scholarly journals Meta-analysis of the effect of oral administration and external application of traditional Chinese medicine on reducing blood uric acid level in patients with gout

2021 ◽  
Author(s):  
Zhiyuan MAO ◽  
◽  
Qingyu XIE ◽  
Yang SU ◽  
Ziyi SHEN ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Oral Administration ◽  
Uric Acid Level ◽  
Acid Level ◽  
Meta Analysis ◽  
External Application ◽  
Blood Uric Acid

Blood Uric Acid Level and IQ: A Study in Twin Families

1984 ◽  
Vol 33 (2) ◽  
pp. 237-242 ◽  
Author(s):  
E. Inouye ◽  
K.S. Park ◽  
A. Asaka
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Quantitative Traits ◽  
Acid Level ◽  
Genetic Basis ◽  
Plasma Uric Acid ◽  
Blood Uric Acid ◽  
Twin Children ◽  
Twin Families ◽  
Familial Environment

AbstractApplying newly devised model, heritability (VA/VP) of plasma uric acid level, corrected for age and sex and standardized, was estimated at 0.8 in families consisting of twin parents, spouses and children. Correlation between spouses due to common genotype (ρ) was approximately 0.1, and variance due to common familial environment (VEC/Vp) was -0.3. Analysis of families of selected twin children and their parents resulted in two estimates of heritability: approximately 0.7 and 0.3, ρ being 0.34 and 0.04, and VEC/Vp being 0.04 and 0.34, respectively. Regression of IQ (y) on corrected and standardized plasma uric acid level (x) in the twin children was y = 5.56x + 123, correlation being 0.334 (p < 0.025). The result indicates a genetic basis of blood uric acid level, which may have resulted from polymorphisms in purine metabolism pathway, end product of which is uric acid in man. The significant correlation between plasma uric acid level and IQ suggests a contribution of partly common gene loci to the two quantitative traits.

GW24-e1836 Correlation between blood uric acid level and severity of coronary lesions

Heart ◽  
2013 ◽  
Vol 99 (Suppl 3) ◽  
pp. A177.1-A177
Author(s):  
Zhang Quan-Yu ◽  
Han yaling
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Blood Uric Acid ◽  
Coronary Lesions

scholarly journals External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Xin Li ◽  
Qing-qing Xiao ◽  
Kan Ze ◽  
Su Li ◽  
Yi-fei Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Conventional Therapy ◽  
Meta Analysis ◽  
Recurrence Rates ◽  
External Application ◽  
Venous Ulcers ◽  
Dichotomous Data ◽  
Mean Differences

Objective. To evaluate the effectiveness of external application of traditional Chinese medicine (EA-TCM) on venous ulcers.Methods. Seven databases were searched until April 2015 for randomized controlled trials (RCTs) of EA-TCM for venous ulcers. Risk of bias was assessed using Cochrane Handbook guidelines. Study outcomes were presented as risk ratios (RRs) for dichotomous data or mean differences (MDs) for continuous data.Results. Sixteen of 193 potentially relevant trials met the inclusion criteria; however, their methodological qualities were low. Comparison of the same intervention strategies revealed significant differences in total effectiveness rates between EA-TCM and conventional therapy groups (RR = 1.22, 95% confidence interval [CI] = 1.16–1.29, andP<0.00001). Compared to conventional therapy, EA-TCM combined with conventional therapy had a superior total effectiveness rate (RR = 1.11, 95% CI = 1.04–1.19, andP=0.003). There were no significant differences in recurrence rates during followup and final pain measurements between the experimental and those in the control groups (RR = 0.86, 95% CI = 0.31–2.39, andP=0.85; MD −0.75, 95% CI = −2.15–0.65, andP=0.29).Conclusion. The evidence that EA-TCM is an effective treatment for venous ulcers is encouraging, but not conclusive due to the low methodological quality of the RCTs. Therefore, more high-quality RCTs with larger sample sizes are required.

