Quality of life of patients undergoing specific allergen  immunotherapy in allergic rhinitis

Introduction. Specific allergen immunotherapy (STI) is the causal treatment of asthma. SIT gives a specific response to the changing LT response (deviation of the immune response), induction of anergy (decrease of LTh2), induces tolerance and modifies the inflammatory response. Pollen produces in our country seasonal allergic asthma in children and adults. Materials and methods. Our study was conducted using grass pollen extracts and comprised a total of 47 children with asthma, allergic to pollens, aged 5-14. Administration was seasonal (November to April), oral (sublingual solutions). It was indicated in the treatment of children with asthma and rhinitis with definite diagnosis where eviction was not possible. There have been previously detailed history and a careful clinical examination, skin prick tests to pollens with intense response, more elevated IgE, and spirometry confirming bronchospasm. Grass pollen extracts with initial low doses were used, gradually increasing the amount and concentration, and a gradual decrease, at a total of 6 months per year, with a duration of three years. Discussion. The evaluation was performed by clinical follow-up (symptom score and drug consumption), spirometry and by improving the quality of life assessment. There were no serious side effects during treatment. Conclusion. SIT in children with pollens allergic asthma is the causal therapeutic method; treating asthmatic children over 3 years old; reduces asthma symptoms to extinction; decreases other medical needs; improves quality of life of the child; no side effect were distinguished.

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Allergic rhinitis and quality of life after one year of allergen immunotherapy

Journal of Allergy and Clinical Immunology ◽

10.1016/s0091-6749(02)81482-8 ◽

2002 ◽

Vol 109 (1) ◽

pp. S121-S121

Author(s):

S Echechipia ◽

BE Garcia ◽

MT Lizaso ◽

MT Aldunate ◽

JM Olaguibel ◽

...

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Allergen Immunotherapy ◽

One Year

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Reduced work/academic performance and quality of life in patients with allergic rhinitis and impact of allergen immunotherapy

Allergy Asthma & Clinical Immunology ◽

10.1186/s13223-016-0146-9 ◽

2016 ◽

Vol 12 (1) ◽

Cited By ~ 11

Author(s):

A. Roger ◽

E. Arcalá Campillo ◽

M. C. Torres ◽

C. Millan ◽

I. Jáuregui ◽

...

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Academic Performance ◽

Allergen Immunotherapy

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Treatment strategy of allergic rhinitis in the face of modern world threats

Otolaryngologia Polska ◽

10.5604/01.3001.0011.8057 ◽

2018 ◽

Vol 72 (2) ◽

pp. 1-12 ◽

Cited By ~ 4

Author(s):

Piotr Rapiejko ◽

Dariusz Jurkiewicz ◽

Wioletta Pietruszewska ◽

Beata Zielnik-Jurkiewicz ◽

Jarosław Woroń ◽

...

Keyword(s):

Allergic Rhinitis ◽

Allergen Immunotherapy ◽

Modern World ◽

Proper Treatment ◽

Treatment Persistence ◽

Factors Affecting ◽

The Face ◽

Selection Of ◽

Specific Allergen

Allergic rhinitis (AR) is the most common form of allergy, which - as epidemiological research has shown - applies to nearly 25% of the population. AR significantly affects the quality of life of the patient, and the more severe the disease, the greater the risk of developing bronchial asthma. One of the factors affecting the severity of symptoms and the degree of their control is air pollution. In some patients, despite proper treatment, persistence or only partial remission of symptoms (uncontrolled allergic rhinitis) is observed. This can lead to an increase in comorbidities - inflammation of the paranasal sinuses, otitis media and asthma - both in children and in adults. The treatment of allergic rhinitis, in accordance with the standards, consists in: education of the patient, elimination of the allergen from the environment and factors intensifying the course of the disease, selection of proper pharmacotherapy and specific allergen immunotherapy. Many factors influence the selection of the antihistamine used, e.g., the opportunity of safe increase of the dosage.

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Long-term efficacy of injected allergen immunotherapy for treatment of grass pollen allergy in elderly patients with allergic rhinitis

Allergy and Asthma Proceedings ◽

10.2500/aap.2020.41.200035 ◽

2020 ◽

Vol 41 (4) ◽

pp. 271-277

Author(s):

Andrzej Bozek ◽

Anna Cudak ◽

Giorgio Walter Canonica

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Placebo Group ◽

Elderly Patients ◽

Grass Pollen ◽

Allergen Immunotherapy ◽

Pollen Allergy ◽

Life Questionnaire ◽

Grass Pollen Allergy

Background: The effect of prolonged allergen immunotherapy is still insufficiently known, especially in elderly patients. Objective: The effect after a 3-year course of injected allergen-specific immunotherapy (AIT) for grass pollen allergy in elderly patients with allergic rhinitis was observed. Methods: Thirty-eight elderly patients (mean ± standard deviation, 66.2 ± 2.7 years old) who received preseasonal injected AIT or placebo for grass pollen allergy were monitored for 3 years and compared with a placebo group. The combined symptom medication score (CSMS), serum level of immunoglobulin G4 (IgG4) to phleum pratense 5 (Phl p5) and quality of life were assessed immediately after AIT and 3 years later. Results: After AIT, the CSMS was significantly decreased from 2.15 (range, 1.27‐3.00) to 1.13 (range, 0.79‐1.36) (p = 0.03) and remained lower (1.41 ± 0.72 versus 2.41 ± 1.11) than that in the placebo group during the 3 years after AIT. Serum-specific IgG4 against increased during the course of AIT and remained at a high level during further observation. Quality of life, based on the Rhinoconjunctivitis Quality of Life Questionnaire, was significantly decreased in the patients who received AIT from 1.51 (95% confidence interval [CI], 1.21‐1.84) to 1.01 (95% CI, 0.93‐1.87) (p < 0.05) and was decreased to 0.97‐1.26 (95% CI, 0.88‐1.82) during the 3 years after discontinuation of AIT. Conclusion: A prolonged positive effect after AIT for grass pollen allergy was observed in elderly patients with allergic rhinitis. Further trials are needed to confirm this effect.Clinical trial MC56871/12, <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">www.clinicaltrials.gov</ext-link>.

