scholarly journals SPECIFIC ALLERGEN IMMUNOTHERAPY RESULTS IN CHILDREN WITH ASTHMA DUE TO POLLENS ALLERGY. CLINICAL STUDY

2016 ◽  
Vol 63 (2) ◽  
pp. 178-182
Author(s):  
Georgeta Sinitchi ◽  
◽  
Aurica Rugina ◽  
Smaranda Diaconescu ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Asthma ◽  
Grass Pollen ◽  
Allergen Immunotherapy ◽  
Life Assessment ◽  
Medical Needs ◽  
Careful Clinical Examination ◽  
Children With Asthma ◽  
Specific Allergen

Introduction. Specific allergen immunotherapy (STI) is the causal treatment of asthma. SIT gives a specific response to the changing LT response (deviation of the immune response), induction of anergy (decrease of LTh2), induces tolerance and modifies the inflammatory response. Pollen produces in our country seasonal allergic asthma in children and adults. Materials and methods. Our study was conducted using grass pollen extracts and comprised a total of 47 children with asthma, allergic to pollens, aged 5-14. Administration was seasonal (November to April), oral (sublingual solutions). It was indicated in the treatment of children with asthma and rhinitis with definite diagnosis where eviction was not possible. There have been previously detailed history and a careful clinical examination, skin prick tests to pollens with intense response, more elevated IgE, and spirometry confirming bronchospasm. Grass pollen extracts with initial low doses were used, gradually increasing the amount and concentration, and a gradual decrease, at a total of 6 months per year, with a duration of three years. Discussion. The evaluation was performed by clinical follow-up (symptom score and drug consumption), spirometry and by improving the quality of life assessment. There were no serious side effects during treatment. Conclusion. SIT in children with pollens allergic asthma is the causal therapeutic method; treating asthmatic children over 3 years old; reduces asthma symptoms to extinction; decreases other medical needs; improves quality of life of the child; no side effect were distinguished.

scholarly journals Impact of subcutaneous specific-allergen immunotherapy in the quality of life of brazilian moderate/severe atopic dermatitis patients

2015 ◽  
Vol 8 ◽  
pp. A74
Author(s):  
Ana Julia Teixeira ◽  
Luciana Kase Tanno ◽  
Luciana Kase Tanno ◽  
Romero Kopke ◽  
Cintia Bassani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Allergen Immunotherapy ◽  
Severe Atopic Dermatitis ◽  
Specific Allergen

Long-term efficacy of injected allergen immunotherapy for treatment of grass pollen allergy in elderly patients with allergic rhinitis

2020 ◽  
Vol 41 (4) ◽  
pp. 271-277
Author(s):  
Andrzej Bozek ◽  
Anna Cudak ◽  
Giorgio Walter Canonica
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Placebo Group ◽  
Elderly Patients ◽  
Grass Pollen ◽  
Allergen Immunotherapy ◽  
Pollen Allergy ◽  
Life Questionnaire ◽  
Grass Pollen Allergy

Background: The effect of prolonged allergen immunotherapy is still insufficiently known, especially in elderly patients. Objective: The effect after a 3-year course of injected allergen-specific immunotherapy (AIT) for grass pollen allergy in elderly patients with allergic rhinitis was observed. Methods: Thirty-eight elderly patients (mean ± standard deviation, 66.2 ± 2.7 years old) who received preseasonal injected AIT or placebo for grass pollen allergy were monitored for 3 years and compared with a placebo group. The combined symptom medication score (CSMS), serum level of immunoglobulin G4 (IgG4) to phleum pratense 5 (Phl p5) and quality of life were assessed immediately after AIT and 3 years later. Results: After AIT, the CSMS was significantly decreased from 2.15 (range, 1.27‐3.00) to 1.13 (range, 0.79‐1.36) (p = 0.03) and remained lower (1.41 ± 0.72 versus 2.41 ± 1.11) than that in the placebo group during the 3 years after AIT. Serum-specific IgG4 against increased during the course of AIT and remained at a high level during further observation. Quality of life, based on the Rhinoconjunctivitis Quality of Life Questionnaire, was significantly decreased in the patients who received AIT from 1.51 (95% confidence interval [CI], 1.21‐1.84) to 1.01 (95% CI, 0.93‐1.87) (p < 0.05) and was decreased to 0.97‐1.26 (95% CI, 0.88‐1.82) during the 3 years after discontinuation of AIT. Conclusion: A prolonged positive effect after AIT for grass pollen allergy was observed in elderly patients with allergic rhinitis. Further trials are needed to confirm this effect.Clinical trial MC56871/12, <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">www.clinicaltrials.gov</ext-link>.