scholarly journals Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246416
Author(s):  
Mingzhu Ma ◽  
Liangxu Wang ◽  
Wenjing Huang ◽  
Xiaoni Zhong ◽  
Longfei Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Subgroup Analysis ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Meta Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for statistical analysis. The standardized mean difference (SMD) and 95% confidence interval (95% CI) were calculated by a random effect model to estimate the correlation. Publication bias was assessed using the Begg and Egger tests. The stability of these results was evaluated using sensitivity analyses. Results Fifteen studies were included with a total sample size of 11382, including 7597 participants in the high uric acid group and 3785 in the control group, on the basis of the inclusion and exclusion criteria. According to the evaluation of the JBI scale, the literature was of high quality. The average age ranged from 42 to 74. Meta-analysis showed that CIMT in the high uric acid group was significantly higher than that in the control group (SMD = 0.53, 95% CI: [0.38, 0.68]), and the difference was significant (z = 6.98, P < 0.00001). The heterogeneity among the 15 articles was obvious (I2 = 89%, P < 0.00001). Subgroup analysis by disease status illustrated a positive relationship between SUA and CIMT in healthy people and people with diseases. SUA was shown to be positively correlated with CIMT in people aged 45–60 years and ≥60 years by subgroup analysis by age. SUA was also found to be positively correlated with CIMT in a population with BMI>24 kg/m2 by subgroup analysis by BMI. In addition, subgroup analysis of other risk factors for CIMT, including TC, SBP, DBP, triglycerides, and LDL-C, all showed a positive correlation between SUA and CIMT. Conclusions There is a significant correlation between serum uric acid level and carotid intima-media thickness, and a high concentration of serum uric acid is related to carotid artery intima-media thickness.

The Effect of Uric Acid Level, Hyperuricemia and Gout on the Risk of Type 2 Diabetes: A Meta-Analysis of Cohort Studies

2020 ◽  
Author(s):  
Yuchai Huang ◽  
Yong Gan ◽  
Wei Xiong ◽  
Yiling Lou ◽  
Chuangliang Qiu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Cohort Studies ◽  
Uric Acid Level ◽  
Acid Level ◽  
Meta Analysis

Relationship Between Blood Uric Acid Level and Personality Traits

1990 ◽  
Vol 39 (1) ◽  
pp. 117-122 ◽  
Author(s):  
S. Ooki ◽  
K. Yamada ◽  
A. Asaka
Keyword(s):  
Uric Acid ◽  
Personality Traits ◽  
Uric Acid Level ◽  
Acid Level ◽  
Intraclass Correlation ◽  
Blood Uric Acid ◽  
Males And Females ◽  
Mz Twins ◽  
The Relationship ◽  
High Uric Acid

AbstractThe present study deals with the relationship between blood uric acid level and human behavior. Subjects were 37 MZ and 7 DZ twins aged from 18 to 45 years. In males, blood uric acid level increased with age, while it decreased with age in females. Blood uric acid level was corrected and standardized using regression lines separately for males and females. The distribution of standardized uric acid level corresponded well with the theoretical curve of normal distribution. The intraclass correlation coefficient for standardized uric acid level was r = 0.370 (P < 0.05) for the 37 MZ twins, but not significant for the 7 DZ twins. These findings suggest that blood uric acid level is genetically controlled. By the analysis of 12 personality traits in YG (Yatabe-Guilford) character test, it was revealed that “General activity” was more controlled by genetically than environmentally. In the evaluation of the correlation between standardized uric acid level and the YG 12 personality traits, significant correlation was observed in “Lack of agreeableness” and “Rhathymia”. Since these two personality traits include the factor of “activity”, it is concluded that the plasma uric acid level and activity in a broader sense are under genetic control. This conclusion is consistent with the generally accepted view that persons with high uric acid level are more active and energetic than those with low level.

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