DEVELOPMENT OF OSTEOPLASTIC MATERIAL IMPREGNATED WITH PLASMID ENCODING BONE MORPHOGENETIC PROTEIN-2

2020 ◽  
pp. 63-65
Author(s):  
T. Bukharova ◽  
A. Vasilyev ◽  
A. Kulakov ◽  
D. Goldstein
Keyword(s):  
Bone Morphogenetic Protein ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
New Gene ◽  
Osteoplastic Material

A new gene-activated osteoplastic based on chitosan material impregnated with plasmid with the BMP-2 gene has been developed. The material had an osteoinductive effect on mesenchymal stromal cells (MSC).

Development of osteoplastic Material Impregnated with Plasmid Encoding Bone Morphogenetic Protein-2

2020 ◽  
Vol 36 (4) ◽  
pp. 59-64
Author(s):  
T.B. Bukharova ◽  
Yu.D. Zagoskin ◽  
A.V. Vasilyev ◽  
T.E. Grigoriev ◽  
V.O. Mokrousova ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Biological Properties ◽  
Bone Morphogenetic Protein 2 ◽  
Russian Science ◽  
Morphogenetic Protein ◽  
Osteoplastic Material

The biological properties of a new gene-activated osteoplastic material based on chitosan sponges impregnated with plasmids with the gene for the bone morphogenetic protein-2 (BMP2) have been studied. The optimal conditions for transfection of multipotent mesenchymal stromal cells with TurboFect reagent were selected. The in vitro osteoinducing effect of the developed material associated with an increase in the expression of osteogenic markers in mesenchymal stromal cells was shown. The designed gene-activated material can be used to repair bone defects. gene-activated material, plasmids, BMP-2, gene therapy, bone regeneration The work was supported by the Russian Science Foundation (Grant no. 16-15-00298).

Bone Morphogenetic Protein-2, But Not Mesenchymal Stromal Cells, Exert Regenerative Effects on Canine and Human Nucleus Pulposus Cells

2017 ◽  
Vol 23 (5-6) ◽  
pp. 233-242 ◽  
Author(s):  
Frances C. Bach ◽  
Alberto Miranda-Bedate ◽  
Ferdi W.M. van Heel ◽  
Frank M. Riemers ◽  
Margot C.M.E. Müller ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Nucleus Pulposus ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Nucleus Pulposus Cells ◽  
Morphogenetic Protein

Design of hydroxyapatite bioceramics with micro-/nano-topographies to regulate the osteogenic activities of bone morphogenetic protein-2 and bone marrow stromal cells

Nanoscale ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 7284-7300 ◽  
Author(s):  
Xiangfeng Li ◽  
Minjun Liu ◽  
Fuying Chen ◽  
Yuyi Wang ◽  
Menglu Wang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Natural Bone ◽  
Morphogenetic Protein ◽  
Bone Apatite

Biomimicking the nanostructure of natural bone apatite to enhance the bioactivity of hydroxyapatite (HA) biomaterials is an eternal topic in the bone regeneration field.

scholarly journals Effect of the Bone Morphogenetic Protein-2 Doses on the Osteogenic Potential of Human Multipotent Stromal Cells- Containing Tissue Engineered Constructs

2019 ◽  
Vol 25 (7-8) ◽  
pp. 642-651 ◽  
Author(s):  
Adeline Decambron ◽  
Nausikaa Devriendt ◽  
Nathanael Larochette ◽  
Mathieu Manassero ◽  
Marianne Bourguignon ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Stromal Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Osteogenic Potential ◽  
Multipotent Stromal Cells ◽  
Morphogenetic Protein

Development of Osteoplastic Material Impregnated with Plasmid Encoding Bone Morphogenetic Protein-2

2021 ◽  
Vol 57 (7) ◽  
pp. 818-822
Author(s):  
I. A. Nedorubova ◽  
T. B. Bukharova ◽  
Yu. D. Zagoskin ◽  
A. V. Vasilyev ◽  
T. E. Grigoriev ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Osteoplastic Material
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