electromagnetically coupled (neck loop) FM receivers with contemporary CI sound processors containing telecoils. Purpose: The primary goal of this study was to compare speech-recognition performance in noise and subjective ratings of adolescents and adults using one of three contemporary CI sound processors coupled to electromagnetically and electrically coupled FM receivers from Oticon. Research Design: A repeated-measures design was used to compare speech-recognition performance in noise and subjective ratings without and with the FM systems across three test sessions (Experiment 1) and to compare performance at different FM-gain settings (Experiment 2). Descriptive statistics were used in Experiment 3 to describe output differences measured through a CI sound processor. Study Sample: Experiment 1 included nine adolescents or adults with unilateral or bilateral Advanced Bionics Harmony (n = 3), Cochlear Nucleus 5 (n = 3), and MED-EL OPUS 2 (n = 3) CI sound processors. In Experiment 2, seven of the original nine participants were tested. In Experiment 3, electroacoustic output was measured from a Nucleus 5 sound processor when coupled to the electromagnetically coupled Oticon Arc neck loop and electrically coupled Oticon R2. Data Collection and Analysis: In Experiment 1, participants completed a field trial with each FM receiver and three test sessions that included speech-recognition performance in noise and a subjective rating scale. In Experiment 2, participants were tested in three receiver-gain conditions. Results in both experiments were analyzed using repeated-measures analysis of variance. Experiment 3 involved electroacoustic-test measures to determine the monitor-earphone output of the CI alone and CI coupled to the two FM receivers. Results: The results in Experiment 1 suggested that both FM receivers provided significantly better speech-recognition performance in noise than the CI alone; however, the electromagnetically coupled receiver provided significantly better speech-recognition performance in noise and better ratings in some situations than the electrically coupled receiver when set to the same gain. In Experiment 2, the primary analysis suggested significantly better speech-recognition performance in noise for the neck-loop versus electrically coupled receiver, but a second analysis, using the best performance across gain settings for each device, revealed no significant differences between the two FM receivers. Experiment 3 revealed monitor-earphone output differences in the Nucleus 5 sound processor for the two FM receivers when set to the +8 setting used in Experiment 1 but equal output when the electrically coupled device was set to a +16 gain setting and the electromagnetically coupled device was set to the +8 gain setting. Conclusions: Individuals with contemporary sound processors may show more favorable speech-recognition performance in noise electromagnetically coupled FM systems (i.e., Oticon Arc), which is most likely related to the input processing and signal processing pathway within the CI sound processor for direct input versus telecoil input. Further research is warranted to replicate these findings with a larger sample size and to develop and validate a more objective approach to fitting FM systems to CI sound processors.


2019 ◽  
Vol 3 (6) ◽  
pp. 993-1002
Author(s):  
Neelima Paladugula ◽  
Zia Fazili ◽  
Maya R Sternberg ◽  
Gwendolyn Gabey ◽  
Christine M Pfeiffer

Abstract Background Serum folate forms, and particularly tetrahydrofolate, are sensitive to oxidation. Methods Using a repeated measures design, we investigated the stability of folate forms in convenience samples with added ascorbic acid (AA; 5 g/L) analyzed initially and after variable (approximately 1–33 weeks) storage time at −70 °C. We examined the recovery of tetrahydrofolate added at different spiking levels to serum with and without AA (5 g/L). We also assessed the long-term frozen storage stability of folate forms. Results Repeat analysis produced consistent results with the initial analysis; the mean relative change (95% CI; Lin's concordance correlation between initial and repeat result; sample size) was 0.08% (−0.24% to 0.39%; rc = 0.999; n = 301) for 5-methyltetrahydrofolate, 4.23% (2.44%–6.05%; rc = 0.984; n = 211) for pyrazino-s-triazine derivative of 4α-hydroxy-5-methyltetrahydrofolate (MeFox), −0.22% (−1.90% to 1.49%; rc = 0.986; n = 214) for folic acid, and 1.49% (−2.71% to 5.88%; rc = 0.889; n = 81) for tetrahydrofolate. Linear regression testing for a time trend indicated an estimated average percent change of less than ±5% for samples retested after 4 months: 5-methyltetrahydrofolate Ptrend = 0.0007, folic acid Ptrend &lt; 0.0001, MeFox Ptrend = 0.38, and tetrahydrofolate Ptrend = 0.0256. The mean ± SD tetrahydrofolate spiking recovery was 96.7% ± 9.4% for serum with added AA, but &lt;50% for serum without added AA. We observed ≤10% loss for most serum folate forms during 4 years of storage at −70 °C. Conclusions Serum containing added AA showed acceptable stability of folate forms during repeat analysis from the same vial within 4 months, complete spiking recovery of tetrahydrofolate during sample processing, and long-term frozen storage stability of folate forms.