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Impact of Allergen Immunotherapy on Quality of Life and Health Care Costs in Adults and Children With Grass Pollen-Induced Allergic Rhinitis in Germany

Value in Health ◽

10.1016/j.jval.2014.08.2064 ◽

2014 ◽

Vol 17 (7) ◽

pp. A597

Author(s):

M. Najib ◽

K.Y. Westerhout ◽

B. Verheggen ◽

C.H. Schreder

Keyword(s):

Quality Of Life ◽

Health Care ◽

Allergic Rhinitis ◽

Health Care Costs ◽

Grass Pollen ◽

Allergen Immunotherapy ◽

Adults And Children ◽

Care Costs

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Selected aspects of patients’ functioning before and after desensitization with specific allergen immunotherapy

Pielegniarstwo XXI wieku / Nursing in the 21st Century ◽

10.2478/pielxxiw-2019-0033 ◽

2019 ◽

Vol 18 (4) ◽

pp. 202-206

Author(s):

Ewa Kawalec-Kajstura ◽

Magdalena Chomicka ◽

Joanna Sułkowska ◽

Grażyna Puto ◽

Ilona Kuźmicz

Keyword(s):

Quality Of Life ◽

Life Satisfaction ◽

Allergen Immunotherapy ◽

Allergic Diseases ◽

Well Being ◽

Health Care Facilities ◽

Everyday Functioning ◽

Strict Adherence ◽

Specific Allergen

AbstractIntroduction. Allergic diseases belong to the most important health problems responsible for the incidence of various types of discomfort. The application of specific allergen therapy (SAI) is becoming a more and more frequent method aimed at treating allergic diseases. However, this approach requires a strict adherence to medical treatment, which may affect patients’ quality of life.Aim. Assessment of quality of life and everyday functioning in the group of patients who underwent a specific allergen therapy.Material and methods. The study group consisted of 80 adult patients who decided to undergo SAI treatment and were treated in two health care facilities in Małopolska region. The study included an assessment of life quality and selected aspects of functioning (as well as their retrospective assessment). As far as the applied methods are concerned, the study was based on the authors’ own questionnaire and an abbreviated version of the World Organization Quality of Life-BREF questionnaire.Results. SAI treatment made it possible to reduce both the incidence (Me=4.00 to 2.00; p<0.001) and intensity (Me=4.00 to 2.00; p<0.001) of allergic symptoms. Also the discomfort caused by the allergy was decreased (Me=4.00 to 2.00; p<0.001). Moreover, some improvement in general well-being (Me=4.00 to 5.00; p<0.001) and life satisfaction (Me=4.00 to 5.00; p<0.001) was observed.Conclusions. Specific allergen immunotherapy seems to be worth considering as it improves patients’ life satisfaction and reduces discomfort caused by the allergy itself.

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Quality of Life of Patients Subjected to Specific Allergen Immunotherapy

Health Promotion & Physical Activity ◽

10.5604/01.3001.0010.7589 ◽

2017 ◽

Vol 1 (1) ◽

pp. 48-58

Author(s):

Barbara Kubik ◽

Urszula Romanowska ◽

Elżbieta Bednarz

Keyword(s):

Quality Of Life ◽

Allergen Immunotherapy ◽

Human Life ◽

Allergic Diseases ◽

Well Being ◽

Sf 36 ◽

Positive Assessment ◽

Length Of Therapy ◽

Specific Allergen

Introduction: At present, allergic diseases are some of the most common chronic diseases affecting all spheres of human life. The only form of causative treatment of allergic diseases, apart from elimination of the sensitizing factor, is the specific allergen immunotherapy. The symptoms of allergic diseases can cause a number of consequences, including reduction of patient activity, negatively affect social relationships, ways of spending free time, and also cause sleep disorders. Assessing the quality of life in allergic diseases provides us with knowledge of the patient’s psychological and social functioning, and is a valuable addition to the review of the effectiveness of treatment for allergic diseases, allowing us to assess the patient’s overall well-being. Aim of the study: The aim of the study was to evaluate the quality of life of patients using specific allergen immunotherapy. Material and methods: 128 subjects were included in the study, but 100 questionnaires were used for the analysis. The study group was comprised of patients undergoing specific allergen immunotherapy over the age of 18 years. In this paper a diagnostic survey was used as a research method. The tools used are the standard questionnaire SF-36 and the questionnaire survey. Results: In the present study, it was observed that the overall quality of life of people affected by allergic diseases, as measured by the SF-36 questionnaire, can be assessed as quite good. Respondents subjected to specific allergen immunotherapy consider this method of treatment positively influencing their health as they reduce the symptoms of allergies. As many as 91% of the respondents think that specific immunotherapy affects them to reduce the symptoms of allergies. It has also been shown that the length of therapy has no effect on reducing the symptoms of allergies. Conclusions: The overall quality of life of patients is quite good, best evaluated in the domains of physical fitness, limitation of activity caused by emotional problems and changes in health status. Researchers positively evaluate the effect of immunotherapy on their health as it reduces the symptoms of allergies. Respondents have little knowledge about how to prevent exposure to allergens. Despite a positive assessment of the effectiveness of immunotherapy, the vast majority of respondents feel the need for additional antihistamines.

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