scholarly journals Quality of life of patients undergoing specific allergen immunotherapy in allergic rhinitis

2020 ◽  
Vol 27 (4) ◽  
pp. 657-663
Author(s):  
Magdalena Brodowicz-Król ◽  
Ewa Guz ◽  
Dorota Hawryluk ◽  
Ewa Kulbaka ◽  
Lech Panasiuk ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Allergen Immunotherapy ◽  
Specific Allergen

scholarly journals Selected aspects of patients’ functioning before and after desensitization with specific allergen immunotherapy

2019 ◽  
Vol 18 (4) ◽  
pp. 202-206
Author(s):  
Ewa Kawalec-Kajstura ◽  
Magdalena Chomicka ◽  
Joanna Sułkowska ◽  
Grażyna Puto ◽  
Ilona Kuźmicz
Keyword(s):  
Quality Of Life ◽  
Life Satisfaction ◽  
Allergen Immunotherapy ◽  
Allergic Diseases ◽  
Well Being ◽  
Health Care Facilities ◽  
Everyday Functioning ◽  
Strict Adherence ◽  
Specific Allergen

AbstractIntroduction. Allergic diseases belong to the most important health problems responsible for the incidence of various types of discomfort. The application of specific allergen therapy (SAI) is becoming a more and more frequent method aimed at treating allergic diseases. However, this approach requires a strict adherence to medical treatment, which may affect patients’ quality of life.Aim. Assessment of quality of life and everyday functioning in the group of patients who underwent a specific allergen therapy.Material and methods. The study group consisted of 80 adult patients who decided to undergo SAI treatment and were treated in two health care facilities in Małopolska region. The study included an assessment of life quality and selected aspects of functioning (as well as their retrospective assessment). As far as the applied methods are concerned, the study was based on the authors’ own questionnaire and an abbreviated version of the World Organization Quality of Life-BREF questionnaire.Results. SAI treatment made it possible to reduce both the incidence (Me=4.00 to 2.00; p<0.001) and intensity (Me=4.00 to 2.00; p<0.001) of allergic symptoms. Also the discomfort caused by the allergy was decreased (Me=4.00 to 2.00; p<0.001). Moreover, some improvement in general well-being (Me=4.00 to 5.00; p<0.001) and life satisfaction (Me=4.00 to 5.00; p<0.001) was observed.Conclusions. Specific allergen immunotherapy seems to be worth considering as it improves patients’ life satisfaction and reduces discomfort caused by the allergy itself.

Quality of Life of Patients Subjected to Specific Allergen Immunotherapy

2017 ◽  
Vol 1 (1) ◽  
pp. 48-58
Author(s):  
Barbara Kubik ◽  
Urszula Romanowska ◽  
Elżbieta Bednarz
Keyword(s):  
Quality Of Life ◽  
Allergen Immunotherapy ◽  
Human Life ◽  
Allergic Diseases ◽  
Well Being ◽  
Sf 36 ◽  
Positive Assessment ◽  
Length Of Therapy ◽  
Specific Allergen

<b>Introduction:</b> At present, allergic diseases are some of the most common chronic diseases affecting all spheres of human life. The only form of causative treatment of allergic diseases, apart from elimination of the sensitizing factor, is the specific allergen immunotherapy. The symptoms of allergic diseases can cause a number of consequences, including reduction of patient activity, negatively affect social relationships, ways of spending free time, and also cause sleep disorders. Assessing the quality of life in allergic diseases provides us with knowledge of the patient’s psychological and social functioning, and is a valuable addition to the review of the effectiveness of treatment for allergic diseases, allowing us to assess the patient’s overall well-being. <br/><b>Aim of the study:</b> The aim of the study was to evaluate the quality of life of patients using specific allergen immunotherapy. <br/><b>Material and methods:</b> 128 subjects were included in the study, but 100 questionnaires were used for the analysis. The study group was comprised of patients undergoing specific allergen immunotherapy over the age of 18 years. In this paper a diagnostic survey was used as a research method. The tools used are the standard questionnaire SF-36 and the questionnaire survey. <br/><b>Results:</b> In the present study, it was observed that the overall quality of life of people affected by allergic diseases, as measured by the SF-36 questionnaire, can be assessed as quite good. Respondents subjected to specific allergen immunotherapy consider this method of treatment positively influencing their health as they reduce the symptoms of allergies. As many as 91% of the respondents think that specific immunotherapy affects them to reduce the symptoms of allergies. It has also been shown that the length of therapy has no effect on reducing the symptoms of allergies. <br/><b>Conclusions:</b> The overall quality of life of patients is quite good, best evaluated in the domains of physical fitness, limitation of activity caused by emotional problems and changes in health status. Researchers positively evaluate the effect of immunotherapy on their health as it reduces the symptoms of allergies. Respondents have little knowledge about how to prevent exposure to allergens. Despite a positive assessment of the effectiveness of immunotherapy, the vast majority of respondents feel the need for additional antihistamines.