2010 ◽  
Vol 21 (07) ◽  
pp. 441-451 ◽  
Author(s):  
René H. Gifford ◽  
Lawrence J. Revit

Background: Although cochlear implant patients are achieving increasingly higher levels of performance, speech perception in noise continues to be problematic. The newest generations of implant speech processors are equipped with preprocessing and/or external accessories that are purported to improve listening in noise. Most speech perception measures in the clinical setting, however, do not provide a close approximation to real-world listening environments. Purpose: To assess speech perception for adult cochlear implant recipients in the presence of a realistic restaurant simulation generated by an eight-loudspeaker (R-SPACE™) array in order to determine whether commercially available preprocessing strategies and/or external accessories yield improved sentence recognition in noise. Research Design: Single-subject, repeated-measures design with two groups of participants: Advanced Bionics and Cochlear Corporation recipients. Study Sample: Thirty-four subjects, ranging in age from 18 to 90 yr (mean 54.5 yr), participated in this prospective study. Fourteen subjects were Advanced Bionics recipients, and 20 subjects were Cochlear Corporation recipients. Intervention: Speech reception thresholds (SRTs) in semidiffuse restaurant noise originating from an eight-loudspeaker array were assessed with the subjects' preferred listening programs as well as with the addition of either Beam™ preprocessing (Cochlear Corporation) or the T-Mic® accessory option (Advanced Bionics). Data Collection and Analysis: In Experiment 1, adaptive SRTs with the Hearing in Noise Test sentences were obtained for all 34 subjects. For Cochlear Corporation recipients, SRTs were obtained with their preferred everyday listening program as well as with the addition of Focus preprocessing. For Advanced Bionics recipients, SRTs were obtained with the integrated behind-the-ear (BTE) mic as well as with the T-Mic. Statistical analysis using a repeated-measures analysis of variance (ANOVA) evaluated the effects of the preprocessing strategy or external accessory in reducing the SRT in noise. In addition, a standard t-test was run to evaluate effectiveness across manufacturer for improving the SRT in noise. In Experiment 2, 16 of the 20 Cochlear Corporation subjects were reassessed obtaining an SRT in noise using the manufacturer-suggested “Everyday,” “Noise,” and “Focus” preprocessing strategies. A repeated-measures ANOVA was employed to assess the effects of preprocessing. Results: The primary findings were (i) both Noise and Focus preprocessing strategies (Cochlear Corporation) significantly improved the SRT in noise as compared to Everyday preprocessing, (ii) the T-Mic accessory option (Advanced Bionics) significantly improved the SRT as compared to the BTE mic, and (iii) Focus preprocessing and the T-Mic resulted in similar degrees of improvement that were not found to be significantly different from one another. Conclusion: Options available in current cochlear implant sound processors are able to significantly improve speech understanding in a realistic, semidiffuse noise with both Cochlear Corporation and Advanced Bionics systems. For Cochlear Corporation recipients, Focus preprocessing yields the best speech-recognition performance in a complex listening environment; however, it is recommended that Noise preprocessing be used as the new default for everyday listening environments to avoid the need for switching programs throughout the day. For Advanced Bionics recipients, the T-Mic offers significantly improved performance in noise and is recommended for everyday use in all listening environments.


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