This chapter examines the multi-scale nature of biological materials. It is shown that this characteristic motivated several design attempts within the field of tribological surfaces. These designs were not easy to implement because of a lack of technological means. Until the push for nanoscale material manipulation, many designs, although conceived and conceptually verified, were not technologically possible. The leap in technologies that matured within the past decade resurrected efforts to manufacture many discarded designs on a commercial scale. The material within this chapter presents samples of existing bio-inspired tribological surfaces. The examples are either a direct replica of the bio-analogue or represent a modification of the surface through a combination of chemical and geometrical changes.