Methods for quality of life assessment in children with orphanic diseases

2020 ◽  
Vol 28 (Special Issue) ◽  
Author(s):  
Makarova E. V. ◽  
◽  
Krysanov I. S. ◽  
Vasilyeva T. P. ◽  
Alexandrova O. Yu. ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Life Assessment ◽  
Quality Of Life Assessment

Histamine metabolism disorder in pathogenesis of chronic pelvic pain in patients with external genital endometriosis

2017 ◽  
pp. 56-60
Author(s):  
М.Р. Оразов ◽  
В.Е. Радзинский ◽  
М.Б. Хамошина ◽  
Е.Н. Носенко ◽  
Э.С. Токаева ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pelvic Pain ◽  
Peripheral Blood ◽  
Chronic Pelvic Pain ◽  
Pain Syndrome ◽  
Histamine Level ◽  
Life Assessment ◽  
Assay Method ◽  
Histamine Metabolism

Цель исследования - изучение особенностей обмена гистамина при хронической тазовой боли у пациенток с наружным генитальным эндометриозом. Методика. В сыворотке крови 100 пациенток методом высокоточного (в нг/мл) иммуноферментного твердофазного анализа определяли концентрацию гистамина. Использованы реактивы «Histamine ЕLISA», аппарат BAE-1000 Гистамин (Labor Diagnostika Nord - LDN, Германия). Оценка выраженности болевого синдрома осуществлялась по шкале ВАШ, оценка качества жизни - на основании опросника для оценки качества жизни при эндометриозе (EHR-30), оценка тревожности - опросника Спилбергера-Ханина. Результаты. Показано статистически значимое повышение уровня гистамина у пациенток с высокой интенсивностью болевого синдрома. Женщины с наружным генитальным эндометриозом, сопровождающимся интенсивным болевым синдромом в 100% случаев обнаруживали высокие уровни ситуативной и личностной тревожности, тогда как, лишь у 40% женщин (n = 16) контрольной группы выявлен умеренный уровень тревожности. Депрессивные расстройства выявлены у 58,3% женщин с хронической тазовой болью (n = 35), из них основную часть (n = 20) составили женщины с выраженной степенью болевого синдрома по ВАШ. Заключение. Психоэмоциональное состояние женщин с тазовой болью, ассоциированной с наружным генитальным эндометриозом, характеризуется высокими уровнями депрессивных и тревожных расстройств, значительным снижением уровня качества жизни. Выявлена прямая связь между интенсивностью болевого синдрома и уровнем гистамина в периферической крови пациенток с наружным генитальным эндометриозом. Objective. To study features of histamine metabolism in patients with chronic pelvic pain associated with external genital endometriosis. Methods. For quantitative assessment of histamine level in peripheral blood was taken from 100 patients which than was centrifuged. In blood serum histamine concentration was determined by enzyme-linked immunosorbent assay method with reagents «Histamine ЕLISA» on the machine BAE-1000 Histamine (Labor Diagnostika Nord - LDN, Hermany). A pain syndrome was assessed by Visual Analog Scale (VAS), quality of life assessment - by Endometriosis Health Profile Questionnaire (EHR-30), level of anxiety was determined by Spielberger-Khanin questionnaire. The results. Showed statistically higher histamine level in patients with severe pain according to VAS. After assessment of results obtained from Spielberger-Khanin questionnaire 100% experimental group’s women with external genital endometriosis (n = 60) were noted to be have high level of state and trait anxiety, then 40% women of control group (n = 16) have moderate level of anxiety. The incidence of depression in women with chronic pelvic pain was 58.3% (n = 35) and the main part (n = 20) were women with severe stage of pelvic pain according to VAS. Conclusions. Psycho emotional condition of women with external genital endometriosis associated pelvic pain characterized by higher depression and anxiety levels, with significant decrease quality of life. Direct relationship also was found between pain syndrome intensity and histamine level in peripheral blood in patients with external genital endometriosis.

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